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RUNX3 (RUNX family transcription factor 3)

Gene

864

RUNX family transcription factor 3

RUNX3

AML2, CBFA3, PEBP2aC

1p36.11

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5`-PYGPYGGT-3` found in a number of enhancers and promoters, and

Show/Hide all(264)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000038	hsa-miR-532-5p	Review	20026422
MIRT003316	hsa-miR-130b-3p	qRT-PCR, Western blot	20176475
MIRT000038	hsa-miR-532-5p	Flow, qRT-PCR	19336521
MIRT007055	hsa-miR-130a-3p	Luciferase reporter assay, Western blot	22846564
MIRT007295	hsa-miR-301a-3p	Luciferase reporter assay, qRT-PCR, Western blot	23338485
MIRT019365	hsa-miR-148b-3p	Microarray	17612493
MIRT003316	hsa-miR-130b-3p	Sequencing	20371350
MIRT028012	hsa-miR-93-5p	Sequencing	20371350
MIRT053518	hsa-miR-148a-3p	qRT-PCR, Western blot	23549984
MIRT053564	hsa-miR-106a-5p	Luciferase reporter assay, qRT-PCR, Western blot	23932924
MIRT053564	hsa-miR-106a-5p	Luciferase reporter assay, qRT-PCR, Western blot	23932924
MIRT437468	hsa-miR-106b-5p	Luciferase reporter assay, qRT-PCR, Western blot	23912048
MIRT007055	hsa-miR-130a-3p	Luciferase reporter assay	23874686
MIRT007055	hsa-miR-130a-3p	Luciferase reporter assay	23874686
MIRT568953	hsa-miR-6805-5p	PAR-CLIP	20371350
MIRT568954	hsa-miR-637	PAR-CLIP	20371350
MIRT568952	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT568951	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT568950	hsa-miR-8085	PAR-CLIP	20371350
MIRT568949	hsa-miR-3175	PAR-CLIP	20371350
MIRT568948	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT568947	hsa-miR-5698	PAR-CLIP	20371350
MIRT568946	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT568944	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT568945	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT568943	hsa-miR-4488	PAR-CLIP	20371350
MIRT568941	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT568942	hsa-miR-6795-5p	PAR-CLIP	20371350
MIRT568940	hsa-miR-6887-5p	PAR-CLIP	20371350
MIRT568939	hsa-miR-6835-5p	PAR-CLIP	20371350
MIRT568938	hsa-miR-6752-5p	PAR-CLIP	20371350
MIRT568937	hsa-miR-6842-5p	PAR-CLIP	20371350
MIRT568936	hsa-miR-7110-5p	PAR-CLIP	20371350
MIRT568935	hsa-miR-615-5p	PAR-CLIP	20371350
MIRT568934	hsa-miR-6751-5p	PAR-CLIP	20371350
MIRT568933	hsa-miR-6803-5p	PAR-CLIP	20371350
MIRT561651	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT028012	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT561650	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT561649	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT561648	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT561647	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT437468	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT053564	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT561645	hsa-miR-3609	PAR-CLIP	20371350
MIRT561646	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT561644	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT561643	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT561642	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT561641	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT561640	hsa-miR-4802-5p	PAR-CLIP	20371350
MIRT561639	hsa-miR-4490	PAR-CLIP	20371350
MIRT565941	hsa-miR-3137	PAR-CLIP	20371350
MIRT565940	hsa-miR-20b-3p	PAR-CLIP	20371350
MIRT561638	hsa-miR-3160-3p	PAR-CLIP	20371350
