OASL (2'-5'-oligoadenylate synthetase like)

Gene

• Entrez ID: 8638
• Gene name: 2'-5'-oligoadenylate synthetase like
• Gene symbol: OASL
• Synonyms: OASL1, OASLd, TRIP-14, TRIP14, p59 OASL, p59-OASL, p59OASL
• Chromosome: 12
• Chromosome location: 12q24.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021250	hsa-miR-146a-5p	Microarray	18057241
MIRT022684	hsa-miR-124-3p	Microarray	18668037
MIRT023766	hsa-miR-1-3p	Microarray	18668037
MIRT1201245	hsa-miR-3934	CLIP-seq
MIRT1201246	hsa-miR-5095	CLIP-seq
MIRT1201247	hsa-miR-552	CLIP-seq
MIRT1201248	hsa-miR-610	CLIP-seq
MIRT2058150	hsa-miR-1224-3p	CLIP-seq
MIRT2058151	hsa-miR-1234	CLIP-seq
MIRT2058152	hsa-miR-1260	CLIP-seq
MIRT2058153	hsa-miR-1260b	CLIP-seq
MIRT2058154	hsa-miR-1280	CLIP-seq
MIRT2058155	hsa-miR-4268	CLIP-seq
MIRT2058156	hsa-miR-518e	CLIP-seq
MIRT2058157	hsa-miR-532-3p	CLIP-seq
MIRT2058150	hsa-miR-1224-3p	CLIP-seq
MIRT2058151	hsa-miR-1234	CLIP-seq
MIRT2584635	hsa-miR-1255a	CLIP-seq
MIRT2584636	hsa-miR-1255b	CLIP-seq
MIRT2058152	hsa-miR-1260	CLIP-seq
MIRT2058153	hsa-miR-1260b	CLIP-seq
MIRT2058154	hsa-miR-1280	CLIP-seq
MIRT2584637	hsa-miR-1299	CLIP-seq
MIRT2584638	hsa-miR-150	CLIP-seq
MIRT2584639	hsa-miR-1912	CLIP-seq
MIRT2584640	hsa-miR-3130-5p	CLIP-seq
MIRT2584641	hsa-miR-3176	CLIP-seq
MIRT2584642	hsa-miR-3192	CLIP-seq
MIRT2584643	hsa-miR-3545-3p	CLIP-seq
MIRT2584644	hsa-miR-3649	CLIP-seq
MIRT2584645	hsa-miR-3661	CLIP-seq
MIRT2584646	hsa-miR-3663-5p	CLIP-seq
MIRT2584647	hsa-miR-3919	CLIP-seq
MIRT2584648	hsa-miR-3922-3p	CLIP-seq
MIRT1201245	hsa-miR-3934	CLIP-seq
MIRT2058155	hsa-miR-4268	CLIP-seq
MIRT2584649	hsa-miR-4289	CLIP-seq
MIRT2584650	hsa-miR-4299	CLIP-seq
MIRT2584651	hsa-miR-4314	CLIP-seq
MIRT2584652	hsa-miR-4482	CLIP-seq
MIRT2584653	hsa-miR-4635	CLIP-seq
MIRT2584654	hsa-miR-4638-5p	CLIP-seq
MIRT2584655	hsa-miR-4646-5p	CLIP-seq
MIRT2584656	hsa-miR-4680-5p	CLIP-seq
MIRT2584657	hsa-miR-4713-5p	CLIP-seq
MIRT2584658	hsa-miR-4782-5p	CLIP-seq
MIRT2584659	hsa-miR-4797-5p	CLIP-seq
MIRT2584660	hsa-miR-4802-3p	CLIP-seq
MIRT1201246	hsa-miR-5095	CLIP-seq
MIRT2584661	hsa-miR-516b	CLIP-seq
MIRT2058156	hsa-miR-518e	CLIP-seq
MIRT2058157	hsa-miR-532-3p	CLIP-seq
MIRT2584662	hsa-miR-548a-3p	CLIP-seq
MIRT2584663	hsa-miR-548e	CLIP-seq
MIRT2584664	hsa-miR-548f	CLIP-seq
MIRT1201247	hsa-miR-552	CLIP-seq
MIRT2584665	hsa-miR-582-3p	CLIP-seq
MIRT1201248	hsa-miR-610	CLIP-seq
MIRT2584666	hsa-miR-631	CLIP-seq
MIRT2584667	hsa-miR-661	CLIP-seq
MIRT2584668	hsa-miR-936	CLIP-seq
MIRT2058150	hsa-miR-1224-3p	CLIP-seq
MIRT2058151	hsa-miR-1234	CLIP-seq
MIRT2584635	hsa-miR-1255a	CLIP-seq
MIRT2584636	hsa-miR-1255b	CLIP-seq
MIRT2058152	hsa-miR-1260	CLIP-seq
MIRT2058153	hsa-miR-1260b	CLIP-seq
MIRT2058154	hsa-miR-1280	CLIP-seq
MIRT2584637	hsa-miR-1299	CLIP-seq
MIRT2584638	hsa-miR-150	CLIP-seq
MIRT2584639	hsa-miR-1912	CLIP-seq
MIRT2584640	hsa-miR-3130-5p	CLIP-seq
MIRT2584641	hsa-miR-3176	CLIP-seq
MIRT2584642	hsa-miR-3192	CLIP-seq
MIRT2584643	hsa-miR-3545-3p	CLIP-seq
MIRT2584644	hsa-miR-3649	CLIP-seq
MIRT2584645	hsa-miR-3661	CLIP-seq
MIRT2584646	hsa-miR-3663-5p	CLIP-seq
MIRT2584647	hsa-miR-3919	CLIP-seq
MIRT2584648	hsa-miR-3922-3p	CLIP-seq
MIRT1201245	hsa-miR-3934	CLIP-seq
MIRT2058155	hsa-miR-4268	CLIP-seq
MIRT2584649	hsa-miR-4289	CLIP-seq
MIRT2584650	hsa-miR-4299	CLIP-seq
MIRT2584651	hsa-miR-4314	CLIP-seq
MIRT2584652	hsa-miR-4482	CLIP-seq
MIRT2584653	hsa-miR-4635	CLIP-seq
MIRT2584654	hsa-miR-4638-5p	CLIP-seq
MIRT2584655	hsa-miR-4646-5p	CLIP-seq
MIRT2584656	hsa-miR-4680-5p	CLIP-seq
MIRT2584657	hsa-miR-4713-5p	CLIP-seq
MIRT2584658	hsa-miR-4782-5p	CLIP-seq
MIRT2584659	hsa-miR-4797-5p	CLIP-seq
MIRT2584660	hsa-miR-4802-3p	CLIP-seq
MIRT1201246	hsa-miR-5095	CLIP-seq
MIRT2584661	hsa-miR-516b	CLIP-seq
MIRT2058156	hsa-miR-518e	CLIP-seq
MIRT2058157	hsa-miR-532-3p	CLIP-seq
MIRT2584662	hsa-miR-548a-3p	CLIP-seq
MIRT2584663	hsa-miR-548e	CLIP-seq
MIRT2584664	hsa-miR-548f	CLIP-seq
MIRT1201247	hsa-miR-552	CLIP-seq
MIRT2584665	hsa-miR-582-3p	CLIP-seq
MIRT1201248	hsa-miR-610	CLIP-seq
MIRT2584666	hsa-miR-631	CLIP-seq
MIRT2584667	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001730	Function	2'-5'-oligoadenylate synthetase activity	IDA	9826176
GO:0003677	Function	DNA binding	IDA	9826176
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003725	Function	Double-stranded RNA binding	IBA	21873635
GO:0003725	Function	Double-stranded RNA binding	IDA	9826176
GO:0005515	Function	Protein binding	IPI	30833792
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA	9826176
GO:0005737	Component	Cytoplasm	IDA	9826176
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0009615	Process	Response to virus	IDA	18931074, 20074559
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0045071	Process	Negative regulation of viral genome replication	IBA	21873635
GO:0045071	Process	Negative regulation of viral genome replication	IDA	18931074, 20074559
GO:0046966	Function	Thyroid hormone receptor binding	TAS	7776974
GO:0051607	Process	Defense response to virus	IBA	21873635
GO:0051607	Process	Defense response to virus	IDA	21478870
GO:0051607	Process	Defense response to virus	TAS
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0060337	Process	Type I interferon signaling pathway	TAS
GO:0060700	Process	Regulation of ribonuclease activity	IBA	21873635

