VAMP8 (vesicle associated membrane protein 8)

Gene

• Entrez ID: 8673
• Gene name: Vesicle associated membrane protein 8
• Gene symbol: VAMP8
• Synonyms: EDB, VAMP-8
• Chromosome: 2
• Chromosome location: 2p11.2
• Summary: This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusio

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016522	hsa-miR-193b-3p	Microarray	20304954
MIRT016522	hsa-miR-193b-3p	Proteomics	21512034
MIRT022696	hsa-miR-124-3p	Microarray	18668037
MIRT025757	hsa-miR-7-5p	Microarray	17612493
MIRT031767	hsa-miR-16-5p	Proteomics	18668040
MIRT649546	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT649545	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT649544	hsa-miR-455-3p	HITS-CLIP	23824327
MIRT649543	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT649542	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT649541	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT649540	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT649539	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT649538	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT649537	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT649536	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT649534	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT303877	hsa-miR-4428	PAR-CLIP	20371350
MIRT303878	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT303875	hsa-miR-3125	PAR-CLIP	20371350
MIRT303876	hsa-miR-3916	PAR-CLIP	20371350
MIRT303879	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT561100	hsa-miR-3137	PAR-CLIP	20371350
MIRT561099	hsa-miR-20b-3p	PAR-CLIP	20371350
MIRT025757	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT561098	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT561097	hsa-miR-4732-5p	PAR-CLIP	20371350
MIRT303874	hsa-miR-877-5p	PAR-CLIP	20371350
MIRT649546	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT649545	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT649544	hsa-miR-455-3p	HITS-CLIP	23824327
MIRT649543	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT649542	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT649541	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT649540	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT649539	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT649538	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT649537	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT649536	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT649534	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT303877	hsa-miR-4428	PAR-CLIP	20371350
MIRT303878	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT303875	hsa-miR-3125	PAR-CLIP	20371350
MIRT303876	hsa-miR-3916	PAR-CLIP	20371350
MIRT303879	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT561100	hsa-miR-3137	PAR-CLIP	20371350
MIRT561099	hsa-miR-20b-3p	PAR-CLIP	20371350
MIRT025757	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT561098	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT561097	hsa-miR-4732-5p	PAR-CLIP	20371350
MIRT303874	hsa-miR-877-5p	PAR-CLIP	20371350
MIRT1481910	hsa-miR-103a	CLIP-seq
MIRT1481911	hsa-miR-107	CLIP-seq
MIRT1481912	hsa-miR-1179	CLIP-seq
MIRT1481913	hsa-miR-125a-5p	CLIP-seq
MIRT1481914	hsa-miR-125b	CLIP-seq
MIRT1481915	hsa-miR-15a	CLIP-seq
MIRT1481916	hsa-miR-15b	CLIP-seq
MIRT1481917	hsa-miR-16	CLIP-seq
MIRT1481918	hsa-miR-195	CLIP-seq
MIRT1481919	hsa-miR-214	CLIP-seq
MIRT1481920	hsa-miR-296-3p	CLIP-seq
MIRT1481921	hsa-miR-323b-5p	CLIP-seq
MIRT1481922	hsa-miR-3619-5p	CLIP-seq
MIRT1481923	hsa-miR-3918	CLIP-seq
MIRT1481924	hsa-miR-424	CLIP-seq
MIRT1481925	hsa-miR-4266	CLIP-seq
MIRT1481926	hsa-miR-4310	CLIP-seq
MIRT1481927	hsa-miR-4319	CLIP-seq
MIRT1481928	hsa-miR-4512	CLIP-seq
MIRT1481929	hsa-miR-4646-3p	CLIP-seq
MIRT1481930	hsa-miR-4695-5p	CLIP-seq
MIRT1481931	hsa-miR-4709-3p	CLIP-seq
MIRT1481932	hsa-miR-4729	CLIP-seq
MIRT1481933	hsa-miR-4732-3p	CLIP-seq
MIRT1481934	hsa-miR-4751	CLIP-seq
MIRT1481935	hsa-miR-4779	CLIP-seq
MIRT1481936	hsa-miR-4802-5p	CLIP-seq
MIRT1481937	hsa-miR-497	CLIP-seq
MIRT1481938	hsa-miR-670	CLIP-seq
MIRT1481939	hsa-miR-761	CLIP-seq
MIRT1481940	hsa-miR-885-3p	CLIP-seq
MIRT1481920	hsa-miR-296-3p	CLIP-seq
MIRT2144951	hsa-miR-296-5p	CLIP-seq
MIRT2144952	hsa-miR-3144-5p	CLIP-seq
MIRT1481921	hsa-miR-323b-5p	CLIP-seq
MIRT2144953	hsa-miR-3667-3p	CLIP-seq
MIRT2144954	hsa-miR-3925-3p	CLIP-seq
