SOCS3 (suppressor of cytokine signaling 3)

Gene

• Entrez ID: 9021
• Gene name: Suppressor of cytokine signaling 3
• Gene symbol: SOCS3
• Synonyms: ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3
• Chromosome: 17
• Chromosome location: 17q25.3
• Summary: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005062	hsa-miR-203a-3p	Immunohistochemistry, In situ hybridization, Microarray, Western blot	17622355
MIRT005062	hsa-miR-203a-3p	Luciferase reporter assay, qRT-PCR, Western blot	22207897
MIRT005062	hsa-miR-203a-3p	Luciferase reporter assay, qRT-PCR, Western blot	22207897
MIRT007129	hsa-miR-30c-5p	qRT-PCR	23418453
MIRT054389	hsa-let-7f-5p	Luciferase reporter assay	22894925
MIRT005062	hsa-miR-203a-3p	ELISA, qRT-PCR	23775225
MIRT438883	hsa-miR-155-5p	qRT-PCR	23428672
MIRT438546	hsa-miR-221-3p	Luciferase reporter assay, Western blot	25019494
MIRT438546	hsa-miR-221-3p	Luciferase reporter assay, Western blot	25019494
MIRT438094	hsa-miR-19a-3p	Luciferase reporter assay	23894411
MIRT438094	hsa-miR-19a-3p	Luciferase reporter assay	23894411
MIRT438883	hsa-miR-155-5p	qRT-PCR	23428672
MIRT438546	hsa-miR-221-3p	Luciferase reporter assay, Western blot	25019494
MIRT438546	hsa-miR-221-3p	Luciferase reporter assay, Western blot	25019494
MIRT438094	hsa-miR-19a-3p	Luciferase reporter assay	23894411
MIRT438094	hsa-miR-19a-3p	Luciferase reporter assay	23894411
MIRT534120	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT534119	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT534118	hsa-miR-520f-3p	PAR-CLIP	22012620
MIRT534117	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT534116	hsa-miR-512-3p	PAR-CLIP	22012620
MIRT534115	hsa-miR-4473	PAR-CLIP	22012620
MIRT534114	hsa-miR-4795-3p	PAR-CLIP	22012620
MIRT534113	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT467411	hsa-miR-30b-5p	PAR-CLIP	23592263
MIRT467410	hsa-miR-30a-5p	PAR-CLIP	23592263
MIRT007129	hsa-miR-30c-5p	PAR-CLIP	23592263
MIRT467409	hsa-miR-30d-5p	PAR-CLIP	23592263
MIRT467408	hsa-miR-30e-5p	PAR-CLIP	23592263
MIRT467407	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT467406	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT467405	hsa-miR-8062	PAR-CLIP	23592263
MIRT467404	hsa-miR-126-5p	PAR-CLIP	23592263
MIRT467403	hsa-miR-759	PAR-CLIP	23592263
MIRT467401	hsa-miR-4765	PAR-CLIP	23592263
MIRT467402	hsa-miR-508-3p	PAR-CLIP	23592263
MIRT467400	hsa-miR-4477a	PAR-CLIP	23592263
MIRT467399	hsa-miR-6765-5p	PAR-CLIP	23592263
MIRT467398	hsa-miR-1304-5p	PAR-CLIP	23592263
MIRT438094	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT726475	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT007129	hsa-miR-30c-5p	ELISA, Luciferase reporter assay, qRT-PCR, Western blot	26707189
MIRT732459	hsa-miR-4449	Luciferase reporter assay, qRT-PCR, Western blotting	33854373
MIRT467408	hsa-miR-30e-5p	Luciferase reporter assay, Immunoprecipitaion (IP), ELISA	32688283
MIRT735666	hsa-miR-324-5p	Luciferase reporter assay, Western blotting, qRT-PCR, ELISA	33191336