Other IDs

• MIM: 603281
• HGNC: 8090
• e!Ensembl: ENSG00000135114

Protein

• UniProt ID: Q15646
• Protein name: 2'-5'-oligoadenylate synthase-like protein (2'-5'-OAS-related protein) (2'-5'-OAS-RP) (59 kDa 2'-5'-oligoadenylate synthase-like protein) (Thyroid receptor-interacting protein 14) (TR-interacting protein 14) (TRIP-14) (p59 OASL) (p59OASL)
• Protein function: Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMe
• PDB: 1WH3, 4XQ7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10421	OAS1_C	168 → 351		Domain
  PF00240	ubiquitin	436 → 507	Ubiquitin family	Domain

• Sequence:

  MALMQELYSTPASRLDSFVAQWLQPHREWKEEVLDAVRTVEEFLRQEHFQGKRGLDQDVR
  VLKVVKVGSFGNGTVLRSTREVELVAFLSCFHSFQEAAKHHKDVLRLIWKTMWQSQDLLD
  LGLEDLRMEQRVPDALVFTIQTRGTAEPITVTIVPAYRALGPSLPNSQPPPEVYVSLIKA
  CGGPGNFCPSFSELQRNFVKHRPTKLKSLLRLVKHWYQQYVKARSPRANLPPLYALELLT
  IYAWEMGTEEDENFMLDEGFTTVMDLLLEYEVICIYWTKYYTLHNAIIEDCVRKQLKKER
  PIILDPADPTLNVAEGYRWDIVAQRASQCLKQDCCYDNRENPISSWNVKRARDIHLTVEQ
  RGYPDFNLIVNPYEPIRKVKEKIRRTRGYSGLQRLSFQVPGSERQLLSSRCSLAKYGIFS
  HTHIYLLETIPSEIQVFVKNPDGGSYAYAINPNSFILGLKQQIEDQQGLPKKQQQLEFQG
  QVLQDWLGLGIYGIQDSDTLILSKKKGEALFPAS

• Sequence length: 514

Pathways

KEGG:

Human papillomavirus infection

Reactome:

Interferon gamma signaling
OAS antiviral response
Interferon alpha/beta signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	20581827, 23300278, 21647700, 22885922, 28869590