KSR1 (kinase suppressor of ras 1)

Gene

• Entrez ID: 8844
• Gene name: Kinase suppressor of ras 1
• Gene symbol: KSR1
• Synonyms: KSR, RSU2
• Chromosome: 17
• Chromosome location: 17q11.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT437886	hsa-miR-378a-3p	Luciferase reporter assay	23625957
MIRT437886	hsa-miR-378a-3p	Luciferase reporter assay	23625957
MIRT441642	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT441641	hsa-miR-140-3p	PAR-CLIP	22100165
MIRT441640	hsa-miR-4286	PAR-CLIP	22100165
MIRT440348	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440348	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441642	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT441641	hsa-miR-140-3p	PAR-CLIP	22100165
MIRT441640	hsa-miR-4286	PAR-CLIP	22100165
MIRT1102163	hsa-miR-1915	CLIP-seq
MIRT1102164	hsa-miR-198	CLIP-seq
MIRT1102165	hsa-miR-2278	CLIP-seq
MIRT1102166	hsa-miR-3921	CLIP-seq
MIRT1102167	hsa-miR-4251	CLIP-seq
MIRT1102168	hsa-miR-4274	CLIP-seq
MIRT1102169	hsa-miR-4329	CLIP-seq
MIRT1102170	hsa-miR-4476	CLIP-seq
MIRT1102171	hsa-miR-450b-3p	CLIP-seq
MIRT1102172	hsa-miR-4519	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT1102174	hsa-miR-4653-5p	CLIP-seq
MIRT1102175	hsa-miR-4654	CLIP-seq
MIRT1102176	hsa-miR-4704-3p	CLIP-seq
MIRT1102177	hsa-miR-4713-3p	CLIP-seq
MIRT1102178	hsa-miR-4726-3p	CLIP-seq
MIRT1102179	hsa-miR-4769-5p	CLIP-seq
MIRT1102180	hsa-miR-494	CLIP-seq
MIRT1102181	hsa-miR-638	CLIP-seq
MIRT1102182	hsa-miR-665	CLIP-seq
MIRT1102183	hsa-miR-769-3p	CLIP-seq
MIRT1102184	hsa-miR-935	CLIP-seq
MIRT2027853	hsa-miR-224	CLIP-seq
MIRT2027854	hsa-miR-298	CLIP-seq
MIRT2027855	hsa-miR-33a	CLIP-seq
MIRT2027856	hsa-miR-33b	CLIP-seq
MIRT2027857	hsa-miR-3664-3p	CLIP-seq
MIRT2027858	hsa-miR-4433	CLIP-seq
MIRT2027859	hsa-miR-4459	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT2027860	hsa-miR-4768-3p	CLIP-seq
MIRT2027861	hsa-miR-4795-3p	CLIP-seq
MIRT2027862	hsa-miR-657	CLIP-seq
MIRT2259120	hsa-miR-1301	CLIP-seq
MIRT2259121	hsa-miR-219-2-3p	CLIP-seq
MIRT2027853	hsa-miR-224	CLIP-seq
MIRT2027854	hsa-miR-298	CLIP-seq
MIRT2027855	hsa-miR-33a	CLIP-seq
MIRT2027856	hsa-miR-33b	CLIP-seq
MIRT1102173	hsa-miR-4524	CLIP-seq
MIRT2259122	hsa-miR-4687-5p	CLIP-seq
MIRT2259123	hsa-miR-4690-3p	CLIP-seq
MIRT2259124	hsa-miR-5047	CLIP-seq
MIRT2259125	hsa-miR-579	CLIP-seq
MIRT2259126	hsa-miR-602	CLIP-seq
MIRT2390047	hsa-miR-141	CLIP-seq
MIRT2390048	hsa-miR-200a	CLIP-seq
MIRT2390049	hsa-miR-4661-5p	CLIP-seq
MIRT2390050	hsa-miR-4704-5p	CLIP-seq
MIRT2259126	hsa-miR-602	CLIP-seq
MIRT2259120	hsa-miR-1301	CLIP-seq
MIRT2259123	hsa-miR-4690-3p	CLIP-seq
MIRT2259124	hsa-miR-5047	CLIP-seq
MIRT2259125	hsa-miR-579	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0000185	Process	Activation of MAPKKK activity	IDA	29433126
GO:0004672	Function	Protein kinase activity	IBA	21873635
GO:0005078	Function	MAP-kinase scaffold activity	ISS
GO:0005515	Function	Protein binding	IPI	11909642, 20679487, 22752157, 27086506, 29433126, 31980649
GO:0005524	Function	ATP binding	IDA	29433126
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA	22572157
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IEA
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007265	Process	Ras protein signal transduction	IBA	21873635
GO:0007265	Process	Ras protein signal transduction	ISS
GO:0007265	Process	Ras protein signal transduction	NAS	8521512
GO:0008022	Function	Protein C-terminus binding	IDA	22572157
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0016020	Component	Membrane	IDA	22572157
GO:0019933	Process	CAMP-mediated signaling	ISS
GO:0032587	Component	Ruffle membrane	IEA
GO:0032991	Component	Protein-containing complex	IDA	22572157
GO:0042127	Process	Regulation of cell population proliferation	ISS
GO:0043405	Process	Regulation of MAP kinase activity	ISS
GO:0043410	Process	Positive regulation of MAPK cascade	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0071889	Function	14-3-3 protein binding	IDA	29433126
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA

Other IDs

• MIM: 601132
• HGNC: 6465
• e!Ensembl: ENSG00000141068

Protein

• UniProt ID: Q8IVT5
• Protein name: Kinase suppressor of Ras 1 (EC 2.7.11.1)
• Protein function: Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteri
• PDB: 5VYK, 7JUW, 7JUX, 7JUY, 7JUZ, 7JV0, 7JV1, 9AXH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13543	SAM_KSR1	41 → 168	SAM like domain present in kinase suppressor RAS 1	Domain
  PF07714	PK_Tyr_Ser-Thr	613 → 877	Protein tyrosine and serine/threonine kinase	Domain

• Sequence:

  MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRT
  KCAVSNDLTQQEIRTLEAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRP
  EVVQEIPRDLTLDALLEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGEHKED
  SSWSSLDARRESGSGPSTDTLSAASLPWPPGSSQLGRAGNSAQGPRSISVSALPASDSPT
  PSFSEGLSDTCIPLHASGRLTPRALHSFITPPTTPQLRRHTKLKPPRTPPPPSRKVFQLL
  PSFPTLTRSKSHESQLGNRIDDVSSMRFDLSHGSPQMVRRDIGLSVTHRFSTKSWLSQVC
  HVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFLPLTRLRRTESVPSDINNPVDRAAE
  PHFGTLPKALTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAPFPTSSNPSSATTPPNPSPG
  QRDSRFNFPAAYFIHHRQQFIFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLPEAA
  DGTRLDDQPKADVLEAHEAEAEEPEAGKSEAEDDEDEVDDLPSSRRPWRGPISRKASQTS
  VYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMN
  YRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKG
  MGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQLKLSHDWLCYLA
  PEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEASIWQIGSGEGMK
  RVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLSHPGHFWKSADIN
  SSKVVPRFERFGLGVLESSNPKM

• Sequence length: 923

Pathways

KEGG:

Ras signaling pathway
C-type lectin receptor signaling pathway
Tuberculosis

Reactome:

RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	26192919
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007

Unknown
Disease name	Disease term	dbSNP ID	References
Ankylosing spondylitis	Ankylosing spondylitis		26974007
Cholangitis	Cholangitis, Sclerosing		26974007
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	28067908, 26192919, 26974007, 23128233
Ulcerative colitis	Ulcerative Colitis		26974007