TRPA1 (transient receptor potential cation channel subfamily A member 1)

Gene

• Entrez ID: 8989
• Gene name: Transient receptor potential cation channel subfamily A member 1
• Gene symbol: TRPA1
• Synonyms: ANKTM1, FEPS, FEPS1, p120
• Chromosome: 8
• Chromosome location: 8q21.11
• Summary: The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in si

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023904	hsa-miR-1-3p	Microarray	18668037
MIRT025846	hsa-miR-7-5p	Microarray	17612493
MIRT1457191	hsa-miR-1257	CLIP-seq
MIRT1457192	hsa-miR-1293	CLIP-seq
MIRT1457193	hsa-miR-1324	CLIP-seq
MIRT1457194	hsa-miR-1825	CLIP-seq
MIRT1457195	hsa-miR-199a-5p	CLIP-seq
MIRT1457196	hsa-miR-199b-5p	CLIP-seq
MIRT1457197	hsa-miR-30a	CLIP-seq
MIRT1457198	hsa-miR-30b	CLIP-seq
MIRT1457199	hsa-miR-30c	CLIP-seq
MIRT1457200	hsa-miR-30d	CLIP-seq
MIRT1457201	hsa-miR-30e	CLIP-seq
MIRT1457202	hsa-miR-3134	CLIP-seq
MIRT1457203	hsa-miR-3136-5p	CLIP-seq
MIRT1457204	hsa-miR-409-3p	CLIP-seq
MIRT1457205	hsa-miR-4276	CLIP-seq
MIRT1457206	hsa-miR-4302	CLIP-seq
MIRT1457207	hsa-miR-4434	CLIP-seq
MIRT1457208	hsa-miR-4439	CLIP-seq
MIRT1457209	hsa-miR-4483	CLIP-seq
MIRT1457210	hsa-miR-4513	CLIP-seq
MIRT1457211	hsa-miR-4516	CLIP-seq
MIRT1457212	hsa-miR-4531	CLIP-seq
MIRT1457213	hsa-miR-4534	CLIP-seq
MIRT1457214	hsa-miR-541	CLIP-seq
MIRT1457215	hsa-miR-643	CLIP-seq
MIRT1457216	hsa-miR-654-5p	CLIP-seq
MIRT1457217	hsa-miR-943	CLIP-seq
MIRT2137078	hsa-miR-3151	CLIP-seq
MIRT2137079	hsa-miR-3154	CLIP-seq
MIRT2137080	hsa-miR-4283	CLIP-seq
MIRT2137081	hsa-miR-4489	CLIP-seq
MIRT2137082	hsa-miR-451b	CLIP-seq
MIRT2137083	hsa-miR-664	CLIP-seq
MIRT2357849	hsa-miR-1197	CLIP-seq
MIRT2357850	hsa-miR-3150b-3p	CLIP-seq
MIRT2137078	hsa-miR-3151	CLIP-seq
MIRT2137079	hsa-miR-3154	CLIP-seq
MIRT2137080	hsa-miR-4283	CLIP-seq
MIRT2357851	hsa-miR-4420	CLIP-seq
MIRT2357852	hsa-miR-4457	CLIP-seq
MIRT2137081	hsa-miR-4489	CLIP-seq
MIRT2137082	hsa-miR-451b	CLIP-seq
MIRT2357853	hsa-miR-4639-3p	CLIP-seq
MIRT2357854	hsa-miR-4649-3p	CLIP-seq
MIRT2357855	hsa-miR-4689	CLIP-seq
MIRT2357856	hsa-miR-4731-3p	CLIP-seq
MIRT2357857	hsa-miR-4778-3p	CLIP-seq
MIRT2357858	hsa-miR-4784	CLIP-seq
MIRT2357859	hsa-miR-4789-3p	CLIP-seq
MIRT2357860	hsa-miR-4801	CLIP-seq
MIRT2357861	hsa-miR-4803	CLIP-seq
MIRT2357862	hsa-miR-493	CLIP-seq
MIRT2357863	hsa-miR-642b	CLIP-seq
MIRT2137083	hsa-miR-664	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IMP	20547126, 25855297
GO:0006811	Process	Ion transport	TAS	10066796
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0009409	Process	Response to cold	IEA
GO:0010033	Process	Response to organic substance	IMP	20547126
GO:0014070	Process	Response to organic cyclic compound	IEA
GO:0015267	Function	Channel activity	TAS	10066796
GO:0015278	Function	Calcium-release channel activity	IDA	20547126
GO:0015278	Function	Calcium-release channel activity	IMP	25855297
GO:0019233	Process	Sensory perception of pain	IMP	20547126
GO:0032421	Component	Stereocilium bundle	IEA
GO:0042493	Process	Response to drug	IEA
GO:0042542	Process	Response to hydrogen peroxide	IEA
GO:0042802	Function	Identical protein binding	IPI	25855297
GO:0048265	Process	Response to pain	IEA
GO:0050955	Process	Thermoception	IEA
GO:0050966	Process	Detection of mechanical stimulus involved in sensory perception of pain	IEA
GO:0050968	Process	Detection of chemical stimulus involved in sensory perception of pain	IEA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IEA
GO:0051289	Process	Protein homotetramerization	IDA	25855297
GO:0070588	Process	Calcium ion transmembrane transport	IMP	20547126, 25855297
GO:0070588	Process	Calcium ion transmembrane transport	TAS
GO:0097604	Function	Temperature-gated cation channel activity	IDA	20547126

Other IDs

• MIM: 604775
• HGNC: 497
• e!Ensembl: ENSG00000104321

Protein

• UniProt ID: O75762
• Protein name: Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120) (p120) (Wasabi receptor)
• Protein function: Ligand-activated Ca(2+)-permeable, nonselective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:17259981, PubMed:21195050, PubMed:218739
• PDB: 3J9P, 6HC8, 6PQO, 6PQP, 6PQQ, 6V9V, 6V9W, 6V9X, 6V9Y, 6WJ5, 6X2J, 7JUP, 7OR0, 7OR1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00023	Ank	97 → 129	Ankyrin repeat	Repeat
  PF00023	Ank	240 → 269	Ankyrin repeat	Repeat
  PF00023	Ank	341 → 373	Ankyrin repeat	Repeat
  PF00023	Ank	412 → 442	Ankyrin repeat	Repeat
  PF00023	Ank	481 → 511	Ankyrin repeat	Repeat
  PF00023	Ank	547 → 579	Ankyrin repeat	Repeat
  PF00520	Ion_trans	721 → 972	Ion transport protein	Family

• Sequence:

  MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD
  DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
  GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
  LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
  TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD
  IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
  LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
  CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
  HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
  TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
  RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
  KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
  MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
  SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
  FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
  PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
  VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
  CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
  DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP

• Sequence length: 1119

Pathways

KEGG:

Inflammatory mediator regulation of TRP channels

Reactome:

TRP channels

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	19458046
Episodic pain syndrome	EPISODIC PAIN SYNDROME, FAMILIAL, 1, Familial episodic pain syndrome with predominantly upper body involvement	rs398123010, rs138607170, rs483352921, rs1230622899	20547126, 28436534, 21468319

Unknown
Disease name	Disease term	dbSNP ID	References
Bronchial hyperreactivity	Bronchial Hyperreactivity		19458046