MIRT561637	hsa-miR-558	PAR-CLIP	20371350
MIRT561636	hsa-miR-4487	PAR-CLIP	20371350
MIRT561635	hsa-miR-133a-5p	PAR-CLIP	20371350
MIRT561634	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT561633	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT561632	hsa-miR-765	PAR-CLIP	20371350
MIRT561631	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT565938	hsa-miR-6753-3p	PAR-CLIP	20371350
MIRT565939	hsa-miR-7107-3p	PAR-CLIP	20371350
MIRT561630	hsa-miR-5011-3p	PAR-CLIP	20371350
MIRT561651	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT028012	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT561650	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT561649	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT561648	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT561647	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT437468	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT053564	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT561645	hsa-miR-3609	PAR-CLIP	20371350
MIRT561646	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT561644	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT561643	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT561642	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT561641	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT561640	hsa-miR-4802-5p	PAR-CLIP	20371350
MIRT561639	hsa-miR-4490	PAR-CLIP	20371350
MIRT561638	hsa-miR-3160-3p	PAR-CLIP	20371350
MIRT561637	hsa-miR-558	PAR-CLIP	20371350
MIRT561636	hsa-miR-4487	PAR-CLIP	20371350
MIRT561635	hsa-miR-133a-5p	PAR-CLIP	20371350
MIRT561634	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT561633	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT561632	hsa-miR-765	PAR-CLIP	20371350
MIRT561631	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT561630	hsa-miR-5011-3p	PAR-CLIP	20371350
MIRT439719	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439719	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT007055	hsa-miR-130a-3p	SNU16	26375442
MIRT731247	hsa-miR-495-3p	SNU16	26375442
MIRT007055	hsa-miR-130a-3p	Luciferase reporter assay, qRT-PCR, Western blot	26134263
MIRT007055	hsa-miR-130a-3p	Luciferase reporter assay, qRT-PCR, Western blot	26134263
MIRT007055	hsa-miR-130a-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26375442
MIRT007055	hsa-miR-130a-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26375442
MIRT731247	hsa-miR-495-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26375442
MIRT731247	hsa-miR-495-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26375442
MIRT000038	hsa-miR-532-5p	Luciferase reporter assay, qRT-PCR, Western blot	26515139
MIRT000038	hsa-miR-532-5p	Luciferase reporter assay, qRT-PCR, Western blot	26515139
MIRT561650	hsa-miR-20a-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27748919
MIRT561650	hsa-miR-20a-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27748919
MIRT568945	hsa-miR-1237-5p	PAR-CLIP	26701625
MIRT568945	hsa-miR-1237-5p	PAR-CLIP	26701625
MIRT568949	hsa-miR-3175	PAR-CLIP	26701625
MIRT568949	hsa-miR-3175	PAR-CLIP	26701625
MIRT568943	hsa-miR-4488	PAR-CLIP	26701625
MIRT568943	hsa-miR-4488	PAR-CLIP	26701625
MIRT568941	hsa-miR-4697-5p	PAR-CLIP	26701625
MIRT568941	hsa-miR-4697-5p	PAR-CLIP	26701625
MIRT568948	hsa-miR-4723-5p	PAR-CLIP	26701625
MIRT568947	hsa-miR-5698	PAR-CLIP	26701625
MIRT568935	hsa-miR-615-5p	PAR-CLIP	26701625
