PPP1R3F (protein phosphatase 1 regulatory subunit 3F)

Gene

• Entrez ID: 89801
• Gene name: Protein phosphatase 1 regulatory subunit 3F
• Gene symbol: PPP1R3F
• Synonyms: HB2E, LL0XNC01-7P3.1, R3F
• Chromosome: X
• Chromosome location: Xp11.23
• Summary: This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulator

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT720055	hsa-miR-548n	HITS-CLIP	19536157
MIRT720054	hsa-miR-548az-5p	HITS-CLIP	19536157
MIRT720053	hsa-miR-548t-5p	HITS-CLIP	19536157
MIRT720051	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT720052	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT720050	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT720049	hsa-miR-520f-5p	HITS-CLIP	19536157
MIRT720048	hsa-miR-6509-3p	HITS-CLIP	19536157
MIRT720047	hsa-miR-4436b-5p	HITS-CLIP	19536157
MIRT720046	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT720055	hsa-miR-548n	HITS-CLIP	19536157
MIRT720054	hsa-miR-548az-5p	HITS-CLIP	19536157
MIRT720053	hsa-miR-548t-5p	HITS-CLIP	19536157
MIRT720051	hsa-miR-6777-3p	HITS-CLIP	19536157
MIRT720052	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT720050	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT720049	hsa-miR-520f-5p	HITS-CLIP	19536157
MIRT720048	hsa-miR-6509-3p	HITS-CLIP	19536157
MIRT720047	hsa-miR-4436b-5p	HITS-CLIP	19536157
MIRT720046	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT1256956	hsa-miR-1236	CLIP-seq
MIRT1256957	hsa-miR-127-5p	CLIP-seq
MIRT1256958	hsa-miR-134	CLIP-seq
MIRT1256959	hsa-miR-149	CLIP-seq
MIRT1256960	hsa-miR-15a	CLIP-seq
MIRT1256961	hsa-miR-15b	CLIP-seq
MIRT1256962	hsa-miR-16	CLIP-seq
MIRT1256963	hsa-miR-195	CLIP-seq
MIRT1256964	hsa-miR-214	CLIP-seq
MIRT1256965	hsa-miR-3118	CLIP-seq
MIRT1256966	hsa-miR-3136-5p	CLIP-seq
MIRT1256967	hsa-miR-3164	CLIP-seq
MIRT1256968	hsa-miR-3607-5p	CLIP-seq
MIRT1256969	hsa-miR-3619-5p	CLIP-seq
MIRT1256970	hsa-miR-424	CLIP-seq
MIRT1256971	hsa-miR-4252	CLIP-seq
MIRT1256972	hsa-miR-4292	CLIP-seq
MIRT1256973	hsa-miR-4308	CLIP-seq
MIRT1256974	hsa-miR-4439	CLIP-seq
MIRT1256975	hsa-miR-4501	CLIP-seq
MIRT1256976	hsa-miR-4513	CLIP-seq
MIRT1256977	hsa-miR-4690-5p	CLIP-seq
MIRT1256978	hsa-miR-4691-5p	CLIP-seq
MIRT1256979	hsa-miR-497	CLIP-seq
MIRT1256980	hsa-miR-604	CLIP-seq
MIRT1256981	hsa-miR-647	CLIP-seq
MIRT1256982	hsa-miR-653	CLIP-seq
MIRT1256983	hsa-miR-761	CLIP-seq
MIRT2075649	hsa-miR-1182	CLIP-seq
MIRT2075650	hsa-miR-1224-3p	CLIP-seq
MIRT1256956	hsa-miR-1236	CLIP-seq
MIRT2075651	hsa-miR-1255a	CLIP-seq
MIRT2075652	hsa-miR-1255b	CLIP-seq
MIRT2075653	hsa-miR-1260	CLIP-seq
MIRT2075654	hsa-miR-1260b	CLIP-seq
MIRT2075655	hsa-miR-1280	CLIP-seq
MIRT1256959	hsa-miR-149	CLIP-seq
MIRT2075656	hsa-miR-185	CLIP-seq
MIRT2075657	hsa-miR-188-3p	CLIP-seq
MIRT2075658	hsa-miR-2110	CLIP-seq
MIRT1256966	hsa-miR-3136-5p	CLIP-seq
MIRT2075659	hsa-miR-3150a-3p	CLIP-seq
MIRT2075660	hsa-miR-329	CLIP-seq
MIRT2075661	hsa-miR-362-3p	CLIP-seq
MIRT2075662	hsa-miR-3941	CLIP-seq
MIRT1256971	hsa-miR-4252	CLIP-seq
MIRT1256972	hsa-miR-4292	CLIP-seq
MIRT2075663	hsa-miR-4306	CLIP-seq
MIRT1256973	hsa-miR-4308	CLIP-seq
MIRT1256974	hsa-miR-4439	CLIP-seq
MIRT2075664	hsa-miR-4450	CLIP-seq
MIRT2075665	hsa-miR-4453	CLIP-seq
MIRT2075666	hsa-miR-4491	CLIP-seq
MIRT2075667	hsa-miR-4514	CLIP-seq
MIRT2075668	hsa-miR-4538	CLIP-seq
MIRT2075669	hsa-miR-4644	CLIP-seq
MIRT2075670	hsa-miR-4657	CLIP-seq
MIRT1256978	hsa-miR-4691-5p	CLIP-seq
MIRT2075671	hsa-miR-4692	CLIP-seq
MIRT2075672	hsa-miR-532-3p	CLIP-seq
MIRT2075673	hsa-miR-603	CLIP-seq
MIRT2075674	hsa-miR-943	CLIP-seq
MIRT2075650	hsa-miR-1224-3p	CLIP-seq
MIRT1256956	hsa-miR-1236	CLIP-seq
MIRT2075653	hsa-miR-1260	CLIP-seq
MIRT2075654	hsa-miR-1260b	CLIP-seq
MIRT2075655	hsa-miR-1280	CLIP-seq
MIRT1256959	hsa-miR-149	CLIP-seq
MIRT2302264	hsa-miR-369-3p	CLIP-seq
MIRT2302265	hsa-miR-374a	CLIP-seq
MIRT2302266	hsa-miR-374b	CLIP-seq
MIRT2302267	hsa-miR-410	CLIP-seq
MIRT1256971	hsa-miR-4252	CLIP-seq
MIRT1256972	hsa-miR-4292	CLIP-seq
MIRT1256973	hsa-miR-4308	CLIP-seq
MIRT1256978	hsa-miR-4691-5p	CLIP-seq
MIRT2075672	hsa-miR-532-3p	CLIP-seq
MIRT2075657	hsa-miR-188-3p	CLIP-seq
MIRT2439591	hsa-miR-100	CLIP-seq
MIRT2439592	hsa-miR-642a	CLIP-seq
MIRT2439593	hsa-miR-99a	CLIP-seq
MIRT2439594	hsa-miR-99b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000164	Component	Protein phosphatase type 1 complex	IBA	21873635
GO:0005979	Process	Regulation of glycogen biosynthetic process	IBA	21873635
GO:0005979	Process	Regulation of glycogen biosynthetic process	IDA	21668450
GO:0008157	Function	Protein phosphatase 1 binding	IBA	21873635
GO:0016020	Component	Membrane	IDA	21668450
GO:0016021	Component	Integral component of membrane	IEA
GO:0019903	Function	Protein phosphatase binding	IPI	21668450
GO:2000465	Process	Regulation of glycogen (starch) synthase activity	IDA	21668450
GO:2001069	Function	Glycogen binding	IBA	21873635
GO:2001069	Function	Glycogen binding	IDA	21668450

