TNFRSF10A (TNF receptor superfamily member 10a)

Gene

• Entrez ID: 8797
• Gene name: TNF receptor superfamily member 10a
• Gene symbol: TNFRSF10A
• Synonyms: APO2, CD261, DR4, TRAILR-1, TRAILR1
• Chromosome: 8
• Chromosome location: 8p21.3
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001494	hsa-miR-155-5p	pSILAC	18668040
MIRT001494	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT031670	hsa-miR-16-5p	Proteomics	18668040
MIRT650780	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT650779	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT665121	hsa-miR-4297	HITS-CLIP	23824327
MIRT665120	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT650778	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT650777	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT650780	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT650779	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT650778	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT650777	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT561190	hsa-miR-3133	PAR-CLIP	20371350
MIRT561189	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT561188	hsa-miR-583	PAR-CLIP	20371350
MIRT561185	hsa-miR-5002-5p	PAR-CLIP	20371350
MIRT561183	hsa-miR-183-5p	PAR-CLIP	20371350
MIRT561182	hsa-miR-1262	PAR-CLIP	20371350
MIRT561181	hsa-miR-4701-3p	PAR-CLIP	20371350
MIRT561180	hsa-miR-6736-5p	PAR-CLIP	20371350
MIRT561179	hsa-miR-182-5p	PAR-CLIP	20371350
MIRT561178	hsa-miR-1271-5p	PAR-CLIP	20371350
MIRT561177	hsa-miR-96-5p	PAR-CLIP	20371350
MIRT561190	hsa-miR-3133	PAR-CLIP	20371350
MIRT561189	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT561188	hsa-miR-583	PAR-CLIP	20371350
MIRT561187	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT561186	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT561185	hsa-miR-5002-5p	PAR-CLIP	20371350
MIRT561184	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT561183	hsa-miR-183-5p	PAR-CLIP	20371350
MIRT561182	hsa-miR-1262	PAR-CLIP	20371350
MIRT561181	hsa-miR-4701-3p	PAR-CLIP	20371350
MIRT561180	hsa-miR-6736-5p	PAR-CLIP	20371350
MIRT561179	hsa-miR-182-5p	PAR-CLIP	20371350
MIRT561178	hsa-miR-1271-5p	PAR-CLIP	20371350
MIRT561177	hsa-miR-96-5p	PAR-CLIP	20371350
MIRT650780	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT650779	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT665121	hsa-miR-4297	HITS-CLIP	23824327
MIRT665120	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT650778	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT650777	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT650780	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT650779	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT650778	hsa-miR-4774-3p	HITS-CLIP	23824327
MIRT650777	hsa-miR-3152-5p	HITS-CLIP	23824327
MIRT561190	hsa-miR-3133	PAR-CLIP	20371350
MIRT561189	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT561188	hsa-miR-583	PAR-CLIP	20371350
MIRT561185	hsa-miR-5002-5p	PAR-CLIP	20371350
MIRT561183	hsa-miR-183-5p	PAR-CLIP	20371350
MIRT561182	hsa-miR-1262	PAR-CLIP	20371350
MIRT561181	hsa-miR-4701-3p	PAR-CLIP	20371350
MIRT561180	hsa-miR-6736-5p	PAR-CLIP	20371350
MIRT561179	hsa-miR-182-5p	PAR-CLIP	20371350
MIRT561178	hsa-miR-1271-5p	PAR-CLIP	20371350
MIRT561177	hsa-miR-96-5p	PAR-CLIP	20371350
MIRT561190	hsa-miR-3133	PAR-CLIP	20371350
MIRT561189	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT561188	hsa-miR-583	PAR-CLIP	20371350
MIRT561187	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT561186	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT561185	hsa-miR-5002-5p	PAR-CLIP	20371350
