B4GALT4 (beta-1,4-galactosyltransferase 4)

Gene

• Entrez ID: 8702
• Gene name: Beta-1,4-galactosyltransferase 4
• Gene symbol: B4GALT4
• Synonyms: B4Gal-T4, beta4Gal-T4
• Chromosome: 3
• Chromosome location: 3q13.32
• Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to si

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT813882	hsa-miR-1251	CLIP-seq
MIRT813883	hsa-miR-1324	CLIP-seq
MIRT813884	hsa-miR-137	CLIP-seq
MIRT813885	hsa-miR-181a	CLIP-seq
MIRT813886	hsa-miR-181b	CLIP-seq
MIRT813887	hsa-miR-181c	CLIP-seq
MIRT813888	hsa-miR-181d	CLIP-seq
MIRT813889	hsa-miR-194	CLIP-seq
MIRT813890	hsa-miR-2116	CLIP-seq
MIRT813891	hsa-miR-2117	CLIP-seq
MIRT813892	hsa-miR-214	CLIP-seq
MIRT813893	hsa-miR-25	CLIP-seq
MIRT813894	hsa-miR-3160-3p	CLIP-seq
MIRT813895	hsa-miR-32	CLIP-seq
MIRT813896	hsa-miR-3200-3p	CLIP-seq
MIRT813897	hsa-miR-331-3p	CLIP-seq
MIRT813898	hsa-miR-3616-5p	CLIP-seq
MIRT813899	hsa-miR-3619-5p	CLIP-seq
MIRT813900	hsa-miR-363	CLIP-seq
MIRT813901	hsa-miR-3647-5p	CLIP-seq
MIRT813902	hsa-miR-367	CLIP-seq
MIRT813903	hsa-miR-3926	CLIP-seq
MIRT813904	hsa-miR-4262	CLIP-seq
MIRT813905	hsa-miR-4274	CLIP-seq
MIRT813906	hsa-miR-4291	CLIP-seq
MIRT813907	hsa-miR-4330	CLIP-seq
MIRT813908	hsa-miR-4487	CLIP-seq
MIRT813909	hsa-miR-4493	CLIP-seq
MIRT813910	hsa-miR-4717-5p	CLIP-seq
MIRT813911	hsa-miR-4768-5p	CLIP-seq
MIRT813912	hsa-miR-4804-5p	CLIP-seq
MIRT813913	hsa-miR-558	CLIP-seq
MIRT813914	hsa-miR-573	CLIP-seq
MIRT813915	hsa-miR-645	CLIP-seq
MIRT813916	hsa-miR-646	CLIP-seq
MIRT813917	hsa-miR-761	CLIP-seq
MIRT813918	hsa-miR-922	CLIP-seq
MIRT813919	hsa-miR-92a	CLIP-seq
MIRT813920	hsa-miR-92b	CLIP-seq
MIRT813921	hsa-miR-944	CLIP-seq
MIRT813922	hsa-miR-126	CLIP-seq
MIRT813896	hsa-miR-3200-3p	CLIP-seq
MIRT813912	hsa-miR-4804-5p	CLIP-seq
MIRT1922585	hsa-miR-548ae	CLIP-seq
MIRT1922586	hsa-miR-548aj	CLIP-seq
MIRT1922587	hsa-miR-548am	CLIP-seq
MIRT1922588	hsa-miR-548x	CLIP-seq
MIRT1940552	hsa-miR-1208	CLIP-seq
MIRT1940553	hsa-miR-3657	CLIP-seq
MIRT1940554	hsa-miR-4420	CLIP-seq
MIRT1940555	hsa-miR-4669	CLIP-seq
MIRT1940556	hsa-miR-892a	CLIP-seq
MIRT1940552	hsa-miR-1208	CLIP-seq
MIRT2179514	hsa-miR-1245b-3p	CLIP-seq
MIRT2179515	hsa-miR-132	CLIP-seq
MIRT813883	hsa-miR-1324	CLIP-seq
MIRT2179516	hsa-miR-144	CLIP-seq
MIRT813885	hsa-miR-181a	CLIP-seq
MIRT813886	hsa-miR-181b	CLIP-seq
MIRT813887	hsa-miR-181c	CLIP-seq
MIRT813888	hsa-miR-181d	CLIP-seq
MIRT2179517	hsa-miR-205	CLIP-seq
MIRT813891	hsa-miR-2117	CLIP-seq
MIRT2179518	hsa-miR-212	CLIP-seq
MIRT2179519	hsa-miR-219-5p	CLIP-seq
MIRT2179520	hsa-miR-27a	CLIP-seq
MIRT2179521	hsa-miR-27b	CLIP-seq
MIRT2179522	hsa-miR-3646	CLIP-seq
MIRT1940553	hsa-miR-3657	CLIP-seq
MIRT2179523	hsa-miR-3671	CLIP-seq
MIRT813904	hsa-miR-4262	CLIP-seq
MIRT813907	hsa-miR-4330	CLIP-seq
MIRT1940554	hsa-miR-4420	CLIP-seq
MIRT2179524	hsa-miR-4445	CLIP-seq
MIRT1940555	hsa-miR-4669	CLIP-seq
MIRT2179525	hsa-miR-4700-3p	CLIP-seq
MIRT813911	hsa-miR-4768-5p	CLIP-seq
MIRT2179526	hsa-miR-4782-3p	CLIP-seq
MIRT2179527	hsa-miR-508-3p	CLIP-seq
MIRT2179528	hsa-miR-513a-5p	CLIP-seq
MIRT1940556	hsa-miR-892a	CLIP-seq
MIRT2426590	hsa-miR-520d-5p	CLIP-seq
MIRT2426591	hsa-miR-524-5p	CLIP-seq
MIRT813883	hsa-miR-1324	CLIP-seq
MIRT813885	hsa-miR-181a	CLIP-seq
MIRT813886	hsa-miR-181b	CLIP-seq
MIRT813887	hsa-miR-181c	CLIP-seq
