CFLAR (CASP8 and FADD like apoptosis regulator)
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Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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8837 |
Gene nameGene Name - the full gene name approved by the HGNC.
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CASP8 and FADD like apoptosis regulator |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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CFLAR |
SynonymsGene synonyms aliases
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CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, cFLIP |
ChromosomeChromosome number
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2 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
2q33.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encodin |
miRNAmiRNA information provided by mirtarbase database.
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Transcription factors
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0002020 |
Function |
Protease binding |
IPI |
9208847 |
GO:0005123 |
Function |
Death receptor binding |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
9208847, 11741985, 12887920, 17047155, 23541952, 24438025, 25241761, 25416956, 32296183 |
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
18073330 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006508 |
Process |
Proteolysis |
IEA |
|
GO:0006915 |
Process |
Apoptotic process |
IBA |
21873635 |
GO:0006915 |
Process |
Apoptotic process |
IMP |
21737330 |
GO:0006919 |
Process |
Activation of cysteine-type endopeptidase activity involved in apoptotic process |
IBA |
21873635 |
GO:0007519 |
Process |
Skeletal muscle tissue development |
ISS |
|
GO:0008047 |
Function |
Enzyme activator activity |
IDA |
9208847 |
GO:0010667 |
Process |
Negative regulation of cardiac muscle cell apoptotic process |
IEA |
|
GO:0010976 |
Process |
Positive regulation of neuron projection development |
IEA |
|
GO:0014732 |
Process |
Skeletal muscle atrophy |
ISS |
|
GO:0014842 |
Process |
Regulation of skeletal muscle satellite cell proliferation |
ISS |
|
GO:0014866 |
Process |
Skeletal myofibril assembly |
ISS |
|
GO:0016032 |
Process |
Viral process |
IEA |
|
GO:0031264 |
Component |
Death-inducing signaling complex |
IDA |
21803845 |
GO:0031265 |
Component |
CD95 death-inducing signaling complex |
IEA |
|
GO:0032869 |
Process |
Cellular response to insulin stimulus |
IEA |
|
GO:0033574 |
Process |
Response to testosterone |
IEA |
|
GO:0042060 |
Process |
Wound healing |
ISS |
|
GO:0043066 |
Process |
Negative regulation of apoptotic process |
TAS |
9217161 |
GO:0043123 |
Process |
Positive regulation of I-kappaB kinase/NF-kappaB signaling |
IEP |
12761501 |
GO:0043403 |
Process |
Skeletal muscle tissue regeneration |
ISS |
|
GO:0044877 |
Function |
Protein-containing complex binding |
IEA |
|
GO:0045121 |
Component |
Membrane raft |
IEA |
|
GO:0051092 |
Process |
Positive regulation of NF-kappaB transcription factor activity |
ISS |
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GO:0060544 |
Process |
Regulation of necroptotic process |
IDA |
21737330 |
GO:0070374 |
Process |
Positive regulation of ERK1 and ERK2 cascade |
IEA |
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GO:0071364 |
Process |
Cellular response to epidermal growth factor stimulus |
IEA |
|
GO:0071392 |
Process |
Cellular response to estradiol stimulus |
IEA |
|
GO:0071456 |
Process |
Cellular response to hypoxia |
IEA |
|
GO:0071549 |
Process |
Cellular response to dexamethasone stimulus |
IEA |
|
GO:0071732 |
Process |
Cellular response to nitric oxide |
IEA |
|
GO:0072126 |
Process |
Positive regulation of glomerular mesangial cell proliferation |
IEA |
|
GO:0097153 |
Function |
Cysteine-type endopeptidase activity involved in apoptotic process |
IBA |
21873635 |
GO:0097190 |
Process |
Apoptotic signaling pathway |
IEA |
|
GO:0097194 |
Process |
Execution phase of apoptosis |
IEA |
|
GO:0097199 |
Function |
Cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
IBA |
21873635 |
GO:0097200 |
Function |
Cysteine-type endopeptidase activity involved in execution phase of apoptosis |
IBA |
21873635 |
GO:0097342 |
Component |
Ripoptosome |
IDA |
21737330 |
GO:1901740 |
Process |
Negative regulation of myoblast fusion |
ISS |
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GO:1902041 |
Process |
Regulation of extrinsic apoptotic signaling pathway via death domain receptors |
TAS |
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GO:1902042 |
Process |
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
IBA |
21873635 |
GO:1902042 |
Process |
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
IDA |
26582200 |
GO:1902042 |
Process |
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
IMP |
18202225 |
GO:1902042 |
Process |
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
TAS |
|
GO:1903055 |
Process |
Positive regulation of extracellular matrix organization |
IEA |
|
GO:1903427 |
Process |
Negative regulation of reactive oxygen species biosynthetic process |
IEA |
|
GO:1903845 |
Process |
Negative regulation of cellular response to transforming growth factor beta stimulus |
IEA |
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GO:1903944 |
Process |
Negative regulation of hepatocyte apoptotic process |
IEA |
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GO:2000347 |
Process |
Positive regulation of hepatocyte proliferation |
IEA |
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GO:2001237 |
Process |
Negative regulation of extrinsic apoptotic signaling pathway |
IDA |
9208847 |
GO:2001237 |
Process |
Negative regulation of extrinsic apoptotic signaling pathway |
IMP |
22266862 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
O15519 |
Protein name |
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) |
Protein function |
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-i |
PDB |
2N5R
,
3H11
,
3H13
,
6M6O
,
7DEE
,
7LXC
,
8YBX
,
8YD7
,
8YD8
,
8YM4
,
8YM5
,
8YM6
,
8YNI
,
8YNK
,
8YNL
,
8YNM
,
8YNN
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01335 |
DED |
3 → 77 |
Death effector domain |
Domain |
PF01335 |
DED |
93 → 174 |
Death effector domain |
Domain |
PF00656 |
Peptidase_C14 |
253 → 477 |
|
Domain |
|
Sequence |
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Sequence length |
480 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Breast carcinoma |
Breast Carcinoma |
rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038 |
29059683 |
Leukemia |
leukemia |
rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 |
12970779 |
Lymphoma |
Lymphoma, Extranodal NK-T-Cell |
rs11540652, rs1592119138, rs1592123162, rs1599367044 |
15924153 |
Myelodysplastic syndrome |
MYELODYSPLASTIC SYNDROME |
rs193303018, rs387906631, rs1576745225, rs373145711, rs752746786, rs377023736, rs373221034, rs1576749014, rs1600586587 |
16105982 |
Pancreatic cancer |
Malignant neoplasm of pancreas |
rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431, rs200612497 |
20876774 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Classical hodgkin lymphoma |
Mixed Cellularity Hodgkin Lymphoma, Lymphocyte Rich Classical Hodgkin Lymphoma, Nodular Lymphocyte Predominant Hodgkin Lymphoma |
|
17659339 |
Extranodal nk t cell lymphoma |
Nasal Type Extranodal NK/T-Cell Lymphoma |
|
15924153 |
Hodgkin disease |
Hodgkin Disease |
|
17659339 |
Hodgkin lymphoma |
Adult Hodgkin Lymphoma |
rs387906223, rs56391007, rs121913527, rs747694886 |
17659339 |
Hodgkin lymphoma, lymphocyte depletion |
Hodgkin lymphoma, lymphocyte depletion |
|
17659339 |
Lymphocytic leukemia |
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma |
|
28165464 |
Pancreatic neoplasm |
Pancreatic Neoplasm |
|
20876774 |
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