SQSTM1 (sequestosome 1)

Gene

• Entrez ID: 8878
• Gene name: Sequestosome 1
• Gene symbol: SQSTM1
• Synonyms: A170, DMRV, EBIAP, FTDALS3, NADGP, OSIL, PDB3, ZIP3, p60, p62, p62B
• Chromosome: 5
• Chromosome location: 5q35.3
• Summary: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to m

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs104893941	C>T	Likely-pathogenic, pathogenic, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs200396166	C>G,T	Pathogenic, likely-benign	Intron variant, missense variant, coding sequence variant
rs776749939	C>T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs796051869	->T	Pathogenic	Coding sequence variant, stop gained
rs796051870	G>A	Pathogenic	Splice donor variant
rs796052213	A>T	Pathogenic	Coding sequence variant, stop gained
rs796052214	GAA>-	Uncertain-significance, pathogenic	Coding sequence variant, inframe deletion
rs886039780	T>A	Pathogenic	Initiator codon variant, intron variant, missense variant
rs886039781	AG>-	Pathogenic	Coding sequence variant, frameshift variant
rs886039782	C>T	Pathogenic	Coding sequence variant, stop gained
rs1064794783	->CGAGGCTGCGGCGGGTCCG	Not-provided, likely-pathogenic	Coding sequence variant, intron variant, frameshift variant
rs1273214757	AG>-	Pathogenic	Coding sequence variant, frameshift variant
rs1331685476	TCTG>-	Pathogenic	Frameshift variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001410	hsa-miR-16-5p	pSILAC	18668040
MIRT001410	hsa-miR-16-5p	pSILAC	18668040
MIRT018399	hsa-miR-335-5p	Microarray	18185580
MIRT025851	hsa-miR-7-5p	Microarray	19073608
MIRT001410	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT042028	hsa-miR-484	CLASH	23622248
MIRT038085	hsa-miR-423-5p	CLASH	23622248
MIRT038085	hsa-miR-423-5p	CLASH	23622248
MIRT037277	hsa-miR-877-5p	CLASH	23622248
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	21572407
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	21572407
MIRT096296	hsa-miR-646	PAR-CLIP	21572407
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	21572407
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	21572407
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	21572407
MIRT096305	hsa-miR-8069	PAR-CLIP	21572407
MIRT096303	hsa-miR-5093	PAR-CLIP	21572407
MIRT499049	hsa-miR-5087	PAR-CLIP	21572407
MIRT096301	hsa-miR-3978	PAR-CLIP	21572407
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	21572407
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	21572407
MIRT096296	hsa-miR-646	PAR-CLIP	21572407
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	21572407
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	21572407
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	21572407
MIRT096305	hsa-miR-8069	PAR-CLIP	21572407
MIRT096306	hsa-miR-8075	PAR-CLIP	21572407
MIRT096303	hsa-miR-5093	PAR-CLIP	21572407
MIRT499049	hsa-miR-5087	PAR-CLIP	21572407
MIRT096301	hsa-miR-3978	PAR-CLIP	21572407
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	24398324
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	24398324
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	24398324
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	24398324
MIRT096296	hsa-miR-646	PAR-CLIP	24398324
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	24398324
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	24398324
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	24398324
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	24398324
MIRT096305	hsa-miR-8069	PAR-CLIP	24398324
MIRT096306	hsa-miR-8075	PAR-CLIP	24398324
MIRT096303	hsa-miR-5093	PAR-CLIP	24398324
MIRT499049	hsa-miR-5087	PAR-CLIP	24398324
MIRT096301	hsa-miR-3978	PAR-CLIP	24398324
MIRT096312	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT096308	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439548	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT096312	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT096307	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT096319	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT096309	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT096329	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT096308	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439548	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	21572407
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	21572407
MIRT096296	hsa-miR-646	PAR-CLIP	21572407
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	21572407
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	21572407
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	21572407
MIRT096305	hsa-miR-8069	PAR-CLIP	21572407
