PEX11A (peroxisomal biogenesis factor 11 alpha)

Gene

• Entrez ID: 8800
• Gene name: Peroxisomal biogenesis factor 11 alpha
• Gene symbol: PEX11A
• Synonyms: PEX11-ALPHA, PEX11alpha, PMP28, hsPEX11p
• Chromosome: 15
• Chromosome location: 15q26.1
• Summary: This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside sti

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030311	hsa-miR-26b-5p	Microarray	19088304
MIRT723915	hsa-miR-141-3p	HITS-CLIP	19536157
MIRT723914	hsa-miR-200a-3p	HITS-CLIP	19536157
MIRT723913	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT723912	hsa-miR-3145-5p	HITS-CLIP	19536157
MIRT723911	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT723910	hsa-miR-6872-3p	HITS-CLIP	19536157
MIRT723909	hsa-miR-4735-5p	HITS-CLIP	19536157
MIRT723908	hsa-miR-4794	HITS-CLIP	19536157
MIRT723907	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT723906	hsa-miR-1254	HITS-CLIP	19536157
MIRT723905	hsa-miR-3116	HITS-CLIP	19536157
MIRT723904	hsa-miR-661	HITS-CLIP	19536157
MIRT723903	hsa-miR-4775	HITS-CLIP	19536157
MIRT723902	hsa-miR-302c-5p	HITS-CLIP	19536157
MIRT723901	hsa-miR-552-5p	HITS-CLIP	19536157
MIRT723915	hsa-miR-141-3p	HITS-CLIP	19536157
MIRT723914	hsa-miR-200a-3p	HITS-CLIP	19536157
MIRT723913	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT723912	hsa-miR-3145-5p	HITS-CLIP	19536157
MIRT723911	hsa-miR-508-5p	HITS-CLIP	19536157
MIRT723910	hsa-miR-6872-3p	HITS-CLIP	19536157
MIRT723909	hsa-miR-4735-5p	HITS-CLIP	19536157
MIRT723908	hsa-miR-4794	HITS-CLIP	19536157
MIRT723907	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT723906	hsa-miR-1254	HITS-CLIP	19536157
MIRT723905	hsa-miR-3116	HITS-CLIP	19536157
MIRT723904	hsa-miR-661	HITS-CLIP	19536157
MIRT723903	hsa-miR-4775	HITS-CLIP	19536157
MIRT723902	hsa-miR-302c-5p	HITS-CLIP	19536157
MIRT723901	hsa-miR-552-5p	HITS-CLIP	19536157
MIRT1225371	hsa-miR-3179	CLIP-seq
MIRT1225372	hsa-miR-4668-5p	CLIP-seq
MIRT1225373	hsa-miR-4705	CLIP-seq
MIRT1225374	hsa-miR-501-3p	CLIP-seq
MIRT1225375	hsa-miR-502-3p	CLIP-seq
MIRT2065821	hsa-miR-1224-3p	CLIP-seq
MIRT2065822	hsa-miR-1260	CLIP-seq
MIRT2065823	hsa-miR-1260b	CLIP-seq
MIRT2065824	hsa-miR-1280	CLIP-seq
MIRT2065825	hsa-miR-4529-5p	CLIP-seq
MIRT2065821	hsa-miR-1224-3p	CLIP-seq
MIRT2065822	hsa-miR-1260	CLIP-seq
MIRT2065823	hsa-miR-1260b	CLIP-seq
MIRT2065824	hsa-miR-1280	CLIP-seq
MIRT2293561	hsa-miR-3156-3p	CLIP-seq
MIRT2293562	hsa-miR-4291	CLIP-seq
MIRT2293563	hsa-miR-4301	CLIP-seq
MIRT2065825	hsa-miR-4529-5p	CLIP-seq
MIRT1225373	hsa-miR-4705	CLIP-seq
MIRT1225374	hsa-miR-501-3p	CLIP-seq
MIRT1225375	hsa-miR-502-3p	CLIP-seq
MIRT2293564	hsa-miR-532-3p	CLIP-seq
MIRT2293565	hsa-miR-545	CLIP-seq
MIRT2065821	hsa-miR-1224-3p	CLIP-seq
MIRT2065822	hsa-miR-1260	CLIP-seq
MIRT2065823	hsa-miR-1260b	CLIP-seq
MIRT2065824	hsa-miR-1280	CLIP-seq
MIRT2591541	hsa-miR-300	CLIP-seq
MIRT2591542	hsa-miR-381	CLIP-seq
MIRT2065825	hsa-miR-4529-5p	CLIP-seq
MIRT2591543	hsa-miR-4666-3p	CLIP-seq
MIRT2591544	hsa-miR-4789-5p	CLIP-seq
MIRT2591545	hsa-miR-548a-5p	CLIP-seq
MIRT2591546	hsa-miR-548ab	CLIP-seq
MIRT2591547	hsa-miR-548ak	CLIP-seq
MIRT2591548	hsa-miR-548b-5p	CLIP-seq
MIRT2591549	hsa-miR-548c-5p	CLIP-seq
MIRT2591550	hsa-miR-548d-5p	CLIP-seq
MIRT2591551	hsa-miR-548h	CLIP-seq
MIRT2591552	hsa-miR-548i	CLIP-seq
MIRT2591553	hsa-miR-548j	CLIP-seq
MIRT2591554	hsa-miR-548k	CLIP-seq
MIRT2591555	hsa-miR-548l	CLIP-seq
MIRT2591556	hsa-miR-548w	CLIP-seq
MIRT2591557	hsa-miR-548y	CLIP-seq
MIRT2591558	hsa-miR-559	CLIP-seq
MIRT2591559	hsa-miR-654-3p	CLIP-seq
MIRT2065821	hsa-miR-1224-3p	CLIP-seq
MIRT2065822	hsa-miR-1260	CLIP-seq
MIRT2065823	hsa-miR-1260b	CLIP-seq
MIRT2065824	hsa-miR-1280	CLIP-seq
MIRT2591541	hsa-miR-300	CLIP-seq
MIRT2591542	hsa-miR-381	CLIP-seq
MIRT2687606	hsa-miR-3923	CLIP-seq
MIRT2065825	hsa-miR-4529-5p	CLIP-seq
MIRT2591543	hsa-miR-4666-3p	CLIP-seq
MIRT2591544	hsa-miR-4789-5p	CLIP-seq
MIRT2591545	hsa-miR-548a-5p	CLIP-seq
MIRT2591546	hsa-miR-548ab	CLIP-seq
MIRT2591547	hsa-miR-548ak	CLIP-seq
MIRT2591548	hsa-miR-548b-5p	CLIP-seq
MIRT2591549	hsa-miR-548c-5p	CLIP-seq
MIRT2591550	hsa-miR-548d-5p	CLIP-seq
MIRT2591551	hsa-miR-548h	CLIP-seq
MIRT2591552	hsa-miR-548i	CLIP-seq
MIRT2591553	hsa-miR-548j	CLIP-seq
MIRT2591554	hsa-miR-548k	CLIP-seq
MIRT2591555	hsa-miR-548l	CLIP-seq
MIRT2591556	hsa-miR-548w	CLIP-seq
MIRT2591557	hsa-miR-548y	CLIP-seq
MIRT2591558	hsa-miR-559	CLIP-seq
MIRT2591559	hsa-miR-654-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	20826455
GO:0005777	Component	Peroxisome	IDA	9922452, 18782765, 19114594, 20826455
GO:0005778	Component	Peroxisomal membrane	IBA	21873635
GO:0005778	Component	Peroxisomal membrane	TAS
GO:0005779	Component	Integral component of peroxisomal membrane	IDA	9714566, 9792670
GO:0007031	Process	Peroxisome organization	IMP	9792670
GO:0007165	Process	Signal transduction	IMP	9792670
GO:0016557	Process	Peroxisome membrane biogenesis	IEA
GO:0016559	Process	Peroxisome fission	IBA	21873635
GO:0016559	Process	Peroxisome fission	IDA	20826455
GO:0019216	Process	Regulation of lipid metabolic process	TAS
GO:0032991	Component	Protein-containing complex	IDA	20826455
GO:0042803	Function	Protein homodimerization activity	IDA	20826455
GO:0044375	Process	Regulation of peroxisome size	IBA	21873635
GO:0044375	Process	Regulation of peroxisome size	IDA	20826455
GO:0050873	Process	Brown fat cell differentiation	IEA