MIRT568935	hsa-miR-615-5p	PAR-CLIP	26701625
MIRT568954	hsa-miR-637	PAR-CLIP	26701625
MIRT568954	hsa-miR-637	PAR-CLIP	26701625
MIRT568951	hsa-miR-6731-5p	PAR-CLIP	26701625
MIRT568951	hsa-miR-6731-5p	PAR-CLIP	26701625
MIRT568934	hsa-miR-6751-5p	PAR-CLIP	26701625
MIRT568934	hsa-miR-6751-5p	PAR-CLIP	26701625
MIRT568938	hsa-miR-6752-5p	PAR-CLIP	26701625
MIRT568938	hsa-miR-6752-5p	PAR-CLIP	26701625
MIRT568942	hsa-miR-6795-5p	PAR-CLIP	26701625
MIRT568942	hsa-miR-6795-5p	PAR-CLIP	26701625
MIRT568933	hsa-miR-6803-5p	PAR-CLIP	26701625
MIRT568933	hsa-miR-6803-5p	PAR-CLIP	26701625
MIRT568939	hsa-miR-6835-5p	PAR-CLIP	26701625
MIRT568939	hsa-miR-6835-5p	PAR-CLIP	26701625
MIRT568937	hsa-miR-6842-5p	PAR-CLIP	26701625
MIRT568937	hsa-miR-6842-5p	PAR-CLIP	26701625
MIRT568946	hsa-miR-6870-5p	PAR-CLIP	26701625
MIRT568940	hsa-miR-6887-5p	PAR-CLIP	26701625
MIRT568940	hsa-miR-6887-5p	PAR-CLIP	26701625
MIRT568936	hsa-miR-7110-5p	PAR-CLIP	26701625
MIRT568936	hsa-miR-7110-5p	PAR-CLIP	26701625
MIRT568944	hsa-miR-7111-5p	PAR-CLIP	26701625
MIRT568950	hsa-miR-8085	PAR-CLIP	26701625
MIRT568950	hsa-miR-8085	PAR-CLIP	26701625
MIRT568953	hsa-miR-6805-5p	PAR-CLIP	20371350
MIRT568954	hsa-miR-637	PAR-CLIP	20371350
MIRT568952	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT568951	hsa-miR-6731-5p	PAR-CLIP	20371350
MIRT568950	hsa-miR-8085	PAR-CLIP	20371350
MIRT568949	hsa-miR-3175	PAR-CLIP	20371350
MIRT568948	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT568947	hsa-miR-5698	PAR-CLIP	20371350
MIRT568946	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT568944	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT568945	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT568943	hsa-miR-4488	PAR-CLIP	20371350
MIRT568941	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT568942	hsa-miR-6795-5p	PAR-CLIP	20371350
MIRT568940	hsa-miR-6887-5p	PAR-CLIP	20371350
MIRT568939	hsa-miR-6835-5p	PAR-CLIP	20371350
MIRT568938	hsa-miR-6752-5p	PAR-CLIP	20371350
MIRT568937	hsa-miR-6842-5p	PAR-CLIP	20371350
MIRT568936	hsa-miR-7110-5p	PAR-CLIP	20371350
MIRT568935	hsa-miR-615-5p	PAR-CLIP	20371350
MIRT568934	hsa-miR-6751-5p	PAR-CLIP	20371350
MIRT568933	hsa-miR-6803-5p	PAR-CLIP	20371350
MIRT561651	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT028012	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT561650	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT561649	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT561648	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT561647	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT437468	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT053564	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT561645	hsa-miR-3609	PAR-CLIP	20371350
MIRT561646	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT561644	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT561643	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT561642	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT561641	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT561640	hsa-miR-4802-5p	PAR-CLIP	20371350
MIRT561639	hsa-miR-4490	PAR-CLIP	20371350
MIRT565941	hsa-miR-3137	PAR-CLIP	20371350
MIRT565940	hsa-miR-20b-3p	PAR-CLIP	20371350
MIRT561638	hsa-miR-3160-3p	PAR-CLIP	20371350
MIRT561637	hsa-miR-558	PAR-CLIP	20371350
MIRT561636	hsa-miR-4487	PAR-CLIP	20371350
MIRT561635	hsa-miR-133a-5p	PAR-CLIP	20371350
