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EIF3A (eukaryotic translation initiation factor 3 subunit A)

Gene

Eukaryotic translation initiation factor 3 subunit A

EIF3A

EIF3, EIF3S10, P167, TIF32, eIF3-p170, eIF3-theta, p180, p185

10

10q26.11

Show/Hide all(183)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020771	hsa-miR-155-5p	Proteomics	18668040
MIRT031705	hsa-miR-16-5p	Proteomics	18668040
MIRT051776	hsa-let-7c-5p	CLASH	23622248
MIRT042324	hsa-miR-484	CLASH	23622248
MIRT040974	hsa-miR-18a-3p	CLASH	23622248
MIRT040734	hsa-miR-92b-3p	CLASH	23622248
MIRT737296	hsa-miR-875-5p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR	33000235
MIRT957446	hsa-miR-105	CLIP-seq
MIRT957447	hsa-miR-1280	CLIP-seq
MIRT957448	hsa-miR-1297	CLIP-seq
MIRT957449	hsa-miR-182	CLIP-seq
MIRT957450	hsa-miR-186	CLIP-seq
MIRT957451	hsa-miR-2054	CLIP-seq
MIRT957452	hsa-miR-23a	CLIP-seq
MIRT957453	hsa-miR-23b	CLIP-seq
MIRT957454	hsa-miR-23c	CLIP-seq
MIRT957455	hsa-miR-26a	CLIP-seq
MIRT957456	hsa-miR-26b	CLIP-seq
MIRT957457	hsa-miR-3133	CLIP-seq
MIRT957458	hsa-miR-3148	CLIP-seq
MIRT957459	hsa-miR-3179	CLIP-seq
MIRT957460	hsa-miR-3655	CLIP-seq
MIRT957461	hsa-miR-3680	CLIP-seq
MIRT957462	hsa-miR-3682-5p	CLIP-seq
MIRT957463	hsa-miR-3688-3p	CLIP-seq
MIRT957464	hsa-miR-409-3p	CLIP-seq
MIRT957465	hsa-miR-4263	CLIP-seq
MIRT957466	hsa-miR-4282	CLIP-seq
MIRT957467	hsa-miR-4465	CLIP-seq
MIRT957468	hsa-miR-4509	CLIP-seq
MIRT957469	hsa-miR-4668-3p	CLIP-seq
MIRT957470	hsa-miR-4744	CLIP-seq
MIRT957471	hsa-miR-4768-5p	CLIP-seq
MIRT957472	hsa-miR-4798-3p	CLIP-seq
MIRT957473	hsa-miR-4799-5p	CLIP-seq
MIRT957474	hsa-miR-512-5p	CLIP-seq
MIRT957475	hsa-miR-513a-3p	CLIP-seq
MIRT957476	hsa-miR-513c	CLIP-seq
MIRT957477	hsa-miR-514b-5p	CLIP-seq
MIRT957478	hsa-miR-548ae	CLIP-seq
MIRT957479	hsa-miR-548aj	CLIP-seq
MIRT957480	hsa-miR-548am	CLIP-seq
MIRT957481	hsa-miR-548x	CLIP-seq
MIRT957482	hsa-miR-576-5p	CLIP-seq
MIRT957483	hsa-miR-605	CLIP-seq
MIRT957484	hsa-miR-616	CLIP-seq
MIRT957485	hsa-miR-885-5p	CLIP-seq
MIRT957486	hsa-miR-942	CLIP-seq
MIRT957450	hsa-miR-186	CLIP-seq
MIRT1983659	hsa-miR-1914	CLIP-seq
MIRT957457	hsa-miR-3133	CLIP-seq
MIRT1983660	hsa-miR-3201	CLIP-seq
MIRT1983661	hsa-miR-3622b-5p	CLIP-seq
MIRT957461	hsa-miR-3680	CLIP-seq
MIRT1983662	hsa-miR-3691-5p	CLIP-seq
MIRT957466	hsa-miR-4282	CLIP-seq
MIRT1983663	hsa-miR-4694-5p	CLIP-seq
MIRT1983664	hsa-miR-4752	CLIP-seq
MIRT1983665	hsa-miR-4786-5p	CLIP-seq
MIRT1983666	hsa-miR-4791	CLIP-seq
MIRT957472	hsa-miR-4798-3p	CLIP-seq
MIRT1983667	hsa-miR-505	CLIP-seq
MIRT1983668	hsa-miR-548m	CLIP-seq
MIRT1983669	hsa-miR-577	CLIP-seq
MIRT1983670	hsa-miR-769-5p	CLIP-seq
MIRT1983671	hsa-miR-888	CLIP-seq
MIRT957449	hsa-miR-182	CLIP-seq
MIRT957450	hsa-miR-186	CLIP-seq
MIRT2218935	hsa-miR-302f	CLIP-seq
MIRT2218936	hsa-miR-3180-5p	CLIP-seq
MIRT957460	hsa-miR-3655	CLIP-seq
MIRT2218937	hsa-miR-377	CLIP-seq
