TNFSF14 (TNF superfamily member 14)

Gene

• Entrez ID: 8740
• Gene name: TNF superfamily member 14
• Gene symbol: TNFSF14
• Synonyms: CD258, HVEML, LIGHT, LTg
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry media

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT685905	hsa-miR-4438	HITS-CLIP	23313552
MIRT685904	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT685903	hsa-miR-5095	HITS-CLIP	23313552
MIRT685902	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT650331	hsa-miR-4705	HITS-CLIP	23824327
MIRT561166	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT561165	hsa-miR-4735-5p	PAR-CLIP	20371350
MIRT561163	hsa-miR-4775	PAR-CLIP	20371350
MIRT561164	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT561162	hsa-miR-3149	PAR-CLIP	20371350
MIRT561166	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT561165	hsa-miR-4735-5p	PAR-CLIP	20371350
MIRT561163	hsa-miR-4775	PAR-CLIP	20371350
MIRT561164	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT561162	hsa-miR-3149	PAR-CLIP	20371350
MIRT532290	hsa-miR-2114-5p	PAR-CLIP	22012620
MIRT532289	hsa-miR-3691-3p	PAR-CLIP	22012620
MIRT532288	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT532287	hsa-miR-361-3p	PAR-CLIP	22012620
MIRT532286	hsa-miR-4308	PAR-CLIP	22012620
MIRT532285	hsa-miR-4292	PAR-CLIP	22012620
MIRT532284	hsa-miR-6791-5p	PAR-CLIP	22012620
MIRT532283	hsa-miR-4670-3p	PAR-CLIP	22012620
MIRT532282	hsa-miR-4480	PAR-CLIP	22012620
MIRT532281	hsa-miR-6744-5p	PAR-CLIP	22012620
MIRT532280	hsa-miR-1255a	PAR-CLIP	22012620
MIRT532279	hsa-miR-1255b-5p	PAR-CLIP	22012620
MIRT532278	hsa-miR-3691-5p	PAR-CLIP	22012620
MIRT532277	hsa-miR-188-3p	PAR-CLIP	22012620
MIRT532276	hsa-miR-1260a	PAR-CLIP	22012620
MIRT532275	hsa-miR-1260b	PAR-CLIP	22012620
MIRT532274	hsa-miR-3156-3p	PAR-CLIP	22012620
MIRT532273	hsa-miR-4433b-5p	PAR-CLIP	22012620
MIRT461943	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461942	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT461941	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT461940	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT461939	hsa-miR-1307-3p	PAR-CLIP	23592263
MIRT461938	hsa-miR-4638-5p	PAR-CLIP	23592263
MIRT461937	hsa-miR-4695-3p	PAR-CLIP	23592263
MIRT461936	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT461935	hsa-miR-504-3p	PAR-CLIP	23592263
MIRT461934	hsa-miR-122-5p	PAR-CLIP	23592263
MIRT461933	hsa-miR-3650	PAR-CLIP	23592263
MIRT461932	hsa-miR-143-5p	PAR-CLIP	23592263
MIRT461931	hsa-miR-7977	PAR-CLIP	23592263
MIRT461930	hsa-miR-7641	PAR-CLIP	23592263
MIRT461929	hsa-miR-3198	PAR-CLIP	23592263
MIRT461928	hsa-miR-4309	PAR-CLIP	23592263
MIRT461927	hsa-miR-3689d	PAR-CLIP	23592263
MIRT461926	hsa-miR-5698	PAR-CLIP	23592263
MIRT685905	hsa-miR-4438	HITS-CLIP	23313552
MIRT685904	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT685903	hsa-miR-5095	HITS-CLIP	23313552
MIRT685902	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT650331	hsa-miR-4705	HITS-CLIP	23824327
MIRT561166	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT561165	hsa-miR-4735-5p	PAR-CLIP	20371350
MIRT561163	hsa-miR-4775	PAR-CLIP	20371350
