CBR1 (carbonyl reductase 1)

Gene

• Entrez ID: 873
• Gene name: Carbonyl reductase 1
• Gene symbol: CBR1
• Synonyms: CBR, PG-9-KR, SDR21C1, hCBR1
• Chromosome: 21
• Chromosome location: 21q22.12
• Summary: The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049536	hsa-miR-92a-3p	CLASH	23622248
MIRT045152	hsa-miR-186-5p	CLASH	23622248
MIRT042005	hsa-miR-484	CLASH	23622248
MIRT038897	hsa-miR-93-3p	CLASH	23622248
MIRT526062	hsa-miR-323a-3p	PAR-CLIP	22012620
MIRT526061	hsa-miR-5694	PAR-CLIP	22012620
MIRT526060	hsa-miR-3174	PAR-CLIP	22012620
MIRT526059	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT526058	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT526057	hsa-miR-1909-5p	PAR-CLIP	22012620
MIRT526056	hsa-miR-3606-5p	PAR-CLIP	22012620
MIRT526055	hsa-miR-921	PAR-CLIP	22012620
MIRT526054	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT526053	hsa-miR-3161	PAR-CLIP	22012620
MIRT526052	hsa-miR-599	PAR-CLIP	22012620
MIRT526062	hsa-miR-323a-3p	PAR-CLIP	22012620
MIRT526061	hsa-miR-5694	PAR-CLIP	22012620
MIRT526060	hsa-miR-3174	PAR-CLIP	22012620
MIRT526059	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT526058	hsa-miR-153-5p	PAR-CLIP	22012620
MIRT526057	hsa-miR-1909-5p	PAR-CLIP	22012620
MIRT526056	hsa-miR-3606-5p	PAR-CLIP	22012620
MIRT526055	hsa-miR-921	PAR-CLIP	22012620
MIRT526054	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT526053	hsa-miR-3161	PAR-CLIP	22012620
MIRT526052	hsa-miR-599	PAR-CLIP	22012620
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT1956746	hsa-miR-3660	CLIP-seq
MIRT1956747	hsa-miR-4257	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT1956748	hsa-miR-4526	CLIP-seq
MIRT1956749	hsa-miR-4711-5p	CLIP-seq
MIRT2194021	hsa-miR-3145-3p	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT2194022	hsa-miR-3606	CLIP-seq
MIRT2194023	hsa-miR-365	CLIP-seq
MIRT2194024	hsa-miR-425	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT2497391	hsa-miR-1193	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT2194021	hsa-miR-3145-3p	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT2194022	hsa-miR-3606	CLIP-seq
MIRT2497392	hsa-miR-3619-3p	CLIP-seq
MIRT2194023	hsa-miR-365	CLIP-seq
MIRT2497393	hsa-miR-3664-3p	CLIP-seq
MIRT2497394	hsa-miR-3675-5p	CLIP-seq
MIRT2497395	hsa-miR-410	CLIP-seq
MIRT2194024	hsa-miR-425	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT2497396	hsa-miR-4436a	CLIP-seq