MIRT726475	hsa-miR-19b-3p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR	31667786
MIRT534120	hsa-miR-340-5p	PAR-CLIP	22012620
MIRT534119	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT534118	hsa-miR-520f-3p	PAR-CLIP	22012620
MIRT534117	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT534116	hsa-miR-512-3p	PAR-CLIP	22012620
MIRT534115	hsa-miR-4473	PAR-CLIP	22012620
MIRT534114	hsa-miR-4795-3p	PAR-CLIP	22012620
MIRT534113	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT467411	hsa-miR-30b-5p	PAR-CLIP	23592263
MIRT467410	hsa-miR-30a-5p	PAR-CLIP	23592263
MIRT007129	hsa-miR-30c-5p	PAR-CLIP	23592263
MIRT467409	hsa-miR-30d-5p	PAR-CLIP	23592263
MIRT467408	hsa-miR-30e-5p	PAR-CLIP	23592263
MIRT467407	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT467406	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT467405	hsa-miR-8062	PAR-CLIP	23592263
MIRT467404	hsa-miR-126-5p	PAR-CLIP	23592263
MIRT467403	hsa-miR-759	PAR-CLIP	23592263
MIRT467401	hsa-miR-4765	PAR-CLIP	23592263
MIRT467402	hsa-miR-508-3p	PAR-CLIP	23592263
MIRT467400	hsa-miR-4477a	PAR-CLIP	23592263
MIRT467399	hsa-miR-6765-5p	PAR-CLIP	23592263
MIRT467398	hsa-miR-1304-5p	PAR-CLIP	23592263
MIRT755584	hsa-miR-181a	Luciferase reporter assay, Western blotting, qRT-PCR	34873301
MIRT755584	hsa-miR-181a	Luciferase reporter assay, Western blotting, qRT-PCR	34873301
MIRT726475	hsa-miR-19b-3p	Luciferase reporter assay, Western blotting, qRT-PCR	36484970
MIRT1378519	hsa-miR-1266	CLIP-seq
MIRT1378520	hsa-miR-1290	CLIP-seq
MIRT1378521	hsa-miR-1291	CLIP-seq
MIRT1378522	hsa-miR-148a	CLIP-seq
MIRT1378523	hsa-miR-148b	CLIP-seq
MIRT1378524	hsa-miR-152	CLIP-seq
MIRT1378525	hsa-miR-1827	CLIP-seq
MIRT1378526	hsa-miR-183	CLIP-seq
MIRT1378527	hsa-miR-1908	CLIP-seq
MIRT1378528	hsa-miR-19a	CLIP-seq
MIRT1378529	hsa-miR-19b	CLIP-seq
MIRT1378530	hsa-miR-203	CLIP-seq
MIRT1378531	hsa-miR-216b	CLIP-seq
MIRT1378532	hsa-miR-2467-3p	CLIP-seq
MIRT1378533	hsa-miR-2861	CLIP-seq
MIRT1378534	hsa-miR-3202	CLIP-seq
MIRT1378535	hsa-miR-3529	CLIP-seq
MIRT1378536	hsa-miR-3612	CLIP-seq
MIRT1378537	hsa-miR-3663-3p	CLIP-seq
MIRT1378538	hsa-miR-3664-3p	CLIP-seq
MIRT1378539	hsa-miR-378g	CLIP-seq
MIRT1378540	hsa-miR-379	CLIP-seq
MIRT1378541	hsa-miR-383	CLIP-seq
MIRT1378542	hsa-miR-3927	CLIP-seq
MIRT1378543	hsa-miR-4269	CLIP-seq
MIRT1378544	hsa-miR-4270	CLIP-seq
MIRT1378545	hsa-miR-4271	CLIP-seq
MIRT1378546	hsa-miR-4278	CLIP-seq
MIRT1378547	hsa-miR-4292	CLIP-seq
MIRT1378548	hsa-miR-4313	CLIP-seq
MIRT1378549	hsa-miR-4420	CLIP-seq
MIRT1378550	hsa-miR-4427	CLIP-seq
MIRT1378551	hsa-miR-4437	CLIP-seq
MIRT1378552	hsa-miR-4441	CLIP-seq
MIRT1378553	hsa-miR-4443	CLIP-seq
MIRT1378554	hsa-miR-4455	CLIP-seq
MIRT1378555	hsa-miR-4476	CLIP-seq
MIRT1378556	hsa-miR-4477b	CLIP-seq
MIRT1378557	hsa-miR-450b-3p	CLIP-seq
MIRT1378558	hsa-miR-4512	CLIP-seq
MIRT1378559	hsa-miR-4514	CLIP-seq
MIRT1378560	hsa-miR-4518	CLIP-seq
MIRT1378561	hsa-miR-4674	CLIP-seq
MIRT1378562	hsa-miR-4680-3p	CLIP-seq
MIRT1378563	hsa-miR-4692	CLIP-seq
MIRT1378564	hsa-miR-4716-3p	CLIP-seq