MIRT561164	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT561162	hsa-miR-3149	PAR-CLIP	20371350
MIRT561166	hsa-miR-590-3p	PAR-CLIP	20371350
MIRT561165	hsa-miR-4735-5p	PAR-CLIP	20371350
MIRT561163	hsa-miR-4775	PAR-CLIP	20371350
MIRT561164	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT561162	hsa-miR-3149	PAR-CLIP	20371350
MIRT532290	hsa-miR-2114-5p	PAR-CLIP	22012620
MIRT532289	hsa-miR-3691-3p	PAR-CLIP	22012620
MIRT532288	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT532287	hsa-miR-361-3p	PAR-CLIP	22012620
MIRT532286	hsa-miR-4308	PAR-CLIP	22012620
MIRT532285	hsa-miR-4292	PAR-CLIP	22012620
MIRT532284	hsa-miR-6791-5p	PAR-CLIP	22012620
MIRT532283	hsa-miR-4670-3p	PAR-CLIP	22012620
MIRT532282	hsa-miR-4480	PAR-CLIP	22012620
MIRT532281	hsa-miR-6744-5p	PAR-CLIP	22012620
MIRT532280	hsa-miR-1255a	PAR-CLIP	22012620
MIRT532279	hsa-miR-1255b-5p	PAR-CLIP	22012620
MIRT532278	hsa-miR-3691-5p	PAR-CLIP	22012620
MIRT532277	hsa-miR-188-3p	PAR-CLIP	22012620
MIRT532276	hsa-miR-1260a	PAR-CLIP	22012620
MIRT532275	hsa-miR-1260b	PAR-CLIP	22012620
MIRT532274	hsa-miR-3156-3p	PAR-CLIP	22012620
MIRT532273	hsa-miR-4433b-5p	PAR-CLIP	22012620
MIRT461943	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT461942	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT461941	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT461940	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT461939	hsa-miR-1307-3p	PAR-CLIP	23592263
MIRT461938	hsa-miR-4638-5p	PAR-CLIP	23592263
MIRT461937	hsa-miR-4695-3p	PAR-CLIP	23592263
MIRT461936	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT461935	hsa-miR-504-3p	PAR-CLIP	23592263
MIRT461934	hsa-miR-122-5p	PAR-CLIP	23592263
MIRT461933	hsa-miR-3650	PAR-CLIP	23592263
MIRT461932	hsa-miR-143-5p	PAR-CLIP	23592263
MIRT461931	hsa-miR-7977	PAR-CLIP	23592263
MIRT461930	hsa-miR-7641	PAR-CLIP	23592263
MIRT461929	hsa-miR-3198	PAR-CLIP	23592263
MIRT461928	hsa-miR-4309	PAR-CLIP	23592263
MIRT461927	hsa-miR-3689d	PAR-CLIP	23592263
MIRT461926	hsa-miR-5698	PAR-CLIP	23592263
MIRT1443384	hsa-miR-1200	CLIP-seq
MIRT1443385	hsa-miR-1207-3p	CLIP-seq
MIRT1443386	hsa-miR-2053	CLIP-seq
MIRT1443387	hsa-miR-3074-3p	CLIP-seq
MIRT1443388	hsa-miR-3140-5p	CLIP-seq
MIRT1443389	hsa-miR-3157-5p	CLIP-seq
MIRT1443390	hsa-miR-323b-5p	CLIP-seq
MIRT1443391	hsa-miR-34a	CLIP-seq
MIRT1443392	hsa-miR-34c-5p	CLIP-seq
MIRT1443393	hsa-miR-4269	CLIP-seq
MIRT1443394	hsa-miR-4427	CLIP-seq
MIRT1443395	hsa-miR-4436a	CLIP-seq
MIRT1443396	hsa-miR-449a	CLIP-seq
MIRT1443397	hsa-miR-449b	CLIP-seq
MIRT1443398	hsa-miR-4514	CLIP-seq
MIRT1443399	hsa-miR-4691-3p	CLIP-seq
MIRT1443400	hsa-miR-4692	CLIP-seq
MIRT1443401	hsa-miR-4742-5p	CLIP-seq
MIRT2132689	hsa-miR-122	CLIP-seq
MIRT2132690	hsa-miR-1281	CLIP-seq
MIRT2132691	hsa-miR-1915	CLIP-seq
MIRT2132692	hsa-miR-3151	CLIP-seq
MIRT2132693	hsa-miR-342-5p	CLIP-seq
MIRT2132694	hsa-miR-378g	CLIP-seq
MIRT2132695	hsa-miR-4283	CLIP-seq
MIRT2132696	hsa-miR-433	CLIP-seq
MIRT2132697	hsa-miR-4437	CLIP-seq
MIRT2132698	hsa-miR-4489	CLIP-seq
MIRT2132699	hsa-miR-4492	CLIP-seq
MIRT2132700	hsa-miR-4498	CLIP-seq
MIRT2132701	hsa-miR-4503	CLIP-seq
MIRT2132702	hsa-miR-4505	CLIP-seq