MIRT2218938	hsa-miR-4320	CLIP-seq
MIRT2218939	hsa-miR-452	CLIP-seq
MIRT2218940	hsa-miR-4676-3p	CLIP-seq
MIRT1983667	hsa-miR-505	CLIP-seq
MIRT957474	hsa-miR-512-5p	CLIP-seq
MIRT2218941	hsa-miR-520a-5p	CLIP-seq
MIRT2218942	hsa-miR-525-5p	CLIP-seq
MIRT957478	hsa-miR-548ae	CLIP-seq
MIRT957479	hsa-miR-548aj	CLIP-seq
MIRT957480	hsa-miR-548am	CLIP-seq
MIRT957481	hsa-miR-548x	CLIP-seq
MIRT957484	hsa-miR-616	CLIP-seq
MIRT957460	hsa-miR-3655	CLIP-seq
MIRT957484	hsa-miR-616	CLIP-seq
MIRT2522236	hsa-miR-127-5p	CLIP-seq
MIRT957447	hsa-miR-1280	CLIP-seq
MIRT957448	hsa-miR-1297	CLIP-seq
MIRT957450	hsa-miR-186	CLIP-seq
MIRT957451	hsa-miR-2054	CLIP-seq
MIRT2522237	hsa-miR-208a	CLIP-seq
MIRT2522238	hsa-miR-208b	CLIP-seq
MIRT957455	hsa-miR-26a	CLIP-seq
MIRT957456	hsa-miR-26b	CLIP-seq
MIRT2218935	hsa-miR-302f	CLIP-seq
MIRT957457	hsa-miR-3133	CLIP-seq
MIRT2522239	hsa-miR-3143	CLIP-seq
MIRT2522240	hsa-miR-3616-5p	CLIP-seq
MIRT2522241	hsa-miR-3617	CLIP-seq
MIRT2522242	hsa-miR-362-5p	CLIP-seq
MIRT2522243	hsa-miR-3647-5p	CLIP-seq
MIRT957460	hsa-miR-3655	CLIP-seq
MIRT2522244	hsa-miR-3658	CLIP-seq
MIRT957461	hsa-miR-3680	CLIP-seq
MIRT957462	hsa-miR-3682-5p	CLIP-seq
MIRT2522245	hsa-miR-369-3p	CLIP-seq
MIRT2522246	hsa-miR-374a	CLIP-seq
MIRT2522247	hsa-miR-374b	CLIP-seq
MIRT957464	hsa-miR-409-3p	CLIP-seq
MIRT957465	hsa-miR-4263	CLIP-seq
MIRT957466	hsa-miR-4282	CLIP-seq
MIRT957467	hsa-miR-4465	CLIP-seq
MIRT957468	hsa-miR-4509	CLIP-seq
MIRT957469	hsa-miR-4668-3p	CLIP-seq
MIRT957470	hsa-miR-4744	CLIP-seq
MIRT2522248	hsa-miR-4760-5p	CLIP-seq
MIRT957471	hsa-miR-4768-5p	CLIP-seq
MIRT1983665	hsa-miR-4786-5p	CLIP-seq
MIRT957472	hsa-miR-4798-3p	CLIP-seq
MIRT957473	hsa-miR-4799-5p	CLIP-seq
MIRT2522249	hsa-miR-4803	CLIP-seq
MIRT2522250	hsa-miR-494	CLIP-seq
MIRT2522251	hsa-miR-499-5p	CLIP-seq
MIRT2522252	hsa-miR-500a	CLIP-seq
MIRT2522253	hsa-miR-500b	CLIP-seq
MIRT2522254	hsa-miR-509-3p	CLIP-seq
MIRT957475	hsa-miR-513a-3p	CLIP-seq
MIRT957476	hsa-miR-513c	CLIP-seq
MIRT957477	hsa-miR-514b-5p	CLIP-seq
MIRT2522255	hsa-miR-563	CLIP-seq
MIRT2522256	hsa-miR-573	CLIP-seq
MIRT957482	hsa-miR-576-5p	CLIP-seq
MIRT957484	hsa-miR-616	CLIP-seq
MIRT2522257	hsa-miR-641	CLIP-seq
MIRT1983670	hsa-miR-769-5p	CLIP-seq
MIRT957486	hsa-miR-942	CLIP-seq
MIRT2522236	hsa-miR-127-5p	CLIP-seq
MIRT957447	hsa-miR-1280	CLIP-seq
MIRT957448	hsa-miR-1297	CLIP-seq
MIRT957450	hsa-miR-186	CLIP-seq
MIRT957451	hsa-miR-2054	CLIP-seq
MIRT2522237	hsa-miR-208a	CLIP-seq
MIRT2522238	hsa-miR-208b	CLIP-seq
MIRT957455	hsa-miR-26a	CLIP-seq
MIRT957456	hsa-miR-26b	CLIP-seq
MIRT2218935	hsa-miR-302f	CLIP-seq
MIRT957457	hsa-miR-3133	CLIP-seq
MIRT2522239	hsa-miR-3143	CLIP-seq
MIRT2522240	hsa-miR-3616-5p	CLIP-seq
MIRT2522242	hsa-miR-362-5p	CLIP-seq
MIRT2522243	hsa-miR-3647-5p	CLIP-seq
MIRT957460	hsa-miR-3655	CLIP-seq
MIRT2522244	hsa-miR-3658	CLIP-seq
MIRT957461	hsa-miR-3680	CLIP-seq
MIRT957462	hsa-miR-3682-5p	CLIP-seq