MIRT813888	hsa-miR-181d	CLIP-seq
MIRT813891	hsa-miR-2117	CLIP-seq
MIRT813892	hsa-miR-214	CLIP-seq
MIRT813899	hsa-miR-3619-5p	CLIP-seq
MIRT813904	hsa-miR-4262	CLIP-seq
MIRT813905	hsa-miR-4274	CLIP-seq
MIRT813906	hsa-miR-4291	CLIP-seq
MIRT813907	hsa-miR-4330	CLIP-seq
MIRT813911	hsa-miR-4768-5p	CLIP-seq
MIRT813917	hsa-miR-761	CLIP-seq
MIRT813918	hsa-miR-922	CLIP-seq
MIRT2179514	hsa-miR-1245b-3p	CLIP-seq
MIRT813922	hsa-miR-126	CLIP-seq
MIRT2179515	hsa-miR-132	CLIP-seq
MIRT813883	hsa-miR-1324	CLIP-seq
MIRT2179516	hsa-miR-144	CLIP-seq
MIRT813885	hsa-miR-181a	CLIP-seq
MIRT813886	hsa-miR-181b	CLIP-seq
MIRT813887	hsa-miR-181c	CLIP-seq
MIRT813888	hsa-miR-181d	CLIP-seq
MIRT2482960	hsa-miR-1914	CLIP-seq
MIRT813891	hsa-miR-2117	CLIP-seq
MIRT2179518	hsa-miR-212	CLIP-seq
MIRT813892	hsa-miR-214	CLIP-seq
MIRT2179519	hsa-miR-219-5p	CLIP-seq
MIRT2179520	hsa-miR-27a	CLIP-seq
MIRT2179521	hsa-miR-27b	CLIP-seq
MIRT2482961	hsa-miR-3074-5p	CLIP-seq
MIRT813896	hsa-miR-3200-3p	CLIP-seq
MIRT813899	hsa-miR-3619-5p	CLIP-seq
MIRT2179522	hsa-miR-3646	CLIP-seq
MIRT813904	hsa-miR-4262	CLIP-seq
MIRT813905	hsa-miR-4274	CLIP-seq
MIRT813906	hsa-miR-4291	CLIP-seq
MIRT813907	hsa-miR-4330	CLIP-seq
MIRT2179524	hsa-miR-4445	CLIP-seq
MIRT2179525	hsa-miR-4700-3p	CLIP-seq
MIRT2482962	hsa-miR-4733-5p	CLIP-seq
MIRT813911	hsa-miR-4768-5p	CLIP-seq
MIRT2179526	hsa-miR-4782-3p	CLIP-seq
MIRT813912	hsa-miR-4804-5p	CLIP-seq
MIRT2179527	hsa-miR-508-3p	CLIP-seq
MIRT2179528	hsa-miR-513a-5p	CLIP-seq
MIRT2482963	hsa-miR-663b	CLIP-seq
MIRT813917	hsa-miR-761	CLIP-seq
MIRT813918	hsa-miR-922	CLIP-seq
MIRT2179514	hsa-miR-1245b-3p	CLIP-seq
MIRT813922	hsa-miR-126	CLIP-seq
MIRT2179515	hsa-miR-132	CLIP-seq
MIRT813883	hsa-miR-1324	CLIP-seq
MIRT2179516	hsa-miR-144	CLIP-seq
MIRT813885	hsa-miR-181a	CLIP-seq
MIRT813886	hsa-miR-181b	CLIP-seq
MIRT813887	hsa-miR-181c	CLIP-seq
MIRT813888	hsa-miR-181d	CLIP-seq
MIRT2482960	hsa-miR-1914	CLIP-seq
MIRT813891	hsa-miR-2117	CLIP-seq
MIRT2179518	hsa-miR-212	CLIP-seq
MIRT813892	hsa-miR-214	CLIP-seq
MIRT2179519	hsa-miR-219-5p	CLIP-seq
MIRT2179520	hsa-miR-27a	CLIP-seq
MIRT2179521	hsa-miR-27b	CLIP-seq
MIRT2482961	hsa-miR-3074-5p	CLIP-seq
MIRT813896	hsa-miR-3200-3p	CLIP-seq
MIRT813899	hsa-miR-3619-5p	CLIP-seq
MIRT2179522	hsa-miR-3646	CLIP-seq
MIRT813904	hsa-miR-4262	CLIP-seq
MIRT813905	hsa-miR-4274	CLIP-seq
MIRT813906	hsa-miR-4291	CLIP-seq
MIRT813907	hsa-miR-4330	CLIP-seq
MIRT2179524	hsa-miR-4445	CLIP-seq
MIRT2179525	hsa-miR-4700-3p	CLIP-seq
MIRT813911	hsa-miR-4768-5p	CLIP-seq
MIRT2179526	hsa-miR-4782-3p	CLIP-seq
MIRT813912	hsa-miR-4804-5p	CLIP-seq
MIRT2179527	hsa-miR-508-3p	CLIP-seq
MIRT2179528	hsa-miR-513a-5p	CLIP-seq
MIRT2482963	hsa-miR-663b	CLIP-seq
MIRT813917	hsa-miR-761	CLIP-seq
MIRT813918	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0003945	Function	N-acetyllactosamine synthase activity	IEA
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006643	Process	Membrane lipid metabolic process	TAS	9792633
GO:0008378	Function	Galactosyltransferase activity	IBA	21873635
GO:0008378	Function	Galactosyltransferase activity	TAS	9792633
GO:0016021	Component	Integral component of membrane	IEA
GO:0018146	Process	Keratan sulfate biosynthetic process	TAS
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070085	Process	Glycosylation	IBA	21873635

