VNN2 (vanin 2)

Gene

• Entrez ID: 8875
• Gene name: Vanin 2
• Gene symbol: VNN2
• Synonyms: FOAP-4, GPI-80
• Chromosome: 6
• Chromosome location: 6q23.2
• Summary: This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to particip

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016760	hsa-miR-335-5p	Microarray	18185580
MIRT022124	hsa-miR-124-3p	Microarray	18668037
MIRT028816	hsa-miR-26b-5p	Microarray	19088304
MIRT1485707	hsa-miR-1236	CLIP-seq
MIRT1485708	hsa-miR-2467-5p	CLIP-seq
MIRT1485709	hsa-miR-3135b	CLIP-seq
MIRT1485710	hsa-miR-3188	CLIP-seq
MIRT1485711	hsa-miR-3652	CLIP-seq
MIRT1485712	hsa-miR-3975	CLIP-seq
MIRT1485713	hsa-miR-4430	CLIP-seq
MIRT1485714	hsa-miR-4487	CLIP-seq
MIRT1485715	hsa-miR-4633-3p	CLIP-seq
MIRT1485716	hsa-miR-4653-3p	CLIP-seq
MIRT1485717	hsa-miR-4729	CLIP-seq
MIRT1485718	hsa-miR-4753-3p	CLIP-seq
MIRT1485719	hsa-miR-485-5p	CLIP-seq
MIRT1485720	hsa-miR-579	CLIP-seq
MIRT2366500	hsa-miR-1272	CLIP-seq
MIRT2366501	hsa-miR-1322	CLIP-seq
MIRT2366502	hsa-miR-298	CLIP-seq
MIRT2366503	hsa-miR-3157-5p	CLIP-seq
MIRT2366504	hsa-miR-4691-3p	CLIP-seq
MIRT1485707	hsa-miR-1236	CLIP-seq
MIRT1485718	hsa-miR-4753-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0015939	Process	Pantothenate metabolic process	IBA	21873635
GO:0015939	Process	Pantothenate metabolic process	IDA	11491533
GO:0015939	Process	Pantothenate metabolic process	TAS
GO:0017159	Function	Pantetheine hydrolase activity	IBA	21873635
GO:0017159	Function	Pantetheine hydrolase activity	IDA	11491533
GO:0031225	Component	Anchored component of membrane	IEA

Other IDs

• MIM: 603571
• HGNC: 12706
• e!Ensembl: ENSG00000112303

Protein

• UniProt ID: O95498
• Protein name: Pantetheine hydrolase VNN2 (EC 3.5.1.92) (Glycosylphosphatidyl inositol-anchored protein GPI-80) (Protein FOAP-4) (Vascular non-inflammatory molecule 2) (Vanin-2)
• Protein function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine (PubMed:11491533). Involved in the thymus homing of bone marrow cells. May regulate
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00795	CN_hydrolase	51 → 262	Carbon-nitrogen hydrolase	Family
  PF19018	Vanin_C	337 → 487	Vanin C-terminal domain	Domain

• Sequence:

  MVTSSFPISVAVFALITLQVGTQDSFIAAVYEHAVILPNKTETPVSQEDALNLMNENIDI
  LETAIKQAAEQGARIIVTPEDALYGWKFTRETVFPYLEDIPDPQVNWIPCQDPHRFGHTP
  VQARLSCLAKDNSIYVLANLGDKKPCNSRDSTCPPNGYFQYNTNVVYNTEGKLVARYHKY
  HLYSEPQFNVPEKPELVTFNTAFGRFGIFTCFDIFFYDPGVTLVKDFHVDTILFPTAWMN
  VLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNMTGSGIYAPNGPKVYHYDMKTELGKLL
  LSEVDSHPLSSLAYPTAVNWNAYATTIKPFPVQKNTFRGFISRDGFNFTELFENAGNLTV
  CQKELCCHLSYRMLQKEENEVYVLGAFTGLHGRRRREYWQVCTLLKCKTTNLTTCGRPVE
  TASTRFEMFSLSGTFGTEYVFPEVLLTEIHLSPGKFEVLKDGRLVNKNGSSGPILTVSLF
  GRWYTKDSLYSSCGTSNSAITYLLIFILLMIIALQNIVML

• Sequence length: 520

Pathways

KEGG:

Pantothenate and CoA biosynthesis
Metabolic pathways

Reactome:

Post-translational modification: synthesis of GPI-anchored proteins
Vitamin B5 (pantothenate) metabolism

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Dermatitis, Atopic	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	19322213
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	19322213

Unknown
Disease name	Disease term	dbSNP ID	References
Eczema	Eczema, Infantile		19322213
Palmoplantar pustules	Pustulosis of Palms and Soles		19322213