MIRT2132703	hsa-miR-4532	CLIP-seq
MIRT2132704	hsa-miR-4651	CLIP-seq
MIRT2132705	hsa-miR-4664-5p	CLIP-seq
MIRT2132706	hsa-miR-4674	CLIP-seq
MIRT2132707	hsa-miR-548p	CLIP-seq
MIRT2132708	hsa-miR-608	CLIP-seq
MIRT2132709	hsa-miR-629	CLIP-seq
MIRT2132710	hsa-miR-762	CLIP-seq
MIRT2353730	hsa-miR-106a	CLIP-seq
MIRT2353731	hsa-miR-106b	CLIP-seq
MIRT2132689	hsa-miR-122	CLIP-seq
MIRT2353732	hsa-miR-125a-3p	CLIP-seq
MIRT2353733	hsa-miR-150	CLIP-seq
MIRT2353734	hsa-miR-17	CLIP-seq
MIRT2132691	hsa-miR-1915	CLIP-seq
MIRT2353735	hsa-miR-20a	CLIP-seq
MIRT2353736	hsa-miR-20b	CLIP-seq
MIRT2353737	hsa-miR-302a	CLIP-seq
MIRT2353738	hsa-miR-302b	CLIP-seq
MIRT2353739	hsa-miR-302c	CLIP-seq
MIRT2353740	hsa-miR-302d	CLIP-seq
MIRT2353741	hsa-miR-302e	CLIP-seq
MIRT2353742	hsa-miR-3663-5p	CLIP-seq
MIRT2353743	hsa-miR-372	CLIP-seq
MIRT2353744	hsa-miR-373	CLIP-seq
MIRT2353745	hsa-miR-3934	CLIP-seq
MIRT2353746	hsa-miR-4312	CLIP-seq
MIRT2353747	hsa-miR-4454	CLIP-seq
MIRT2353748	hsa-miR-4662a-5p	CLIP-seq
MIRT2353749	hsa-miR-4676-5p	CLIP-seq
MIRT2353750	hsa-miR-4755-3p	CLIP-seq
MIRT2353751	hsa-miR-4757-5p	CLIP-seq
MIRT2353752	hsa-miR-4763-5p	CLIP-seq
MIRT2353753	hsa-miR-512-3p	CLIP-seq
MIRT2353754	hsa-miR-519d	CLIP-seq
MIRT2353755	hsa-miR-520a-3p	CLIP-seq
MIRT2353756	hsa-miR-520b	CLIP-seq
MIRT2353757	hsa-miR-520c-3p	CLIP-seq
MIRT2353758	hsa-miR-520d-3p	CLIP-seq
MIRT2353759	hsa-miR-520e	CLIP-seq
MIRT2353760	hsa-miR-520g	CLIP-seq
MIRT2353761	hsa-miR-520h	CLIP-seq
MIRT2353762	hsa-miR-575	CLIP-seq
MIRT2353763	hsa-miR-764	CLIP-seq
MIRT2353764	hsa-miR-93	CLIP-seq
MIRT2462092	hsa-miR-1273f	CLIP-seq
MIRT2462093	hsa-miR-411	CLIP-seq
MIRT1443393	hsa-miR-4269	CLIP-seq
MIRT2462094	hsa-miR-940	CLIP-seq
MIRT2462092	hsa-miR-1273f	CLIP-seq
MIRT2462093	hsa-miR-411	CLIP-seq
MIRT2647870	hsa-miR-1179	CLIP-seq
MIRT2132689	hsa-miR-122	CLIP-seq
MIRT2132690	hsa-miR-1281	CLIP-seq
MIRT2647871	hsa-miR-1307	CLIP-seq
MIRT2647872	hsa-miR-18a	CLIP-seq
MIRT2647873	hsa-miR-18b	CLIP-seq
MIRT2132691	hsa-miR-1915	CLIP-seq
MIRT2647874	hsa-miR-2114	CLIP-seq
MIRT1443389	hsa-miR-3157-5p	CLIP-seq
MIRT2647875	hsa-miR-323-5p	CLIP-seq
MIRT2647876	hsa-miR-370	CLIP-seq
MIRT1443393	hsa-miR-4269	CLIP-seq
MIRT2132695	hsa-miR-4283	CLIP-seq
MIRT2647877	hsa-miR-4284	CLIP-seq
MIRT2132698	hsa-miR-4489	CLIP-seq
MIRT2132703	hsa-miR-4532	CLIP-seq
MIRT2647878	hsa-miR-4536	CLIP-seq
MIRT1443399	hsa-miR-4691-3p	CLIP-seq
MIRT2647879	hsa-miR-4731-5p	CLIP-seq
MIRT2647880	hsa-miR-4735-3p	CLIP-seq
MIRT2353752	hsa-miR-4763-5p	CLIP-seq
MIRT2647881	hsa-miR-4772-3p	CLIP-seq
MIRT2647882	hsa-miR-550a	CLIP-seq
MIRT2647883	hsa-miR-876-3p	CLIP-seq
MIRT2462094	hsa-miR-940	CLIP-seq
MIRT2647870	hsa-miR-1179	CLIP-seq
MIRT2462092	hsa-miR-1273f	CLIP-seq
MIRT1443389	hsa-miR-3157-5p	CLIP-seq
MIRT2647875	hsa-miR-323-5p	CLIP-seq
MIRT2462093	hsa-miR-411	CLIP-seq
MIRT1443393	hsa-miR-4269	CLIP-seq
MIRT2647878	hsa-miR-4536	CLIP-seq
MIRT1443399	hsa-miR-4691-3p	CLIP-seq
MIRT2647883	hsa-miR-876-3p	CLIP-seq
MIRT2462094	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ETS1	Activation	12215452
NFKB1	Unknown	21243522
RELA	Unknown	21243522
SP1	Activation	12215452