MIRT096303	hsa-miR-5093	PAR-CLIP	21572407
MIRT499049	hsa-miR-5087	PAR-CLIP	21572407
MIRT096301	hsa-miR-3978	PAR-CLIP	21572407
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	21572407
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	21572407
MIRT096296	hsa-miR-646	PAR-CLIP	21572407
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	21572407
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	21572407
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	21572407
MIRT096305	hsa-miR-8069	PAR-CLIP	21572407
MIRT096306	hsa-miR-8075	PAR-CLIP	21572407
MIRT096303	hsa-miR-5093	PAR-CLIP	21572407
MIRT499049	hsa-miR-5087	PAR-CLIP	21572407
MIRT096301	hsa-miR-3978	PAR-CLIP	21572407
MIRT096298	hsa-miR-548e-5p	PAR-CLIP	24398324
MIRT096299	hsa-miR-1252-3p	PAR-CLIP	24398324
MIRT096300	hsa-miR-3925-5p	PAR-CLIP	24398324
MIRT166151	hsa-miR-7161-3p	PAR-CLIP	24398324
MIRT096296	hsa-miR-646	PAR-CLIP	24398324
MIRT096302	hsa-miR-4712-3p	PAR-CLIP	24398324
MIRT166138	hsa-miR-146a-5p	PAR-CLIP	24398324
MIRT166141	hsa-miR-146b-5p	PAR-CLIP	24398324
MIRT166150	hsa-miR-7153-5p	PAR-CLIP	24398324
MIRT096305	hsa-miR-8069	PAR-CLIP	24398324
MIRT096306	hsa-miR-8075	PAR-CLIP	24398324
MIRT096303	hsa-miR-5093	PAR-CLIP	24398324
MIRT499049	hsa-miR-5087	PAR-CLIP	24398324
MIRT096301	hsa-miR-3978	PAR-CLIP	24398324
MIRT1387478	hsa-miR-135a	CLIP-seq
MIRT1387479	hsa-miR-135b	CLIP-seq
MIRT1387480	hsa-miR-205	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT1387482	hsa-miR-2355-5p	CLIP-seq
MIRT1387483	hsa-miR-3065-3p	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT1387486	hsa-miR-370	CLIP-seq
MIRT1387487	hsa-miR-4261	CLIP-seq
MIRT1387488	hsa-miR-4287	CLIP-seq
MIRT1387489	hsa-miR-4496	CLIP-seq
MIRT1387490	hsa-miR-4685-3p	CLIP-seq
MIRT1387491	hsa-miR-4694-3p	CLIP-seq
MIRT1387492	hsa-miR-4757-5p	CLIP-seq
MIRT1387493	hsa-miR-4763-5p	CLIP-seq
MIRT1387494	hsa-miR-494	CLIP-seq
MIRT1387495	hsa-miR-522	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT1387497	hsa-miR-596	CLIP-seq
MIRT1387498	hsa-miR-628-5p	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT1387500	hsa-miR-106a	CLIP-seq
MIRT1387501	hsa-miR-106b	CLIP-seq
MIRT1387502	hsa-miR-1205	CLIP-seq
MIRT1387503	hsa-miR-1207-5p	CLIP-seq
MIRT1387504	hsa-miR-1283	CLIP-seq
MIRT1387505	hsa-miR-1321	CLIP-seq
MIRT1387506	hsa-miR-139-5p	CLIP-seq
MIRT1387507	hsa-miR-146a	CLIP-seq
MIRT1387508	hsa-miR-1587	CLIP-seq
MIRT1387509	hsa-miR-17	CLIP-seq
MIRT1387510	hsa-miR-1827	CLIP-seq
MIRT1387511	hsa-miR-1909	CLIP-seq
MIRT1387512	hsa-miR-193a-3p	CLIP-seq
MIRT1387513	hsa-miR-193a-5p	CLIP-seq
MIRT1387514	hsa-miR-193b	CLIP-seq
MIRT1387480	hsa-miR-205	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT1387515	hsa-miR-20a	CLIP-seq
MIRT1387516	hsa-miR-20b	CLIP-seq
MIRT1387482	hsa-miR-2355-5p	CLIP-seq
MIRT1387517	hsa-miR-2392	CLIP-seq
MIRT1387518	hsa-miR-298	CLIP-seq
MIRT1387519	hsa-miR-302a	CLIP-seq
MIRT1387520	hsa-miR-302b	CLIP-seq
MIRT1387521	hsa-miR-302c	CLIP-seq
MIRT1387522	hsa-miR-302d	CLIP-seq
MIRT1387523	hsa-miR-302e	CLIP-seq
MIRT1387524	hsa-miR-3184	CLIP-seq
MIRT1387525	hsa-miR-3185	CLIP-seq
MIRT1387526	hsa-miR-3189-3p	CLIP-seq
MIRT1387527	hsa-miR-3192	CLIP-seq
MIRT1387528	hsa-miR-3199	CLIP-seq
MIRT1387529	hsa-miR-3609	CLIP-seq
MIRT1387530	hsa-miR-3612	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT1387531	hsa-miR-3690	CLIP-seq
MIRT1387486	hsa-miR-370	CLIP-seq
MIRT1387532	hsa-miR-3714	CLIP-seq
MIRT1387533	hsa-miR-372	CLIP-seq
MIRT1387534	hsa-miR-373	CLIP-seq
MIRT1387535	hsa-miR-3919	CLIP-seq
MIRT1387536	hsa-miR-3943	CLIP-seq
MIRT1387537	hsa-miR-4254	CLIP-seq
MIRT1387538	hsa-miR-4264	CLIP-seq
MIRT1387539	hsa-miR-4270	CLIP-seq
MIRT1387540	hsa-miR-4276	CLIP-seq
MIRT1387541	hsa-miR-4311	CLIP-seq
MIRT1387542	hsa-miR-4314	CLIP-seq
MIRT1387543	hsa-miR-4323	CLIP-seq
MIRT1387544	hsa-miR-4433	CLIP-seq
MIRT1387545	hsa-miR-4441	CLIP-seq
MIRT1387546	hsa-miR-4445	CLIP-seq
MIRT1387547	hsa-miR-4459	CLIP-seq
MIRT1387548	hsa-miR-4492	CLIP-seq
MIRT1387549	hsa-miR-4498	CLIP-seq
MIRT1387550	hsa-miR-4515	CLIP-seq
MIRT1387551	hsa-miR-4646-5p	CLIP-seq
MIRT1387552	hsa-miR-4656	CLIP-seq
MIRT1387553	hsa-miR-4660	CLIP-seq
MIRT1387554	hsa-miR-4675	CLIP-seq
MIRT1387555	hsa-miR-4688	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT1387557	hsa-miR-4709-3p	CLIP-seq
MIRT1387558	hsa-miR-4728-5p	CLIP-seq
MIRT1387559	hsa-miR-4736	CLIP-seq
MIRT1387560	hsa-miR-4738-3p	CLIP-seq
MIRT1387561	hsa-miR-4739	CLIP-seq
MIRT1387562	hsa-miR-4741	CLIP-seq
MIRT1387563	hsa-miR-4756-5p	CLIP-seq
MIRT1387492	hsa-miR-4757-5p	CLIP-seq
MIRT1387564	hsa-miR-4760-5p	CLIP-seq
MIRT1387565	hsa-miR-4763-3p	CLIP-seq
MIRT1387493	hsa-miR-4763-5p	CLIP-seq