MIRT1378565	hsa-miR-4723-5p	CLIP-seq
MIRT1378566	hsa-miR-4725-3p	CLIP-seq
MIRT1378567	hsa-miR-4733-3p	CLIP-seq
MIRT1378568	hsa-miR-4742-5p	CLIP-seq
MIRT1378569	hsa-miR-4762-3p	CLIP-seq
MIRT1378570	hsa-miR-4772-5p	CLIP-seq
MIRT1378571	hsa-miR-498	CLIP-seq
MIRT1378572	hsa-miR-518a-5p	CLIP-seq
MIRT1378573	hsa-miR-524-3p	CLIP-seq
MIRT1378574	hsa-miR-525-3p	CLIP-seq
MIRT1378575	hsa-miR-527	CLIP-seq
MIRT1378576	hsa-miR-561	CLIP-seq
MIRT1378577	hsa-miR-591	CLIP-seq
MIRT1378578	hsa-miR-649	CLIP-seq
MIRT1378579	hsa-miR-650	CLIP-seq
MIRT1378580	hsa-miR-653	CLIP-seq
MIRT1378581	hsa-miR-663	CLIP-seq
MIRT1378582	hsa-miR-668	CLIP-seq
MIRT1378583	hsa-miR-769-3p	CLIP-seq
MIRT1378584	hsa-miR-890	CLIP-seq
MIRT2112968	hsa-miR-1203	CLIP-seq
MIRT1378522	hsa-miR-148a	CLIP-seq
MIRT1378523	hsa-miR-148b	CLIP-seq
MIRT1378524	hsa-miR-152	CLIP-seq
MIRT1378526	hsa-miR-183	CLIP-seq
MIRT2112969	hsa-miR-34a	CLIP-seq
MIRT2112970	hsa-miR-34c-5p	CLIP-seq
MIRT1378541	hsa-miR-383	CLIP-seq
MIRT2112971	hsa-miR-3938	CLIP-seq
MIRT1378544	hsa-miR-4270	CLIP-seq
MIRT1378547	hsa-miR-4292	CLIP-seq
MIRT2112972	hsa-miR-4308	CLIP-seq
MIRT1378549	hsa-miR-4420	CLIP-seq
MIRT1378552	hsa-miR-4441	CLIP-seq
MIRT2112973	hsa-miR-449a	CLIP-seq
MIRT2112974	hsa-miR-449b	CLIP-seq
MIRT1378559	hsa-miR-4514	CLIP-seq
MIRT2112975	hsa-miR-4691-5p	CLIP-seq
MIRT1378563	hsa-miR-4692	CLIP-seq
MIRT2112976	hsa-miR-4699-5p	CLIP-seq
MIRT2112977	hsa-miR-4709-3p	CLIP-seq
MIRT1378570	hsa-miR-4772-5p	CLIP-seq
MIRT1378576	hsa-miR-561	CLIP-seq
MIRT1378582	hsa-miR-668	CLIP-seq
MIRT2112978	hsa-miR-670	CLIP-seq
MIRT2335851	hsa-miR-1184	CLIP-seq
MIRT2335852	hsa-miR-1205	CLIP-seq
MIRT2335853	hsa-miR-1909	CLIP-seq
MIRT1378532	hsa-miR-2467-3p	CLIP-seq
MIRT2335854	hsa-miR-3158-5p	CLIP-seq
MIRT2335855	hsa-miR-3616-3p	CLIP-seq
MIRT1378537	hsa-miR-3663-3p	CLIP-seq
MIRT1378538	hsa-miR-3664-3p	CLIP-seq
MIRT1378544	hsa-miR-4270	CLIP-seq
MIRT2335856	hsa-miR-4274	CLIP-seq
MIRT1378548	hsa-miR-4313	CLIP-seq
MIRT2335857	hsa-miR-4436b-3p	CLIP-seq
MIRT1378552	hsa-miR-4441	CLIP-seq
MIRT1378558	hsa-miR-4512	CLIP-seq
MIRT2335858	hsa-miR-4532	CLIP-seq
MIRT2335859	hsa-miR-455-3p	CLIP-seq
MIRT2335860	hsa-miR-4651	CLIP-seq
MIRT1378571	hsa-miR-498	CLIP-seq
MIRT2335861	hsa-miR-544	CLIP-seq
MIRT2335862	hsa-miR-599	CLIP-seq
MIRT2335863	hsa-miR-608	CLIP-seq
MIRT2335864	hsa-miR-642b	CLIP-seq
MIRT2335865	hsa-miR-885-3p	CLIP-seq
MIRT1378533	hsa-miR-2861	CLIP-seq
MIRT1378536	hsa-miR-3612	CLIP-seq
MIRT1378546	hsa-miR-4278	CLIP-seq
MIRT1378548	hsa-miR-4313	CLIP-seq
MIRT1378558	hsa-miR-4512	CLIP-seq
MIRT1378564	hsa-miR-4716-3p	CLIP-seq
MIRT1378565	hsa-miR-4723-5p	CLIP-seq
MIRT2394948	hsa-miR-4726-3p	CLIP-seq
MIRT2394949	hsa-miR-4728-5p	CLIP-seq
MIRT2335862	hsa-miR-599	CLIP-seq
MIRT2335864	hsa-miR-642b	CLIP-seq
MIRT1378579	hsa-miR-650	CLIP-seq
MIRT1378520	hsa-miR-1290	CLIP-seq
MIRT1378528	hsa-miR-19a	CLIP-seq
MIRT1378529	hsa-miR-19b	CLIP-seq
MIRT1378530	hsa-miR-203	CLIP-seq
MIRT1378533	hsa-miR-2861	CLIP-seq
MIRT2433351	hsa-miR-331-3p	CLIP-seq
