CCKAR (cholecystokinin A receptor)

Gene

• Entrez ID: 886
• Gene name: Cholecystokinin A receptor
• Gene symbol: CCKAR
• Synonyms: CCK-1R, CCK-A, CCK1-R, CCK1R, CCKRA
• Chromosome: 4
• Chromosome location: 4p15.2
• Summary: This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallb

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT870838	hsa-miR-1200	CLIP-seq
MIRT870839	hsa-miR-1236	CLIP-seq
MIRT870840	hsa-miR-1468	CLIP-seq
MIRT870841	hsa-miR-4695-3p	CLIP-seq
MIRT870842	hsa-miR-4734	CLIP-seq
MIRT870843	hsa-miR-4746-3p	CLIP-seq
MIRT870844	hsa-miR-4778-3p	CLIP-seq
MIRT870839	hsa-miR-1236	CLIP-seq
MIRT1958588	hsa-miR-1237	CLIP-seq
MIRT1958589	hsa-miR-1248	CLIP-seq
MIRT1958590	hsa-miR-136	CLIP-seq
MIRT1958591	hsa-miR-3194-3p	CLIP-seq
MIRT1958592	hsa-miR-4268	CLIP-seq
MIRT1958593	hsa-miR-4448	CLIP-seq
MIRT1958594	hsa-miR-4753-3p	CLIP-seq
MIRT1958595	hsa-miR-767-3p	CLIP-seq
MIRT1958596	hsa-miR-942	CLIP-seq
MIRT2446452	hsa-miR-2681	CLIP-seq
MIRT2446453	hsa-miR-4286	CLIP-seq
MIRT2446454	hsa-miR-4519	CLIP-seq
MIRT2446455	hsa-miR-4758-3p	CLIP-seq
MIRT2446452	hsa-miR-2681	CLIP-seq
MIRT2446453	hsa-miR-4286	CLIP-seq
MIRT2446454	hsa-miR-4519	CLIP-seq
MIRT2446455	hsa-miR-4758-3p	CLIP-seq
MIRT2446452	hsa-miR-2681	CLIP-seq
MIRT2446453	hsa-miR-4286	CLIP-seq
MIRT2446454	hsa-miR-4519	CLIP-seq
MIRT2446455	hsa-miR-4758-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	IEA
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004951	Function	Cholecystokinin receptor activity	IBA	21873635
GO:0004951	Function	Cholecystokinin receptor activity	IDA	8503909
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	TAS	8343165
GO:0007409	Process	Axonogenesis	IEA
GO:0016020	Component	Membrane	IDA	8503909
GO:0017046	Function	Peptide hormone binding	IPI	8503909
GO:0030900	Process	Forebrain development	IEA
GO:0038188	Process	Cholecystokinin signaling pathway	IDA	8503909
GO:0046883	Process	Regulation of hormone secretion	IBA	21873635

Other IDs

• MIM: 118444
• HGNC: 1570
• e!Ensembl: ENSG00000163394

Protein

• UniProt ID: P32238
• Protein name: Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R)
• Protein function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced
• PDB: 1D6G, 1HZN, 7EZH, 7EZK, 7EZM, 7F8U, 7F8X, 7F8Y, 7MBX, 7MBY, 7XOU, 7XOV, 9BKJ, 9BKK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09193	CholecysA-Rec_N	1 → 47	Cholecystokinin A receptor, N-terminal	Domain
  PF00001	7tm_1	58 → 370	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT
  LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF
  MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS
  NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI
  KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS
  SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY
  TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH
  MSASVPPQ

• Sequence length: 428

Pathways

KEGG:

Calcium signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
Insulin secretion
Pancreatic secretion

Reactome:

Peptide ligand-binding receptors
G alpha (q) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Gallbladder cancer	Malignant neoplasm of gallbladder	rs121913530, rs377767360, rs121913529, rs730882029, rs730882005, rs786202799, rs876659802, rs1057519718, rs764146326	25025063
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	19753663, 22825913, 15363473, 17413452, 17413443

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		21978736
Neoplasm of gallbladder	gallbladder neoplasm		25025063
Mental depression	Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	15927089
Paranoid schizophrenia	Paranoid Schizophrenia		22825913
Psychosis	Psychotic Disorders		17413443