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CFLAR (CASP8 and FADD like apoptosis regulator)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8837
Gene nameGene Name - the full gene name approved by the HGNC.
CASP8 and FADD like apoptosis regulator
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CFLAR
SynonymsGene synonyms aliases
CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, cFLIP
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q33.1
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encodin
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004228 hsa-miR-346 Microarray 16822819
MIRT025744 hsa-miR-7-5p Microarray 19073608
MIRT050158 hsa-miR-26a-5p CLASH 23622248
MIRT053401 hsa-miR-629-5p Microarray 23807165
MIRT887612 hsa-miR-103a CLIP-seq
Transcription factors
Transcription factor Regulation Reference
ATM Activation 19351839
ATM Repression 20876284
DEDD Unknown 17193921
HDAC9 Activation 20087862
HDAC9 Repression 15540114
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IPI 9208847
GO:0005123 Function Death receptor binding IEA
GO:0005515 Function Protein binding IPI 9208847, 11741985, 12887920, 17047155, 23541952, 24438025, 25241761, 25416956, 32296183
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005737 Component Cytoplasm IDA 18073330
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O15519
Protein name CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1)
Protein function Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-i
PDB 2N5R , 3H11 , 3H13 , 6M6O , 7DEE , 7LXC , 8YBX , 8YD7 , 8YD8 , 8YM4 , 8YM5 , 8YM6 , 8YNI , 8YNK , 8YNL , 8YNM , 8YNN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01335 DED
3 77
Death effector domain
Domain
PF01335 DED
93 174
Death effector domain
Domain
PF00656 Peptidase_C14
253 477
Domain
Sequence
Sequence length 480
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  NF-kappa B signaling pathway
Autophagy - animal
Apoptosis
Necroptosis
TNF signaling pathway
Chagas disease
Hepatitis C
  Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038 29059683
Leukemia leukemia rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 12970779
Lymphoma Lymphoma, Extranodal NK-T-Cell rs11540652, rs1592119138, rs1592123162, rs1599367044 15924153
Myelodysplastic syndrome MYELODYSPLASTIC SYNDROME rs193303018, rs387906631, rs1576745225, rs373145711, rs752746786, rs377023736, rs373221034, rs1576749014, rs1600586587 16105982
Unknown
Disease name Disease term dbSNP ID References
Classical hodgkin lymphoma Mixed Cellularity Hodgkin Lymphoma, Lymphocyte Rich Classical Hodgkin Lymphoma, Nodular Lymphocyte Predominant Hodgkin Lymphoma 17659339
Extranodal nk t cell lymphoma Nasal Type Extranodal NK/T-Cell Lymphoma 15924153
Hodgkin disease Hodgkin Disease 17659339
Hodgkin lymphoma Adult Hodgkin Lymphoma rs387906223, rs56391007, rs121913527, rs747694886 17659339

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