MIRT561184	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT561183	hsa-miR-183-5p	PAR-CLIP	20371350
MIRT561182	hsa-miR-1262	PAR-CLIP	20371350
MIRT561181	hsa-miR-4701-3p	PAR-CLIP	20371350
MIRT561180	hsa-miR-6736-5p	PAR-CLIP	20371350
MIRT561179	hsa-miR-182-5p	PAR-CLIP	20371350
MIRT561178	hsa-miR-1271-5p	PAR-CLIP	20371350
MIRT561177	hsa-miR-96-5p	PAR-CLIP	20371350
MIRT1442537	hsa-miR-106a	CLIP-seq
MIRT1442538	hsa-miR-106b	CLIP-seq
MIRT1442539	hsa-miR-1245	CLIP-seq
MIRT1442540	hsa-miR-150	CLIP-seq
MIRT1442541	hsa-miR-17	CLIP-seq
MIRT1442542	hsa-miR-20a	CLIP-seq
MIRT1442543	hsa-miR-20b	CLIP-seq
MIRT1442544	hsa-miR-302a	CLIP-seq
MIRT1442545	hsa-miR-302b	CLIP-seq
MIRT1442546	hsa-miR-302c	CLIP-seq
MIRT1442547	hsa-miR-302d	CLIP-seq
MIRT1442548	hsa-miR-302e	CLIP-seq
MIRT1442549	hsa-miR-3545-3p	CLIP-seq
MIRT1442550	hsa-miR-3663-5p	CLIP-seq
MIRT1442551	hsa-miR-372	CLIP-seq
MIRT1442552	hsa-miR-373	CLIP-seq
MIRT1442553	hsa-miR-4256	CLIP-seq
MIRT1442554	hsa-miR-4635	CLIP-seq
MIRT1442555	hsa-miR-4731-5p	CLIP-seq
MIRT1442556	hsa-miR-512-3p	CLIP-seq
MIRT1442557	hsa-miR-519d	CLIP-seq
MIRT1442558	hsa-miR-520a-3p	CLIP-seq
MIRT1442559	hsa-miR-520b	CLIP-seq
MIRT1442560	hsa-miR-520c-3p	CLIP-seq
MIRT1442561	hsa-miR-520d-3p	CLIP-seq
MIRT1442562	hsa-miR-520e	CLIP-seq
MIRT1442563	hsa-miR-520g	CLIP-seq
MIRT1442564	hsa-miR-520h	CLIP-seq
MIRT1442565	hsa-miR-640	CLIP-seq
MIRT1442566	hsa-miR-93	CLIP-seq
MIRT1442537	hsa-miR-106a	CLIP-seq
MIRT1442538	hsa-miR-106b	CLIP-seq
MIRT1442539	hsa-miR-1245	CLIP-seq
MIRT1442540	hsa-miR-150	CLIP-seq
MIRT1442541	hsa-miR-17	CLIP-seq
MIRT1442542	hsa-miR-20a	CLIP-seq
MIRT1442543	hsa-miR-20b	CLIP-seq
MIRT1442544	hsa-miR-302a	CLIP-seq
MIRT1442545	hsa-miR-302b	CLIP-seq
MIRT1442546	hsa-miR-302c	CLIP-seq
MIRT1442547	hsa-miR-302d	CLIP-seq
MIRT1442548	hsa-miR-302e	CLIP-seq
MIRT1442549	hsa-miR-3545-3p	CLIP-seq
MIRT1442551	hsa-miR-372	CLIP-seq
MIRT1442552	hsa-miR-373	CLIP-seq
MIRT1442553	hsa-miR-4256	CLIP-seq
MIRT2132487	hsa-miR-4438	CLIP-seq
MIRT1442554	hsa-miR-4635	CLIP-seq
MIRT2132488	hsa-miR-5095	CLIP-seq
MIRT1442556	hsa-miR-512-3p	CLIP-seq
MIRT1442557	hsa-miR-519d	CLIP-seq
MIRT1442558	hsa-miR-520a-3p	CLIP-seq
MIRT1442559	hsa-miR-520b	CLIP-seq
MIRT1442560	hsa-miR-520c-3p	CLIP-seq
MIRT1442561	hsa-miR-520d-3p	CLIP-seq
MIRT1442562	hsa-miR-520e	CLIP-seq
MIRT1442563	hsa-miR-520g	CLIP-seq
MIRT1442564	hsa-miR-520h	CLIP-seq
MIRT1442565	hsa-miR-640	CLIP-seq
MIRT1442566	hsa-miR-93	CLIP-seq
MIRT1442537	hsa-miR-106a	CLIP-seq
MIRT1442538	hsa-miR-106b	CLIP-seq
MIRT1442539	hsa-miR-1245	CLIP-seq
MIRT1442540	hsa-miR-150	CLIP-seq
MIRT1442541	hsa-miR-17	CLIP-seq
MIRT1442542	hsa-miR-20a	CLIP-seq
MIRT1442543	hsa-miR-20b	CLIP-seq
MIRT1442544	hsa-miR-302a	CLIP-seq
MIRT1442545	hsa-miR-302b	CLIP-seq
MIRT1442546	hsa-miR-302c	CLIP-seq
MIRT1442547	hsa-miR-302d	CLIP-seq
MIRT1442548	hsa-miR-302e	CLIP-seq
MIRT1442551	hsa-miR-372	CLIP-seq
MIRT1442552	hsa-miR-373	CLIP-seq
MIRT2132487	hsa-miR-4438	CLIP-seq
MIRT1442555	hsa-miR-4731-5p	CLIP-seq
MIRT2132488	hsa-miR-5095	CLIP-seq
MIRT1442556	hsa-miR-512-3p	CLIP-seq
MIRT1442557	hsa-miR-519d	CLIP-seq
MIRT1442558	hsa-miR-520a-3p	CLIP-seq
MIRT1442559	hsa-miR-520b	CLIP-seq
MIRT1442560	hsa-miR-520c-3p	CLIP-seq
MIRT1442561	hsa-miR-520d-3p	CLIP-seq
MIRT1442562	hsa-miR-520e	CLIP-seq
MIRT1442563	hsa-miR-520g	CLIP-seq
MIRT1442564	hsa-miR-520h	CLIP-seq
MIRT1442565	hsa-miR-640	CLIP-seq
MIRT1442566	hsa-miR-93	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HDAC1	Unknown	18408217
JUN	Unknown	12082627
NFKB1	Unknown	21243522
RELA	Unknown	21243522
TP53	Activation	11313989