MIRT1378536	hsa-miR-3612	CLIP-seq
MIRT1378550	hsa-miR-4427	CLIP-seq
MIRT1378557	hsa-miR-450b-3p	CLIP-seq
MIRT1378558	hsa-miR-4512	CLIP-seq
MIRT1378562	hsa-miR-4680-3p	CLIP-seq
MIRT1378569	hsa-miR-4762-3p	CLIP-seq
MIRT1378571	hsa-miR-498	CLIP-seq
MIRT1378572	hsa-miR-518a-5p	CLIP-seq
MIRT1378575	hsa-miR-527	CLIP-seq
MIRT1378576	hsa-miR-561	CLIP-seq
MIRT1378579	hsa-miR-650	CLIP-seq
MIRT1378580	hsa-miR-653	CLIP-seq
MIRT1378583	hsa-miR-769-3p	CLIP-seq
MIRT1378584	hsa-miR-890	CLIP-seq
MIRT2335851	hsa-miR-1184	CLIP-seq
MIRT2440625	hsa-miR-1193	CLIP-seq
MIRT2335852	hsa-miR-1205	CLIP-seq
MIRT2440626	hsa-miR-1207-3p	CLIP-seq
MIRT2440627	hsa-miR-1226	CLIP-seq
MIRT2440628	hsa-miR-1236	CLIP-seq
MIRT2440629	hsa-miR-1265	CLIP-seq
MIRT2440630	hsa-miR-1321	CLIP-seq
MIRT1378522	hsa-miR-148a	CLIP-seq
MIRT1378523	hsa-miR-148b	CLIP-seq
MIRT1378524	hsa-miR-152	CLIP-seq
MIRT2440631	hsa-miR-1587	CLIP-seq
MIRT2440632	hsa-miR-1825	CLIP-seq
MIRT1378525	hsa-miR-1827	CLIP-seq
MIRT1378526	hsa-miR-183	CLIP-seq
MIRT1378527	hsa-miR-1908	CLIP-seq
MIRT2335853	hsa-miR-1909	CLIP-seq
MIRT2440633	hsa-miR-1915	CLIP-seq
MIRT2440634	hsa-miR-1976	CLIP-seq
MIRT2440635	hsa-miR-2392	CLIP-seq
MIRT1378532	hsa-miR-2467-3p	CLIP-seq
MIRT1378533	hsa-miR-2861	CLIP-seq
MIRT2440636	hsa-miR-299-3p	CLIP-seq
MIRT2440637	hsa-miR-3064-3p	CLIP-seq
MIRT2440638	hsa-miR-3064-5p	CLIP-seq
MIRT2440639	hsa-miR-30a	CLIP-seq
MIRT2440640	hsa-miR-30b	CLIP-seq
MIRT2440641	hsa-miR-30c	CLIP-seq
MIRT2440642	hsa-miR-30d	CLIP-seq
MIRT2440643	hsa-miR-30e	CLIP-seq
MIRT2440644	hsa-miR-3124-3p	CLIP-seq
MIRT2440645	hsa-miR-3150b-3p	CLIP-seq
MIRT2440646	hsa-miR-3151	CLIP-seq
MIRT2440647	hsa-miR-3155	CLIP-seq
MIRT2440648	hsa-miR-3155b	CLIP-seq
MIRT2335854	hsa-miR-3158-5p	CLIP-seq
MIRT2440649	hsa-miR-3183	CLIP-seq
MIRT2440650	hsa-miR-3184	CLIP-seq
MIRT2440651	hsa-miR-3192	CLIP-seq
MIRT2440652	hsa-miR-3194-5p	CLIP-seq
MIRT2440653	hsa-miR-342-5p	CLIP-seq
MIRT2112969	hsa-miR-34a	CLIP-seq
MIRT2112970	hsa-miR-34c-5p	CLIP-seq
MIRT2440654	hsa-miR-3605-5p	CLIP-seq
MIRT1378536	hsa-miR-3612	CLIP-seq
MIRT2440655	hsa-miR-361-3p	CLIP-seq
MIRT2335855	hsa-miR-3616-3p	CLIP-seq
MIRT2440656	hsa-miR-3622b-5p	CLIP-seq
MIRT2440657	hsa-miR-3649	CLIP-seq
MIRT2440658	hsa-miR-3661	CLIP-seq
MIRT1378537	hsa-miR-3663-3p	CLIP-seq
MIRT1378538	hsa-miR-3664-3p	CLIP-seq
MIRT2440659	hsa-miR-3679-3p	CLIP-seq
MIRT2440660	hsa-miR-3689a-3p	CLIP-seq
MIRT2440661	hsa-miR-3689c	CLIP-seq
MIRT1378541	hsa-miR-383	CLIP-seq
MIRT2440662	hsa-miR-3944-5p	CLIP-seq
MIRT2440663	hsa-miR-423-5p	CLIP-seq
MIRT2440664	hsa-miR-4265	CLIP-seq
MIRT2440665	hsa-miR-4267	CLIP-seq
MIRT1378544	hsa-miR-4270	CLIP-seq
MIRT2335856	hsa-miR-4274	CLIP-seq
MIRT2440666	hsa-miR-4286	CLIP-seq
MIRT1378547	hsa-miR-4292	CLIP-seq
MIRT2440667	hsa-miR-4296	CLIP-seq
MIRT2112972	hsa-miR-4308	CLIP-seq
MIRT2440668	hsa-miR-4322	CLIP-seq
MIRT2440669	hsa-miR-4417	CLIP-seq
MIRT2440670	hsa-miR-4419a	CLIP-seq
MIRT1378549	hsa-miR-4420	CLIP-seq
MIRT2440671	hsa-miR-4436a	CLIP-seq
MIRT2335857	hsa-miR-4436b-3p	CLIP-seq
