CDC123 (cell division cycle 123)

Gene

• Entrez ID: 8872
• Gene name: Cell division cycle 123
• Gene symbol: CDC123
• Synonyms: C10orf7, D123
• Chromosome: 10
• Chromosome location: 10p14-p13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020104	hsa-miR-361-5p	Sequencing	20371350
MIRT027249	hsa-miR-101-3p	Sequencing	20371350
MIRT028390	hsa-miR-30a-5p	Proteomics	18668040
MIRT031400	hsa-miR-16-5p	Proteomics	18668040
MIRT043215	hsa-miR-324-5p	CLASH	23622248
MIRT039270	hsa-miR-671-5p	CLASH	23622248
MIRT036838	hsa-miR-877-3p	CLASH	23622248
MIRT036838	hsa-miR-877-3p	CLASH	23622248
MIRT036407	hsa-miR-1227-3p	CLASH	23622248
MIRT876762	hsa-miR-1257	CLIP-seq
MIRT876763	hsa-miR-125a-3p	CLIP-seq
MIRT876764	hsa-miR-1468	CLIP-seq
MIRT876765	hsa-miR-1470	CLIP-seq
MIRT876766	hsa-miR-2114	CLIP-seq
MIRT876767	hsa-miR-2355-5p	CLIP-seq
MIRT876768	hsa-miR-2964a-5p	CLIP-seq
MIRT876769	hsa-miR-3156-5p	CLIP-seq
MIRT876770	hsa-miR-3679-3p	CLIP-seq
MIRT876771	hsa-miR-4446-5p	CLIP-seq
MIRT876772	hsa-miR-4667-3p	CLIP-seq
MIRT876773	hsa-miR-4726-3p	CLIP-seq
MIRT876774	hsa-miR-4795-3p	CLIP-seq
MIRT876775	hsa-miR-4796-3p	CLIP-seq
MIRT876776	hsa-miR-548p	CLIP-seq
MIRT876777	hsa-miR-548t	CLIP-seq
MIRT876778	hsa-miR-562	CLIP-seq
MIRT876762	hsa-miR-1257	CLIP-seq
MIRT876763	hsa-miR-125a-3p	CLIP-seq
MIRT876764	hsa-miR-1468	CLIP-seq
MIRT876765	hsa-miR-1470	CLIP-seq
MIRT876766	hsa-miR-2114	CLIP-seq
MIRT876767	hsa-miR-2355-5p	CLIP-seq
MIRT876770	hsa-miR-3679-3p	CLIP-seq
MIRT1959802	hsa-miR-376a	CLIP-seq
MIRT1959803	hsa-miR-376b	CLIP-seq
MIRT1959804	hsa-miR-4422	CLIP-seq
MIRT876771	hsa-miR-4446-5p	CLIP-seq
MIRT876772	hsa-miR-4667-3p	CLIP-seq
MIRT876773	hsa-miR-4726-3p	CLIP-seq
MIRT876774	hsa-miR-4795-3p	CLIP-seq
MIRT876776	hsa-miR-548p	CLIP-seq
MIRT876778	hsa-miR-562	CLIP-seq
MIRT876762	hsa-miR-1257	CLIP-seq
MIRT876763	hsa-miR-125a-3p	CLIP-seq
MIRT2196849	hsa-miR-145	CLIP-seq
MIRT876764	hsa-miR-1468	CLIP-seq
MIRT876765	hsa-miR-1470	CLIP-seq
MIRT876766	hsa-miR-2114	CLIP-seq
MIRT876767	hsa-miR-2355-5p	CLIP-seq
MIRT876768	hsa-miR-2964a-5p	CLIP-seq
MIRT2196850	hsa-miR-3163	CLIP-seq
MIRT876770	hsa-miR-3679-3p	CLIP-seq
MIRT2196851	hsa-miR-3925-3p	CLIP-seq
MIRT2196852	hsa-miR-423-3p	CLIP-seq
MIRT876771	hsa-miR-4446-5p	CLIP-seq
MIRT876772	hsa-miR-4667-3p	CLIP-seq
MIRT2196853	hsa-miR-4712-5p	CLIP-seq
MIRT876773	hsa-miR-4726-3p	CLIP-seq
MIRT876774	hsa-miR-4795-3p	CLIP-seq
MIRT876775	hsa-miR-4796-3p	CLIP-seq
MIRT2196854	hsa-miR-515-5p	CLIP-seq
MIRT876776	hsa-miR-548p	CLIP-seq
MIRT876777	hsa-miR-548t	CLIP-seq
MIRT2196855	hsa-miR-574-3p	CLIP-seq
MIRT2196856	hsa-miR-766	CLIP-seq
MIRT2196857	hsa-miR-770-5p	CLIP-seq
MIRT2196858	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	10942595
GO:0007050	Process	Cell cycle arrest	TAS	8601400
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	8601400
GO:0045948	Process	Positive regulation of translational initiation	ISS
GO:0051301	Process	Cell division	IEA
GO:1905143	Process	Eukaryotic translation initiation factor 2 complex assembly	ISS

Other IDs

• MIM: 617708
• HGNC: 16827
• e!Ensembl: ENSG00000151465

Protein

• UniProt ID: O75794
• Protein name: Translation initiation factor eIF2 assembly protein (Cell division cycle protein 123 homolog) (Protein D123) (HT-1080) (PZ32)
• Protein function: ATP-dependent protein-folding chaperone for the eIF2 complex (PubMed:35031321, PubMed:37507029). Binds to the gamma subunit of the eIF2 complex which allows the subunit to assemble with the alpha and beta subunits (By similarity). {ECO:0000250|U
• PDB: 8PHD, 8PHV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07065	D123	14 → 314	D123	Family

• Sequence:

  MKKEHVLHCQFSAWYPFFRGVTIKSVILPLPQNVKDYLLDDGTLVVSGRDDPPTHSQPDS
  DDEAEEIQWSDDENTATLTAPEFPEFATKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNS
  SLKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCIEYELVLRKWCELIPGAEFRC
  FVKENKLIGISQRDYTQYYDHISKQKEEIRRCIQDFFKKHIQYKFLDEDFVFDIYRDSRG
  KVWLIDFNPFGEVTDSLLFTWEELISENNLNGDFSEVDAQEQDSPAFRCTNSEVTVQPSP
  YLSYRLPKDFVDLSTGEDAHKLIDFLKLKRNQQEDD

• Sequence length: 336

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	30804561
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	31118516, 22158537