PABPC4 (poly(A) binding protein cytoplasmic 4)

Gene

• Entrez ID: 8761
• Gene name: Poly(A) binding protein cytoplasmic 4
• Gene symbol: PABPC4
• Synonyms: APP-1, APP1, PABP4, iPABP
• Chromosome: 1
• Chromosome location: 1p34.3
• Summary: Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 m

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022926	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT024565	hsa-miR-215-5p	Microarray	19074876
MIRT026691	hsa-miR-192-5p	Microarray	19074876
MIRT027746	hsa-miR-98-5p	Microarray	19088304
MIRT031882	hsa-miR-16-5p	Proteomics	18668040
MIRT031882	hsa-miR-16-5p	CLASH	23622248
MIRT046051	hsa-miR-125b-5p	CLASH	23622248
MIRT044975	hsa-miR-186-5p	CLASH	23622248
MIRT039627	hsa-miR-615-3p	CLASH	23622248
MIRT440057	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440057	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1209546	hsa-miR-1197	CLIP-seq
MIRT1209547	hsa-miR-1231	CLIP-seq
MIRT1209548	hsa-miR-1264	CLIP-seq
MIRT1209549	hsa-miR-1275	CLIP-seq
MIRT1209550	hsa-miR-1285	CLIP-seq
MIRT1209551	hsa-miR-1323	CLIP-seq
MIRT1209552	hsa-miR-141	CLIP-seq
MIRT1209553	hsa-miR-200a	CLIP-seq
MIRT1209554	hsa-miR-2054	CLIP-seq
MIRT1209555	hsa-miR-219-1-3p	CLIP-seq
MIRT1209556	hsa-miR-3119	CLIP-seq
MIRT1209557	hsa-miR-3120-5p	CLIP-seq
MIRT1209558	hsa-miR-3133	CLIP-seq
MIRT1209559	hsa-miR-3140-3p	CLIP-seq
MIRT1209560	hsa-miR-3148	CLIP-seq
MIRT1209561	hsa-miR-3187-5p	CLIP-seq
MIRT1209562	hsa-miR-3189-3p	CLIP-seq
MIRT1209563	hsa-miR-362-5p	CLIP-seq
MIRT1209564	hsa-miR-378g	CLIP-seq
MIRT1209565	hsa-miR-3936	CLIP-seq
MIRT1209566	hsa-miR-3977	CLIP-seq
MIRT1209567	hsa-miR-4314	CLIP-seq
MIRT1209568	hsa-miR-4452	CLIP-seq
MIRT1209569	hsa-miR-4476	CLIP-seq
MIRT1209570	hsa-miR-4486	CLIP-seq
MIRT1209571	hsa-miR-450b-5p	CLIP-seq
MIRT1209572	hsa-miR-4525	CLIP-seq
MIRT1209573	hsa-miR-4640-5p	CLIP-seq
MIRT1209574	hsa-miR-4665-5p	CLIP-seq
MIRT1209575	hsa-miR-4667-5p	CLIP-seq
MIRT1209576	hsa-miR-4668-5p	CLIP-seq
MIRT1209577	hsa-miR-4694-5p	CLIP-seq
MIRT1209578	hsa-miR-4700-5p	CLIP-seq
MIRT1209579	hsa-miR-4723-5p	CLIP-seq
MIRT1209580	hsa-miR-4726-5p	CLIP-seq
MIRT1209581	hsa-miR-500a	CLIP-seq
MIRT1209582	hsa-miR-500b	CLIP-seq
MIRT1209583	hsa-miR-513a-3p	CLIP-seq
MIRT1209584	hsa-miR-548c-3p	CLIP-seq
MIRT1209585	hsa-miR-548o	CLIP-seq
MIRT1209586	hsa-miR-571	CLIP-seq
MIRT1209587	hsa-miR-587	CLIP-seq
MIRT1209588	hsa-miR-612	CLIP-seq
MIRT1209589	hsa-miR-625	CLIP-seq
MIRT1209590	hsa-miR-637	CLIP-seq
MIRT1209591	hsa-miR-922	CLIP-seq
MIRT1209556	hsa-miR-3119	CLIP-seq
MIRT1209559	hsa-miR-3140-3p	CLIP-seq
MIRT1209565	hsa-miR-3936	CLIP-seq
MIRT1209587	hsa-miR-587	CLIP-seq
MIRT1209546	hsa-miR-1197	CLIP-seq
MIRT2288519	hsa-miR-1225-5p	CLIP-seq
MIRT1209548	hsa-miR-1264	CLIP-seq
MIRT2288520	hsa-miR-192	CLIP-seq
MIRT1209554	hsa-miR-2054	CLIP-seq
MIRT2288521	hsa-miR-215	CLIP-seq
MIRT1209555	hsa-miR-219-1-3p	CLIP-seq
MIRT1209556	hsa-miR-3119	CLIP-seq
MIRT1209559	hsa-miR-3140-3p	CLIP-seq
MIRT1209562	hsa-miR-3189-3p	CLIP-seq
MIRT1209563	hsa-miR-362-5p	CLIP-seq
MIRT1209565	hsa-miR-3936	CLIP-seq
MIRT1209566	hsa-miR-3977	CLIP-seq
MIRT2288522	hsa-miR-4432	CLIP-seq
MIRT1209568	hsa-miR-4452	CLIP-seq
MIRT1209569	hsa-miR-4476	CLIP-seq
MIRT1209577	hsa-miR-4694-5p	CLIP-seq
MIRT2288523	hsa-miR-499-3p	CLIP-seq
MIRT2288524	hsa-miR-499-5p	CLIP-seq
MIRT2288525	hsa-miR-499a-3p	CLIP-seq
MIRT1209581	hsa-miR-500a	CLIP-seq
MIRT1209582	hsa-miR-500b	CLIP-seq
MIRT1209583	hsa-miR-513a-3p	CLIP-seq
MIRT1209586	hsa-miR-571	CLIP-seq
MIRT1209587	hsa-miR-587	CLIP-seq
MIRT1209546	hsa-miR-1197	CLIP-seq
MIRT1209548	hsa-miR-1264	CLIP-seq
MIRT2288520	hsa-miR-192	CLIP-seq
MIRT1209554	hsa-miR-2054	CLIP-seq
MIRT2288521	hsa-miR-215	CLIP-seq
MIRT1209555	hsa-miR-219-1-3p	CLIP-seq
MIRT1209562	hsa-miR-3189-3p	CLIP-seq
MIRT1209563	hsa-miR-362-5p	CLIP-seq
MIRT2586590	hsa-miR-3662	CLIP-seq