Other IDs

• MIM: 603866
• HGNC: 8852
• e!Ensembl: ENSG00000166821

Protein

• UniProt ID: O75192
• Protein name: Peroxisomal membrane protein 11A (HsPEX11p) (28 kDa peroxisomal integral membrane protein) (PMP28) (Peroxin-11A) (Peroxisomal biogenesis factor 11A) (Protein PEX11 homolog alpha) (PEX11-alpha)
• Protein function: May be involved in peroxisomal proliferation and may regulate peroxisomes division (PubMed:9792670). May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxis
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05648	PEX11	1 → 238	Peroxisomal biogenesis factor 11 (PEX11)	Family

• Sequence:

  MDAFTRFTNQTQGRDRLFRATQYTCMLLRYLLEPKAGKEKVVMKLKKLESSVSTGRKWFR
  LGNVVHAIQATEQSIHATDLVPRLCLTLANLNRVIYFICDTILWVRSVGLTSGINKEKWR
  TRAAHHYYYSLLLSLVRDLYEISLQMKRVTCDRAKKEKSASQDPLWFSVAEEETEWLQSF
  LLLLFRSLKQHPPLLLDTVKNLCDILNPLDQLGIYKSNPGIIGLGGLVSSIAGMITVAYP
  QMKLKTR

• Sequence length: 247

Pathways

KEGG:

Peroxisome

Reactome:

PPARA activates gene expression

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	30585412
Zellweger syndrome	Zellweger Syndrome	rs62641228, rs28940308, rs61752129, rs74315506, rs61752133, rs267608190, rs61752117, rs267608185, rs267608183, rs61752095, rs61750434, rs61750435, rs61750420, rs121434455, rs1554372074, rs61750415, rs61752116, rs104893661, rs104894616, rs61752103, rs28936697, rs61752097, rs202143236, rs28936698, rs1805137, rs121909151, rs121909152, rs121909153, rs63535662, rs148591292, rs121909154, rs61753238, rs61753233, rs267608213, rs112298166, rs62641231, rs1554128347, rs61752138, rs61752137, rs61752123, rs61752119, rs1571138735, rs387906809, rs1590793006, rs397514472, rs267608252, rs62653611, rs397515419, rs398123301, rs398123302, rs398123303, rs398123305, rs398123409, rs61752122, rs61752128, rs61752127, rs724159999, rs724160000, rs724160002, rs61752092, rs724160029, rs727504076, rs267608254, rs764346452, rs61753245, rs769836601, rs267608180, rs267608179, rs61750426, rs61750423, rs61750414, rs61750418, rs786204606, rs786204743, rs786204638, rs749067142, rs786204544, rs786204704, rs776731688, rs786205655, rs786205656, rs267608241, rs794729652, rs797045062, rs61753219, rs863225083, rs370483961, rs756876301, rs61753224, rs267608216, rs61750427, rs886037783, rs869312935, rs774131564, rs878853044, rs61750422, rs886041314, rs62641225, rs886043479, rs886043558, rs764771123, rs886044436, rs61752093, rs369965266, rs62636519, rs1057516882, rs763514968, rs62653604, rs1057516827, rs1057516989, rs1057517257, rs778862698, rs1057517467, rs1057517480, rs759183382, rs1057517509, rs1057517518, rs1057517531, rs762324548, rs1057517481, rs1057517472, rs1057517484, rs1057517503, rs1057517485, rs1057517470, rs1057517499, rs1057517468, rs61750412, rs1057517486, rs1057517529, rs1057517464, rs1057517478, rs267608176, rs1057517489, rs1057517490, rs1057517469, rs754983126, rs1057517497, rs1057517463, rs1057517520, rs61750406, rs1057517465, rs1057517488, rs1057517505, rs1057517522, rs149806989, rs1057517506, rs1057517479, rs1057517500, rs1057517487, rs1028247729, rs766020928, rs1057517501, rs267608188, rs61752107, rs62642859, rs144259891, rs61752113, rs1057519507, rs62641229, rs201179294, rs1064794320, rs1064793563, rs61752102, rs1258472160, rs62636524, rs760739894, rs781984979, rs781939614, rs1554366802, rs1554372756, rs61753230, rs1554127491, rs763459576, rs267608227, rs61750428, rs1556586479, rs1010184002, rs61753209, rs61752100, rs1190462422, rs1235008965, rs1438831421, rs1473858573, rs768893724, rs1553231820, rs1325771720, rs1553231739, rs1335685844, rs1553231896, rs867305222, rs1553232917, rs1553231787, rs1554127533, rs1554328952, rs61753248, rs267608242, rs1554127383, rs267608229, rs1554128501, rs1491384052, rs61753229, rs1443107232, rs766483138, rs1554127415, rs63749004, rs61753212, rs1554128461, rs1160117945, rs1554368097, rs767877383, rs1554370868, rs1554373787, rs762852144, rs1554376597, rs762679408, rs1554366766, rs1554367358, rs1256376226, rs1554369234, rs1478905473, rs1554372180, rs1554375511, rs61750409, rs1554372561, rs1554373578, rs1554367284, rs61750425, rs1398892633, rs61750407, rs1554373801, rs1554375599, rs1554375661, rs866144313, rs61752124, rs1554584505, rs749650201, rs1555549841, rs1199283977, rs1555549855, rs767447750, rs747099919, rs1238451790, rs754193088, rs888633730, rs904972651, rs764657253, rs61752108, rs61752106, rs61752105, rs1555549876, rs765404768, rs267608184, rs1555549754, rs1562846113, rs769772100, rs369851185, rs553968959, rs781475201, rs1561823098, rs866184460, rs1559035738, rs267608249, rs894289737, rs1562846257, rs778871894, rs752904598, rs1557910651, rs62653602, rs1561830903, rs1565673352, rs267608193, rs1557910202, rs61753225, rs61752140, rs61750417, rs1567730901, rs755716911, rs1562857198, rs1585260993, rs1554126955, rs201306028, rs1585231093, rs1585254187, rs63545361, rs1586069639, rs1586070043, rs1586070089, rs267608253, rs1582744649, rs1585224312, rs1581760572, rs61753211, rs201415996, rs1582757650, rs764924345, rs267608178, rs751829426, rs1585214453, rs1585238595, rs1585244586, rs1774099032, rs62641232, rs1178535907, rs1312351030, rs1792186595, rs756891007, rs1290469936, rs1641167602, rs773406384, rs1792018845, rs770447891	11839773, 25608554

Unknown
Disease name	Disease term	dbSNP ID	References
Dyslipidemias	Dyslipidemias		30585412