TRIM15 (tripartite motif containing 15)

Gene

• Entrez ID: 89870
• Gene name: Tripartite motif containing 15
• Gene symbol: TRIM15
• Synonyms: RNF93, ZNF178, ZNFB7
• Chromosome: 6
• Chromosome location: 6p22.1
• Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternativ

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1453174	hsa-miR-1321	CLIP-seq
MIRT1453175	hsa-miR-24	CLIP-seq
MIRT1453176	hsa-miR-2467-5p	CLIP-seq
MIRT1453177	hsa-miR-3664-3p	CLIP-seq
MIRT1453178	hsa-miR-4270	CLIP-seq
MIRT1453179	hsa-miR-4436a	CLIP-seq
MIRT1453180	hsa-miR-4441	CLIP-seq
MIRT1453181	hsa-miR-4739	CLIP-seq
MIRT1453182	hsa-miR-4756-5p	CLIP-seq
MIRT1453183	hsa-miR-513a-5p	CLIP-seq
MIRT1453174	hsa-miR-1321	CLIP-seq
MIRT1453176	hsa-miR-2467-5p	CLIP-seq
MIRT1453178	hsa-miR-4270	CLIP-seq
MIRT1453180	hsa-miR-4441	CLIP-seq
MIRT1453181	hsa-miR-4739	CLIP-seq
MIRT1453182	hsa-miR-4756-5p	CLIP-seq
MIRT1453183	hsa-miR-513a-5p	CLIP-seq
MIRT2356894	hsa-miR-494	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IDA	23077300
GO:0005515	Function	Protein binding	IPI	25416956, 26871637, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0007500	Process	Mesodermal cell fate determination	TAS	10207104
GO:0008270	Function	Zinc ion binding	IEA
GO:0010468	Process	Regulation of gene expression	IBA	21873635
GO:0016567	Process	Protein ubiquitination	IBA	21873635
GO:0032481	Process	Positive regulation of type I interferon production	IMP	23077300
GO:0045087	Process	Innate immune response	IBA	21873635
GO:0045087	Process	Innate immune response	IMP	18248090
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IEA
GO:0051091	Process	Positive regulation of DNA-binding transcription factor activity	IMP	23077300
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IBA	21873635
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IDA	23077300
GO:0061630	Function	Ubiquitin protein ligase activity	IBA	21873635
GO:1900246	Process	Positive regulation of RIG-I signaling pathway	IMP	23077300
GO:1901253	Process	Negative regulation of intracellular transport of viral material	IMP	18248090
GO:1902187	Process	Negative regulation of viral release from host cell	IDA	18248090
GO:1902187	Process	Negative regulation of viral release from host cell	IMP	18248090

Other IDs

• MIM: HGNC
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9C019
• Protein name: E3 ubiquitin-protein ligase TRIM15 (EC 2.3.2.27) (RING finger protein 93) (Zinc finger protein 178) (Zinc finger protein B7)
• Protein function: E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:23077300, PubMed:34142270). Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promotin
• PDB: 7QS2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00097	zf-C3HC4	16 → 60	Zinc finger, C3HC4 type (RING finger)	Domain
  PF00643	zf-B_box	79 → 120	B-box zinc finger	Domain
  PF13765	PRY	296 → 344	SPRY-associated domain	Family
  PF00622	SPRY	348 → 465	SPRY domain	Family

• Sequence:

  MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLC
  QEEEQAETPMAPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFLD
  EAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQEL
  EQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVRV
  NQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVITLDP
  QTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDG
  GGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALD
  YEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG

• Sequence length: 465

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	17804836, 19503088

Unknown
Disease name	Disease term	dbSNP ID	References
Ulcerative colitis	Ulcerative Colitis		29562276
Vitiligo	Vitiligo		20526339