SLC25A21 (solute carrier family 25 member 21)

Gene

• Entrez ID: 89874
• Gene name: Solute carrier family 25 member 21
• Gene symbol: SLC25A21
• Synonyms: MTDPS18, ODC, ODC1
• Chromosome: 14
• Chromosome location: 14q13.3
• Summary: SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1389068504	T>C	Pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT710658	hsa-miR-4666a-3p	HITS-CLIP	19536157
MIRT710657	hsa-miR-4289	HITS-CLIP	19536157
MIRT710656	hsa-miR-3611	HITS-CLIP	19536157
MIRT710655	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT495812	hsa-miR-3148	PAR-CLIP	22291592
MIRT495811	hsa-miR-4668-5p	PAR-CLIP	22291592
MIRT495812	hsa-miR-3148	PAR-CLIP	22291592
MIRT495811	hsa-miR-4668-5p	PAR-CLIP	22291592
MIRT495810	hsa-miR-625-5p	PAR-CLIP	22291592
MIRT710658	hsa-miR-4666a-3p	HITS-CLIP	19536157
MIRT710657	hsa-miR-4289	HITS-CLIP	19536157
MIRT710656	hsa-miR-3611	HITS-CLIP	19536157
MIRT710655	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT495812	hsa-miR-3148	PAR-CLIP	22291592
MIRT495811	hsa-miR-4668-5p	PAR-CLIP	22291592
MIRT495812	hsa-miR-3148	PAR-CLIP	22291592
MIRT495811	hsa-miR-4668-5p	PAR-CLIP	22291592
MIRT495810	hsa-miR-625-5p	PAR-CLIP	22291592
MIRT1355593	hsa-miR-1253	CLIP-seq
MIRT1355594	hsa-miR-298	CLIP-seq
MIRT1355595	hsa-miR-3618	CLIP-seq
MIRT1355596	hsa-miR-4433	CLIP-seq
MIRT1355597	hsa-miR-4434	CLIP-seq
MIRT1355598	hsa-miR-4459	CLIP-seq
MIRT1355599	hsa-miR-4516	CLIP-seq
MIRT1355600	hsa-miR-4768-3p	CLIP-seq
MIRT1355601	hsa-miR-4802-3p	CLIP-seq
MIRT1355602	hsa-miR-130a	CLIP-seq
MIRT1355603	hsa-miR-130b	CLIP-seq
MIRT1355604	hsa-miR-301a	CLIP-seq
MIRT1355605	hsa-miR-301b	CLIP-seq
MIRT1355606	hsa-miR-3152-3p	CLIP-seq
MIRT1355607	hsa-miR-3591-5p	CLIP-seq
MIRT1355608	hsa-miR-3653	CLIP-seq
MIRT1355609	hsa-miR-3658	CLIP-seq
MIRT1355610	hsa-miR-3666	CLIP-seq
MIRT1355611	hsa-miR-3673	CLIP-seq
MIRT1355612	hsa-miR-4282	CLIP-seq
MIRT1355613	hsa-miR-4295	CLIP-seq
MIRT1355614	hsa-miR-4325	CLIP-seq
MIRT1355615	hsa-miR-4473	CLIP-seq
MIRT1355616	hsa-miR-454	CLIP-seq
MIRT1355617	hsa-miR-4671-3p	CLIP-seq
MIRT1355618	hsa-miR-4799-5p	CLIP-seq
MIRT1355619	hsa-miR-578	CLIP-seq
MIRT1355620	hsa-miR-581	CLIP-seq
MIRT1922378	hsa-miR-4666-3p	CLIP-seq
MIRT1355593	hsa-miR-1253	CLIP-seq
MIRT1355596	hsa-miR-4433	CLIP-seq
MIRT1355597	hsa-miR-4434	CLIP-seq
MIRT1355598	hsa-miR-4459	CLIP-seq
MIRT1355599	hsa-miR-4516	CLIP-seq
MIRT1355600	hsa-miR-4768-3p	CLIP-seq
MIRT2329883	hsa-miR-1236	CLIP-seq
MIRT2329884	hsa-miR-3907	CLIP-seq
MIRT2329885	hsa-miR-409-3p	CLIP-seq
MIRT2329886	hsa-miR-4652-3p	CLIP-seq
MIRT2329887	hsa-miR-4778-3p	CLIP-seq
MIRT2442634	hsa-miR-2276	CLIP-seq
MIRT2442635	hsa-miR-4708-3p	CLIP-seq
MIRT2442636	hsa-miR-556-3p	CLIP-seq
MIRT2459589	hsa-miR-3129-3p	CLIP-seq
MIRT2459590	hsa-miR-3647-3p	CLIP-seq
MIRT2459591	hsa-miR-409-5p	CLIP-seq
MIRT2459592	hsa-miR-4428	CLIP-seq
MIRT2459593	hsa-miR-490-3p	CLIP-seq
MIRT2459594	hsa-miR-499-3p	CLIP-seq
MIRT2459595	hsa-miR-499a-3p	CLIP-seq
MIRT2459596	hsa-miR-548a-3p	CLIP-seq
MIRT2459597	hsa-miR-548e	CLIP-seq
MIRT2459598	hsa-miR-548f	CLIP-seq
MIRT2459599	hsa-miR-649	CLIP-seq
MIRT2442634	hsa-miR-2276	CLIP-seq
MIRT2442635	hsa-miR-4708-3p	CLIP-seq
MIRT2442636	hsa-miR-556-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005743	Component	Mitochondrial inner membrane	ISS
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0006554	Process	Lysine catabolic process	TAS
GO:0015139	Function	Alpha-ketoglutarate transmembrane transporter activity	IDA	11083877
GO:0015139	Function	Alpha-ketoglutarate transmembrane transporter activity	IMP	29517768
GO:0015139	Function	Alpha-ketoglutarate transmembrane transporter activity	TAS
GO:0016021	Component	Integral component of membrane	IEA
GO:1990550	Process	Mitochondrial alpha-ketoglutarate transmembrane transport	IC	11083877
GO:1990550	Process	Mitochondrial alpha-ketoglutarate transmembrane transport	IMP	29517768

Other IDs

• MIM: 607571
• HGNC: 14411
• e!Ensembl: ENSG00000183032

Protein

• UniProt ID: Q9BQT8
• Protein name: Mitochondrial 2-oxodicarboxylate carrier (ODC) (Mitochondrial 2-oxoadipate carrier) (Solute carrier family 25 member 21)
• Protein function: Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism (PubMed:11083877). Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00153	Mito_carr	11 → 104	Mitochondrial carrier protein	Family
  PF00153	Mito_carr	107 → 201	Mitochondrial carrier protein	Family
  PF00153	Mito_carr	204 → 299	Mitochondrial carrier protein	Family

• Sequence:

  MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSF
  RMIFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVSLSPALTFAIAGLGSG
  LTEAIVVNPFEVVKVGLQANRNTFAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHG
  VFNMVYFGFYYNVKNMIPVNKDPILEFWRKFGIGLLSGTIASVINIPFDVAKSRIQGPQP
  VPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW

• Sequence length: 299

Pathways

Reactome:

Lysine catabolism

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059683