HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3)

Gene

• Entrez ID: 8916
• Gene name: HECT and RLD domain containing E3 ubiquitin protein ligase 3
• Gene symbol: HERC3
• Synonyms: -
• Chromosome: 4
• Chromosome location: 4q22.1
• Summary: This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced tra

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025153	hsa-miR-181a-5p	Microarray	17612493
MIRT046255	hsa-miR-23b-3p	CLASH	23622248
MIRT1044341	hsa-miR-137	CLIP-seq
MIRT1044342	hsa-miR-153	CLIP-seq
MIRT1044343	hsa-miR-25	CLIP-seq
MIRT1044344	hsa-miR-3122	CLIP-seq
MIRT1044345	hsa-miR-3153	CLIP-seq
MIRT1044346	hsa-miR-32	CLIP-seq
MIRT1044347	hsa-miR-338-5p	CLIP-seq
MIRT1044348	hsa-miR-3545-3p	CLIP-seq
MIRT1044349	hsa-miR-363	CLIP-seq
MIRT1044350	hsa-miR-367	CLIP-seq
MIRT1044351	hsa-miR-3913-5p	CLIP-seq
MIRT1044352	hsa-miR-3976	CLIP-seq
MIRT1044353	hsa-miR-432	CLIP-seq
MIRT1044354	hsa-miR-448	CLIP-seq
MIRT1044355	hsa-miR-4520a-3p	CLIP-seq
MIRT1044356	hsa-miR-4520b-3p	CLIP-seq
MIRT1044357	hsa-miR-4668-5p	CLIP-seq
MIRT1044358	hsa-miR-4795-3p	CLIP-seq
MIRT1044359	hsa-miR-4799-5p	CLIP-seq
MIRT1044360	hsa-miR-5096	CLIP-seq
MIRT1044361	hsa-miR-513a-3p	CLIP-seq
MIRT1044362	hsa-miR-548a-5p	CLIP-seq
MIRT1044363	hsa-miR-548ab	CLIP-seq
MIRT1044364	hsa-miR-548ak	CLIP-seq
MIRT1044365	hsa-miR-548b-5p	CLIP-seq
MIRT1044366	hsa-miR-548c-5p	CLIP-seq
MIRT1044367	hsa-miR-548d-5p	CLIP-seq
MIRT1044368	hsa-miR-548h	CLIP-seq
MIRT1044369	hsa-miR-548i	CLIP-seq
MIRT1044370	hsa-miR-548j	CLIP-seq
MIRT1044371	hsa-miR-548w	CLIP-seq
MIRT1044372	hsa-miR-548y	CLIP-seq
MIRT1044373	hsa-miR-559	CLIP-seq
MIRT1044374	hsa-miR-561	CLIP-seq
MIRT1044375	hsa-miR-577	CLIP-seq
MIRT1044376	hsa-miR-578	CLIP-seq
MIRT1044377	hsa-miR-622	CLIP-seq
MIRT1044378	hsa-miR-92a	CLIP-seq
MIRT1044379	hsa-miR-92b	CLIP-seq
MIRT2009655	hsa-miR-1238	CLIP-seq
MIRT2009656	hsa-miR-1910	CLIP-seq
MIRT2009657	hsa-miR-3121-5p	CLIP-seq
MIRT2009658	hsa-miR-3124-3p	CLIP-seq
MIRT2009659	hsa-miR-3673	CLIP-seq
MIRT2009660	hsa-miR-3908	CLIP-seq
MIRT2009661	hsa-miR-3942-5p	CLIP-seq
MIRT2009662	hsa-miR-4691-5p	CLIP-seq
MIRT2009663	hsa-miR-4703-5p	CLIP-seq
MIRT2009664	hsa-miR-4766-3p	CLIP-seq
MIRT2009665	hsa-miR-548ac	CLIP-seq
MIRT2009666	hsa-miR-548ae	CLIP-seq
MIRT2009667	hsa-miR-548aj	CLIP-seq
MIRT2009668	hsa-miR-548am	CLIP-seq
MIRT2009669	hsa-miR-548d-3p	CLIP-seq
MIRT2009670	hsa-miR-548x	CLIP-seq
MIRT2009671	hsa-miR-548z	CLIP-seq
MIRT2241933	hsa-miR-130a	CLIP-seq
MIRT2241934	hsa-miR-130b	CLIP-seq
MIRT2241935	hsa-miR-181a	CLIP-seq
MIRT2241936	hsa-miR-181b	CLIP-seq
MIRT2241937	hsa-miR-181c	CLIP-seq
MIRT2241938	hsa-miR-181d	CLIP-seq
MIRT2241939	hsa-miR-301a	CLIP-seq
MIRT2241940	hsa-miR-301b	CLIP-seq
MIRT2241941	hsa-miR-3177-5p	CLIP-seq
MIRT2241942	hsa-miR-338-3p	CLIP-seq
MIRT2241943	hsa-miR-3666	CLIP-seq
MIRT2009659	hsa-miR-3673	CLIP-seq
MIRT2241944	hsa-miR-3691-3p	CLIP-seq
MIRT2009660	hsa-miR-3908	CLIP-seq
MIRT2009661	hsa-miR-3942-5p	CLIP-seq
MIRT2241945	hsa-miR-4262	CLIP-seq
MIRT2241946	hsa-miR-4295	CLIP-seq
MIRT2241947	hsa-miR-4457	CLIP-seq
MIRT2241948	hsa-miR-4530	CLIP-seq
MIRT2241949	hsa-miR-454	CLIP-seq
MIRT2009663	hsa-miR-4703-5p	CLIP-seq
MIRT2009664	hsa-miR-4766-3p	CLIP-seq
MIRT2241950	hsa-miR-4797-5p	CLIP-seq
MIRT2241951	hsa-miR-513b	CLIP-seq
MIRT2241952	hsa-miR-759	CLIP-seq
MIRT2241953	hsa-miR-922	CLIP-seq
MIRT2451129	hsa-miR-4668-3p	CLIP-seq
MIRT2451130	hsa-miR-548c-3p	CLIP-seq
MIRT1044374	hsa-miR-561	CLIP-seq
MIRT2545646	hsa-miR-1283	CLIP-seq
MIRT2009659	hsa-miR-3673	CLIP-seq
MIRT2009660	hsa-miR-3908	CLIP-seq
MIRT2009661	hsa-miR-3942-5p	CLIP-seq
MIRT2009663	hsa-miR-4703-5p	CLIP-seq
MIRT2009664	hsa-miR-4766-3p	CLIP-seq
MIRT2009665	hsa-miR-548ac	CLIP-seq
MIRT2009666	hsa-miR-548ae	CLIP-seq
MIRT2009667	hsa-miR-548aj	CLIP-seq
MIRT2009668	hsa-miR-548am	CLIP-seq
MIRT2451130	hsa-miR-548c-3p	CLIP-seq
MIRT2009669	hsa-miR-548d-3p	CLIP-seq
MIRT2545647	hsa-miR-548p	CLIP-seq
MIRT2009670	hsa-miR-548x	CLIP-seq
MIRT2009671	hsa-miR-548z	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005829	Component	Cytosol	IDA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA

Other IDs

• MIM: 605200
• HGNC: 4876
• e!Ensembl: ENSG00000138641

Protein

• UniProt ID: Q15034
• Protein name: Probable E3 ubiquitin-protein ligase HERC3 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 3) (HECT-type E3 ubiquitin transferase HERC3)
• Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00415	RCC1	52 → 99	Regulator of chromosome condensation (RCC1) repeat	Repeat
  PF00415	RCC1	102 → 152	Regulator of chromosome condensation (RCC1) repeat	Repeat
  PF00415	RCC1	155 → 205	Regulator of chromosome condensation (RCC1) repeat	Repeat
  PF00415	RCC1	208 → 257	Regulator of chromosome condensation (RCC1) repeat	Repeat
  PF00415	RCC1	260 → 309	Regulator of chromosome condensation (RCC1) repeat	Repeat
  PF00415	RCC1	313 → 377	Regulator of chromosome condensation (RCC1) repeat	Repeat
  PF00632	HECT	752 → 1050	HECT-domain (ubiquitin-transferase)	Domain

• Sequence:

  MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL
  NTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT
  TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS
  PQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLR
  TQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIA
  CGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFK
  YHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLSEHNNA
  NTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILE
  QILNSFESCLIPQLSSSPPDVEAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLDTNP
  SKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKV
  NLKVKHVEYDTFYIPEISNLVDIQEDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQ
  AKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELS
  IHSDIDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDT
  CFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQE
  LLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQI
  SVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHP
  TVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYN
  LLDLPKYSSKEILSARLTQALDNYEGFSLA

• Sequence length: 1050

Pathways

KEGG:

Ubiquitin mediated proteolysis

Reactome:

Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver neoplasms	Liver neoplasms		19233941
Liver cancer	Malignant neoplasm of liver		19233941