MIRT1378552	hsa-miR-4441	CLIP-seq
MIRT2440672	hsa-miR-4446-3p	CLIP-seq
MIRT2440673	hsa-miR-4447	CLIP-seq
MIRT1378554	hsa-miR-4455	CLIP-seq
MIRT2440674	hsa-miR-4456	CLIP-seq
MIRT2440675	hsa-miR-4459	CLIP-seq
MIRT2440676	hsa-miR-4472	CLIP-seq
MIRT2440677	hsa-miR-4492	CLIP-seq
MIRT2440678	hsa-miR-4498	CLIP-seq
MIRT2112973	hsa-miR-449a	CLIP-seq
MIRT2112974	hsa-miR-449b	CLIP-seq
MIRT2440679	hsa-miR-4508	CLIP-seq
MIRT2440680	hsa-miR-4510	CLIP-seq
MIRT1378559	hsa-miR-4514	CLIP-seq
MIRT2335858	hsa-miR-4532	CLIP-seq
MIRT2335859	hsa-miR-455-3p	CLIP-seq
MIRT2440681	hsa-miR-4645-5p	CLIP-seq
MIRT2440682	hsa-miR-4648	CLIP-seq
MIRT2335860	hsa-miR-4651	CLIP-seq
MIRT2440683	hsa-miR-4656	CLIP-seq
MIRT2440684	hsa-miR-4661-3p	CLIP-seq
MIRT2440685	hsa-miR-4664-5p	CLIP-seq
MIRT2440686	hsa-miR-4673	CLIP-seq
MIRT2440687	hsa-miR-4675	CLIP-seq
MIRT2440688	hsa-miR-4687-3p	CLIP-seq
MIRT1378563	hsa-miR-4692	CLIP-seq
MIRT2440689	hsa-miR-4700-3p	CLIP-seq
MIRT2440690	hsa-miR-4721	CLIP-seq
MIRT2440691	hsa-miR-4722-5p	CLIP-seq
MIRT2440692	hsa-miR-4723-3p	CLIP-seq
MIRT2394948	hsa-miR-4726-3p	CLIP-seq
MIRT2394949	hsa-miR-4728-5p	CLIP-seq
MIRT1378567	hsa-miR-4733-3p	CLIP-seq
MIRT2440693	hsa-miR-4739	CLIP-seq
MIRT2440694	hsa-miR-4741	CLIP-seq
MIRT2440695	hsa-miR-4756-5p	CLIP-seq
MIRT2440696	hsa-miR-4764-5p	CLIP-seq
MIRT1378570	hsa-miR-4772-5p	CLIP-seq
MIRT2440697	hsa-miR-4779	CLIP-seq
MIRT2440698	hsa-miR-4784	CLIP-seq
MIRT2440699	hsa-miR-484	CLIP-seq
MIRT2440700	hsa-miR-486-3p	CLIP-seq
MIRT2440701	hsa-miR-491-5p	CLIP-seq
MIRT2440702	hsa-miR-492	CLIP-seq
MIRT2440703	hsa-miR-515-5p	CLIP-seq
MIRT2440704	hsa-miR-541	CLIP-seq
MIRT2335861	hsa-miR-544	CLIP-seq
MIRT2440705	hsa-miR-548v	CLIP-seq
MIRT1378577	hsa-miR-591	CLIP-seq
MIRT2335862	hsa-miR-599	CLIP-seq
MIRT2335863	hsa-miR-608	CLIP-seq
MIRT2440706	hsa-miR-629	CLIP-seq
MIRT2440707	hsa-miR-631	CLIP-seq
MIRT2335864	hsa-miR-642b	CLIP-seq
MIRT1378579	hsa-miR-650	CLIP-seq
MIRT2440708	hsa-miR-654-5p	CLIP-seq
MIRT2440709	hsa-miR-661	CLIP-seq
MIRT1378581	hsa-miR-663	CLIP-seq
MIRT1378582	hsa-miR-668	CLIP-seq
MIRT2112978	hsa-miR-670	CLIP-seq
MIRT2440710	hsa-miR-718	CLIP-seq
MIRT2440711	hsa-miR-762	CLIP-seq
MIRT2440712	hsa-miR-765	CLIP-seq
MIRT2440713	hsa-miR-766	CLIP-seq
MIRT2335865	hsa-miR-885-3p	CLIP-seq
MIRT2440714	hsa-miR-940	CLIP-seq
MIRT2440626	hsa-miR-1207-3p	CLIP-seq
MIRT2440632	hsa-miR-1825	CLIP-seq
MIRT1378525	hsa-miR-1827	CLIP-seq
MIRT2440636	hsa-miR-299-3p	CLIP-seq
MIRT2440639	hsa-miR-30a	CLIP-seq
MIRT2440640	hsa-miR-30b	CLIP-seq
MIRT2440641	hsa-miR-30c	CLIP-seq
MIRT2440642	hsa-miR-30d	CLIP-seq
MIRT2440643	hsa-miR-30e	CLIP-seq
MIRT2630125	hsa-miR-3119	CLIP-seq
MIRT2440644	hsa-miR-3124-3p	CLIP-seq
MIRT2440651	hsa-miR-3192	CLIP-seq
MIRT2630126	hsa-miR-337-3p	CLIP-seq
MIRT2630127	hsa-miR-3685	CLIP-seq
MIRT2440660	hsa-miR-3689a-3p	CLIP-seq
MIRT2440661	hsa-miR-3689c	CLIP-seq
MIRT2630128	hsa-miR-384	CLIP-seq
MIRT2630129	hsa-miR-3929	CLIP-seq
MIRT2440666	hsa-miR-4286	CLIP-seq
MIRT1378547	hsa-miR-4292	CLIP-seq
