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NAT1 (N-acetyltransferase 1)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9
Gene nameGene Name - the full gene name approved by the HGNC.
N-acetyltransferase 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
NAT1
SynonymsGene synonyms aliases
AAC1, MNAT, NAT-1, NATI
ChromosomeChromosome number
8
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p22
SummarySummary of gene provided in NCBI Entrez Gene.
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT030309 hsa-miR-26b-5p Microarray 19088304
MIRT050208 hsa-miR-25-3p CLASH 23622248
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
AR Activation 17210686
HSF1 Activation 20176657
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0004060 Function Arylamine N-acetyltransferase activity IBA 21873635
GO:0004060 Function Arylamine N-acetyltransferase activity TAS
GO:0005829 Component Cytosol TAS
GO:0006805 Process Xenobiotic metabolic process TAS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P18440
Protein name Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N-acetyltransferase type 1) (NAT-1)
Protein function Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
PDB 2DSS , 2GWU , 2IJA , 2PQT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00797 Acetyltransf_2
20 → 280
N-acetyltransferase
 Family
Sequence
Sequence length 290
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
KEGG
  
Reactome
  Caffeine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Chemical carcinogenesis - DNA adducts 		  Acetylation
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Disease name Disease term References
Benign Neoplasm
Malignant neoplasm of urinary bladder
Bladder Neoplasm
Dermatitis, Occupational
Industrial Dermatosis

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