MIRT2144955	hsa-miR-4497	CLIP-seq
MIRT2144956	hsa-miR-4521	CLIP-seq
MIRT1481929	hsa-miR-4646-3p	CLIP-seq
MIRT2144957	hsa-miR-4690-3p	CLIP-seq
MIRT2144958	hsa-miR-4709-5p	CLIP-seq
MIRT2144959	hsa-miR-4724-3p	CLIP-seq
MIRT2144960	hsa-miR-4731-5p	CLIP-seq
MIRT1481936	hsa-miR-4802-5p	CLIP-seq
MIRT2144961	hsa-miR-766	CLIP-seq
MIRT2144951	hsa-miR-296-5p	CLIP-seq
MIRT2144954	hsa-miR-3925-3p	CLIP-seq
MIRT2144957	hsa-miR-4690-3p	CLIP-seq
MIRT2144960	hsa-miR-4731-5p	CLIP-seq
MIRT2144961	hsa-miR-766	CLIP-seq
MIRT2396780	hsa-miR-3154	CLIP-seq
MIRT2396781	hsa-miR-3665	CLIP-seq
MIRT2396782	hsa-miR-4436b-3p	CLIP-seq
MIRT1481931	hsa-miR-4709-3p	CLIP-seq
MIRT2396783	hsa-miR-4736	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002479	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS
GO:0005484	Function	SNAP receptor activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	22118466, 23217709, 25419848, 31806350
GO:0005737	Component	Cytoplasm	IDA	18253931
GO:0005765	Component	Lysosomal membrane	IDA	23217709
GO:0005769	Component	Early endosome	TAS	9614193
GO:0005829	Component	Cytosol	IDA	22589474
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	18253931
GO:0005886	Component	Plasma membrane	TAS
GO:0006892	Process	Post-Golgi vesicle-mediated transport	TAS
GO:0006906	Process	Vesicle fusion	IBA	21873635
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IDA	16677249
GO:0016021	Component	Integral component of membrane	IEA
GO:0016240	Process	Autophagosome membrane docking	IDA	25686604
GO:0019869	Function	Chloride channel inhibitor activity	IDA	18570918
GO:0019905	Function	Syntaxin binding	IBA	21873635
GO:0030665	Component	Clathrin-coated vesicle membrane	TAS
GO:0030667	Component	Secretory granule membrane	IDA	16677249
GO:0030667	Component	Secretory granule membrane	TAS
GO:0030670	Component	Phagocytic vesicle membrane	TAS
GO:0031201	Component	SNARE complex	IBA	21873635
GO:0031201	Component	SNARE complex	IDA	12130530, 18253931, 23217709, 24550300
GO:0031901	Component	Early endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	IDA	23217709
GO:0031982	Component	Vesicle	IDA	18570918
GO:0035493	Process	SNARE complex assembly	IBA	21873635
GO:0035577	Component	Azurophil granule membrane	IDA	16677249
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0035579	Component	Specific granule membrane	TAS
GO:0043308	Process	Eosinophil degranulation	IMP	16677249
GO:0043312	Process	Neutrophil degranulation	IMP	16677249
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0046718	Process	Viral entry into host cell	IMP	24550300
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	18570918
GO:0051607	Process	Defense response to virus	IEA
GO:0055037	Component	Recycling endosome	IDA	18570918
GO:0055038	Component	Recycling endosome membrane	TAS
GO:0061024	Process	Membrane organization	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337
GO:0070254	Process	Mucus secretion	IBA	21873635
GO:0070254	Process	Mucus secretion	IMP	22144578
GO:0070821	Component	Tertiary granule membrane	TAS
GO:0097352	Process	Autophagosome maturation	IMP	23217709
GO:0098594	Component	Mucin granule	IBA	21873635
GO:0098594	Component	Mucin granule	IDA	22144578
GO:1903076	Process	Regulation of protein localization to plasma membrane	IDA	18570918
GO:1903531	Process	Negative regulation of secretion by cell	IDA	12130530
GO:1903595	Process	Positive regulation of histamine secretion by mast cell	IMP	18253931

Other IDs

• MIM: 603177
• HGNC: 12647
• e!Ensembl: ENSG00000118640

Protein

• UniProt ID: Q9BV40
• Protein name: Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
• Protein function: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four al
• PDB: 4WY4, 7BV6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00957	Synaptobrevin	9 → 97	Synaptobrevin	Family

• Sequence:

  MEEASEGGGNDRVRNLQSEVEGVKNIMTQNVERILARGENLEHLRNKTEDLEATSEHFKT
  TSQKVARKFWWKNVKMIVLICVIVFIIILFIVLFATGAFS

• Sequence length: 100

Pathways

KEGG:

SNARE interactions in vesicular transport
Autophagy - animal
Platelet activation

Reactome:

ER-Phagosome pathway
trans-Golgi Network Vesicle Budding
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	16316942
Prostate cancer	Malignant neoplasm of prostate, Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	21743467, 26034056, 21743467, 29892016

Unknown
Disease name	Disease term	dbSNP ID	References
Anaplastic carcinoma	Anaplastic carcinoma		16316942