KCNK5 (potassium two pore domain channel subfamily K member 5)

Gene

• Entrez ID: 8645
• Gene name: Potassium two pore domain channel subfamily K member 5
• Gene symbol: KCNK5
• Synonyms: K2p5.1, KCNK5b, TASK-2, TASK2
• Chromosome: 6
• Chromosome location: 6p21.2
• Summary: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017258	hsa-miR-335-5p	Microarray	18185580
MIRT610745	hsa-miR-602	HITS-CLIP	23824327
MIRT610745	hsa-miR-602	HITS-CLIP	23313552
MIRT610746	hsa-miR-8485	HITS-CLIP	23824327
MIRT610746	hsa-miR-8485	HITS-CLIP	23313552
MIRT614942	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT614943	hsa-miR-1-5p	HITS-CLIP	23824327
MIRT614944	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT614944	hsa-miR-5003-3p	HITS-CLIP	19536157
MIRT616587	hsa-miR-487a-3p	HITS-CLIP	23824327
MIRT616588	hsa-miR-154-3p	HITS-CLIP	23824327
MIRT623502	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT623502	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT623503	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT623503	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT623504	hsa-miR-5590-5p	HITS-CLIP	23824327
MIRT623505	hsa-miR-513a-5p	HITS-CLIP	23824327
MIRT623506	hsa-miR-6817-5p	HITS-CLIP	23824327
MIRT623507	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT623508	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT657012	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT657013	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT657014	hsa-miR-3122	HITS-CLIP	23824327
MIRT657015	hsa-miR-4298	HITS-CLIP	23824327
MIRT657016	hsa-miR-1302	HITS-CLIP	23824327
MIRT657017	hsa-miR-302d-5p	HITS-CLIP	23824327
MIRT657018	hsa-miR-302b-5p	HITS-CLIP	23824327
MIRT657019	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT657020	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT657021	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT657022	hsa-miR-500b-5p	HITS-CLIP	23824327
MIRT657023	hsa-miR-362-5p	HITS-CLIP	23824327
MIRT657024	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT657025	hsa-miR-28-3p	HITS-CLIP	23824327
MIRT657026	hsa-miR-6776-3p	HITS-CLIP	23824327
MIRT670393	hsa-miR-7977	HITS-CLIP	23824327
MIRT670394	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT670395	hsa-miR-4284	HITS-CLIP	23824327
MIRT670396	hsa-miR-564	HITS-CLIP	23824327
MIRT670397	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT713800	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT713801	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT713802	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT713803	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT713804	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT713805	hsa-miR-3065-5p	HITS-CLIP	19536157
MIRT713806	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT713807	hsa-miR-3529-3p	HITS-CLIP	19536157
MIRT722768	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT722769	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT722770	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT722771	hsa-miR-29b-2-5p	HITS-CLIP	19536157
MIRT722772	hsa-miR-4753-3p	HITS-CLIP	19536157
MIRT722773	hsa-miR-29b-1-5p	HITS-CLIP	19536157
MIRT722774	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT722775	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT722776	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT736542	hsa-miR-1253	PAR-CLIP	26701625
MIRT736869	hsa-miR-1273h-5p	PAR-CLIP	26701625
MIRT738994	hsa-miR-214-3p	PAR-CLIP	26701625
MIRT739759	hsa-miR-30b-3p	PAR-CLIP	26701625
MIRT739820	hsa-miR-30c-1-3p	PAR-CLIP	26701625
MIRT739863	hsa-miR-30c-2-3p	PAR-CLIP	26701625
MIRT741717	hsa-miR-3619-5p	PAR-CLIP	26701625
MIRT742051	hsa-miR-3665	PAR-CLIP	26701625
MIRT742261	hsa-miR-3689a-3p	PAR-CLIP	26701625
MIRT742331	hsa-miR-3689b-3p	PAR-CLIP	26701625
MIRT742401	hsa-miR-3689c	PAR-CLIP	26701625
MIRT744306	hsa-miR-4428	PAR-CLIP	26701625
MIRT744401	hsa-miR-4434	PAR-CLIP	26701625
MIRT745703	hsa-miR-4514	PAR-CLIP	26701625
MIRT745754	hsa-miR-4516	PAR-CLIP	26701625
MIRT746015	hsa-miR-4533	PAR-CLIP	26701625
MIRT748244	hsa-miR-4747-5p	PAR-CLIP	26701625
MIRT749549	hsa-miR-504-3p	PAR-CLIP	26701625
MIRT750028	hsa-miR-5196-5p	PAR-CLIP	26701625
MIRT751357	hsa-miR-5703	PAR-CLIP	26701625
MIRT752509	hsa-miR-6165	PAR-CLIP	26701625
MIRT753500	hsa-miR-657	PAR-CLIP	26701625
MIRT755500	hsa-miR-6779-5p	PAR-CLIP	26701625
MIRT755576	hsa-miR-6780a-5p	PAR-CLIP	26701625
MIRT755972	hsa-miR-6788-5p	PAR-CLIP	26701625
MIRT759468	hsa-miR-761	PAR-CLIP	26701625
MIRT760409	hsa-miR-887-5p	PAR-CLIP	26701625
MIRT760885	hsa-miR-9500	PAR-CLIP	26701625
MIRT790044	hsa-miR-1207-5p	HITS-CLIP	28735896
MIRT790134	hsa-miR-1827	HITS-CLIP	28735896
MIRT790179	hsa-miR-2115-3p	HITS-CLIP	28735896
MIRT790402	hsa-miR-4270	HITS-CLIP	28735896
MIRT790417	hsa-miR-4300	HITS-CLIP	28735896
MIRT790452	hsa-miR-4441	HITS-CLIP	28735896
MIRT790483	hsa-miR-4487	HITS-CLIP	28735896
MIRT790622	hsa-miR-4763-3p	HITS-CLIP	28735896
MIRT790767	hsa-miR-5591-5p	HITS-CLIP	28735896
MIRT790890	hsa-miR-6726-5p	HITS-CLIP	28735896
MIRT790928	hsa-miR-6754-5p	HITS-CLIP	28735896
MIRT790979	hsa-miR-6808-5p	HITS-CLIP	28735896
MIRT791084	hsa-miR-6893-5p	HITS-CLIP	28735896
MIRT791155	hsa-miR-920	HITS-CLIP	28735896
MIRT791170	hsa-miR-940	HITS-CLIP	28735896