MIRT2497397	hsa-miR-4520b-3p	CLIP-seq
MIRT2497398	hsa-miR-4529-3p	CLIP-seq
MIRT2497399	hsa-miR-4534	CLIP-seq
MIRT2497400	hsa-miR-4535	CLIP-seq
MIRT2497401	hsa-miR-4633-3p	CLIP-seq
MIRT2497402	hsa-miR-4641	CLIP-seq
MIRT2497403	hsa-miR-4677-3p	CLIP-seq
MIRT2497404	hsa-miR-4698	CLIP-seq
MIRT2497405	hsa-miR-4776-5p	CLIP-seq
MIRT2497406	hsa-miR-490-5p	CLIP-seq
MIRT2497407	hsa-miR-510	CLIP-seq
MIRT2497408	hsa-miR-624	CLIP-seq
MIRT2497409	hsa-miR-938	CLIP-seq
MIRT865731	hsa-miR-1178	CLIP-seq
MIRT2497391	hsa-miR-1193	CLIP-seq
MIRT2677471	hsa-miR-1225-3p	CLIP-seq
MIRT2677472	hsa-miR-1233	CLIP-seq
MIRT865732	hsa-miR-1244	CLIP-seq
MIRT865733	hsa-miR-1277	CLIP-seq
MIRT2194021	hsa-miR-3145-3p	CLIP-seq
MIRT865734	hsa-miR-323-3p	CLIP-seq
MIRT2194022	hsa-miR-3606	CLIP-seq
MIRT2497392	hsa-miR-3619-3p	CLIP-seq
MIRT2194023	hsa-miR-365	CLIP-seq
MIRT2497393	hsa-miR-3664-3p	CLIP-seq
MIRT2497394	hsa-miR-3675-5p	CLIP-seq
MIRT2497395	hsa-miR-410	CLIP-seq
MIRT2194024	hsa-miR-425	CLIP-seq
MIRT865735	hsa-miR-4275	CLIP-seq
MIRT2497396	hsa-miR-4436a	CLIP-seq
MIRT2497397	hsa-miR-4520b-3p	CLIP-seq
MIRT2497398	hsa-miR-4529-3p	CLIP-seq
MIRT2497399	hsa-miR-4534	CLIP-seq
MIRT2497400	hsa-miR-4535	CLIP-seq
MIRT2497401	hsa-miR-4633-3p	CLIP-seq
MIRT2497402	hsa-miR-4641	CLIP-seq
MIRT2497403	hsa-miR-4677-3p	CLIP-seq
MIRT2497404	hsa-miR-4698	CLIP-seq
MIRT2497405	hsa-miR-4776-5p	CLIP-seq
MIRT2497406	hsa-miR-490-5p	CLIP-seq
MIRT2497407	hsa-miR-510	CLIP-seq
MIRT2497408	hsa-miR-624	CLIP-seq
MIRT2497409	hsa-miR-938	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IBA	21873635
GO:0004090	Function	Carbonyl reductase (NADPH) activity	IDA	18449627
GO:0005829	Component	Cytosol	TAS
GO:0016655	Function	Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	19442656
GO:0017144	Process	Drug metabolic process	IDA	18449627
GO:0019371	Process	Cyclooxygenase pathway	TAS
GO:0030855	Process	Epithelial cell differentiation	IEP	21492153
GO:0042373	Process	Vitamin K metabolic process	IDA	18449627
GO:0047020	Function	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	IEA
GO:0047021	Function	15-hydroxyprostaglandin dehydrogenase (NADP+) activity	ISS
GO:0050221	Function	Prostaglandin-E2 9-reductase activity	ISS
GO:0050221	Function	Prostaglandin-E2 9-reductase activity	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:1903561	Component	Extracellular vesicle	HDA	24769233