MIRT1387566	hsa-miR-4768-3p	CLIP-seq
MIRT1387567	hsa-miR-4786-5p	CLIP-seq
MIRT1387568	hsa-miR-4796-3p	CLIP-seq
MIRT1387569	hsa-miR-4797-3p	CLIP-seq
MIRT1387570	hsa-miR-4804-3p	CLIP-seq
MIRT1387571	hsa-miR-512-3p	CLIP-seq
MIRT1387572	hsa-miR-519d	CLIP-seq
MIRT1387573	hsa-miR-520a-3p	CLIP-seq
MIRT1387574	hsa-miR-520b	CLIP-seq
MIRT1387575	hsa-miR-520c-3p	CLIP-seq
MIRT1387576	hsa-miR-520d-3p	CLIP-seq
MIRT1387577	hsa-miR-520d-5p	CLIP-seq
MIRT1387578	hsa-miR-520e	CLIP-seq
MIRT1387579	hsa-miR-524-5p	CLIP-seq
MIRT1387580	hsa-miR-541	CLIP-seq
MIRT1387581	hsa-miR-548ah	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT1387497	hsa-miR-596	CLIP-seq
MIRT1387582	hsa-miR-598	CLIP-seq
MIRT1387583	hsa-miR-616	CLIP-seq
MIRT1387498	hsa-miR-628-5p	CLIP-seq
MIRT1387584	hsa-miR-650	CLIP-seq
MIRT1387585	hsa-miR-654-5p	CLIP-seq
MIRT1387586	hsa-miR-657	CLIP-seq
MIRT1387587	hsa-miR-665	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT1387588	hsa-miR-7	CLIP-seq
MIRT1387589	hsa-miR-762	CLIP-seq
MIRT1387590	hsa-miR-769-5p	CLIP-seq
MIRT1387591	hsa-miR-93	CLIP-seq
MIRT1387541	hsa-miR-4311	CLIP-seq
MIRT1557123	hsa-miR-4729	CLIP-seq
MIRT1387478	hsa-miR-135a	CLIP-seq
MIRT1387479	hsa-miR-135b	CLIP-seq
MIRT2116105	hsa-miR-1910	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT2116106	hsa-miR-214	CLIP-seq
MIRT1387482	hsa-miR-2355-5p	CLIP-seq
MIRT1387483	hsa-miR-3065-3p	CLIP-seq
MIRT2116107	hsa-miR-3137	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT2116108	hsa-miR-3614-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT2116109	hsa-miR-3619-5p	CLIP-seq
MIRT1387486	hsa-miR-370	CLIP-seq
MIRT1387532	hsa-miR-3714	CLIP-seq
MIRT1387538	hsa-miR-4264	CLIP-seq
MIRT1387539	hsa-miR-4270	CLIP-seq
MIRT1387540	hsa-miR-4276	CLIP-seq
MIRT1387545	hsa-miR-4441	CLIP-seq
MIRT1387547	hsa-miR-4459	CLIP-seq
MIRT2116110	hsa-miR-4530	CLIP-seq
MIRT2116111	hsa-miR-455-3p	CLIP-seq
MIRT1387553	hsa-miR-4660	CLIP-seq
MIRT2116112	hsa-miR-4668-3p	CLIP-seq
MIRT1387491	hsa-miR-4694-3p	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT2116113	hsa-miR-4754	CLIP-seq
MIRT1387492	hsa-miR-4757-5p	CLIP-seq
MIRT1387493	hsa-miR-4763-5p	CLIP-seq
MIRT1387568	hsa-miR-4796-3p	CLIP-seq
MIRT1387569	hsa-miR-4797-3p	CLIP-seq
MIRT1387495	hsa-miR-522	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT1387497	hsa-miR-596	CLIP-seq
MIRT1387498	hsa-miR-628-5p	CLIP-seq
MIRT2116114	hsa-miR-645	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT2116115	hsa-miR-759	CLIP-seq
MIRT2116116	hsa-miR-761	CLIP-seq
MIRT2116117	hsa-miR-938	CLIP-seq
MIRT1387500	hsa-miR-106a	CLIP-seq
MIRT1387501	hsa-miR-106b	CLIP-seq
MIRT1387504	hsa-miR-1283	CLIP-seq
MIRT1387478	hsa-miR-135a	CLIP-seq
MIRT1387479	hsa-miR-135b	CLIP-seq
MIRT1387506	hsa-miR-139-5p	CLIP-seq
MIRT2338533	hsa-miR-141	CLIP-seq
MIRT1387507	hsa-miR-146a	CLIP-seq
MIRT1387509	hsa-miR-17	CLIP-seq
MIRT1387510	hsa-miR-1827	CLIP-seq
MIRT2116105	hsa-miR-1910	CLIP-seq
MIRT1387512	hsa-miR-193a-3p	CLIP-seq
MIRT1387514	hsa-miR-193b	CLIP-seq
MIRT2338534	hsa-miR-200a	CLIP-seq
MIRT1387480	hsa-miR-205	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT1387515	hsa-miR-20a	CLIP-seq
MIRT1387516	hsa-miR-20b	CLIP-seq
MIRT2116106	hsa-miR-214	CLIP-seq
MIRT1387482	hsa-miR-2355-5p	CLIP-seq
MIRT1387517	hsa-miR-2392	CLIP-seq
MIRT1387518	hsa-miR-298	CLIP-seq
MIRT1387519	hsa-miR-302a	CLIP-seq
MIRT1387520	hsa-miR-302b	CLIP-seq
MIRT1387521	hsa-miR-302c	CLIP-seq
MIRT1387522	hsa-miR-302d	CLIP-seq
MIRT1387523	hsa-miR-302e	CLIP-seq
MIRT1387483	hsa-miR-3065-3p	CLIP-seq
MIRT2116107	hsa-miR-3137	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT1387524	hsa-miR-3184	CLIP-seq
MIRT1387525	hsa-miR-3185	CLIP-seq
MIRT1387529	hsa-miR-3609	CLIP-seq
MIRT1387530	hsa-miR-3612	CLIP-seq
MIRT2116108	hsa-miR-3614-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT2116109	hsa-miR-3619-5p	CLIP-seq
MIRT2338535	hsa-miR-3649	CLIP-seq
MIRT1387531	hsa-miR-3690	CLIP-seq
MIRT1387486	hsa-miR-370	CLIP-seq
MIRT1387533	hsa-miR-372	CLIP-seq
MIRT1387534	hsa-miR-373	CLIP-seq
MIRT1387537	hsa-miR-4254	CLIP-seq
MIRT1387487	hsa-miR-4261	CLIP-seq
MIRT1387538	hsa-miR-4264	CLIP-seq
MIRT1387539	hsa-miR-4270	CLIP-seq
MIRT1387540	hsa-miR-4276	CLIP-seq
MIRT1387488	hsa-miR-4287	CLIP-seq
MIRT1387541	hsa-miR-4311	CLIP-seq
MIRT2338536	hsa-miR-4423-3p	CLIP-seq
MIRT1387544	hsa-miR-4433	CLIP-seq
MIRT1387545	hsa-miR-4441	CLIP-seq
MIRT1387546	hsa-miR-4445	CLIP-seq
MIRT1387547	hsa-miR-4459	CLIP-seq
MIRT1387489	hsa-miR-4496	CLIP-seq
MIRT2116110	hsa-miR-4530	CLIP-seq
MIRT2116111	hsa-miR-455-3p	CLIP-seq
MIRT2338537	hsa-miR-455-5p	CLIP-seq
MIRT1387553	hsa-miR-4660	CLIP-seq
MIRT2116112	hsa-miR-4668-3p	CLIP-seq
MIRT1387490	hsa-miR-4685-3p	CLIP-seq
