KLC4 (kinesin light chain 4)

Gene

• Entrez ID: 89953
• Gene name: Kinesin light chain 4
• Gene symbol: KLC4
• Synonyms: CONDRHN, KNSL8, bA387M24.3
• Chromosome: 6
• Chromosome location: 6p21.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018861	hsa-miR-335-5p	Microarray	18185580
MIRT035911	hsa-miR-1180-3p	CLASH	23622248
MIRT1095681	hsa-miR-15a	CLIP-seq
MIRT1095682	hsa-miR-15b	CLIP-seq
MIRT1095683	hsa-miR-16	CLIP-seq
MIRT1095684	hsa-miR-195	CLIP-seq
MIRT1095685	hsa-miR-214	CLIP-seq
MIRT1095686	hsa-miR-3182	CLIP-seq
MIRT1095687	hsa-miR-3616-3p	CLIP-seq
MIRT1095688	hsa-miR-3619-5p	CLIP-seq
MIRT1095689	hsa-miR-3921	CLIP-seq
MIRT1095690	hsa-miR-424	CLIP-seq
MIRT1095691	hsa-miR-4436b-3p	CLIP-seq
MIRT1095692	hsa-miR-4530	CLIP-seq
MIRT1095693	hsa-miR-4649-3p	CLIP-seq
MIRT1095694	hsa-miR-4653-5p	CLIP-seq
MIRT1095695	hsa-miR-4690-5p	CLIP-seq
MIRT1095696	hsa-miR-4721	CLIP-seq
MIRT1095697	hsa-miR-497	CLIP-seq
MIRT1095698	hsa-miR-761	CLIP-seq
MIRT2025705	hsa-miR-4260	CLIP-seq
MIRT2025706	hsa-miR-4324	CLIP-seq
MIRT2256889	hsa-miR-3144-5p	CLIP-seq
MIRT2256890	hsa-miR-711	CLIP-seq
MIRT2558294	hsa-miR-1208	CLIP-seq
MIRT2558295	hsa-miR-1224-3p	CLIP-seq
MIRT2558296	hsa-miR-1260	CLIP-seq
MIRT2558297	hsa-miR-1260b	CLIP-seq
MIRT2558298	hsa-miR-1280	CLIP-seq
MIRT2558299	hsa-miR-1294	CLIP-seq
MIRT1095681	hsa-miR-15a	CLIP-seq
MIRT1095682	hsa-miR-15b	CLIP-seq
MIRT1095683	hsa-miR-16	CLIP-seq
MIRT1095684	hsa-miR-195	CLIP-seq
MIRT2558300	hsa-miR-2110	CLIP-seq
MIRT1095685	hsa-miR-214	CLIP-seq
MIRT2558301	hsa-miR-3127-3p	CLIP-seq
MIRT1095686	hsa-miR-3182	CLIP-seq
MIRT2558302	hsa-miR-3189-3p	CLIP-seq
MIRT1095687	hsa-miR-3616-3p	CLIP-seq
MIRT1095688	hsa-miR-3619-5p	CLIP-seq
MIRT2558303	hsa-miR-3908	CLIP-seq
MIRT1095689	hsa-miR-3921	CLIP-seq
MIRT1095690	hsa-miR-424	CLIP-seq
MIRT2025705	hsa-miR-4260	CLIP-seq
MIRT2558304	hsa-miR-4271	CLIP-seq
MIRT2558305	hsa-miR-4316	CLIP-seq
MIRT2558306	hsa-miR-4420	CLIP-seq
MIRT1095691	hsa-miR-4436b-3p	CLIP-seq
MIRT1095692	hsa-miR-4530	CLIP-seq
MIRT1095693	hsa-miR-4649-3p	CLIP-seq
MIRT2558307	hsa-miR-4651	CLIP-seq
MIRT1095694	hsa-miR-4653-5p	CLIP-seq
MIRT2558308	hsa-miR-4677-3p	CLIP-seq
MIRT1095695	hsa-miR-4690-5p	CLIP-seq
MIRT1095696	hsa-miR-4721	CLIP-seq