Other IDs

• MIM: 604015
• HGNC: 927
• e!Ensembl: ENSG00000121578

Protein

• UniProt ID: O60513
• Protein name: Beta-1,4-galactosyltransferase 4 (Beta-1,4-GalTase 4) (Beta4Gal-T4) (b4Gal-T4) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Lactotriaosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.275) (N-acetyllactosamine sy
• Protein function: Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids (PubMed:12511560, PubMed:17690104, PubMed:32827291, PubMed:9792633). Catalyzes t
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13733	Glyco_transf_7N	77 → 209	N-terminal region of glycosyl transferase group 7	Domain
  PF02709	Glyco_transf_7C	213 → 290	N-terminal domain of galactosyltransferase	Family

• Sequence:

  MGFNLTFHLSYKFRLLLLLTLCLTVVGWATSNYFVGAIQEIPKAKEFMANFHKTLILGKG
  KTLTNEASTKKVELDNCPSVSPYLRGQSKLIFKPDLTLEEVQAENPKVSRGRYRPQECKA
  LQRVAILVPHRNREKHLMYLLEHLHPFLQRQQLDYGIYVIHQAEGKKFNRAKLLNVGYLE
  ALKEENWDCFIFHDVDLVPENDFNLYKCEEHPKHLVVGRNSTGYRLRYSGYFGGVTALSR
  EQFFKVNGFSNNYWGWGGEDDDLRLRVELQRMKISRPLPEVGKYTMVFHTRDKGNEVNAE
  RMKLLHQVSRVWRTDGLSSCSYKLVSVEHNPLYINITVDFWFGA

• Sequence length: 344

Pathways

KEGG:

Glycosaminoglycan biosynthesis - keratan sulfate
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways

Reactome:

Keratan sulfate biosynthesis
N-Glycan antennae elongation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881