Other IDs

• MIM: 114830
• HGNC: 1548
• e!Ensembl: ENSG00000159228

Protein

• UniProt ID: P16152
• Protein name: Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (
• Protein function: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthrac
• PDB: 1WMA, 2PFG, 3BHI, 3BHJ, 3BHM, 4Z3D
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00106	adh_short	6 → 152	short chain dehydrogenase	Domain

• Sequence:

  MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
  QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
  VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
  KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
  TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW

• Sequence length: 277

Pathways

KEGG:

Arachidonic acid metabolism
Folate biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - reactive oxygen species

Reactome:

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Cardiomyopathy	Cardiomyopathies, Primary, Cardiomyopathies	rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377, rs2856655, rs587776700, rs397514444, rs387906397, rs137854607, rs28935197, rs199473684, rs121964858, rs74315379, rs74315380, rs104894724, rs104894727, rs104894728, rs104894729, rs104894730, rs121917760, rs267607125, rs104894503, rs267607155, rs267607156, rs121918597, rs121918600, rs28933979, rs121918070, rs76992529, rs111033559, rs111033560, rs104894368, rs104894369, rs104894370, rs121913624, rs3218713, rs121913625, rs121913626, rs121913627, rs121913628, rs121913629, rs121913630, rs121913631, rs121913632, rs3218714, rs121913637, rs121913638, rs121913641, rs121913642, rs121913651, rs267606911, rs267606908, rs730880850, rs61046466, rs57520892, rs28933091, rs28933092, rs28933093, rs121913008, rs121913003, rs121912996, rs121912997, rs193922680, rs387906875, rs199474703, rs199476315, rs199476316, rs199476317, rs199476321, rs199476311, rs193922683, rs193922668, rs386134243, rs267607578, rs36211723, rs193922390, rs193922672, rs193922697, rs387907267, rs45546039, rs387907218, rs397515870, rs397515893, rs397515894, rs397515903, rs397515905, rs375882485, rs397515907, rs397515912, rs397515916, rs397515925, rs397515926, rs397515934, rs397515937, rs397515943, rs397515944, rs397515947, rs397515954, rs112738974, rs111729952, rs397515960, rs397515963, rs397515973, rs397515974, rs397515977, rs376395543, rs397515979, rs397515982, rs397515990, rs397515991, rs397515992, rs397516005, rs113358486, rs397516006, rs397516007, rs397516008, rs373746463, rs397516019, rs397516023, rs397516029, rs397516031, rs397516037, rs397516040, rs397516042, rs397516044, rs397516049, rs397516057, rs397516059, rs397516068, rs397516070, rs397516072, rs397516073, rs397516074, rs397516076, rs397516077, rs397516080, rs397516082, rs397516083, rs397516088, rs397516089, rs397516103, rs397516123, rs397516127, rs371898076, rs397516132, rs397516142, rs3218716, rs397516154, rs397516161, rs397516165, rs397516170, rs397516178, rs397516179, rs397516187, rs397516201, rs397516202, rs145213771, rs397516207, rs397516209, rs397516212, rs397516248, rs397516252, rs397516254, rs397516258, rs397516260, rs45516091, rs397516264, rs397516269, rs397516347, rs397516349, rs397516352, rs397516353, rs397516355, rs397516356, rs397516357, rs397516364, rs397516370, rs397516371, rs397516373, rs397516386, rs397516406, rs397516454, rs397516456, rs397516461, rs397516463, rs397516464, rs45525839, rs397516471, rs45578238, rs111377893, rs397516607, rs62636495, rs397516784, rs397516881, rs397516913, rs397516915, rs397516927, rs397516940, rs397516943, rs397516945, rs397516955, rs397516956, rs397516973, rs397516986, rs397516989, rs372827156, rs397516992, rs397516993, rs397516994, rs397516997, rs397517003, rs397517008, rs397517010, rs397517012, rs397517021, rs397517065, rs397517547, rs397517576, rs397517580, rs397517584, rs397517586, rs397517587, rs397517589, rs397517601, rs397517620, rs397517624, rs397517626, rs397517628, rs72646831, rs397517633, rs397517643, rs72646846, rs397517664, rs397517679, rs397517689, rs397517695, rs397517696, rs397517698, rs397517721, rs397517735, rs397517741, rs397517749, rs397517750, rs397517758, rs397517776, rs397517787, rs397517830, rs397517887, rs397517888, rs397517889, rs58013325, rs397517895, rs56984562, rs267607646, rs58917027, rs267607594, rs397517904, rs61195471, rs60682848, rs267607573, rs397517908, rs58978449, rs397517909, rs267607593, rs397517911, rs56816490, rs397517915, rs267607554, rs397514742, rs886