MIRT1387555	hsa-miR-4688	CLIP-seq
MIRT1387491	hsa-miR-4694-3p	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT1387557	hsa-miR-4709-3p	CLIP-seq
MIRT1557123	hsa-miR-4729	CLIP-seq
MIRT1387564	hsa-miR-4760-5p	CLIP-seq
MIRT1387493	hsa-miR-4763-5p	CLIP-seq
MIRT1387566	hsa-miR-4768-3p	CLIP-seq
MIRT1387567	hsa-miR-4786-5p	CLIP-seq
MIRT1387568	hsa-miR-4796-3p	CLIP-seq
MIRT1387569	hsa-miR-4797-3p	CLIP-seq
MIRT2338538	hsa-miR-4797-5p	CLIP-seq
MIRT1387570	hsa-miR-4804-3p	CLIP-seq
MIRT1387494	hsa-miR-494	CLIP-seq
MIRT1387571	hsa-miR-512-3p	CLIP-seq
MIRT1387572	hsa-miR-519d	CLIP-seq
MIRT1387573	hsa-miR-520a-3p	CLIP-seq
MIRT1387574	hsa-miR-520b	CLIP-seq
MIRT1387575	hsa-miR-520c-3p	CLIP-seq
MIRT1387576	hsa-miR-520d-3p	CLIP-seq
MIRT1387577	hsa-miR-520d-5p	CLIP-seq
MIRT1387578	hsa-miR-520e	CLIP-seq
MIRT1387495	hsa-miR-522	CLIP-seq
MIRT1387579	hsa-miR-524-5p	CLIP-seq
MIRT1387580	hsa-miR-541	CLIP-seq
MIRT1387581	hsa-miR-548ah	CLIP-seq
MIRT2338539	hsa-miR-548t	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT1387497	hsa-miR-596	CLIP-seq
MIRT1387583	hsa-miR-616	CLIP-seq
MIRT1387498	hsa-miR-628-5p	CLIP-seq
MIRT2116114	hsa-miR-645	CLIP-seq
MIRT1387584	hsa-miR-650	CLIP-seq
MIRT1387585	hsa-miR-654-5p	CLIP-seq
MIRT1387587	hsa-miR-665	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT2338540	hsa-miR-671-5p	CLIP-seq
MIRT1387588	hsa-miR-7	CLIP-seq
MIRT2116115	hsa-miR-759	CLIP-seq
MIRT2116116	hsa-miR-761	CLIP-seq
MIRT1387590	hsa-miR-769-5p	CLIP-seq
MIRT1387591	hsa-miR-93	CLIP-seq
MIRT2116117	hsa-miR-938	CLIP-seq
MIRT1387506	hsa-miR-139-5p	CLIP-seq
MIRT1387507	hsa-miR-146a	CLIP-seq
MIRT1387557	hsa-miR-4709-3p	CLIP-seq
MIRT1387567	hsa-miR-4786-5p	CLIP-seq
MIRT1387503	hsa-miR-1207-5p	CLIP-seq
MIRT2460517	hsa-miR-124	CLIP-seq
MIRT2460518	hsa-miR-1258	CLIP-seq
MIRT2460519	hsa-miR-154	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT1387518	hsa-miR-298	CLIP-seq
MIRT2460520	hsa-miR-3126-5p	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT2460521	hsa-miR-3664-5p	CLIP-seq
MIRT1387532	hsa-miR-3714	CLIP-seq
MIRT2460522	hsa-miR-3910	CLIP-seq
MIRT2460523	hsa-miR-4266	CLIP-seq
MIRT2460524	hsa-miR-4477a	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT2460525	hsa-miR-4714-5p	CLIP-seq
MIRT1387559	hsa-miR-4736	CLIP-seq
MIRT1387565	hsa-miR-4763-3p	CLIP-seq
MIRT2460526	hsa-miR-4779	CLIP-seq
MIRT2460527	hsa-miR-506	CLIP-seq
MIRT1387580	hsa-miR-541	CLIP-seq
MIRT1387585	hsa-miR-654-5p	CLIP-seq
MIRT1387586	hsa-miR-657	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT1387502	hsa-miR-1205	CLIP-seq
MIRT1387503	hsa-miR-1207-5p	CLIP-seq
MIRT2460517	hsa-miR-124	CLIP-seq
MIRT2460518	hsa-miR-1258	CLIP-seq
MIRT1387505	hsa-miR-1321	CLIP-seq
MIRT1387478	hsa-miR-135a	CLIP-seq
MIRT1387479	hsa-miR-135b	CLIP-seq
MIRT2338533	hsa-miR-141	CLIP-seq
MIRT2632051	hsa-miR-1538	CLIP-seq
MIRT2460519	hsa-miR-154	CLIP-seq
MIRT1387508	hsa-miR-1587	CLIP-seq
MIRT1387511	hsa-miR-1909	CLIP-seq
MIRT2116105	hsa-miR-1910	CLIP-seq
MIRT1387512	hsa-miR-193a-3p	CLIP-seq
MIRT1387513	hsa-miR-193a-5p	CLIP-seq
MIRT1387514	hsa-miR-193b	CLIP-seq
MIRT2338534	hsa-miR-200a	CLIP-seq
MIRT1387480	hsa-miR-205	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT2116106	hsa-miR-214	CLIP-seq
MIRT2632052	hsa-miR-2276	CLIP-seq
MIRT1387482	hsa-miR-2355-5p	CLIP-seq
MIRT1387518	hsa-miR-298	CLIP-seq
MIRT1387483	hsa-miR-3065-3p	CLIP-seq
MIRT2460520	hsa-miR-3126-5p	CLIP-seq
MIRT2116107	hsa-miR-3137	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT2632053	hsa-miR-3173-5p	CLIP-seq
MIRT2632054	hsa-miR-3176	CLIP-seq
MIRT1387524	hsa-miR-3184	CLIP-seq
MIRT1387525	hsa-miR-3185	CLIP-seq
MIRT1387526	hsa-miR-3189-3p	CLIP-seq
MIRT2632055	hsa-miR-3607-3p	CLIP-seq
MIRT1387529	hsa-miR-3609	CLIP-seq
MIRT2116108	hsa-miR-3614-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT2116109	hsa-miR-3619-5p	CLIP-seq
MIRT2338535	hsa-miR-3649	CLIP-seq
MIRT2460521	hsa-miR-3664-5p	CLIP-seq
MIRT2632056	hsa-miR-3678-5p	CLIP-seq
MIRT2632057	hsa-miR-3686	CLIP-seq
MIRT1387531	hsa-miR-3690	CLIP-seq
MIRT1387486	hsa-miR-370	CLIP-seq
MIRT1387532	hsa-miR-3714	CLIP-seq
MIRT2632058	hsa-miR-378g	CLIP-seq
MIRT2460522	hsa-miR-3910	CLIP-seq
MIRT1387535	hsa-miR-3919	CLIP-seq
MIRT2632059	hsa-miR-3922-3p	CLIP-seq
MIRT1387536	hsa-miR-3943	CLIP-seq
MIRT1387537	hsa-miR-4254	CLIP-seq
MIRT1387487	hsa-miR-4261	CLIP-seq
MIRT1387538	hsa-miR-4264	CLIP-seq
MIRT2460523	hsa-miR-4266	CLIP-seq
MIRT1387539	hsa-miR-4270	CLIP-seq
MIRT1387488	hsa-miR-4287	CLIP-seq
MIRT1387541	hsa-miR-4311	CLIP-seq
MIRT1387543	hsa-miR-4323	CLIP-seq
MIRT2338536	hsa-miR-4423-3p	CLIP-seq
MIRT1387544	hsa-miR-4433	CLIP-seq
MIRT1387545	hsa-miR-4441	CLIP-seq