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005244	Function	Voltage-gated ion channel activity	IEA
GO:0005267	Function	Potassium channel activity	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006813	Process	Potassium ion transport	TAS	9812978
GO:0007588	Process	Excretion	TAS	9812978
GO:0022841	Function	Potassium ion leak channel activity	IBA	21873635
GO:0030322	Process	Stabilization of membrane potential	IBA	21873635
GO:0034765	Process	Regulation of ion transmembrane transport	IEA
GO:0060075	Process	Regulation of resting membrane potential	ISS
GO:0071805	Process	Potassium ion transmembrane transport	IBA	21873635
GO:0097623	Process	Potassium ion export across plasma membrane	ISS

Other IDs

• MIM: 603493
• HGNC: 6280
• e!Ensembl: ENSG00000164626

Protein

• UniProt ID: O95279
• Protein name: Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2)
• Protein function: pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07885	Ion_trans_2	60 → 138	Ion channel	Family
  PF07885	Ion_trans_2	160 → 251	Ion channel	Family

• Sequence:

  MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKI
  LEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGL
  FGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPF
  VFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSL
  FVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEET
  YNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQ
  TLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASI
  TFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELS
  VPYEQLMNEYNKANSPKGT

• Sequence length: 499

Pathways

KEGG:

Taste transduction
Protein digestion and absorption

Reactome:

Phase 4 - resting membrane potential

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1, Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	23202125, 29212778
Migraine	Migraine Disorders	rs794727411	23793025, 27322543, 27182965

Unknown
Disease name	Disease term	dbSNP ID	References
Grand mal status epilepticus	Grand Mal Status Epilepticus		19220408
Nonconvulsive status epilepticus	Non-Convulsive Status Epilepticus		19220408
Petit mal status	Petit mal status		19220408
Status epilepticus	Status Epilepticus, Complex Partial Status Epilepticus, Status Epilepticus, Subclinical		19220408