VNN1 (vanin 1)

Gene

• Entrez ID: 8876
• Gene name: Vanin 1
• Gene symbol: VNN1
• Synonyms: HDLCQ8, Tiff66
• Chromosome: 6
• Chromosome location: 6q23.2
• Summary: This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participa

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT446019	hsa-miR-5004-5p	PAR-CLIP	22100165
MIRT446018	hsa-miR-4751	PAR-CLIP	22100165
MIRT446016	hsa-miR-924	PAR-CLIP	22100165
MIRT446017	hsa-miR-1289	PAR-CLIP	22100165
MIRT446015	hsa-miR-4294	PAR-CLIP	22100165
MIRT446014	hsa-miR-4796-5p	PAR-CLIP	22100165
MIRT446013	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446012	hsa-miR-3915	PAR-CLIP	22100165
MIRT446011	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446010	hsa-miR-4689	PAR-CLIP	22100165
MIRT446008	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446009	hsa-miR-3198	PAR-CLIP	22100165
MIRT446007	hsa-miR-4309	PAR-CLIP	22100165
MIRT446019	hsa-miR-5004-5p	PAR-CLIP	22100165
MIRT446018	hsa-miR-4751	PAR-CLIP	22100165
MIRT446016	hsa-miR-924	PAR-CLIP	22100165
MIRT446017	hsa-miR-1289	PAR-CLIP	22100165
MIRT446015	hsa-miR-4294	PAR-CLIP	22100165
MIRT446014	hsa-miR-4796-5p	PAR-CLIP	22100165
MIRT446013	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446012	hsa-miR-3915	PAR-CLIP	22100165
MIRT446011	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446010	hsa-miR-4689	PAR-CLIP	22100165
MIRT446008	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446009	hsa-miR-3198	PAR-CLIP	22100165
MIRT446007	hsa-miR-4309	PAR-CLIP	22100165
MIRT446019	hsa-miR-5004-5p	PAR-CLIP	22100165
MIRT446018	hsa-miR-4751	PAR-CLIP	22100165
MIRT446016	hsa-miR-924	PAR-CLIP	22100165
MIRT446017	hsa-miR-1289	PAR-CLIP	22100165
MIRT446015	hsa-miR-4294	PAR-CLIP	22100165
MIRT446014	hsa-miR-4796-5p	PAR-CLIP	22100165
MIRT446013	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446012	hsa-miR-3915	PAR-CLIP	22100165
MIRT446011	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446010	hsa-miR-4689	PAR-CLIP	22100165
MIRT446008	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446009	hsa-miR-3198	PAR-CLIP	22100165
MIRT446007	hsa-miR-4309	PAR-CLIP	22100165
MIRT446019	hsa-miR-5004-5p	PAR-CLIP	22100165
MIRT446018	hsa-miR-4751	PAR-CLIP	22100165
MIRT446016	hsa-miR-924	PAR-CLIP	22100165
MIRT446017	hsa-miR-1289	PAR-CLIP	22100165
MIRT446015	hsa-miR-4294	PAR-CLIP	22100165
MIRT446014	hsa-miR-4796-5p	PAR-CLIP	22100165
MIRT446013	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446012	hsa-miR-3915	PAR-CLIP	22100165
MIRT446011	hsa-miR-1224-5p	PAR-CLIP	22100165
MIRT446010	hsa-miR-4689	PAR-CLIP	22100165
MIRT446008	hsa-miR-6858-5p	PAR-CLIP	22100165
MIRT446009	hsa-miR-3198	PAR-CLIP	22100165
MIRT446007	hsa-miR-4309	PAR-CLIP	22100165
MIRT1485676	hsa-miR-10a	CLIP-seq
MIRT1485677	hsa-miR-10b	CLIP-seq
MIRT1485678	hsa-miR-1207-5p	CLIP-seq
MIRT1485679	hsa-miR-1255a	CLIP-seq
MIRT1485680	hsa-miR-1255b	CLIP-seq
MIRT1485681	hsa-miR-1290	CLIP-seq
MIRT1485682	hsa-miR-1305	CLIP-seq
MIRT1485683	hsa-miR-296-3p	CLIP-seq
MIRT1485684	hsa-miR-3133	CLIP-seq
MIRT1485685	hsa-miR-3182	CLIP-seq
MIRT1485686	hsa-miR-339-5p	CLIP-seq
MIRT1485687	hsa-miR-3667-5p	CLIP-seq
MIRT1485688	hsa-miR-3671	CLIP-seq
MIRT1485689	hsa-miR-4307	CLIP-seq
MIRT1485690	hsa-miR-4318	CLIP-seq
MIRT1485691	hsa-miR-432	CLIP-seq
MIRT1485692	hsa-miR-4421	CLIP-seq
MIRT1485693	hsa-miR-4474-3p	CLIP-seq
MIRT1485694	hsa-miR-4652-3p	CLIP-seq
MIRT1485695	hsa-miR-4659a-3p	CLIP-seq
MIRT1485696	hsa-miR-4659b-3p	CLIP-seq
MIRT1485697	hsa-miR-4725-5p	CLIP-seq
MIRT1485698	hsa-miR-4736	CLIP-seq
MIRT1485699	hsa-miR-4761-5p	CLIP-seq
MIRT1485700	hsa-miR-4763-3p	CLIP-seq
MIRT1485701	hsa-miR-504	CLIP-seq
MIRT1485702	hsa-miR-515-5p	CLIP-seq
MIRT1485703	hsa-miR-548u	CLIP-seq
MIRT1485704	hsa-miR-578	CLIP-seq
MIRT1485705	hsa-miR-607	CLIP-seq
MIRT1485706	hsa-miR-888	CLIP-seq
MIRT2146015	hsa-miR-3652	CLIP-seq
MIRT2146016	hsa-miR-4430	CLIP-seq
MIRT1485699	hsa-miR-4761-5p	CLIP-seq
MIRT2146017	hsa-miR-485-5p	CLIP-seq
MIRT2366485	hsa-miR-219-1-3p	CLIP-seq
MIRT2366486	hsa-miR-23a	CLIP-seq
MIRT2366487	hsa-miR-23b	CLIP-seq
MIRT2366488	hsa-miR-23c	CLIP-seq
MIRT2366489	hsa-miR-335	CLIP-seq
MIRT2366490	hsa-miR-3977	CLIP-seq
MIRT2366491	hsa-miR-4303	CLIP-seq
MIRT2366492	hsa-miR-4473	CLIP-seq
MIRT2366493	hsa-miR-4495	CLIP-seq
MIRT2366494	hsa-miR-4649-3p	CLIP-seq
MIRT2366495	hsa-miR-4682	CLIP-seq
MIRT2366496	hsa-miR-4704-3p	CLIP-seq
MIRT2366497	hsa-miR-512-3p	CLIP-seq
MIRT2366498	hsa-miR-520f	CLIP-seq
MIRT2366499	hsa-miR-571	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002526	Process	Acute inflammatory response	ISS	14966568
GO:0002544	Process	Chronic inflammatory response	ISS	14966568
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006954	Process	Inflammatory response	ISS	15282320
GO:0006979	Process	Response to oxidative stress	TAS	17145956
GO:0015939	Process	Pantothenate metabolic process	IBA	21873635
GO:0015939	Process	Pantothenate metabolic process	IDA	11491533, 25478849
GO:0015939	Process	Pantothenate metabolic process	TAS
GO:0016021	Component	Integral component of membrane	TAS	17145956
GO:0017159	Function	Pantetheine hydrolase activity	IBA	21873635
GO:0017159	Function	Pantetheine hydrolase activity	IDA	11491533, 25478849
GO:0031225	Component	Anchored component of membrane	IEA
GO:0033089	Process	Positive regulation of T cell differentiation in thymus	ISS	11491533
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045087	Process	Innate immune response	ISS	14966568
GO:0098609	Process	Cell-cell adhesion	ISS	11491533
GO:1902176	Process	Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISS	15282320