MIRT1387547	hsa-miR-4459	CLIP-seq
MIRT2460524	hsa-miR-4477a	CLIP-seq
MIRT1387548	hsa-miR-4492	CLIP-seq
MIRT1387489	hsa-miR-4496	CLIP-seq
MIRT1387549	hsa-miR-4498	CLIP-seq
MIRT2116110	hsa-miR-4530	CLIP-seq
MIRT2116111	hsa-miR-455-3p	CLIP-seq
MIRT2338537	hsa-miR-455-5p	CLIP-seq
MIRT1387552	hsa-miR-4656	CLIP-seq
MIRT2116112	hsa-miR-4668-3p	CLIP-seq
MIRT1387554	hsa-miR-4675	CLIP-seq
MIRT1387490	hsa-miR-4685-3p	CLIP-seq
MIRT2632060	hsa-miR-4685-5p	CLIP-seq
MIRT1387555	hsa-miR-4688	CLIP-seq
MIRT1387491	hsa-miR-4694-3p	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT2632061	hsa-miR-4708-3p	CLIP-seq
MIRT2460525	hsa-miR-4714-5p	CLIP-seq
MIRT1387558	hsa-miR-4728-5p	CLIP-seq
MIRT1557123	hsa-miR-4729	CLIP-seq
MIRT2632062	hsa-miR-4731-5p	CLIP-seq
MIRT1387559	hsa-miR-4736	CLIP-seq
MIRT1387560	hsa-miR-4738-3p	CLIP-seq
MIRT1387561	hsa-miR-4739	CLIP-seq
MIRT1387562	hsa-miR-4741	CLIP-seq
MIRT2632063	hsa-miR-4745-3p	CLIP-seq
MIRT2116113	hsa-miR-4754	CLIP-seq
MIRT1387563	hsa-miR-4756-5p	CLIP-seq
MIRT1387492	hsa-miR-4757-5p	CLIP-seq
MIRT1387565	hsa-miR-4763-3p	CLIP-seq
MIRT1387493	hsa-miR-4763-5p	CLIP-seq
MIRT1387566	hsa-miR-4768-3p	CLIP-seq
MIRT2460526	hsa-miR-4779	CLIP-seq
MIRT1387568	hsa-miR-4796-3p	CLIP-seq
MIRT1387569	hsa-miR-4797-3p	CLIP-seq
MIRT2338538	hsa-miR-4797-5p	CLIP-seq
MIRT1387570	hsa-miR-4804-3p	CLIP-seq
MIRT1387494	hsa-miR-494	CLIP-seq
MIRT2460527	hsa-miR-506	CLIP-seq
MIRT1387495	hsa-miR-522	CLIP-seq
MIRT1387580	hsa-miR-541	CLIP-seq
MIRT1387581	hsa-miR-548ah	CLIP-seq
MIRT2338539	hsa-miR-548t	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT1387497	hsa-miR-596	CLIP-seq
MIRT1387498	hsa-miR-628-5p	CLIP-seq
MIRT2116114	hsa-miR-645	CLIP-seq
MIRT1387585	hsa-miR-654-5p	CLIP-seq
MIRT1387586	hsa-miR-657	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT2338540	hsa-miR-671-5p	CLIP-seq
MIRT1387588	hsa-miR-7	CLIP-seq
MIRT2116115	hsa-miR-759	CLIP-seq
MIRT2116116	hsa-miR-761	CLIP-seq
MIRT1387589	hsa-miR-762	CLIP-seq
MIRT1387590	hsa-miR-769-5p	CLIP-seq
MIRT2116117	hsa-miR-938	CLIP-seq
MIRT1387503	hsa-miR-1207-5p	CLIP-seq
MIRT2460517	hsa-miR-124	CLIP-seq
MIRT2460518	hsa-miR-1258	CLIP-seq
MIRT1387478	hsa-miR-135a	CLIP-seq
MIRT1387479	hsa-miR-135b	CLIP-seq
MIRT2632051	hsa-miR-1538	CLIP-seq
MIRT2460519	hsa-miR-154	CLIP-seq
MIRT2116105	hsa-miR-1910	CLIP-seq
MIRT1387512	hsa-miR-193a-3p	CLIP-seq
MIRT1387514	hsa-miR-193b	CLIP-seq
MIRT1387480	hsa-miR-205	CLIP-seq
MIRT1387481	hsa-miR-2052	CLIP-seq
MIRT2116106	hsa-miR-214	CLIP-seq
MIRT1387518	hsa-miR-298	CLIP-seq
MIRT2460520	hsa-miR-3126-5p	CLIP-seq
MIRT2116107	hsa-miR-3137	CLIP-seq
MIRT1387484	hsa-miR-3157-3p	CLIP-seq
MIRT1387524	hsa-miR-3184	CLIP-seq
MIRT1387525	hsa-miR-3185	CLIP-seq
MIRT1387529	hsa-miR-3609	CLIP-seq
MIRT2116108	hsa-miR-3614-3p	CLIP-seq
MIRT1387485	hsa-miR-3614-5p	CLIP-seq
MIRT2116109	hsa-miR-3619-5p	CLIP-seq
MIRT2338535	hsa-miR-3649	CLIP-seq
MIRT2632056	hsa-miR-3678-5p	CLIP-seq
MIRT1387531	hsa-miR-3690	CLIP-seq
MIRT1387532	hsa-miR-3714	CLIP-seq
MIRT2460522	hsa-miR-3910	CLIP-seq
MIRT1387535	hsa-miR-3919	CLIP-seq
MIRT1387537	hsa-miR-4254	CLIP-seq
MIRT1387538	hsa-miR-4264	CLIP-seq
MIRT2460523	hsa-miR-4266	CLIP-seq
MIRT1387539	hsa-miR-4270	CLIP-seq
MIRT1387488	hsa-miR-4287	CLIP-seq
MIRT1387541	hsa-miR-4311	CLIP-seq
MIRT1387545	hsa-miR-4441	CLIP-seq
MIRT2460524	hsa-miR-4477a	CLIP-seq
MIRT2116110	hsa-miR-4530	CLIP-seq
MIRT2116111	hsa-miR-455-3p	CLIP-seq
MIRT2116112	hsa-miR-4668-3p	CLIP-seq
MIRT1387490	hsa-miR-4685-3p	CLIP-seq
MIRT1387555	hsa-miR-4688	CLIP-seq
MIRT1387491	hsa-miR-4694-3p	CLIP-seq
MIRT1387556	hsa-miR-4695-5p	CLIP-seq
MIRT1557123	hsa-miR-4729	CLIP-seq
MIRT1387559	hsa-miR-4736	CLIP-seq
MIRT1387560	hsa-miR-4738-3p	CLIP-seq
MIRT2632063	hsa-miR-4745-3p	CLIP-seq
MIRT2116113	hsa-miR-4754	CLIP-seq
MIRT1387565	hsa-miR-4763-3p	CLIP-seq
MIRT2460526	hsa-miR-4779	CLIP-seq
MIRT1387568	hsa-miR-4796-3p	CLIP-seq
MIRT1387569	hsa-miR-4797-3p	CLIP-seq
MIRT2338538	hsa-miR-4797-5p	CLIP-seq
MIRT1387570	hsa-miR-4804-3p	CLIP-seq
MIRT2460527	hsa-miR-506	CLIP-seq
MIRT1387495	hsa-miR-522	CLIP-seq
MIRT1387580	hsa-miR-541	CLIP-seq
MIRT1387581	hsa-miR-548ah	CLIP-seq
MIRT2338539	hsa-miR-548t	CLIP-seq
MIRT1387496	hsa-miR-549	CLIP-seq
MIRT2116114	hsa-miR-645	CLIP-seq
MIRT1387585	hsa-miR-654-5p	CLIP-seq
MIRT1387586	hsa-miR-657	CLIP-seq
MIRT1387499	hsa-miR-668	CLIP-seq
MIRT2338540	hsa-miR-671-5p	CLIP-seq
MIRT1387588	hsa-miR-7	CLIP-seq
MIRT2116115	hsa-miR-759	CLIP-seq
MIRT2116116	hsa-miR-761	CLIP-seq
MIRT1387590	hsa-miR-769-5p	CLIP-seq
MIRT2116117	hsa-miR-938	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ETS1	Unknown	9762895
NFKB1	Unknown	9762895
SP1	Unknown	9762895
SPDEF	Activation	12700667

