SEC16B (SEC16 homolog B, endoplasmic reticulum export factor)

Gene

• Entrez ID: 89866
• Gene name: SEC16 homolog B, endoplasmic reticulum export factor
• Gene symbol: SEC16B
• Synonyms: LZTR2, PGPR-p117, RGPR, RGPR-p117, SEC16S
• Chromosome: 1
• Chromosome location: 1q25.2
• Summary: SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017884	hsa-miR-335-5p	Microarray	18185580
MIRT1332491	hsa-miR-3184	CLIP-seq
MIRT1332492	hsa-miR-3192	CLIP-seq
MIRT1332493	hsa-miR-3529	CLIP-seq
MIRT1332494	hsa-miR-379	CLIP-seq
MIRT1332495	hsa-miR-423-5p	CLIP-seq
MIRT1332496	hsa-miR-4451	CLIP-seq
MIRT1332497	hsa-miR-4492	CLIP-seq
MIRT1332498	hsa-miR-4498	CLIP-seq
MIRT1332499	hsa-miR-4505	CLIP-seq
MIRT1332500	hsa-miR-4650-3p	CLIP-seq
MIRT1332501	hsa-miR-762	CLIP-seq
MIRT2323007	hsa-miR-3163	CLIP-seq
MIRT2323008	hsa-miR-3942-5p	CLIP-seq
MIRT2323009	hsa-miR-4703-5p	CLIP-seq
MIRT2394145	hsa-miR-3607-5p	CLIP-seq
MIRT2394146	hsa-miR-3944-5p	CLIP-seq
MIRT2394147	hsa-miR-4639-3p	CLIP-seq
MIRT2394148	hsa-miR-668	CLIP-seq
MIRT2394149	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	21478858, 22355596
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IMP	21478858
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS	22355596
GO:0006914	Process	Autophagy	IEA
GO:0007029	Process	Endoplasmic reticulum organization	IBA	21873635
GO:0007029	Process	Endoplasmic reticulum organization	IDA	21768384
GO:0007030	Process	Golgi organization	IBA	21873635
GO:0007031	Process	Peroxisome organization	IDA	21768384
GO:0010628	Process	Positive regulation of gene expression	IMP	21768384
GO:0012507	Component	ER to Golgi transport vesicle membrane	IBA	21873635
GO:0015031	Process	Protein transport	IEA
GO:0016559	Process	Peroxisome fission	IMP	21768384
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA	21768384
GO:0048208	Process	COPII vesicle coating	IBA	21873635
GO:0048208	Process	COPII vesicle coating	TAS
GO:0070863	Process	Positive regulation of protein exit from endoplasmic reticulum	IBA	21873635
GO:0070863	Process	Positive regulation of protein exit from endoplasmic reticulum	IMP	21768384
GO:0070971	Component	Endoplasmic reticulum exit site	IBA	21873635
GO:0070971	Component	Endoplasmic reticulum exit site	IDA	21478858, 22355596
GO:0070973	Process	Protein localization to endoplasmic reticulum exit site	IBA	21873635

Other IDs

• MIM: 612855
• HGNC: 30301
• e!Ensembl: ENSG00000120341

Protein

• UniProt ID: Q96JE7
• Protein name: Protein transport protein Sec16B (Leucine zipper transcription regulator 2) (Regucalcin gene promoter region-related protein p117) (RGPR-p117) (SEC16 homolog B)
• Protein function: Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411,
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12932	Sec16	279 → 378	Vesicle coat trafficking protein Sec16 mid-region	Domain
  PF12931	Sec16_C	445 → 715	Sec23-binding domain of Sec16	Domain

• Sequence:

  MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGERFHQWQDNRGSPQPQQ
  EPRADHQQQPHYASRPGDWHQPVSGVDYYEGGYRNQLYSRPGYENSYQSYQSPTMREEYA
  YGSYYYHGHPQWLQEERVPRQRSPYIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSN
  SRNPCKDSPASNSGQEWPGELFPGSLLAEAQKNKPSLASESNLLQQRESGLSSSSYELSQ
  YIRDAPERDDPPASAAWSPVQADVSSAGPKAPMKFYIPHVPVSFGPGGQLVHVGPSSPTD
  GQAALVELHSMEVILNDSEEQEEMRSFSGPLIREDVHKVDIMTFCQQKAAQSCKSETLGS
  RDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLS
  SGTPNLLTGEIPPSVETPAQIVEKFTRLLYYGRKKEALEWAMKNHLWGHALFLSSKMDPQ
  TYSWVMSGFTSTLALNDPLQTLFQLMSGRIPQAATCCGEKQWGDWRPHLAVILSNQAGDP
  ELYQRAIVAIGDTLAGKGLVEAAHFCYLMAHVPFGHYTVKTDHLVLLGSSHSQEFLKFAT
  TEAIQRTEIFEYCQMLGRPKSFIPSFQVYKLLYASRLADYGLVSQALHYCEAIGAAVLSQ
  GESSHPVLLVELIKLAEKLKLSDPLVLERRSGDRDLEPDWLAQLRRQLEQKVAGDIGDPH
  PTRSDISGAGGTTTENTFYQDFSGCQGYSEAPGYRSALWLTPEQTCLLQPSPQQPFPLQP
  GSYPAGGGAGQTGTPRPFYSVPETHLPGTGSSVAVTEATGGTVWEEMLQTHLGPGENTVS
  QETSQPPDGQEVISKPQTPLAARPRSISESSASSAKEDEKESSDEADKNSPRNTAQRGKL
  GDGKEHTKSSGFGWFSWFRSKPTKNASPAGDEDSSDSPDSEETPRASSPHQAGLGLSLTP
  SPESPPLPDVSAFSRGRGGGEGRGSASSGGAAAGAGVGGLSGPESVSFELCSNPGVLLPP
  PALKGAVPLYNPSQVPQLPTATSLNRPNRLAQRRYPTQPC

• Sequence length: 1060

Pathways

Reactome:

COPII-mediated vesicle transport

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	22484627