Other IDs

• MIM: 301104
• HGNC: 14944
• e!Ensembl: ENSG00000049769

Protein

• UniProt ID: Q6ZSY5
• Protein name: Protein phosphatase 1 regulatory subunit 3F (R3F)
• Protein function: Glycogen-targeting subunit for protein phosphatase 1 (PP1).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03370	CBM_21	151 → 284	Carbohydrate/starch-binding module (family 21)	Domain

• Sequence:

  MARTAPVEPPLRHSAPPSPAAGEPRTSVEAAVAPRRVLFADEALGLPLAQLRRYRPWGGP
  GAGKMAAAAGQDGGGGGGADEDDDGEDGDEGEEEEEACPEPSPLCPVPAGGGFYLVPTFS
  LPPAPGRLERLGRVMVELEALLPPPGAVPGGAGVWVPGGRPPVLRGLVRVLNRSFEKAVH
  VRASHDGWASFCDHPARYVPRSPPWAGAGGTGAGDPILDPGLGLGPGQASASSPDDGGRT
  DRFAFQLPFAEGAGDGARLDFVVRYETPEGTFWANNHGRNYTVLLRIAPAPTPTDAEGLP
  QQQQLPQLEPQPECQGPVEAEARQLKSCMKPVRRRPAEEELKTKNMDDNTFAMAEHPDVQ
  ESVGPLVAPTPLRPWPQMTLQVSDVPMTGNPAEEGDVPRSSPPVAFTEVLQAPAIRIPPS
  SPLCGLGGSPRDQASGPDASEGATGPFLEPSQQQAEATWGVSSENGGGLEAVSGSEELLG
  EDTIDQELEQLYLSHLSRLRAAVAAGGAGGGGEGSTDGGMSPSHPLGILTDRDLILKWPG
  PERALNSALAEEITLHYARLGRGVELIKDTEDPDDEGEGEEGLSVTPSSPEGDSPKESPP
  EILSGARSVVATMGDVWLPWAEGSGCDGPVVLGTEGQFIGDPEKGMGKDTSSLHMNRVIA
  GVTESLGEAGTEAQIEVTSEWAGSLDPISGKEPASPVLLQGQNPTLLSPLGAEVCLSSVA
  RPHVSSQDEKDAGPSLEPPKKSPTLAVPAECVCALPPQLRGPLTQTLGVLAGLVVVPVAL
  NSGVSLLVLALCLSLAWFS

• Sequence length: 799

Pathways

KEGG:

Insulin signaling pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	30929738