SUCLG2 (succinate-CoA ligase GDP-forming subunit beta)

Gene

• Entrez ID: 8801
• Gene name: Succinate-CoA ligase GDP-forming subunit beta
• Gene symbol: SUCLG2
• Synonyms: G-SCS, GBETA, GTPSCS
• Chromosome: 3
• Chromosome location: 3p14.1
• Summary: This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudoge

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001830	hsa-miR-124-3p	Microarray, qRT-PCR	16549876
MIRT001830	hsa-miR-124-3p	Microarray	16549876
MIRT001830	hsa-miR-124-3p	qRT-PCR;Other	16549876
MIRT049822	hsa-miR-92a-3p	CLASH	23622248
MIRT648151	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT648149	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT648150	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT648148	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT648147	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT648146	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648145	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT648144	hsa-miR-4297	HITS-CLIP	23824327
MIRT648143	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT648142	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT648141	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT648140	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT648139	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT648138	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT648151	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT648149	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT648150	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT648148	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT648147	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT648146	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648145	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT648144	hsa-miR-4297	HITS-CLIP	23824327
MIRT648143	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT648142	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT648141	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT648140	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT648139	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT648138	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT1402226	hsa-miR-587	CLIP-seq
MIRT1402227	hsa-miR-938	CLIP-seq
MIRT1402228	hsa-let-7a	CLIP-seq
MIRT1402229	hsa-let-7b	CLIP-seq
MIRT1402230	hsa-let-7c	CLIP-seq
MIRT1402231	hsa-let-7d	CLIP-seq
MIRT1402232	hsa-let-7e	CLIP-seq
MIRT1402233	hsa-let-7f	CLIP-seq
MIRT1402234	hsa-let-7g	CLIP-seq
MIRT1402235	hsa-let-7i	CLIP-seq
MIRT1402236	hsa-miR-1284	CLIP-seq
MIRT1402237	hsa-miR-1294	CLIP-seq
MIRT1402238	hsa-miR-144	CLIP-seq
MIRT1402239	hsa-miR-150	CLIP-seq
MIRT1402240	hsa-miR-202	CLIP-seq
MIRT1402241	hsa-miR-203	CLIP-seq
MIRT1402242	hsa-miR-2115	CLIP-seq
MIRT1402243	hsa-miR-30a	CLIP-seq
MIRT1402244	hsa-miR-30b	CLIP-seq
MIRT1402245	hsa-miR-30c	CLIP-seq
MIRT1402246	hsa-miR-30d	CLIP-seq
MIRT1402247	hsa-miR-30e	CLIP-seq
MIRT1402248	hsa-miR-3120-5p	CLIP-seq
MIRT1402249	hsa-miR-3159	CLIP-seq
MIRT1402250	hsa-miR-329	CLIP-seq
MIRT1402251	hsa-miR-338-5p	CLIP-seq
MIRT1402252	hsa-miR-3591-5p	CLIP-seq
MIRT1402253	hsa-miR-362-3p	CLIP-seq
MIRT1402254	hsa-miR-3671	CLIP-seq
MIRT1402255	hsa-miR-3941	CLIP-seq
MIRT1402256	hsa-miR-4272	CLIP-seq
MIRT1402257	hsa-miR-4276	CLIP-seq
MIRT1402258	hsa-miR-4316	CLIP-seq
MIRT1402259	hsa-miR-4436b-5p	CLIP-seq
MIRT1402260	hsa-miR-4458	CLIP-seq
MIRT1402261	hsa-miR-4500	CLIP-seq
MIRT1402262	hsa-miR-4517	CLIP-seq
MIRT1402263	hsa-miR-4635	CLIP-seq
MIRT1402264	hsa-miR-4694-3p	CLIP-seq
MIRT1402265	hsa-miR-4719	CLIP-seq
MIRT1402266	hsa-miR-4778-5p	CLIP-seq
MIRT1402267	hsa-miR-4789-5p	CLIP-seq
MIRT1402268	hsa-miR-4796-5p	CLIP-seq
MIRT1402269	hsa-miR-514	CLIP-seq
MIRT1402270	hsa-miR-514b-3p	CLIP-seq
MIRT1402271	hsa-miR-603	CLIP-seq
MIRT1402272	hsa-miR-607	CLIP-seq
MIRT1402273	hsa-miR-642b	CLIP-seq
MIRT1402274	hsa-miR-648	CLIP-seq
MIRT1402275	hsa-miR-671-5p	CLIP-seq
MIRT1402276	hsa-miR-98	CLIP-seq
MIRT2120553	hsa-miR-1272	CLIP-seq
MIRT2120554	hsa-miR-3658	CLIP-seq
MIRT2120555	hsa-miR-376c	CLIP-seq
MIRT2120556	hsa-miR-513b	CLIP-seq
MIRT2120557	hsa-miR-570	CLIP-seq
MIRT2342671	hsa-miR-3187-3p	CLIP-seq
MIRT2120554	hsa-miR-3658	CLIP-seq
MIRT2120555	hsa-miR-376c	CLIP-seq
MIRT2342672	hsa-miR-4435	CLIP-seq
MIRT2342673	hsa-miR-4701-5p	CLIP-seq
MIRT2342674	hsa-miR-4756-3p	CLIP-seq