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IPI	12393901
GO:0005125	Function	Cytokine activity	IEA
GO:0005164	Function	Tumor necrosis factor receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	9462508, 10318773, 26977880, 27152329, 32296183
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	TAS	10799510
GO:0006955	Process	Immune response	IEA
GO:0007165	Process	Signal transduction	NAS	12393901
GO:0016021	Component	Integral component of membrane	IEA
GO:0031295	Process	T cell costimulation	IDA	10754304
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS
GO:0042098	Process	T cell proliferation	NAS	9765287
GO:0042110	Process	T cell activation	NAS	12393901
GO:0043027	Function	Cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA	12393901
GO:0043029	Process	T cell homeostasis	NAS	12393901
GO:0043154	Process	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445
GO:1901224	Process	Positive regulation of NIK/NF-kappaB signaling	IDA	12393901

Other IDs

• MIM: 604520
• HGNC: 11930
• e!Ensembl: ENSG00000125735

Protein

• UniProt ID: O43557
• Protein name: Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor
• Protein function: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:10754304, PubMed:9462508). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, le
• PDB: 4EN0, 4J6G, 4KG8, 4KGG, 4KGQ, 4RSU, 7MSG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00229	TNF	112 → 240	TNF(Tumour Necrosis Factor) family	Domain

• Sequence:

  MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARVGLGLLLLLMGAGLAVQGWFLLQ
  LHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTGANSSLTGSGGPLLWETQLGL
  AFLRGLSYHDGALVVTKAGYYYIYSKVQLGGVGCPLGLASTITHGLYKRTPRYPEELELL
  VSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV
  

• Sequence length: 240

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
NF-kappa B signaling pathway
Herpes simplex virus 1 infection

Reactome:

TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Multiple sclerosis	Multiple Sclerosis, Multiple Sclerosis, Acute Fulminating	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	24076602, 21833088, 24076602
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	20008919