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CPNE1 (copine 1)

Gene

8904

Copine 1

CPNE1

COPN1, CPN1

20q11.22

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like

Show/Hide all(117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032109	hsa-let-7d-5p	Sequencing	20371350
MIRT043882	hsa-miR-378a-3p	CLASH	23622248
MIRT040983	hsa-miR-532-5p	CLASH	23622248
MIRT037995	hsa-miR-500a-5p	CLASH	23622248
MIRT036389	hsa-miR-1229-3p	CLASH	23622248
MIRT727953	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727952	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT727951	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727950	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT906491	hsa-miR-106a	CLIP-seq
MIRT906492	hsa-miR-106b	CLIP-seq
MIRT906493	hsa-miR-1253	CLIP-seq
MIRT906494	hsa-miR-15a	CLIP-seq
MIRT906495	hsa-miR-15b	CLIP-seq
MIRT906496	hsa-miR-16	CLIP-seq
MIRT906497	hsa-miR-17	CLIP-seq
MIRT906498	hsa-miR-195	CLIP-seq
MIRT906499	hsa-miR-20a	CLIP-seq
MIRT906500	hsa-miR-20b	CLIP-seq
MIRT906501	hsa-miR-2278	CLIP-seq
MIRT906502	hsa-miR-296-3p	CLIP-seq
MIRT906503	hsa-miR-302a	CLIP-seq
MIRT906504	hsa-miR-302b	CLIP-seq
MIRT906505	hsa-miR-302c	CLIP-seq
MIRT906506	hsa-miR-302d	CLIP-seq
MIRT906507	hsa-miR-302e	CLIP-seq
MIRT906508	hsa-miR-3150b-3p	CLIP-seq
MIRT906509	hsa-miR-3154	CLIP-seq
MIRT906510	hsa-miR-3163	CLIP-seq
MIRT906511	hsa-miR-335	CLIP-seq
MIRT906512	hsa-miR-3613-3p	CLIP-seq
MIRT906513	hsa-miR-372	CLIP-seq
MIRT906514	hsa-miR-373	CLIP-seq
MIRT906515	hsa-miR-3940-5p	CLIP-seq
MIRT906516	hsa-miR-424	CLIP-seq
MIRT906517	hsa-miR-4433	CLIP-seq
MIRT906518	hsa-miR-4459	CLIP-seq
MIRT906519	hsa-miR-4507	CLIP-seq
MIRT906520	hsa-miR-450b-3p	CLIP-seq
MIRT906521	hsa-miR-4654	CLIP-seq
MIRT906522	hsa-miR-4689	CLIP-seq
MIRT906523	hsa-miR-4693-3p	CLIP-seq
MIRT906524	hsa-miR-4713-3p	CLIP-seq
MIRT906525	hsa-miR-4768-3p	CLIP-seq
MIRT906526	hsa-miR-4769-5p	CLIP-seq
MIRT906527	hsa-miR-4784	CLIP-seq
MIRT906528	hsa-miR-497	CLIP-seq
MIRT906529	hsa-miR-519d	CLIP-seq
MIRT906530	hsa-miR-520a-3p	CLIP-seq
MIRT906531	hsa-miR-520b	CLIP-seq
MIRT906532	hsa-miR-520c-3p	CLIP-seq
MIRT906533	hsa-miR-520d-3p	CLIP-seq
MIRT906534	hsa-miR-520d-5p	CLIP-seq
MIRT906535	hsa-miR-520e	CLIP-seq
MIRT906536	hsa-miR-520g	CLIP-seq
MIRT906537	hsa-miR-520h	CLIP-seq
MIRT906538	hsa-miR-524-5p	CLIP-seq
MIRT906539	hsa-miR-545	CLIP-seq
MIRT906540	hsa-miR-548l	CLIP-seq
MIRT906541	hsa-miR-548n	CLIP-seq
MIRT906542	hsa-miR-548p	CLIP-seq
MIRT906543	hsa-miR-548t	CLIP-seq
MIRT906544	hsa-miR-621	CLIP-seq
MIRT906545	hsa-miR-638	CLIP-seq
MIRT906546	hsa-miR-769-3p	CLIP-seq
MIRT906547	hsa-miR-93	CLIP-seq
MIRT906494	hsa-miR-15a	CLIP-seq
MIRT906495	hsa-miR-15b	CLIP-seq
MIRT906496	hsa-miR-16	CLIP-seq
MIRT906498	hsa-miR-195	CLIP-seq
MIRT906501	hsa-miR-2278	CLIP-seq
MIRT906502	hsa-miR-296-3p	CLIP-seq
MIRT906548	hsa-miR-323b-5p	CLIP-seq
MIRT906511	hsa-miR-335	CLIP-seq
MIRT906549	hsa-miR-3663-5p	CLIP-seq
MIRT906516	hsa-miR-424	CLIP-seq
MIRT906517	hsa-miR-4433	CLIP-seq
MIRT906518	hsa-miR-4459	CLIP-seq
MIRT906520	hsa-miR-450b-3p	CLIP-seq
MIRT906521	hsa-miR-4654	CLIP-seq
MIRT906524	hsa-miR-4713-3p	CLIP-seq
MIRT906525	hsa-miR-4768-3p	CLIP-seq
MIRT906526	hsa-miR-4769-5p	CLIP-seq
MIRT906528	hsa-miR-497	CLIP-seq
MIRT906539	hsa-miR-545	CLIP-seq
MIRT906542	hsa-miR-548p	CLIP-seq
MIRT906545	hsa-miR-638	CLIP-seq
MIRT906546	hsa-miR-769-3p	CLIP-seq
MIRT906502	hsa-miR-296-3p	CLIP-seq
MIRT906548	hsa-miR-323b-5p	CLIP-seq
MIRT906549	hsa-miR-3663-5p	CLIP-seq
MIRT906550	hsa-miR-412	CLIP-seq
MIRT906551	hsa-miR-4420	CLIP-seq
MIRT906517	hsa-miR-4433	CLIP-seq
MIRT906518	hsa-miR-4459	CLIP-seq
MIRT906525	hsa-miR-4768-3p	CLIP-seq
MIRT906494	hsa-miR-15a	CLIP-seq
MIRT906495	hsa-miR-15b	CLIP-seq
MIRT906496	hsa-miR-16	CLIP-seq
MIRT906498	hsa-miR-195	CLIP-seq
MIRT906501	hsa-miR-2278	CLIP-seq
MIRT906502	hsa-miR-296-3p	CLIP-seq
MIRT906548	hsa-miR-323b-5p	CLIP-seq
MIRT906511	hsa-miR-335	CLIP-seq
MIRT906516	hsa-miR-424	CLIP-seq
MIRT906517	hsa-miR-4433	CLIP-seq
MIRT906518	hsa-miR-4459	CLIP-seq
MIRT906520	hsa-miR-450b-3p	CLIP-seq
MIRT906521	hsa-miR-4654	CLIP-seq
MIRT906524	hsa-miR-4713-3p	CLIP-seq
MIRT906525	hsa-miR-4768-3p	CLIP-seq
MIRT906526	hsa-miR-4769-5p	CLIP-seq
MIRT906528	hsa-miR-497	CLIP-seq
MIRT906539	hsa-miR-545	CLIP-seq
MIRT906542	hsa-miR-548p	CLIP-seq
MIRT906545	hsa-miR-638	CLIP-seq
MIRT906546	hsa-miR-769-3p	CLIP-seq