MIRT2522245	hsa-miR-369-3p	CLIP-seq
MIRT2522246	hsa-miR-374a	CLIP-seq
MIRT2522247	hsa-miR-374b	CLIP-seq
MIRT957464	hsa-miR-409-3p	CLIP-seq
MIRT957466	hsa-miR-4282	CLIP-seq
MIRT957467	hsa-miR-4465	CLIP-seq
MIRT957468	hsa-miR-4509	CLIP-seq
MIRT957469	hsa-miR-4668-3p	CLIP-seq
MIRT957470	hsa-miR-4744	CLIP-seq
MIRT2522248	hsa-miR-4760-5p	CLIP-seq
MIRT957471	hsa-miR-4768-5p	CLIP-seq
MIRT1983665	hsa-miR-4786-5p	CLIP-seq
MIRT957472	hsa-miR-4798-3p	CLIP-seq
MIRT2522249	hsa-miR-4803	CLIP-seq
MIRT2522250	hsa-miR-494	CLIP-seq
MIRT2522251	hsa-miR-499-5p	CLIP-seq
MIRT2522252	hsa-miR-500a	CLIP-seq
MIRT2522253	hsa-miR-500b	CLIP-seq
MIRT2522254	hsa-miR-509-3p	CLIP-seq
MIRT957475	hsa-miR-513a-3p	CLIP-seq
MIRT957476	hsa-miR-513c	CLIP-seq
MIRT957477	hsa-miR-514b-5p	CLIP-seq
MIRT2522255	hsa-miR-563	CLIP-seq
MIRT2522256	hsa-miR-573	CLIP-seq
MIRT957484	hsa-miR-616	CLIP-seq
MIRT1983670	hsa-miR-769-5p	CLIP-seq
MIRT957486	hsa-miR-942	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001732	Process	Formation of cytoplasmic translation initiation complex	IBA	21873635
GO:0001732	Process	Formation of cytoplasmic translation initiation complex	IDA	17581632
GO:0002188	Process	Translation reinitiation	IBA	21873635
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IDA	25849773, 27462815
GO:0003729	Function	MRNA binding	IBA	21873635
GO:0003743	Function	Translation initiation factor activity	IBA	21873635
GO:0003743	Function	Translation initiation factor activity	IC	17322308, 18599441
GO:0003743	Function	Translation initiation factor activity	IDA	17581632, 25849773
GO:0005198	Function	Structural molecule activity	NAS	9150439
GO:0005515	Function	Protein binding	IPI	11169732, 14688252, 17468741, 18423202, 18599441, 18628297, 19245811, 21124883, 22190034, 23623729, 25416956
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	NAS	9150439
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005852	Component	Eukaryotic translation initiation factor 3 complex	IDA	17322308, 17581632, 18599441, 25849773
GO:0005874	Component	Microtubule	IEA
GO:0006413	Process	Translational initiation	IC	17322308, 18599441
GO:0006413	Process	Translational initiation	TAS
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016282	Component	Eukaryotic 43S preinitiation complex	IEA
GO:0030971	Function	Receptor tyrosine kinase binding	IEA
GO:0033290	Component	Eukaryotic 48S preinitiation complex	IEA
GO:0043614	Component	Multi-eIF complex	IBA	21873635
GO:0070373	Process	Negative regulation of ERK1 and ERK2 cascade	IEA
GO:0071540	Component	Eukaryotic translation initiation factor 3 complex, eIF3e	IBA	21873635
GO:0071541	Component	Eukaryotic translation initiation factor 3 complex, eIF3m	IBA	21873635
GO:0075522	Process	IRES-dependent viral translational initiation	IDA	9573242, 23766293, 24357634
GO:0075525	Process	Viral translational termination-reinitiation	IDA	21347434