MIRT1209565	hsa-miR-3936	CLIP-seq
MIRT1209568	hsa-miR-4452	CLIP-seq
MIRT1209569	hsa-miR-4476	CLIP-seq
MIRT1209571	hsa-miR-450b-5p	CLIP-seq
MIRT1209577	hsa-miR-4694-5p	CLIP-seq
MIRT2586591	hsa-miR-4698	CLIP-seq
MIRT1209581	hsa-miR-500a	CLIP-seq
MIRT1209582	hsa-miR-500b	CLIP-seq
MIRT1209583	hsa-miR-513a-3p	CLIP-seq
MIRT1209586	hsa-miR-571	CLIP-seq
MIRT1209587	hsa-miR-587	CLIP-seq
MIRT1209546	hsa-miR-1197	CLIP-seq
MIRT1209548	hsa-miR-1264	CLIP-seq
MIRT2288520	hsa-miR-192	CLIP-seq
MIRT1209554	hsa-miR-2054	CLIP-seq
MIRT2288521	hsa-miR-215	CLIP-seq
MIRT1209555	hsa-miR-219-1-3p	CLIP-seq
MIRT1209562	hsa-miR-3189-3p	CLIP-seq
MIRT1209563	hsa-miR-362-5p	CLIP-seq
MIRT2586590	hsa-miR-3662	CLIP-seq
MIRT1209569	hsa-miR-4476	CLIP-seq
MIRT1209571	hsa-miR-450b-5p	CLIP-seq
MIRT1209577	hsa-miR-4694-5p	CLIP-seq
MIRT2586591	hsa-miR-4698	CLIP-seq
MIRT1209581	hsa-miR-500a	CLIP-seq
MIRT1209582	hsa-miR-500b	CLIP-seq
MIRT1209583	hsa-miR-513a-3p	CLIP-seq
MIRT1209586	hsa-miR-571	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003730	Function	MRNA 3'-UTR binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	11369516, 27871484
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	21940797
GO:0005737	Component	Cytoplasm	IDA	8524242, 21940797
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0006396	Process	RNA processing	TAS	8524242
GO:0006401	Process	RNA catabolic process	TAS	8524242
GO:0006412	Process	Translation	TAS	8524242
GO:0007596	Process	Blood coagulation	TAS	9030741
GO:0008143	Function	Poly(A) binding	IBA	21873635
GO:0008143	Function	Poly(A) binding	IDA	8524242
GO:0008266	Function	Poly(U) RNA binding	IBA	21873635
GO:0008266	Function	Poly(U) RNA binding	IDA	8524242
GO:0010494	Component	Cytoplasmic stress granule	IBA	21873635
GO:0010494	Component	Cytoplasmic stress granule	IDA	21940797
GO:0017130	Function	Poly(C) RNA binding	IDA	8524242
GO:0043488	Process	Regulation of mRNA stability	IEA
GO:0061515	Process	Myeloid cell development	IEA
GO:1990904	Component	Ribonucleoprotein complex	IBA	21873635
GO:1990904	Component	Ribonucleoprotein complex	IDA	17289661

Other IDs

• MIM: 603407
• HGNC: 8557
• e!Ensembl: ENSG00000090621

Protein

• UniProt ID: Q13310
• Protein name: Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
• Protein function: Binds the poly(A) tail of mRNA (PubMed:8524242). Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation (PubMed:37009826). May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytopla
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	13 → 83	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	101 → 168	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	193 → 261	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00076	RRM_1	296 → 364	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF00658	PABP	556 → 623	Poly-adenylate binding protein, unique domain	Family

• Sequence:

  MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQ
  QPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFS
  AFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKERE
  AELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEK
  HEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKN
  LDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGS
  KPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRP
  PYYTPNQLAQMRPNPRWQQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGSECPDRLAMDF
  GGAGAAQQGLTDSCQSGGVPTAVQNLAPRAAVAAAAPRAVAPYKYASSVRSPHPAIQPLQ
  APQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNS
  ELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAATS

• Sequence length: 644

Pathways

KEGG:

mRNA surveillance pathway
RNA degradation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	30595370, 29358691, 27189021
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	27602772