AOC3 (amine oxidase copper containing 3)

Gene

• Entrez ID: 8639
• Gene name: Amine oxidase copper containing 3
• Gene symbol: AOC3
• Synonyms: HPAO, SSAO, VAP-1, VAP1
• Chromosome: 17
• Chromosome location: 17q21.31
• Summary: This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell sur

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT562752	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT562751	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT562750	hsa-miR-126-5p	PAR-CLIP	20371350
MIRT562749	hsa-miR-3622a-3p	PAR-CLIP	20371350
MIRT562748	hsa-miR-3622b-3p	PAR-CLIP	20371350
MIRT562746	hsa-miR-6765-3p	PAR-CLIP	20371350
MIRT562747	hsa-miR-4699-5p	PAR-CLIP	20371350
MIRT562745	hsa-miR-556-3p	PAR-CLIP	20371350
MIRT562744	hsa-miR-5096	PAR-CLIP	20371350
MIRT562743	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT562742	hsa-miR-1282	PAR-CLIP	20371350
MIRT451329	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT451328	hsa-miR-4459	PAR-CLIP	23592263
MIRT451327	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT451326	hsa-miR-765	PAR-CLIP	23592263
MIRT451325	hsa-miR-6800-5p	PAR-CLIP	23592263
MIRT562752	hsa-miR-5580-3p	PAR-CLIP	20371350
MIRT562751	hsa-miR-6504-3p	PAR-CLIP	20371350
MIRT562750	hsa-miR-126-5p	PAR-CLIP	20371350
MIRT562749	hsa-miR-3622a-3p	PAR-CLIP	20371350
MIRT562748	hsa-miR-3622b-3p	PAR-CLIP	20371350
MIRT562746	hsa-miR-6765-3p	PAR-CLIP	20371350
MIRT562747	hsa-miR-4699-5p	PAR-CLIP	20371350
MIRT562745	hsa-miR-556-3p	PAR-CLIP	20371350
MIRT562744	hsa-miR-5096	PAR-CLIP	20371350
MIRT562743	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT562742	hsa-miR-1282	PAR-CLIP	20371350
MIRT451329	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT451328	hsa-miR-4459	PAR-CLIP	23592263
MIRT451327	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT451326	hsa-miR-765	PAR-CLIP	23592263
MIRT451325	hsa-miR-6800-5p	PAR-CLIP	23592263
MIRT786709	hsa-miR-1293	CLIP-seq
MIRT786710	hsa-miR-22	CLIP-seq
MIRT786711	hsa-miR-3064-5p	CLIP-seq
MIRT786712	hsa-miR-3126-5p	CLIP-seq
MIRT786713	hsa-miR-3187-3p	CLIP-seq
MIRT786714	hsa-miR-326	CLIP-seq
MIRT786715	hsa-miR-330-5p	CLIP-seq
MIRT786716	hsa-miR-361-5p	CLIP-seq
MIRT786717	hsa-miR-3652	CLIP-seq
MIRT786718	hsa-miR-3664-5p	CLIP-seq
MIRT786719	hsa-miR-3714	CLIP-seq
MIRT786720	hsa-miR-3920	CLIP-seq
MIRT786721	hsa-miR-3925-3p	CLIP-seq
MIRT786722	hsa-miR-4278	CLIP-seq
MIRT786723	hsa-miR-4430	CLIP-seq
MIRT786724	hsa-miR-4435	CLIP-seq
MIRT786725	hsa-miR-4483	CLIP-seq
MIRT786726	hsa-miR-4505	CLIP-seq
MIRT786727	hsa-miR-4519	CLIP-seq
MIRT786728	hsa-miR-4520a-3p	CLIP-seq
MIRT786729	hsa-miR-4520b-3p	CLIP-seq
MIRT786730	hsa-miR-4667-3p	CLIP-seq
MIRT786731	hsa-miR-4667-5p	CLIP-seq
MIRT786732	hsa-miR-4685-5p	CLIP-seq
MIRT786733	hsa-miR-4700-5p	CLIP-seq
MIRT786734	hsa-miR-4701-5p	CLIP-seq
MIRT786735	hsa-miR-4714-5p	CLIP-seq
MIRT786736	hsa-miR-4749-3p	CLIP-seq
MIRT786737	hsa-miR-548s	CLIP-seq
MIRT786738	hsa-miR-588	CLIP-seq
MIRT786739	hsa-miR-615-5p	CLIP-seq
MIRT786740	hsa-miR-637	CLIP-seq
MIRT786741	hsa-miR-766	CLIP-seq
MIRT786742	hsa-miR-873	CLIP-seq
MIRT786743	hsa-miR-940	CLIP-seq
MIRT786744	hsa-miR-944	CLIP-seq
MIRT1932036	hsa-miR-1255a	CLIP-seq
MIRT1932037	hsa-miR-1255b	CLIP-seq
MIRT1932038	hsa-miR-1291	CLIP-seq
MIRT1932039	hsa-miR-150	CLIP-seq
MIRT1932040	hsa-miR-1913	CLIP-seq
MIRT1932041	hsa-miR-1972	CLIP-seq
MIRT1932042	hsa-miR-3173-5p	CLIP-seq
MIRT786713	hsa-miR-3187-3p	CLIP-seq
MIRT1932043	hsa-miR-3189-5p	CLIP-seq
MIRT1932044	hsa-miR-324-3p	CLIP-seq
MIRT1932045	hsa-miR-4438	CLIP-seq
MIRT1932046	hsa-miR-4474-3p	CLIP-seq
MIRT1932047	hsa-miR-4755-3p	CLIP-seq
MIRT1932048	hsa-miR-4758-3p	CLIP-seq
MIRT1932049	hsa-miR-508-5p	CLIP-seq
MIRT786741	hsa-miR-766	CLIP-seq
MIRT1932039	hsa-miR-150	CLIP-seq
MIRT2172464	hsa-miR-3160-3p	CLIP-seq
MIRT786713	hsa-miR-3187-3p	CLIP-seq
MIRT2172465	hsa-miR-3692	CLIP-seq
MIRT786719	hsa-miR-3714	CLIP-seq
MIRT2172466	hsa-miR-4436b-5p	CLIP-seq
MIRT2172467	hsa-miR-4487	CLIP-seq
MIRT1932049	hsa-miR-508-5p	CLIP-seq
MIRT2172468	hsa-miR-558	CLIP-seq
MIRT2172469	hsa-miR-626	CLIP-seq
MIRT786741	hsa-miR-766	CLIP-seq
MIRT786742	hsa-miR-873	CLIP-seq
MIRT786743	hsa-miR-940	CLIP-seq
MIRT2475425	hsa-miR-374c	CLIP-seq
MIRT2475426	hsa-miR-4698	CLIP-seq
MIRT2475427	hsa-miR-4704-3p	CLIP-seq
MIRT2475428	hsa-miR-4717-3p	CLIP-seq
MIRT2475429	hsa-miR-655	CLIP-seq
MIRT2475425	hsa-miR-374c	CLIP-seq
MIRT2475426	hsa-miR-4698	CLIP-seq
MIRT2475427	hsa-miR-4704-3p	CLIP-seq
MIRT2475428	hsa-miR-4717-3p	CLIP-seq
MIRT2475429	hsa-miR-655	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005507	Function	Copper ion binding	IBA	21873635
GO:0005507	Function	Copper ion binding	IDA	16046623, 19764817
GO:0005509	Function	Calcium ion binding	IDA	16046623, 19764817
GO:0005515	Function	Protein binding	IPI	23349812, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IDA	23349812
GO:0005769	Component	Early endosome	IBA	21873635
GO:0005769	Component	Early endosome	IDA	23474851
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IDA	23474851
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA	23474851
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	9653080
GO:0005886	Component	Plasma membrane	TAS
GO:0005902	Component	Microvillus	IDA	23349812
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0006954	Process	Inflammatory response	TAS	9653080
GO:0007155	Process	Cell adhesion	IDA	9653080
GO:0008131	Function	Primary amine oxidase activity	IDA	9653080, 19764817, 23349812, 23474851
GO:0008131	Function	Primary amine oxidase activity	IDA	23349812
GO:0009308	Process	Amine metabolic process	IBA	21873635
GO:0009308	Process	Amine metabolic process	IDA	9653080
GO:0009986	Component	Cell surface	IDA	9653080, 23349812
GO:0016021	Component	Integral component of membrane	IDA	9653080
GO:0042802	Function	Identical protein binding	IPI	16046623
GO:0046677	Process	Response to antibiotic	IBA	21873635
GO:0046677	Process	Response to antibiotic	IDA	19764817
GO:0046982	Function	Protein heterodimerization activity	IPI	23349812
GO:0048038	Function	Quinone binding	IDA	9653080
GO:0052593	Function	Tryptamine:oxygen oxidoreductase (deaminating) activity	IEA
GO:0052594	Function	Aminoacetone:oxygen oxidoreductase(deaminating) activity	IEA
GO:0052595	Function	Aliphatic-amine oxidase activity	IEA
GO:0052596	Function	Phenethylamine:oxygen oxidoreductase (deaminating) activity	IEA
GO:1902283	Process	Negative regulation of primary amine oxidase activity	IBA	21873635
GO:1902283	Process	Negative regulation of primary amine oxidase activity	IDA	23349812