MIRT2342675	hsa-miR-548s	CLIP-seq
MIRT1402226	hsa-miR-587	CLIP-seq
MIRT2342676	hsa-miR-588	CLIP-seq
MIRT1402274	hsa-miR-648	CLIP-seq
MIRT2636478	hsa-miR-340	CLIP-seq
MIRT1402228	hsa-let-7a	CLIP-seq
MIRT1402229	hsa-let-7b	CLIP-seq
MIRT1402230	hsa-let-7c	CLIP-seq
MIRT1402231	hsa-let-7d	CLIP-seq
MIRT1402232	hsa-let-7e	CLIP-seq
MIRT1402233	hsa-let-7f	CLIP-seq
MIRT1402234	hsa-let-7g	CLIP-seq
MIRT1402235	hsa-let-7i	CLIP-seq
MIRT2692396	hsa-miR-124	CLIP-seq
MIRT1402237	hsa-miR-1294	CLIP-seq
MIRT2692397	hsa-miR-142-5p	CLIP-seq
MIRT1402238	hsa-miR-144	CLIP-seq
MIRT2692398	hsa-miR-146a	CLIP-seq
MIRT2692399	hsa-miR-146b-5p	CLIP-seq
MIRT1402239	hsa-miR-150	CLIP-seq
MIRT1402240	hsa-miR-202	CLIP-seq
MIRT1402242	hsa-miR-2115	CLIP-seq
MIRT1402243	hsa-miR-30a	CLIP-seq
MIRT1402244	hsa-miR-30b	CLIP-seq
MIRT1402245	hsa-miR-30c	CLIP-seq
MIRT1402246	hsa-miR-30d	CLIP-seq
MIRT1402247	hsa-miR-30e	CLIP-seq
MIRT2636478	hsa-miR-340	CLIP-seq
MIRT1402252	hsa-miR-3591-5p	CLIP-seq
MIRT2692400	hsa-miR-3714	CLIP-seq
MIRT2692401	hsa-miR-3910	CLIP-seq
MIRT1402256	hsa-miR-4272	CLIP-seq
MIRT1402258	hsa-miR-4316	CLIP-seq
MIRT1402259	hsa-miR-4436b-5p	CLIP-seq
MIRT1402260	hsa-miR-4458	CLIP-seq
MIRT2692402	hsa-miR-4477a	CLIP-seq
MIRT1402261	hsa-miR-4500	CLIP-seq
MIRT1402264	hsa-miR-4694-3p	CLIP-seq
MIRT2692403	hsa-miR-4712-3p	CLIP-seq
MIRT1402265	hsa-miR-4719	CLIP-seq
MIRT2692404	hsa-miR-4731-3p	CLIP-seq
MIRT2692405	hsa-miR-4795-3p	CLIP-seq
MIRT2692406	hsa-miR-4801	CLIP-seq
MIRT2692407	hsa-miR-506	CLIP-seq
MIRT2692408	hsa-miR-548l	CLIP-seq
MIRT2692409	hsa-miR-548n	CLIP-seq
MIRT2692410	hsa-miR-548u	CLIP-seq
MIRT2692411	hsa-miR-589	CLIP-seq
MIRT1402273	hsa-miR-642b	CLIP-seq
MIRT1402274	hsa-miR-648	CLIP-seq
MIRT2692412	hsa-miR-656	CLIP-seq
MIRT1402275	hsa-miR-671-5p	CLIP-seq
MIRT1402276	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0004775	Function	Succinate-CoA ligase (ADP-forming) activity	IEA
GO:0004776	Function	Succinate-CoA ligase (GDP-forming) activity	IBA	21873635
GO:0004776	Function	Succinate-CoA ligase (GDP-forming) activity	NAS	9765291
GO:0005515	Function	Protein binding	IPI	24606901, 28380382, 28514442, 32627745
GO:0005524	Function	ATP binding	IEA
GO:0005525	Function	GTP binding	IEA
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006099	Process	Tricarboxylic acid cycle	IBA	21873635
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006099	Process	Tricarboxylic acid cycle	TAS
GO:0006104	Process	Succinyl-CoA metabolic process	IBA	21873635
GO:0006104	Process	Succinyl-CoA metabolic process	NAS	9765291
GO:0006105	Process	Succinate metabolic process	IEA
GO:0019003	Function	GDP binding	IEA
GO:0042709	Component	Succinate-CoA ligase complex	IBA	21873635
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045244	Component	Succinate-CoA ligase complex (GDP-forming)	IEA

Other IDs

• MIM: 603922
• HGNC: 11450
• e!Ensembl: ENSG00000172340

Protein

• UniProt ID: Q96I99
• Protein name: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG)
• Protein function: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit prov
• PDB: 6WCV, 7MSR, 7MSS, 7MST, 8Z02, 8Z03
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08442	ATP-grasp_2	39 → 247	ATP-grasp domain	Domain
  PF00549	Ligase_CoA	306 → 426	CoA-ligase	Domain

• Sequence:

  MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMSDNGVRVQRFF
  VADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNVVGQLAKQM
  IGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEV
  AASNPELIFKEQIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQV
  EVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKYDLKYIGLD
  GNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILV
  NIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVQEAQKILNNSGLPITSAIDLED
  AAKKAVASVAKK

• Sequence length: 432

Pathways

KEGG:

Citrate cycle (TCA cycle)
Propanoate metabolism
Metabolic pathways
Carbon metabolism

Reactome:

Citric acid cycle (TCA cycle)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	25027320
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	27602772
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	20882379
Prostate cancer	Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	26307654

Unknown
Disease name	Disease term	dbSNP ID	References
Endometrioma	Endometrioma		23284138
Endometriosis	Endometriosis	rs1800629, rs1143634	23284138