MIM	HGNC	e!Ensembl
602039	3271	ENSG00000107581

Protein

UniProt ID

Protein name

Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)

Protein function

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S rib

PDB

3J8B , 3J8C , 6YBD , 6YBT , 6ZMW , 6ZON , 6ZP4 , 6ZVJ , 7A09 , 7QP6 , 7QP7 , 8OZ0 , 8PJ1 , 8PJ2 , 8PJ3 , 8PJ4 , 8PJ5 , 8PJ6 , 8PPL , 8RG0 , 8XXN , 9BLN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01399	PCI	365 → 495	PCI domain	Domain

Sequence

MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPIMLKYLELCVD
LRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKMAEEKTEAAKEESQQMVLDIEDLDN
IQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSRVERLYHDIAQQ
AFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSA
ISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLY
HLSREMRKNLTQDEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLG
LQAPPTRIGLINDMVRFNVLQYVVPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEK
EPELQQYVPQLQNNTILRLLQQVSQIYQSIEFSRLTSLVPFVDAFQLERAIVDAARHCDL
QVRIDHTSRTLSFGSDLNYATREDAPIGPHLQSMPSEQIRNQLTAMSSVLAKALEVIKPA
HILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAE
LQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIED
LEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIK
DMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFE
ERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEE
LREYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWR
KGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRR
GMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRR
GLDEDRGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDDDRGPR
RGMDDDRGPRRGMDDDRGPRRGMDDDRGPRRGLDDDRGPWRNADDDRIPRRGAEDDRGPW
RNMDDDRLSRRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWGPPRESRPSEE
REWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWR
DSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDR
VEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDRESLRRTKNETDEDGWTTV
RR

Sequence length

1382

Interactions

View interactions

	Reactome
			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881

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