MIRT2112972	hsa-miR-4308	CLIP-seq
MIRT2630130	hsa-miR-4419b	CLIP-seq
MIRT2630131	hsa-miR-4474-3p	CLIP-seq
MIRT2630132	hsa-miR-4478	CLIP-seq
MIRT2630133	hsa-miR-4491	CLIP-seq
MIRT2630134	hsa-miR-4657	CLIP-seq
MIRT2630135	hsa-miR-4728-3p	CLIP-seq
MIRT2394949	hsa-miR-4728-5p	CLIP-seq
MIRT2630136	hsa-miR-495	CLIP-seq
MIRT2630137	hsa-miR-496	CLIP-seq
MIRT2112978	hsa-miR-670	CLIP-seq
MIRT2440710	hsa-miR-718	CLIP-seq
MIRT2440626	hsa-miR-1207-3p	CLIP-seq
MIRT2440631	hsa-miR-1587	CLIP-seq
MIRT2440632	hsa-miR-1825	CLIP-seq
MIRT1378525	hsa-miR-1827	CLIP-seq
MIRT2691727	hsa-miR-199a-5p	CLIP-seq
MIRT2691728	hsa-miR-199b-5p	CLIP-seq
MIRT2691729	hsa-miR-2114	CLIP-seq
MIRT2440636	hsa-miR-299-3p	CLIP-seq
MIRT2440638	hsa-miR-3064-5p	CLIP-seq
MIRT2440639	hsa-miR-30a	CLIP-seq
MIRT2440640	hsa-miR-30b	CLIP-seq
MIRT2440641	hsa-miR-30c	CLIP-seq
MIRT2440642	hsa-miR-30d	CLIP-seq
MIRT2440643	hsa-miR-30e	CLIP-seq
MIRT2630125	hsa-miR-3119	CLIP-seq
MIRT2440644	hsa-miR-3124-3p	CLIP-seq
MIRT2691730	hsa-miR-3174	CLIP-seq
MIRT2440651	hsa-miR-3192	CLIP-seq
MIRT2630126	hsa-miR-337-3p	CLIP-seq
MIRT1378536	hsa-miR-3612	CLIP-seq
MIRT2691731	hsa-miR-3613-3p	CLIP-seq
MIRT2440656	hsa-miR-3622b-5p	CLIP-seq
MIRT2630127	hsa-miR-3685	CLIP-seq
MIRT2440660	hsa-miR-3689a-3p	CLIP-seq
MIRT2440661	hsa-miR-3689c	CLIP-seq
MIRT2630128	hsa-miR-384	CLIP-seq
MIRT2691732	hsa-miR-3925-3p	CLIP-seq
MIRT2630129	hsa-miR-3929	CLIP-seq
MIRT2440664	hsa-miR-4265	CLIP-seq
MIRT2440666	hsa-miR-4286	CLIP-seq
MIRT2691733	hsa-miR-4290	CLIP-seq
MIRT1378547	hsa-miR-4292	CLIP-seq
MIRT2440667	hsa-miR-4296	CLIP-seq
MIRT2112972	hsa-miR-4308	CLIP-seq
MIRT1378548	hsa-miR-4313	CLIP-seq
MIRT2440668	hsa-miR-4322	CLIP-seq
MIRT2440669	hsa-miR-4417	CLIP-seq
MIRT2630130	hsa-miR-4419b	CLIP-seq
MIRT2630131	hsa-miR-4474-3p	CLIP-seq
MIRT2630132	hsa-miR-4478	CLIP-seq
MIRT2630133	hsa-miR-4491	CLIP-seq
MIRT2440677	hsa-miR-4492	CLIP-seq
MIRT2440678	hsa-miR-4498	CLIP-seq
MIRT2440683	hsa-miR-4656	CLIP-seq
MIRT2630134	hsa-miR-4657	CLIP-seq
MIRT2440687	hsa-miR-4675	CLIP-seq
MIRT2440688	hsa-miR-4687-3p	CLIP-seq
MIRT2630135	hsa-miR-4728-3p	CLIP-seq
MIRT2394949	hsa-miR-4728-5p	CLIP-seq
MIRT2440694	hsa-miR-4741	CLIP-seq
MIRT2630137	hsa-miR-496	CLIP-seq
MIRT2691734	hsa-miR-548a-3p	CLIP-seq
MIRT2691735	hsa-miR-548ae	CLIP-seq
MIRT2691736	hsa-miR-548aj	CLIP-seq
MIRT2691737	hsa-miR-548am	CLIP-seq
MIRT2691738	hsa-miR-548e	CLIP-seq
MIRT2691739	hsa-miR-548f	CLIP-seq
MIRT2691740	hsa-miR-548g	CLIP-seq
MIRT2440705	hsa-miR-548v	CLIP-seq
MIRT2691741	hsa-miR-548x	CLIP-seq
MIRT2335862	hsa-miR-599	CLIP-seq
MIRT2440706	hsa-miR-629	CLIP-seq
MIRT2335864	hsa-miR-642b	CLIP-seq
MIRT1378579	hsa-miR-650	CLIP-seq
MIRT2112978	hsa-miR-670	CLIP-seq
MIRT2440710	hsa-miR-718	CLIP-seq
MIRT2440711	hsa-miR-762	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CEBPA	Activation	19332118
NFKB1	Unknown	23335796
RELA	Unknown	23335796
SP3	Unknown	10570957
STAT1	Unknown	19115200
STAT3	Activation	11788008;15184887;19332118;20357037;22179221
STAT3	Unknown	23335796
STAT4	Repression	14559241