MIRT561634	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT561633	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT561632	hsa-miR-765	PAR-CLIP	20371350
MIRT561631	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT565938	hsa-miR-6753-3p	PAR-CLIP	20371350
MIRT565939	hsa-miR-7107-3p	PAR-CLIP	20371350
MIRT561630	hsa-miR-5011-3p	PAR-CLIP	20371350
MIRT561651	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT028012	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT561650	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT561649	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT561648	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT561647	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT437468	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT053564	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT561645	hsa-miR-3609	PAR-CLIP	20371350
MIRT561646	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT561644	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT561643	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT561642	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT561641	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT561640	hsa-miR-4802-5p	PAR-CLIP	20371350
MIRT561639	hsa-miR-4490	PAR-CLIP	20371350
MIRT561638	hsa-miR-3160-3p	PAR-CLIP	20371350
MIRT561637	hsa-miR-558	PAR-CLIP	20371350
MIRT561636	hsa-miR-4487	PAR-CLIP	20371350
MIRT561635	hsa-miR-133a-5p	PAR-CLIP	20371350
MIRT561634	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT561633	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT561632	hsa-miR-765	PAR-CLIP	20371350
MIRT561631	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT561630	hsa-miR-5011-3p	PAR-CLIP	20371350
MIRT1323020	hsa-miR-1265	CLIP-seq
MIRT1323021	hsa-miR-1587	CLIP-seq
MIRT1323022	hsa-miR-214	CLIP-seq
MIRT1323023	hsa-miR-320e	CLIP-seq
MIRT1323024	hsa-miR-3619-5p	CLIP-seq
MIRT1323025	hsa-miR-378g	CLIP-seq
MIRT1323026	hsa-miR-4271	CLIP-seq
MIRT1323027	hsa-miR-4459	CLIP-seq
MIRT1323028	hsa-miR-4474-3p	CLIP-seq
MIRT1323029	hsa-miR-4492	CLIP-seq
MIRT1323030	hsa-miR-4498	CLIP-seq
MIRT1323031	hsa-miR-4505	CLIP-seq
MIRT1323032	hsa-miR-4656	CLIP-seq
MIRT1323033	hsa-miR-4661-3p	CLIP-seq
MIRT1323034	hsa-miR-4675	CLIP-seq
MIRT1323035	hsa-miR-4722-5p	CLIP-seq
MIRT1323036	hsa-miR-4725-3p	CLIP-seq
MIRT1323037	hsa-miR-4741	CLIP-seq
MIRT1323038	hsa-miR-4764-5p	CLIP-seq
MIRT1323039	hsa-miR-4779	CLIP-seq
MIRT1323040	hsa-miR-604	CLIP-seq
MIRT1323041	hsa-miR-624	CLIP-seq
MIRT1323042	hsa-miR-647	CLIP-seq
MIRT1323043	hsa-miR-761	CLIP-seq
MIRT1323044	hsa-miR-762	CLIP-seq
MIRT1323045	hsa-miR-185	CLIP-seq
MIRT1323046	hsa-miR-3150b-3p	CLIP-seq
MIRT1323047	hsa-miR-4306	CLIP-seq
MIRT1323048	hsa-miR-4644	CLIP-seq
MIRT1323049	hsa-miR-4708-5p	CLIP-seq
MIRT1323050	hsa-miR-4784	CLIP-seq
MIRT1323041	hsa-miR-624	CLIP-seq
MIRT2095860	hsa-miR-4302	CLIP-seq
MIRT2320255	hsa-miR-1224-5p	CLIP-seq
MIRT2320256	hsa-miR-1304	CLIP-seq
MIRT2320257	hsa-miR-1915	CLIP-seq
MIRT1323046	hsa-miR-3150b-3p	CLIP-seq
MIRT2320258	hsa-miR-3915	CLIP-seq
MIRT1323027	hsa-miR-4459	CLIP-seq
MIRT2320259	hsa-miR-4689	CLIP-seq
MIRT2320260	hsa-miR-4695-5p	CLIP-seq
MIRT2320261	hsa-miR-4722-3p	CLIP-seq
MIRT1323050	hsa-miR-4784	CLIP-seq
MIRT2320262	hsa-miR-495	CLIP-seq
MIRT2320263	hsa-miR-545	CLIP-seq
MIRT2320264	hsa-miR-665	CLIP-seq
MIRT2393965	hsa-miR-1293	CLIP-seq
MIRT2393966	hsa-miR-4483	CLIP-seq