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000407	Component	Phagophore assembly site	IEA
GO:0000422	Process	Autophagy of mitochondrion	NAS	20098416
GO:0000423	Process	Mitophagy	IBA	21873635
GO:0000423	Process	Mitophagy	IGI	20457763
GO:0000932	Component	P-body	IDA	20357094
GO:0001934	Process	Positive regulation of protein phosphorylation	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002931	Process	Response to ischemia	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	NAS	8618896
GO:0005080	Function	Protein kinase C binding	IBA	21873635
GO:0005080	Function	Protein kinase C binding	IPI	14676191
GO:0005515	Function	Protein binding	IPI	8618896, 8702753, 14676191, 16169070, 16189514, 16874300, 17389358, 17580304, 18083104, 19229298, 19250911, 19427866, 19615732, 20010802, 20168092, 20173742, 20357094, 20417604, 20452972, 20551902, 20562859, 20808283, 21149568, 21900206, 21988832, 22178386, 22190034, 22421968, 23274
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	20168092
GO:0005739	Component	Mitochondrion	IEA
GO:0005770	Component	Late endosome	IEA
GO:0005776	Component	Autophagosome	IDA	17580304, 19640926, 20168092, 22948227, 24954904
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS	8650207
GO:0006468	Process	Protein phosphorylation	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	TAS	8702753
GO:0006914	Process	Autophagy	IDA	20452972
GO:0006914	Process	Autophagy	IMP	17580304
GO:0006914	Process	Autophagy	TAS	19816510
GO:0006915	Process	Apoptotic process	IEA
GO:0007032	Process	Endosome organization	IBA	21873635
GO:0007032	Process	Endosome organization	IDA	27368102
GO:0008104	Process	Protein localization	TAS	8650207
GO:0008270	Function	Zinc ion binding	IEA
GO:0010821	Process	Regulation of mitochondrion organization	NAS	20890124
GO:0016197	Process	Endosomal transport	TAS	12857745
GO:0016234	Component	Inclusion body	IDA	20168092
GO:0016235	Component	Aggresome	IBA	21873635
GO:0016236	Process	Macroautophagy	IMP	20168092
GO:0016236	Process	Macroautophagy	ISS
GO:0016236	Process	Macroautophagy	TAS
GO:0016605	Component	PML body	IDA	20168092
GO:0019899	Function	Enzyme binding	IPI	27368102
GO:0019901	Function	Protein kinase binding	IDA	8650207
GO:0030017	Component	Sarcomere	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030971	Function	Receptor tyrosine kinase binding	TAS	8650207
GO:0031397	Process	Negative regulation of protein ubiquitination	IDA	20452972
GO:0031625	Function	Ubiquitin protein ligase binding	IDA	27368102
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	25127057, 27368102
GO:0035255	Function	Ionotropic glutamate receptor binding	ISS
GO:0035556	Process	Intracellular signal transduction	TAS	8650207
GO:0035973	Process	Aggrephagy	IBA	21873635
GO:0035973	Process	Aggrephagy	IPI	28404643
GO:0042169	Function	SH2 domain binding	IDA	8650207
GO:0042802	Function	Identical protein binding	IPI	16169070, 20562859, 21900206, 25416956, 25686248, 32296183
GO:0043065	Process	Positive regulation of apoptotic process	TAS
GO:0043066	Process	Negative regulation of apoptotic process	TAS
GO:0043122	Process	Regulation of I-kappaB kinase/NF-kappaB signaling	IMP	12857745
GO:0043130	Function	Ubiquitin binding	IDA	12857745
GO:0043130	Function	Ubiquitin binding	TAS
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0044753	Component	Amphisome	IBA	21873635
GO:0044753	Component	Amphisome	IDA	19640926
GO:0044754	Component	Autolysosome	IDA	19640926
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	TAS	12857745
GO:0046578	Process	Regulation of Ras protein signal transduction	NAS	8618896
GO:0061635	Process	Regulation of protein complex stability	IDA	25127057
GO:0061912	Process	Selective autophagy	IMP	22622177
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS
GO:0070530	Function	K63-linked polyubiquitin modification-dependent protein binding	IBA	21873635
GO:0070530	Function	K63-linked polyubiquitin modification-dependent protein binding	IDA	28404643
GO:0097225	Component	Sperm midpiece	IEA
GO:0097413	Component	Lewy body	IEA
GO:0098780	Process	Response to mitochondrial depolarisation	IGI	20457763
GO:1900273	Process	Positive regulation of long-term synaptic potentiation	ISS
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	ISS
GO:1905719	Process	Protein localization to perinuclear region of cytoplasm	IDA	27368102

