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NRP1 (neuropilin 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8829
Gene nameGene Name - the full gene name approved by the HGNC.
Neuropilin 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
NRP1
SynonymsGene synonyms aliases
BDCA4, CD304, NP1, NRP, VEGF165R
ChromosomeChromosome number
10
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p11.22
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, mad
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001352 hsa-miR-1-3p pSILAC 18668040
MIRT017659 hsa-miR-335-5p Microarray 18185580
MIRT021183 hsa-miR-186-5p Sequencing 20371350
MIRT022578 hsa-miR-124-3p Microarray 18668037
MIRT001352 hsa-miR-1-3p Proteomics;Other 18668040
Transcription factors
Transcription factor Regulation Reference
REST Repression 16330548
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IMP 23639442
GO:0001525 Process Angiogenesis ISS 24401374
GO:0001569 Process Branching involved in blood vessel morphogenesis ISS 24401374
GO:0001764 Process Neuron migration ISS
GO:0001938 Process Positive regulation of endothelial cell proliferation TAS 21245381
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O14786
Protein name Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
Protein function Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (
PDB 1KEX , 2QQI , 2QQM , 2QQN , 3I97 , 4DEQ , 4RN5 , 5C7G , 5IJR , 5IYY , 5J1X , 5JGI , 5JGQ , 5JHK , 5L73 , 6FMC , 6FMF , 6TKK , 7JJC , 7O1N , 7P5U , 8C5G , 8PFE , 9EOU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00431 CUB
27 138
CUB domain
Domain
PF00431 CUB
147 262
CUB domain
Domain
PF00754 F5_F8_type_C
290 421
F5/8 type C domain
Domain
PF00754 F5_F8_type_C
446 580
F5/8 type C domain
Domain
PF00629 MAM
650 810
MAM domain, meprin/A5/mu
Domain
PF11980 DUF3481
842 923
C-terminal domain of neuropilin glycoprotein
Family
Sequence
MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
IKFVSDYETHGAGFSIRY
EIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVP
KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
GILSMVFYTDSAIAKEGFSANY
SVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
V
YGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMEL
LGCEVEAPTAGPTTPNGNLV
DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTF
CHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAH
CMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVI
FEGEIGKGNLGGIAVDDISINNHISQEDCA
KPADLDKKNPEIKIDETGSTPGYEGEGEGD
KNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYN
FELVDGVKLKKDKLNTQSTYSEA
Sequence length 923
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Axon guidance
Human T-cell leukemia virus 1 infection
Coronavirus disease - COVID-19
  Neurophilin interactions with VEGF and VEGFR
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Signal transduction by L1
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 27903959
Migraine Migraine Disorders rs794727411 27322543
Pancreatic cancer Malignant neoplasm of pancreas rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431, rs200612497 15956974
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Unknown
Disease name Disease term dbSNP ID References
Endometrioma Endometrioma 21063030
Endometriosis Endometriosis rs1800629, rs1143634 21063030
Pancreatic neoplasm Pancreatic Neoplasm 15956974
Prostatic neoplasms Prostatic Neoplasms 17013881

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