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001784	Function	Phosphotyrosine residue binding	IEA
GO:0004860	Function	Protein kinase inhibitor activity	TAS	9266833
GO:0005515	Function	Protein binding	IPI	19027008, 24728074, 25203322, 25416956, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0005942	Component	Phosphatidylinositol 3-kinase complex	IBA	21873635
GO:0006469	Process	Negative regulation of protein kinase activity	IEA
GO:0007259	Process	Receptor signaling pathway via JAK-STAT	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0040008	Process	Regulation of growth	IEA
GO:0042531	Process	Positive regulation of tyrosine phosphorylation of STAT protein	TAS
GO:0042532	Process	Negative regulation of tyrosine phosphorylation of STAT protein	IMP	25019494
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043551	Process	Regulation of phosphatidylinositol 3-kinase activity	IEA
GO:0043687	Process	Post-translational protein modification	TAS
GO:0045597	Process	Positive regulation of cell differentiation	IEA
GO:0046426	Process	Negative regulation of receptor signaling pathway via JAK-STAT	IMP	25019494
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IEA
GO:0046854	Process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0046935	Function	1-phosphatidylinositol-3-kinase regulator activity	IBA	21873635
GO:0050728	Process	Negative regulation of inflammatory response	IEA
GO:0060334	Process	Regulation of interferon-gamma-mediated signaling pathway	TAS
GO:0060670	Process	Branching involved in labyrinthine layer morphogenesis	IEA
GO:0060674	Process	Placenta blood vessel development	IEA
GO:0060707	Process	Trophoblast giant cell differentiation	IEA
GO:0070102	Process	Interleukin-6-mediated signaling pathway	TAS
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