Other IDs

• MIM: 601530
• HGNC: 11280
• e!Ensembl: ENSG00000161011

Protein

• UniProt ID: Q13501
• Protein name: Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)
• Protein function: Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a bridge between polyubiquitinated proteins and autophagosomes (PubMed:15340068, PubMed:15953362, PubMed:16286508, PubMed:17580304, PubMed:20168092, PubMed:2201787
• PDB: 1Q02, 2JY7, 2JY8, 2K0B, 2KNV, 4MJS, 4UF8, 4UF9, 5YP7, 5YP8, 5YPA, 5YPB, 5YPC, 5YPE, 5YPF, 5YPG, 5YPH, 6JM4, 6KHZ, 6MJ7, 6TGY, 6TH3, 7R1O
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00564	PB1	21 → 102	PB1 domain	Domain
  PF00569	ZZ	122 → 165	Zinc finger, ZZ type	Domain
  PF16577	UBA_5	379 → 440	UBA domain	Domain

• Sequence:

  MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRP
  GGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRN
  MVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
  HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNV
  GESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNV
  EGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPE
  SEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTK
  NYDIGAALDTIQYSKHPPPL

• Sequence length: 440

Pathways

KEGG:

Mitophagy - animal
Autophagy - animal
Necroptosis
Cellular senescence
Osteoclast differentiation
Amyotrophic lateral sclerosis
Pathways of neurodegeneration - multiple diseases
Shigellosis
Fluid shear stress and atherosclerosis

Reactome:

NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Pink/Parkin Mediated Mitophagy
Interleukin-1 signaling
Pexophagy