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002020	Function	Protease binding	IPI	21785459
GO:0005035	Function	Death receptor activity	TAS	9082980
GO:0005515	Function	Protein binding	IPI	17047155, 18165900, 18846110, 19427028, 20103630, 21785459, 30833792
GO:0005794	Component	Golgi apparatus	IDA	22240897
GO:0005829	Component	Cytosol	IDA	22240897
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	22240897
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	NAS	9311998
GO:0006919	Process	Activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS
GO:0007165	Process	Signal transduction	TAS	9082980
GO:0007166	Process	Cell surface receptor signaling pathway	TAS
GO:0007250	Process	Activation of NF-kappaB-inducing kinase activity	NAS	9430227, 11464292
GO:0008134	Function	Transcription factor binding	IPI	18165900
GO:0008625	Process	Extrinsic apoptotic signaling pathway via death domain receptors	NAS	9311998
GO:0009986	Component	Cell surface	IBA	21873635
GO:0009986	Component	Cell surface	IDA	22952982
GO:0016021	Component	Integral component of membrane	IEA
GO:0036462	Process	TRAIL-activated apoptotic signaling pathway	IBA	21873635
GO:0036462	Process	TRAIL-activated apoptotic signaling pathway	IDA	21785459
GO:0036462	Process	TRAIL-activated apoptotic signaling pathway	IMP	19090789
GO:0038023	Function	Signaling receptor activity	NAS	9311998
GO:0042802	Function	Identical protein binding	IDA	19090789
GO:0042981	Process	Regulation of apoptotic process	TAS
GO:0043065	Process	Positive regulation of apoptotic process	IBA	21873635
GO:0045121	Component	Membrane raft	IDA	19090789
GO:0045569	Function	TRAIL binding	NAS	9373179
GO:0050900	Process	Leukocyte migration	TAS
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IDA	21785459
GO:1902041	Process	Regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS
GO:1902042	Process	Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	TAS

Other IDs

• MIM: 603611
• HGNC: 11904
• e!Ensembl: ENSG00000104689

Protein

• UniProt ID: O00220
• Protein name: Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)
• Protein function: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic acti
• PDB: 5CIR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00020	TNFR_c6	148 → 188	TNFR/NGFR cysteine-rich region	Domain
  PF00020	TNFR_c6	190 → 229	TNFR/NGFR cysteine-rich region	Domain
  PF00531	Death	367 → 448	Death domain	Domain

• Sequence:

  MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMG
  QHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGT
  QQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPC
  TTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNI
  WVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEIL
  SNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADP
  TETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTG
  RNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE

• Sequence length: 468

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
p53 signaling pathway
Apoptosis
Necroptosis
Natural killer cell mediated cytotoxicity
Pathogenic Escherichia coli infection
Salmonella infection
Influenza A
Lipid and atherosclerosis

Reactome:

Caspase activation via Death Receptors in the presence of ligand
Cell surface interactions at the vascular wall
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TP53 Regulates Transcription of Death Receptors and Ligands
Dimerization of procaspase-8
TRAIL signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Adenocarcinoma	Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular	rs121913530, rs886039394, rs121913474	21472143
Anemia	Anemia	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505	19652058
Carcinoma	Carcinoma, Cribriform, Carcinoma, Granular Cell	rs121912654, rs555607708, rs786202962, rs1564055259	21472143
Colonic neoplasms	Malignant tumor of colon, Colonic Neoplasms	rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483	17075118
Esophagus neoplasm	Esophageal Neoplasms, Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21472143
Age-related macular degeneration	Age related macular degeneration	rs2133900556, rs199474657, rs2274700, rs1410996, rs61750120, rs1800728, rs62654397, rs61749423, rs61751412, rs61749439, rs61751398, rs61752417, rs62645946, rs1801269, rs62646860, rs61750142, rs61750145, rs61750152, rs61751377, rs61753029, rs61751407, rs61751389, rs61750645, rs61750648, rs879255520, rs752147871, rs886044750, rs886044749, rs746541266, rs756840095, rs886044725, rs749526785, rs1057518955, rs1057518767, rs371489809, rs1064793014, rs1571264574, rs1659524475	21909106
Neutropenia	Neutropenia	rs879253882	19652058
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17199135

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia		19652058
Alopecia, male pattern	Alopecia, Male Pattern		19652058
Androgenetic alopecia	Androgenetic Alopecia		19652058
Anorexia	Anorexia		19652058
Benign neoplasm	Benign Neoplasm		19652058
Malignant neoplasm	Malignant Neoplasms		19652058
Neoplasms	Neoplasms		19652058
Nervous system diseases	Peripheral Nervous System Diseases		19652058
Prostatic neoplasms	Prostatic Neoplasms		17199135
Pseudopelade	Pseudopelade		19652058