Other IDs

• MIM: 604176
• HGNC: 19391
• e!Ensembl: ENSG00000184557

Protein

• UniProt ID: O14543
• Protein name: Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
• Protein function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduc
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00017	SH2	46 → 127	SH2 domain	Domain

• Sequence:

  MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLL
  SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV
  LKLVHHYMPPPGAPSFPSPPTEPSSEVPEQPSAQPLPGSPPRRAYYIYSGGEKIPLVLSR
  PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL

• Sequence length: 225

Pathways

KEGG:

Ubiquitin mediated proteolysis
Osteoclast differentiation
JAK-STAT signaling pathway
TNF signaling pathway
Insulin signaling pathway
Prolactin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease
Growth hormone synthesis, secretion and action
Hepatitis C
Influenza A
Herpes simplex virus 1 infection

Reactome:

Interleukin-6 signaling
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling
Regulation of IFNG signaling
PTK6 Activates STAT3
Neddylation
Interferon alpha/beta signaling
Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Endometrial carcinoma	Endometrial Carcinoma	rs34612342, rs587776667, rs587776701, rs63750955, rs587776706, rs121434629, rs80359605, rs121913530, rs104894365, rs79184941, rs121913478, rs63750781, rs193922343, rs267608094, rs267608077, rs587779206, rs63750439, rs63751405, rs63750741, rs63750854, rs63750909, rs587779212, rs63749874, rs267608076, rs587779220, rs63750735, rs267608082, rs587779227, rs267608068, rs63750075, rs587779232, rs267608058, rs63751127, rs63750138, rs267608065, rs63751017, rs587779246, rs63750111, rs63750563, rs267608073, rs63751407, rs63749999, rs267608042, rs63750833, rs587779255, rs587779256, rs267608078, rs267608092, rs587779263, rs267608098, rs587779267, rs63750194, rs63751327, rs63751328, rs587779284, rs63749942, rs63751058, rs267608114, rs267608118, rs63751319, rs267608128, rs1553333594, rs267608126, rs63750767, rs267608120, rs267608121, rs267608122, rs63750342, rs63749873, rs587779318, rs63750019, rs63749980, rs267608048, rs1553412283, rs146816935, rs63750855, rs63751711, rs267607789, rs587779094, rs63750224, rs267607972, rs63750084, rs587779185, rs587778617, rs398123231, rs398123232, rs398123318, rs587780021, rs63750119, rs267608064, rs587781490, rs587781558, rs587781691, rs63749821, rs587782111, rs587782326, rs587782704, rs587779264, rs587779333, rs587782712, rs587783056, rs730881825, rs730881827, rs730881829, rs730881830, rs786202193, rs587782281, rs786202848, rs786201049, rs750528093, rs786202108, rs267608083, rs786201050, rs786203924, rs587781544, rs786201084, rs1553333738, rs863224829, rs863225398, rs863225409, rs863225412, rs864622041, rs869312769, rs869312770, rs63751077, rs876661205, rs876661025, rs63749919, rs876661073, rs876661222, rs267608041, rs878853702, rs751326348, rs866260675, rs886039666, rs886044911, rs1057517552, rs1057517764, rs1057517763, rs121909224, rs1057520605, rs1060502885, rs1060502918, rs1060502932, rs587779215, rs1060502937, rs1060502886, rs1060502875, rs1060502881, rs267607939, rs1023534466, rs1064793600, rs1064795256, rs1064795591, rs1064794055, rs1064794164, rs1553414010, rs1064793671, rs1064794302, rs1064793489, rs1064794384, rs1064793781, rs1553333500, rs760190301, rs1114167719, rs1114167776, rs1114167704, rs1114167748, rs1114167731, rs753796271, rs267608055, rs1114167746, rs1114167715, rs587782706, rs1114167750, rs1114167765, rs1114167747, rs786204048, rs1114167707, rs1114167767, rs1114167717, rs1114167783, rs1553412966, rs1553333598, rs587779297, rs1554294505, rs988423880, rs1554306353, rs1553408136, rs1553333321, rs1553408388, rs63749973, rs1553412064, rs1553412120, rs1553826166, rs1553413784, rs1553331242, rs1553414519, rs1564568660, rs1558392033, rs878853704, rs765763906, rs1558663559, rs1572720704, rs63750985, rs1572727440, rs587779253, rs1580538168, rs149350323, rs374133543, rs771721952, rs201033017, rs763478027, rs1475633334, rs1580553624, rs1580553669, rs578113271, rs757194485, rs539295465, rs778610412, rs758191157, rs1580597397, rs1580033751, rs751236312, rs376667075, rs1561486630, rs1561486632, rs777054839, rs1204002507, rs766672143, rs1580091499, rs1386063673, rs1450314617, rs1580027713, rs367544716, rs1488467945, rs1580053768, rs1580553607, rs1572720794, rs1572722039, rs1572723786, rs1572725235, rs1572728112, rs1175196087, rs1572741984, rs1580540688, rs1259647122, rs1580546793, rs1234762807, rs1580556516, rs1669245178, rs1669365820, rs756190979, rs371356175, rs766997264, rs1743353294, rs1379605717, rs770330684, rs1462955256, rs1744356274, rs1480047980, rs1744149615	16804899

Unknown
Disease name	Disease term	dbSNP ID	References
Atherosclerosis	Atherosclerosis	rs699947, rs59439148	19330073
Endometrial neoplasms	Endometrial Neoplasms		16804899
Liver carcinoma	Liver carcinoma		16831601
Myocardial ischemia	Myocardial Ischemia		16214533