041395, rs397515482, rs267607490, rs58999456, rs267607555, rs61672878, rs267607618, rs267607577, rs57730570, rs267607582, rs267607581, rs61444459, rs59270054, rs61661343, rs267607570, rs59026483, rs267607571, rs59332535, rs199473161, rs398123262, rs869320740, rs606231324, rs587782927, rs201754030, rs58389804, rs587782958, rs587782961, rs587782962, rs587782986, rs138049878, rs376897125, rs368765949, rs111569862, rs727504247, rs727503537, rs727504535, rs727504550, rs727504679, rs727503546, rs730880365, rs727504646, rs727505014, rs727505288, rs727503557, rs727503559, rs730880343, rs727503615, rs727504825, rs727503565, rs727504655, rs727505352, rs727504466, rs727504531, rs727503567, rs371678190, rs727503586, rs727505319, rs727503547, rs727505076, rs727505224, rs727503552, rs727504856, rs727504782, rs727504660, rs557312035, rs727505284, rs727504851, rs727504589, rs727504499, rs727504843, rs727504452, rs727503697, rs150974575, rs727504498, rs727503598, rs727503602, rs727503607, rs727504801, rs727504738, rs727505115, rs727505283, rs727505109, rs727504271, rs727504321, rs727504289, rs727503172, rs727503180, rs727503182, rs727504265, rs727504334, rs727503192, rs397515932, rs727504287, rs200411226, rs727503204, rs727504269, rs367947846, rs730880335, rs727502897, rs727503166, rs111683277, rs727503195, rs727503203, rs727503212, rs727503738, rs727504381, rs727504356, rs727503261, rs727504238, rs148808089, rs45544633, rs727503246, rs397516171, rs727503253, rs202141173, rs727504310, rs727503258, rs727503260, rs727504320, rs727504240, rs727503263, rs727503269, rs727503278, rs727504432, rs727504243, rs727504285, rs727503499, rs727503504, rs727504242, rs727504379, rs727504389, rs727504275, rs727504557, rs727502994, rs727504184, rs730880336, rs730880362, rs730880199, rs730880246, rs72648265, rs730880243, rs730880242, rs730880241, rs574660186, rs730880245, rs730880082, rs730880092, rs730880093, rs730880055, rs397515939, rs730881119, rs397516020, rs730880675, rs730880719, rs730880672, rs730880671, rs730880718, rs730880666, rs730880717, rs730880655, rs730880715, rs730880654, rs730880714, rs730880651, rs730880648, rs730880713, rs730880546, rs730880695, rs730880533, rs730880531, rs730880639, rs730880689, rs730880686, rs730880629, rs368121566, rs375607980, rs730880704, rs730880698, rs730880750, rs730880748, rs730880875, rs730880845, rs1565623093, rs786204339, rs786204336, rs786204392, rs786204388, rs786204950, rs786204951, rs794727381, rs760576804, rs112188483, rs794728597, rs794728606, rs794728593, rs59564495, rs190140598, rs794728826, rs794728803, rs794728106, rs149701627, rs1554108152, rs770873593, rs794728124, rs141026028, rs794728094, rs794729098, rs794729116, rs764817683, rs751288871, rs201405287, rs794729137, rs794729133, rs766209297, rs767987619, rs769220833, rs794729120, rs112240298, rs748382770, rs794729365, rs794729301, rs757451467, rs794729359, rs794729354, rs794729353, rs794729285, rs794729284, rs794729338, rs794729332, rs368452607, rs794729278, rs794729325, rs794729324, rs754866489, rs794729265, rs751502842, rs794729320, rs794729380, rs748313513, rs797046064, rs863225113, rs863225106, rs761507504, rs864622224, rs1057515421, rs751039219, rs869025555, rs869025546, rs869025554, rs869025559, rs869025545, rs869025558, rs869025557, rs200797552, rs869025550, rs869025549, rs869025544, rs869025552, rs869025548, rs869025556, rs770029258, rs869025523, rs869025398, rs869025399, rs869025395, rs869025365, rs869025469, rs869025483, rs749838192, rs869312028, rs869312037, rs869312038, rs869312039, rs869312040, rs869312041, rs869312042, rs869312044, rs869312046, rs373040154, rs869312047, rs869312048, rs869312049, rs869312050, rs869312051, rs869312052, rs869312054, rs869312055, rs777602537, rs869312056, rs869312057, rs869312058, rs869312059, rs869312060, rs770038577, rs869312061, rs869312062, rs869312063, rs869312064, rs869312065, rs869312066, rs869312067, rs869312068, rs869312069, rs771562210, rs869312070, rs869312071, rs759231562, rs869312072, rs869312073, rs764243269, rs768345594, rs869312074, rs869312075, rs869312076, rs869312077, rs869312078, rs869312079, rs869312080, rs772121356, rs869312081, rs869312082, rs72648250, rs869312083, rs869312084, rs869312085, rs869312086, rs869312087, rs869312100, rs779129892, rs756367933, rs869312102, rs869312103, rs869312104, rs869312105, rs869312106, rs770767998, rs869312107, rs775186117, rs869312108, rs869312109, rs869312110, rs869312111, rs755261062, rs869312