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	24162737
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis, Guam Form	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs1885090126, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs749428135, rs371575563, rs1402429085, rs1218712729, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087	23303844, 24085347, 24138988, 22084127, 19765191, 19765191
Apraxia	Apraxias	rs121908377, rs121908378, rs1135401820, rs1178491246, rs1584969672
Cerebellar ataxia	Progressive cerebellar ataxia	rs28936415, rs199476133, rs540331226, rs797046006, rs863224069, rs138358708, rs1057519429, rs750959420, rs1568440440, rs1597846084, rs759460806, rs761486324, rs1240335250, rs1596489887
Distal myopathy	Distal myopathy, Welander type	rs398123028, rs140614802, rs559454746, rs769542442, rs1572140109
Frontotemporal dementia	Frontotemporal dementia	rs63751273, rs63750376, rs63750424, rs63750972, rs1568327531, rs63750570, rs63750756, rs63751165, rs63750512, rs63751438, rs63750912, rs63750711, rs63750635, rs63750349, rs63750092, rs63749801, rs63751399, rs199476352, rs63751035, rs63749974, rs63750568, rs63750013, rs63751394, rs63750308, rs63751011, rs63750095, rs794729672, rs794729669, rs63749817, rs794729670, rs193026789, rs794729671, rs1085307051, rs1566630811, rs1566630884, rs1567885658, rs1567886206, rs1567886445, rs1567886478, rs1567887015, rs1567887777, rs1567888461, rs1566630791, rs1598408073, rs1570725499, rs1598408336
Frontotemporal dementia with or without amyotrophic lateral sclerosis	FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 3	rs63751126, rs63750355, rs121909334, rs387906789, rs387906790, rs281864934, rs63750652, rs587777574, rs143561967, rs876657404, rs876657405, rs876657406, rs755950225, rs767898276, rs748112833, rs863225291, rs886040872, rs886040888, rs1555204731, rs1565814492, rs1328949478, rs1592362719, rs1592350883, rs1592350887, rs1341055534, rs1402092579, rs1284582102	19589897, 23417734, 25114083, 24042580, 24899140, 11992264, 21515589, 18765443, 25241215, 15493999, 21195346, 22084127, 23942205
Age-related macular degeneration	Age related macular degeneration	rs2133900556, rs199474657, rs2274700, rs1410996, rs61750120, rs1800728, rs62654397, rs61749423, rs61751412, rs61749439, rs61751398, rs61752417, rs62645946, rs1801269, rs62646860, rs61750142, rs61750145, rs61750152, rs61751377, rs61753029, rs61751407, rs61751389, rs61750645, rs61750648, rs879255520, rs752147871, rs886044750, rs886044749, rs746541266, rs756840095, rs886044725, rs749526785, rs1057518955, rs1057518767, rs371489809, rs1064793014, rs1571264574, rs1659524475	23922739
Neurodegeneration with ataxia, dystonia, and gaze palsy	NEURODEGENERATION WITH ATAXIA, DYSTONIA, AND GAZE PALSY, CHILDHOOD-ONSET	rs886039780, rs886039781, rs886039782
Nystagmus	Nystagmus	rs137852207, rs137852208, rs1928435502, rs137852209, rs137852210, rs1929191668, rs137852211, rs137852212, rs2124209414, rs387906720, rs387906721, rs1602791884, rs786205896
Paget disease	NON RARE IN EUROPE: Paget disease of bone, Osteitis Deformans, PAGET DISEASE OF BONE 2, EARLY-ONSET, PAGET DISEASE OF BONE 3	rs796051862, rs796051869, rs796051870, rs796052213, rs1555767678, rs869025582	23417734, 26208961, 12374763, 26627873, 17129171, 15146436, 12374763, 15765181, 19589897, 15176995, 15647816, 14584883, 24042580, 26713335, 18765443, 19931284, 11992264, 21195346, 15125799, 24899140, 18543015, 25241215, 23417734, 15207768, 16813535, 23942205, 21878516, 19257822, 21437228, 20499339, 15493999, 21515589, 17229007
Parkinson disease	Parkinsonian Disorders	rs116074753, rs118203903, rs118203904, rs115735611, rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs74315361, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121917767, rs121918104, rs1589451049, rs104893877, rs104893878, rs283413, rs112176450, rs111290936, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs387906942, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106
Seizure	Tonic - clonic seizures	rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061, rs121912707, rs118192249, rs118192251, rs118192217, rs118192218, rs118192219, rs118192222, rs118192226, rs118192228, rs118192234, rs118192236, rs118192235, rs118192241, rs118192242, rs118192185, rs118192188, rs118192245, rs118192246, rs118192186, rs118192194, rs118192197, rs118192199, rs118192201, rs118192202, rs118192203, rs118192204, rs118192205, rs118192206, rs118192208, rs118192211, rs118192216, rs118192239, rs387906684, rs387906686, rs387906687, rs1596893185, rs387907126, rs387907281, rs397515405, rs587778771, rs730882067, rs730882073, rs397514579, rs397514582, rs587776976, rs398122394, rs121918784, rs121918751, rs121918735, rs398123588, rs587780450, rs61749751, rs587777620, rs727503974, rs730882124, rs794726710, rs794726697, rs794726799, rs794727444, rs794727740, rs796053166, rs794726825, rs796052676, rs796053219, rs796053220, rs796053228, rs796052653, rs759584387, rs796052650, rs796052641, rs796052626, rs796052623, rs796052663, rs796052615, rs796052802, rs797044999, rs797045047, rs797045942, rs797045941, rs118192212, rs797044938, rs777257591, rs864321712, rs879255652, rs886039268, rs886039517, rs886039529, rs199497486, rs886039496, rs886039903, rs886041300, rs769827124, rs886041339, rs886041591, rs587783092, rs1555850151, rs1057516123, rs1057516121, rs1057516115, rs1057516111, rs1057516106, rs1057516105, rs756921902, rs1057516089, rs1057516087, rs1057516080, rs1057516076, rs1060499544, rs1555850512, rs1057517919, rs118192231, rs1057520413, rs1060503101, rs1064796294, rs1064794981, rs1064794632, rs1064797245, rs1131691830, rs1131692231, rs1131691936, rs1554626549, rs1553579225, rs1553531385, rs121918736, rs1554898088, rs1553579282, rs763353895, rs1553463119, rs1554093891, rs77838305, rs1555408401, rs1554627439, rs1554097873, rs1555850403, rs1064794719, rs1315483224, rs1567134495, rs770187706, rs1057518555, rs1576983339, rs1574192005, rs1459374430, rs1586800133, rs1574641522, rs1572096837, rs1572630269, rs1574554892, rs1574556643, rs1574571769, rs1574641605, rs1574697769, rs1574716524, rs1574746733, rs1574746935, rs1574752700, rs1574754680, rs863225030, rs1601545088, rs1600714727, rs1371059392, rs1600767259, rs1339542565, rs1600785769, rs2065899210, rs1600732174, rs1162306056, rs879255709, rs1900111672, rs2066910297, rs1554122080, rs796052941, rs1600789325, rs2082695884, rs1737677036, rs1737495759, rs868389022, rs1737685202, rs1737672350, rs762737130
Welander distal myopathy	Welander Distal Myopathy, Welander distal myopathy, Swedish type	rs747068278	29457785

Unknown
Disease name	Disease term	dbSNP ID	References
Abulia	Abulia
Amyotrophic lateral sclerosis with dementia	Amyotrophic Lateral Sclerosis With Dementia		19765191
Amyotrophy	Generalized amyotrophy
Anxiety disorder	Anxiety
Behavioral variant of frontotemporal dementia	Behavioral variant of frontotemporal dementia		24042580
Bulbar palsy	Bulbar palsy
Cerebral cortical atrophy	Cerebral cortical atrophy
Compulsive hoarding	Compulsive hoarding
Dysarthria	Dysarthria
Dyscalculia	Dyscalculia
Dysgraphia	Dysgraphia
Dyslexia	Dyslexia
Dysphagia	Deglutition Disorders
Dysphasia	Dysphasia
Facial paralysis	Facial paralysis
Frontotemporal cerebral atrophy	Frontotemporal cerebral atrophy
Frontotemporal dementia with motor neuron disease	Frontotemporal Dementia With Motor Neuron Disease		24042580, 12374763, 26627873, 26208961, 17129171, 23417734
Hallucinations	Hallucinations
Inclusion body myopathy	NONAKA MYOPATHY	rs17885240, rs61757385, rs2237857, rs4986939, rs11272867, rs587118, rs11078850, rs532528005, rs532445930, rs184152880, rs886063891, rs879074973, rs45537335, rs139621607, rs375199452, rs376738763, rs377674160, rs769463886, rs573872374, rs200217946, rs141764966, rs150566222, rs201784718, rs886052569, rs116419997, rs886052571, rs886052573, rs371123671, rs138470281, rs886052565, rs780067831, rs754150715, rs563146441, rs765877777, rs148217318, rs886052574, rs886052575, rs886052567, rs753547111, rs374743981, rs200732220, rs138265883, rs756255059, rs778226679, rs886052572, rs74967762	26208961
Language disorders	Language Disorders
Laryngospasm	Laryngospasm
Mental depression	Depressive disorder	rs587778876, rs587778877
Mood swings	Mood swings
Oculomotor apraxia	Oculomotor apraxia
Oculovestibuloauditory syndrome	Oculovestibuloauditory syndrome
Osteosarcoma	Osteosarcoma		21437228, 12374763
Psychosis	Psychotic Disorders
Ptosis	Blepharoptosis, Ptosis	rs139920573
Respiratory failure	Respiratory Failure
Sensorineural hearing loss	Sensorineural hearing loss, bilateral
Stereotyped behavior	Stereotyped Behavior
Supranuclear gaze palsy	Vertical supranuclear gaze palsy