MIRT2558309	hsa-miR-4725-3p	CLIP-seq
MIRT2558310	hsa-miR-4786-5p	CLIP-seq
MIRT2558311	hsa-miR-491-5p	CLIP-seq
MIRT1095697	hsa-miR-497	CLIP-seq
MIRT2558312	hsa-miR-548g	CLIP-seq
MIRT2558313	hsa-miR-608	CLIP-seq
MIRT2558314	hsa-miR-665	CLIP-seq
MIRT1095698	hsa-miR-761	CLIP-seq
MIRT2558315	hsa-miR-769-5p	CLIP-seq
MIRT2558294	hsa-miR-1208	CLIP-seq
MIRT2558295	hsa-miR-1224-3p	CLIP-seq
MIRT2558296	hsa-miR-1260	CLIP-seq
MIRT2558297	hsa-miR-1260b	CLIP-seq
MIRT2558298	hsa-miR-1280	CLIP-seq
MIRT2683531	hsa-miR-140-3p	CLIP-seq
MIRT1095681	hsa-miR-15a	CLIP-seq
MIRT1095682	hsa-miR-15b	CLIP-seq
MIRT1095683	hsa-miR-16	CLIP-seq
MIRT1095684	hsa-miR-195	CLIP-seq
MIRT2558300	hsa-miR-2110	CLIP-seq
MIRT1095685	hsa-miR-214	CLIP-seq
MIRT2683532	hsa-miR-2467-3p	CLIP-seq
MIRT2683533	hsa-miR-3125	CLIP-seq
MIRT2558301	hsa-miR-3127-3p	CLIP-seq
MIRT1095686	hsa-miR-3182	CLIP-seq
MIRT2558302	hsa-miR-3189-3p	CLIP-seq
MIRT1095687	hsa-miR-3616-3p	CLIP-seq
MIRT1095688	hsa-miR-3619-5p	CLIP-seq
MIRT2683534	hsa-miR-3678-3p	CLIP-seq
MIRT2558303	hsa-miR-3908	CLIP-seq
MIRT2683535	hsa-miR-3916	CLIP-seq
MIRT1095689	hsa-miR-3921	CLIP-seq
MIRT1095690	hsa-miR-424	CLIP-seq
MIRT2025705	hsa-miR-4260	CLIP-seq
MIRT2558304	hsa-miR-4271	CLIP-seq
MIRT2558306	hsa-miR-4420	CLIP-seq
MIRT1095691	hsa-miR-4436b-3p	CLIP-seq
MIRT1095692	hsa-miR-4530	CLIP-seq
MIRT1095693	hsa-miR-4649-3p	CLIP-seq
MIRT2558307	hsa-miR-4651	CLIP-seq
MIRT1095694	hsa-miR-4653-5p	CLIP-seq
MIRT1095695	hsa-miR-4690-5p	CLIP-seq
MIRT1095696	hsa-miR-4721	CLIP-seq
MIRT2558309	hsa-miR-4725-3p	CLIP-seq
MIRT2683536	hsa-miR-4751	CLIP-seq
MIRT2558310	hsa-miR-4786-5p	CLIP-seq
MIRT2558311	hsa-miR-491-5p	CLIP-seq
MIRT1095697	hsa-miR-497	CLIP-seq
MIRT2683537	hsa-miR-518d-5p	CLIP-seq
MIRT2683538	hsa-miR-519b-5p	CLIP-seq
MIRT2683539	hsa-miR-519c-5p	CLIP-seq
MIRT2683540	hsa-miR-520c-5p	CLIP-seq
MIRT2683541	hsa-miR-526a	CLIP-seq
MIRT2558312	hsa-miR-548g	CLIP-seq
MIRT2558313	hsa-miR-608	CLIP-seq
MIRT2558314	hsa-miR-665	CLIP-seq
MIRT1095698	hsa-miR-761	CLIP-seq
MIRT2558315	hsa-miR-769-5p	CLIP-seq
MIRT2683542	hsa-miR-877	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005871	Component	Kinesin complex	IEA
GO:0005874	Component	Microtubule	IEA