Other IDs

• MIM: 603735
• HGNC: 550
• e!Ensembl: ENSG00000131471

Protein

• UniProt ID: Q16853
• Protein name: Amine oxidase [copper-containing] 3 (EC 1.4.3.21) (Amine oxidase copper-containing 3) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1)
• Protein function: Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:19588076, PubMed:24304424, PubMed:9653080). Has a preference for the primary monoamines
• PDB: 1PU4, 1US1, 2C10, 2C11, 2Y73, 2Y74, 3ALA, 4BTW, 4BTX, 4BTY, 8S1Z
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02727	Cu_amine_oxidN2	66 → 152	Copper amine oxidase, N2 domain	Domain
  PF02728	Cu_amine_oxidN3	169 → 269	Copper amine oxidase, N3 domain	Domain
  PF01179	Cu_amine_oxid	314 → 721	Copper amine oxidase, enzyme domain	Domain

• Sequence:

  MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
  ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
  AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
  QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
  HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
  SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
  YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
  APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
  PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
  AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
  RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
  SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
  DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN

• Sequence length: 763

Pathways

KEGG:

Glycine, serine and threonine metabolism
Tyrosine metabolism
Phenylalanine metabolism
beta-Alanine metabolism
Metabolic pathways

Reactome:

Phase I - Functionalization of compounds

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	23154672
Hypertension	Hypertensive disease	rs13306026, rs13333226	23154672
Kidney disease	Chronic Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	23154672
Renal insufficiency	Chronic Kidney Insufficiency	rs1596536873	23154672

Unknown
Disease name	Disease term	dbSNP ID	References
Diabetic nephropathy	Diabetic Nephropathy		14977883
Glomerulosclerosis	Nodular glomerulosclerosis		14977883
Paratuberculosis	Paratuberculosis		22633222