112, rs763824247, rs869312113, rs869312114, rs869312115, rs869312116, rs774604740, rs869312117, rs779996703, rs869312118, rs869312119, rs869312120, rs869312121, rs869312122, rs869312045, rs753948675, rs878854371, rs794728589, rs876657650, rs727503512, rs876658027, rs876657672, rs876657671, rs868494032, rs876657670, rs780512337, rs876657669, rs876657668, rs876657666, rs876657665, rs876657664, rs876657663, rs148894066, rs876657634, rs869248137, rs876657705, rs876657704, rs727503213, rs869025496, rs876657662, rs876657884, rs36211715, rs878855234, rs879255521, rs879255639, rs886038928, rs751746401, rs886039030, rs869038795, rs886039343, rs2069544, rs1114167341, rs1114167340, rs886041322, rs886042331, rs886043718, rs747662439, rs886043924, rs773840992, rs886044536, rs1057517903, rs754354190, rs779650200, rs902082118, rs1057518920, rs1057519457, rs1057523045, rs370072439, rs1064792916, rs1060500495, rs1060500575, rs926741242, rs774763657, rs746877365, rs1060500610, rs1060501484, rs1060501479, rs1064792928, rs1060501443, rs1060499604, rs1064793814, rs1064796347, rs977277400, rs1064793429, rs745811346, rs1064794350, rs1555142963, rs1064793983, rs769665204, rs751261054, rs769139957, rs1131691873, rs1131691655, rs1131691673, rs1464253797, rs1408345511, rs1553603152, rs1554398705, rs1322596650, rs1553539995, rs1553611989, rs749961489, rs1444727212, rs1243301263, rs971618751, rs1553662326, rs1389777522, rs764985774, rs1554108287, rs1554105911, rs1249913357, rs1554108012, rs111806457, rs1402879259, rs748416758, rs794727046, rs1425855043, rs869178171, rs1432810664, rs749465164, rs878898365, rs1419374180, rs770878165, rs1553503113, rs1553691320, rs1553577362, rs1553603456, rs1417036453, rs1553741321, rs1553479603, rs1553607425, rs974671846, rs1420159591, rs745688425, rs1554875409, rs1555144459, rs1555338080, rs1555338574, rs1555148035, rs200889953, rs1401116572, rs1285329277, rs974510652, rs1263987728, rs1555122928, rs992189342, rs1555142971, rs1553261855, rs1553265647, rs1553488049, rs1553644307, rs1553663867, rs1553940122, rs28763965, rs758891557, rs762110595, rs1555436118, rs1555435531, rs565910322, rs376766195, rs1562168768, rs763443331, rs1562169661, rs1370579526, rs1561703922, rs1564773559, rs1559003939, rs1559598775, rs1559415567, rs1559877046, rs776970935, rs553526525, rs1561698362, rs1561694696, rs1561702640, rs730880751, rs1060505018, rs766330686, rs1565631430, rs1565050320, rs876657767, rs1565053085, rs1565053147, rs1557778277, rs1557776329, rs886039136, rs771262904, rs727504314, rs1563000044, rs541612157, rs766265889, rs1558988204, rs1559051231, rs1559262463, rs1559448864, rs1559469421, rs1559556267, rs1559746821, rs1559873786, rs1561323791, rs1561445221, rs1561686893, rs1561698714, rs1561702549, rs1565623439, rs1565623713, rs1565626367, rs1565627110, rs1565627145, rs397515889, rs1565628520, rs774316050, rs1592798444, rs1565590309, rs1566967399, rs1569552936, rs1559712733, rs1561690319, rs1561701721, rs869125101, rs1595843553, rs1576018303, rs746115846, rs777315336, rs1431206462, rs1572358674, rs1477669354, rs1575584918, rs1575614351, rs72648222, rs1575799625, rs1576014673, rs1576147786, rs747469275, rs1581805658, rs1227662860, rs1585169831, rs1592729525, rs762753884, rs1596155145, rs1572358821, rs991187915, rs1575649368, rs1060500562, rs1450218521, rs775256998, rs1572332762, rs1571627006, rs1575253896, rs1575616801, rs1575775337, rs1575948935, rs1574083547, rs1574087037, rs1589632398, rs1585171818, rs1603365762, rs768079285, rs1575663327, rs1575796530, rs1574659116, rs267607001, rs1567093598, rs1572359848, rs1060500505, rs1575512482, rs1575872984, rs1161735211, rs1576141328, rs906494713, rs1576685753, rs1266489077, rs1581813564, rs778808038, rs397516363, rs1596386673, rs1575610911, rs727503266, rs1603377936, rs777702465, rs1708504899, rs2054381012, rs1575285509, rs1695435412, rs1699247877, rs879139686, rs2060187635, rs761380979, rs1464886350, rs1956192035, rs752522753, rs1205836993, rs2095894178	11016643
Colonic neoplasms	Malignant tumor of colon, Colonic Neoplasms	rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483	21056497
Dermatitis	Dermatitis, Irritant	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	25818598
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Kidney failure	Kidney Failure, Chronic		26282591
Liver carcinoma	Liver carcinoma		21056497
Myocardial diseases	Myocardial Diseases, Secondary		11016643
Prostatic neoplasms	Prostatic Neoplasms		17013881