Show/Hide all(38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001786	Function	Phosphatidylserine binding	IDA	9430674
GO:0004175	Function	Endopeptidase activity	IDA	18212740
GO:0005215	Function	Transporter activity	TAS	9430674
GO:0005509	Function	Calcium ion binding	IMP	25450385
GO:0005515	Function	Protein binding	IPI	12522145, 32296183
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA	21873635
GO:0005634	Component	Nucleus	IDA	18212740, 21087455
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	21087455, 25450385
GO:0005829	Component	Cytosol	IDA	12949241, 18212740
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IMP	18212740
GO:0006629	Process	Lipid metabolic process	TAS	9430674
GO:0010629	Process	Negative regulation of gene expression	IMP	18212740
GO:0016020	Component	Membrane	IDA	25450385
GO:0016192	Process	Vesicle-mediated transport	TAS	9430674
GO:0031965	Component	Nuclear membrane	IDA
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0042802	Function	Identical protein binding	IPI	18212740
GO:0043122	Process	Regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0043122	Process	Regulation of I-kappaB kinase/NF-kappaB signaling	IMP	14674885
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043392	Process	Negative regulation of DNA binding	IDA	18212740
GO:0045666	Process	Positive regulation of neuron differentiation	IDA	23263657
GO:0045666	Process	Positive regulation of neuron differentiation	IMP	25450385
GO:0046474	Process	Glycerophospholipid biosynthetic process	TAS
GO:0051059	Function	NF-kappaB binding	IPI	18212740
GO:0051897	Process	Positive regulation of protein kinase B signaling	IDA	23263657
GO:0051897	Process	Positive regulation of protein kinase B signaling	IMP	25450385
GO:0070062	Component	Extracellular exosome	HDA	20458337, 23533145
GO:0071277	Process	Cellular response to calcium ion	IBA	21873635
GO:0071277	Process	Cellular response to calcium ion	IMP	14674885
GO:1901223	Process	Negative regulation of NIK/NF-kappaB signaling	IMP	18212740
GO:1903265	Process	Positive regulation of tumor necrosis factor-mediated signaling pathway	IBA	21873635
GO:1903265	Process	Positive regulation of tumor necrosis factor-mediated signaling pathway	IMP	14674885
GO:1990138	Process	Neuron projection extension	IDA	23263657
GO:1990138	Process	Neuron projection extension	IMP	25450385

MIM	HGNC	e!Ensembl
604205	2314	ENSG00000214078

Protein

UniProt ID

Q99829

Protein name

Copine-1 (Chromobindin 17) (Copine I)

Protein function

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calciu

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00168	C2	6 → 116	C2 domain	Domain
PF00168	C2	138 → 255	C2 domain	Domain
PF07002	Copine	304 → 521	Copine	Family

Sequence

MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSK
TLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGK
PAGRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGDGKWHLVYRSEV
IKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAE
FECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDPS
SPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFN
PSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLLL
TDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARDI
VQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPAQAPQA

Sequence length

537

Interactions

View interactions

	Reactome
			Glycerophospholipid biosynthesis Neutrophil degranulation

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	SCHIZOPHRENIA 19	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313

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