Transcription factors

Show/Hide all(7)

Transcription factor	Regulation	Reference
CBFB	Unknown	24648201
DNMT1	Unknown	22274925
EHMT2	Activation	18850007
EZH2	Repression	18430739;20631058;22222375
HDAC1	Activation	18850007
HDAC1	Repression	18850007
HDAC1	Unknown	18430739;22274925

Show/Hide all(36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0000785	Component	Chromatin	ISA
GO:0000785	Component	Chromatin	ISS
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISS
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISS
GO:0001503	Process	Ossification	IBA	21873635
GO:0002062	Process	Chondrocyte differentiation	IBA	21873635
GO:0003700	Function	DNA-binding transcription factor activity	TAS	7607690
GO:0005515	Function	Protein binding	IPI	9751710, 17377532, 18772112, 20100835, 20599712, 24229708
GO:0005524	Function	ATP binding	NAS	7835892
GO:0005634	Component	Nucleus	IDA	20100835, 20599712
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	20100835, 20599712
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006355	Process	Regulation of transcription, DNA-templated	NAS	7622058
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IDA	20100835
GO:0016513	Component	Core-binding factor complex	TAS	18258917
GO:0030097	Process	Hemopoiesis	IBA	21873635
GO:0030182	Process	Neuron differentiation	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043371	Process	Negative regulation of CD4-positive, alpha-beta T cell differentiation	ISS
GO:0043378	Process	Positive regulation of CD8-positive, alpha-beta T cell differentiation	ISS
GO:0045595	Process	Regulation of cell differentiation	IBA	21873635
GO:0045786	Process	Negative regulation of cell cycle	ISS
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	20599712
GO:0048935	Process	Peripheral nervous system neuron development	TAS	20096094
GO:0050680	Process	Negative regulation of epithelial cell proliferation	ISS
GO:0071559	Process	Response to transforming growth factor beta	IDA	20599712
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
600210	10473	ENSG00000020633

Protein

UniProt ID

Q13761

Protein name

Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 a

Protein function

Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their r

PDB

5W69

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00853	Runt	55 → 184	Runt domain	Domain
PF08504	RunxI	316 → 415	Runx inhibition domain	Family

Sequence

MRIPVDPSTSRRFTPPSPAFPCGGGGGKMGENSGALSAQAAVGPGGRARPEVRSMVDVLA
DHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAE
LRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREP
RRHRQKLEDQTKPFPDRFGDLERLRMRVTPSTPSPRGSLSTTSHFSSQPQTPIQGTSELN
PFSDPRQFDRSFPTLPTLTESRFPDPRMHYPGAMSAAFPYSATPSGTSISSLSVAGMPAT
SRFHHTYLPPPYPGAPQNQSGPFQANPSPYHLYYGTSSGSYQFSMVAGSSSGGDRSPTRM
LASCTSSAASVAAGNLMNPSLGGQSDGVEADGSHSNSPTALSTPGRMDEAVWRPY

Sequence length

415

Interactions

View interactions

	KEGG		Reactome
	Th1 and Th2 cell differentiation Epstein-Barr virus infection		Binding of TCF/LEF:CTNNB1 to target gene promoters RUNX3 regulates CDKN1A transcription RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates WNT signaling RUNX3 regulates YAP1-mediated transcription RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF RUNX3 regulates BCL2L11 (BIM) transcription

Associated diseases

Show/Hide Causal Diseases (9)

Causal
Disease name	Disease term	dbSNP ID	References
Adenocarcinoma	Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular	rs121913530, rs886039394, rs121913474	21552421
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	31619474, 29785011
Carcinoma	Carcinoma, Cribriform, Carcinoma, Granular Cell	rs121912654, rs555607708, rs786202962, rs1564055259	21552421
Esophagus neoplasm	Esophageal Neoplasms, Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	18058463
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16367923
Glioblastoma	Glioblastoma, Glioblastoma Multiforme	rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888	16909125
Leukemia	Leukemia, Myelocytic, Acute, Acute Myeloid Leukemia (AML-M2)	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	18206229
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	21552421
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	23143594

Show/Hide Unknown Diseases (13)

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia		28196072
Ankylosing spondylitis	Ankylosing spondylitis		21743469
Celiac disease	Celiac Disease	rs2305764, rs35218876	20190752
Digestive system neuroendocrine neoplasm	Gastro-enteropancreatic neuroendocrine tumor		29915428
Eczema	Eczema		30595370
Giant cell glioblastoma	Giant Cell Glioblastoma		16909125
Liver carcinoma	Liver carcinoma		28458013
Lung neoplasms	Lung Neoplasms		21552421
Myeloid leukemia	Acute Myeloid Leukemia, M1		18206229
Sclerocystic ovaries	Sclerocystic Ovaries		21411543
Palmoplantar pustules	Pustulosis of Palms and Soles		23143594
Polycystic ovary syndrome	Polycystic Ovary Syndrome		21411543
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		16367923

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