Other IDs

• MIM: 603570
• HGNC: 12705
• e!Ensembl: ENSG00000112299

Protein

• UniProt ID: O95497
• Protein name: Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1)
• Protein function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. {ECO:0000269|PubMed:10567687, ECO:0000269|PubMed:11491533, ECO:0000269|PubMed:2547
• PDB: 4CYF, 4CYG, 4CYY, 7SLV, 7SLX, 7SLY, 9IZL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00795	CN_hydrolase	50 → 299	Carbon-nitrogen hydrolase	Family
  PF19018	Vanin_C	331 → 483	Vanin C-terminal domain	Domain

• Sequence:

  MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDIL
  EGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPV
  QERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQN
  LFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMN
  VLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLL
  LSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKD
  LCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETAST
  RFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLY
  EKDWASNASSGLTAQARIIMLIVIAPIVCSLSW

• Sequence length: 513

Pathways

KEGG:

Pantothenate and CoA biosynthesis
Metabolic pathways

Reactome:

Post-translational modification: synthesis of GPI-anchored proteins
Vitamin B5 (pantothenate) metabolism
Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Dermatitis, Atopic	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	19322213
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	17145956
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	19322213

Unknown
Disease name	Disease term	dbSNP ID	References
Celiac disease	Celiac Disease	rs2305764, rs35218876	30097691
Dyslipidemias	Dyslipidemias		17873875
Eczema	Eczema, Infantile		19322213
Palmoplantar pustules	Pustulosis of Palms and Soles		19322213