Other IDs

• MIM: 620909
• HGNC: 21624
• e!Ensembl: ENSG00000137171

Protein

• UniProt ID: Q9NSK0
• Protein name: Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8)
• Protein function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). {ECO:00002
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13424	TPR_12	209 → 285		Repeat
  PF13424	TPR_12	293 → 369		Repeat
  PF13374	TPR_10	294 → 335		Repeat
  PF13424	TPR_12	335 → 409		Repeat
  PF13374	TPR_10	465 → 496		Repeat

• Sequence:

  MSGLVLGQRDEPAGHRLSQEEILGSTRLVSQGLEALRSEHQAVLQSLSQTIECLQQGGHE
  EGLVHEKARQLRRSMENIELGLSEAQVMLALASHLSTVESEKQKLRAQVRRLCQENQWLR
  DELAGTQQRLQRSEQAVAQLEEEKKHLEFLGQLRQYDEDGHTSEEKEGDATKDSLDDLFP
  NEEEEDPSNGLSRGQGATAAQQGGYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALED
  LERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNN
  LAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYY
  QRALAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDD
  HKPIWMHAEEREEMSKSRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKL
  EAAETLEECALRSRRQGTDPISQTKVAELLGESDGRRTSQEGPGDSVKFEGGEDASVAVE
  WSGDGSGTLQRSGSLGKIRDVLRRSSELLVRKLQGTEPRPSSSNMKRAASLNYLNQPSAA
  PLQVSRGLSASTMDLSSSS

• Sequence length: 619

Pathways

KEGG:

Motor proteins
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Salmonella infection

Reactome:

MHC class II antigen presentation
RHO GTPases activate KTN1
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
3m syndrome	Miller-McKusick-Malvaux-Syndrome (3M Syndrome)	rs121918215, rs1335171880, rs121918216, rs121918228, rs121918229, rs730880261, rs730880262, rs730880263, rs752254407, rs1568590155, rs201406974, rs786205651, rs61752334, rs762334954, rs749509661, rs864309521, rs886042376, rs748555538, rs1057518716, rs1064792895, rs775865076, rs1554138553, rs746333044, rs1553538488, rs760910667, rs1561875767, rs1561892336, rs1561898352, rs760929207, rs1559155954, rs1561873941, rs1561881909, rs1559160379, rs1023630527, rs766471384, rs1581962986, rs1581930130, rs773698181	30980518
Scoliosis	Scoliosis, unspecified	rs1057518828, rs147296805, rs758163506, rs1555613564, rs1596852902, rs1596853067, rs1596853085	30980518
Spastic paraplegia	Spastic Paraplegia	rs118204049, rs121918262, rs104894490, rs119476046, rs281865117, rs281865118, rs137853017, rs72554620, rs121908610, rs121908611, rs121908613, rs116171274, rs121434442, rs121434443, rs137852520, rs137852521, rs137852524, rs137852525, rs879253716, rs387906970, rs587776888, rs759947457, rs587776891, rs753426920, rs387907057, rs397514478, rs387907285, rs387907287, rs387907288, rs281865120, rs397514513, rs141431913, rs312262755, rs398123013, rs398123014, rs398122382, rs745744124, rs483352924, rs483352925, rs587777222, rs587779388, rs587783179, rs587783772, rs587784383, rs587784384, rs730882249, rs762947018, rs786204628, rs141315518, rs786204416, rs786204750, rs770866403, rs775059063, rs797044787, rs794729214, rs794729215, rs797045050, rs370828455, rs146262009, rs797045244, rs780247476, rs185246578, rs766773277, rs863224494, rs752669339, rs869320690, rs200737038, rs869312914, rs752283089, rs751713917, rs756205995, rs875989787, rs875989845, rs375817528, rs200440467, rs876661295, rs794727501, rs770285398, rs878854745, rs878854975, rs878855013, rs878855011, rs878855083, rs878853979, rs879255397, rs879255396, rs886039410, rs886039409, rs886039407, rs886039408, rs886039405, rs886039406, rs752598529, rs752059006, rs202199411, rs886041949, rs886041127, rs886042238, rs1057517123, rs747868017, rs1057517294, rs565203731, rs753205260, rs1057517002, rs779338945, rs755186798, rs1057517250, rs1057517060, rs753012964, rs758572409, rs1057516959, rs1057516438, rs145766983, rs1057516689, rs1057516932, rs1057516635, rs1057517366, rs759166250, rs1057517138, rs761089024, rs1057517297, rs1057517311, rs1057516779, rs1057517039, rs1057517285, rs1057516365, rs1057516625, rs1057516987, rs1057516837, rs1057518016, rs1057518880, rs1057518697, rs1057519289, rs1057519290, rs1057519291, rs1057519292, rs1057519293, rs1057521784, rs1060499756, rs1060499771, rs1060502224, rs1060502523, rs371019314, rs1060503431, rs774906736, rs372350326, rs776976178, rs370837940, rs1064793162, rs1064793920, rs1555177629, rs1555394376, rs377445018, rs767024102, rs768176054, rs1557090943, rs1557090161, rs1555178616, rs1555251539, rs754439135, rs1321353475, rs1555186937, rs767871841, rs867249938, rs1440541889, rs1555456727, rs1268722908, rs1557092247, rs1557092248, rs765632065, rs773246271, rs1554380391, rs1554517327, rs200268523, rs1156566314, rs1160357920, rs773182375, rs768366199, rs774809466, rs1555542889, rs915291720, rs1021034246, rs769676029, rs746979262, rs1033093801, rs955142329, rs760559263, rs1557091773, rs1372213267, rs1557091678, rs1402429085, rs1555179091, rs1555179087, rs374128662, rs142209254, rs1553259463, rs1555254256, rs755820725, rs1335804396, rs568176223, rs1555979596, rs780030221, rs1553314978, rs923921184, rs1556840029, rs374894037, rs1553262438, rs1555249362, rs950356390, rs1557091278, rs1557090220, rs1259615333, rs1555249276, rs1555249425, rs1555249479, rs1555249555, rs1555250949, rs1555252349, rs1167474602, rs1175545518, rs1555249648, rs1555249878, rs1400601705, rs1555252086, rs745907077, rs1555249371, rs1555249904, rs1555393393, rs1028098148, rs766711286, rs767164213, rs1470672632, rs1555252184, rs1224762841, rs769329153, rs1555254734, rs1555397331, rs941230062, rs545219731, rs200832994, rs1555250255, rs1240368715, rs1555393338, rs1049504575, rs1485209013, rs868672014, rs1214483973, rs558285072, rs1555398241, rs1186788102, rs981804211, rs935301743, rs1555251822, rs1555255676, rs369459721, rs772400670, rs1558119445, rs759033144, rs1565705251, rs1566055368, rs1566058677, rs1006060877, rs1448182827, rs1569544908, rs754944359, rs754944429, rs1569544723, rs1569285562, rs367916692, rs1566893090, rs1177577061, rs1566881181, rs1569280986, rs1590847310, rs746220436, rs1569281085, rs529495094, rs1563920268, rs1563920252, rs1563920172, rs1563919973, rs1563920000, rs1563920132, rs751568153, rs1569274606, rs1455411788, rs1571908452, rs768640920, rs1578729121, rs1585896928, rs1585808059, rs1588001500, rs1011987148, rs1594915468, rs1594925773, rs1361370524, rs1593121507, rs1365858851, rs1593125341, rs1181477970, rs1593129673, rs1593133395, rs1593133714, rs1593144167, rs1593144544, rs1593144887, rs767435985, rs1593147785, rs994374354, rs1593157923, rs1594900921, rs1594906944, rs1594910045, rs1594913346, rs1594930532, rs1594938339, rs140354725, rs1418885000, rs1603275195, rs1603276234, rs1574077569, rs1603275315, rs1587878722, rs1587879449, rs1593133607, rs770490672, rs1602099961, rs778722037, rs756830713, rs1593121484, rs763869212, rs1594912625, rs1597556143, rs778113360, rs377278120, rs933233143, rs1572337800, rs1573072864, rs1593125290, rs1593126754, rs1593123432, rs1571563769, rs1584514057, rs772704931, rs1587878961, rs1802811311, rs1052410160, rs1298132281, rs748480664, rs139015012, rs1340636078, rs927804920, rs1883405453, rs1883566609, rs1868403104, rs1868480299, rs1868481514, rs1868567420, rs1868626730, rs1868628768, rs1868872666, rs1869006331, rs769212398, rs757179309, rs2039098098, rs2039228359, rs774867891, rs2039613696, rs2039616151, rs2039786680, rs2039997721, rs748149642, rs2040215878, rs760484081, rs1204169977, rs367665974, rs201311640, rs1034820850, rs1930458591, rs1882179247, rs2039758874, rs1885117995, rs1805435464	26423925

Unknown
Disease name	Disease term	dbSNP ID	References
Dolichocephaly	Long narrow head		30980518
Frontal bossing	Frontal bossing		30980518