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CADPS (calcium dependent secretion activator)

Gene

Calcium dependent secretion activator

CADPS

CADPS1, CAPS, CAPS1, UNC-31

3

3p14.2

This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves th

Show/Hide all(128)

miRTarBase ID	miRNA	Experiments	Reference
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	24906430
MIRT608230	hsa-miR-4643	HITS-CLIP	24906430
MIRT608229	hsa-miR-377-3p	HITS-CLIP	24906430
MIRT608228	hsa-miR-5096	HITS-CLIP	24906430
MIRT672808	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT672808	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT672808	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT672808	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT672808	hsa-miR-335-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608229	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT608230	hsa-miR-4643	HITS-CLIP	27418678
MIRT608230	hsa-miR-4643	HITS-CLIP	27418678
MIRT608230	hsa-miR-4643	HITS-CLIP	27418678
MIRT608228	hsa-miR-5096	HITS-CLIP	27418678
MIRT608228	hsa-miR-5096	HITS-CLIP	27418678
MIRT608228	hsa-miR-5096	HITS-CLIP	27418678
MIRT608228	hsa-miR-5096	HITS-CLIP	27418678
MIRT608228	hsa-miR-5096	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	27418678
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608229	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT608228	hsa-miR-5096	HITS-CLIP	23824327
MIRT672808	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT608231	hsa-miR-8485	HITS-CLIP	23824327
MIRT608230	hsa-miR-4643	HITS-CLIP	23824327
MIRT609474	hsa-miR-8064	HITS-CLIP	23824327
MIRT858697	hsa-miR-103a	CLIP-seq
MIRT858698	hsa-miR-107	CLIP-seq
MIRT858699	hsa-miR-1183	CLIP-seq
MIRT858700	hsa-miR-1184	CLIP-seq
MIRT858701	hsa-miR-1205	CLIP-seq
MIRT858702	hsa-miR-124	CLIP-seq
MIRT858703	hsa-miR-1915	CLIP-seq
MIRT858704	hsa-miR-296-3p	CLIP-seq
MIRT858705	hsa-miR-3158-5p	CLIP-seq
MIRT858706	hsa-miR-3688-3p	CLIP-seq
MIRT858707	hsa-miR-3714	CLIP-seq
MIRT858708	hsa-miR-3910	CLIP-seq
MIRT858709	hsa-miR-3944-5p	CLIP-seq
MIRT858710	hsa-miR-3978	CLIP-seq
MIRT858711	hsa-miR-410	CLIP-seq
MIRT858712	hsa-miR-4666-5p	CLIP-seq
MIRT858713	hsa-miR-4802-3p	CLIP-seq
MIRT858714	hsa-miR-506	CLIP-seq
MIRT858715	hsa-miR-545	CLIP-seq
MIRT2495787	hsa-miR-136	CLIP-seq
MIRT2495788	hsa-miR-144	CLIP-seq
MIRT2495789	hsa-miR-186	CLIP-seq
MIRT2495790	hsa-miR-3133	CLIP-seq
MIRT2495791	hsa-miR-4790-3p	CLIP-seq
MIRT2495792	hsa-miR-515-5p	CLIP-seq
MIRT2495787	hsa-miR-136	CLIP-seq
MIRT2495788	hsa-miR-144	CLIP-seq
MIRT2495789	hsa-miR-186	CLIP-seq
MIRT2495790	hsa-miR-3133	CLIP-seq
MIRT2495791	hsa-miR-4790-3p	CLIP-seq
MIRT2495792	hsa-miR-515-5p	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17984325
GO:0005829	Component	Cytosol	TAS	1516133
GO:0006887	Process	Exocytosis	IBA	21873635
GO:0008289	Function	Lipid binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016079	Process	Synaptic vesicle exocytosis	IEA
GO:0019901	Function	Protein kinase binding	ISS
GO:0045921	Process	Positive regulation of exocytosis	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IBA	21873635
GO:0099012	Component	Neuronal dense core vesicle membrane	IEA
GO:1990504	Process	Dense core granule exocytosis	IEA

MIM	HGNC	e!Ensembl
604667	1426	ENSG00000163618

Protein

UniProt ID

Protein name

Calcium-dependent secretion activator 1 (Calcium-dependent activator protein for secretion 1) (CAPS-1)

Protein function

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs.

PDB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	522 → 624	PH domain	Domain
PF06292	DUF1041	836 → 940	Domain of Unknown Function (DUF1041)	Domain

Sequence

MLDPSSSEEESDEIVEEESGKEVLGSAPSGARLSPSRTSEGSAGSAGLGGGGAGAGAGVG
AGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQ
LYVFVMRCIAYPFNAKQPTDMARRQQKISKQQLQTVKDRFQAFLNGETQIMADEAFMNAV
QSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAK
FDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNP
DEQAAQIRRELDGRLQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVS
KGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVVLSFSLEVVIMEVQGLKSLAPNRIVY
CTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRV
ILHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWAIGKNVWKRWK
KRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGD
TVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFYADRA
QKHGMDEFISSNPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNG
VRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFE
EIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRK
CLEQAALVNYSRLSEYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHH
AEPHVDKGEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRT
DYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNL
PNVNLPKVPNLPVNIPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRD
LHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNV
MVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYD
EGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQ
WYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRN
RLTVEEATASVSEGGGLQGISMKDSDEEDEEDD

Sequence length

1353

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Autism spectrum disorder	Autism Spectrum Disorders	rs724159978, rs75184679, rs119103221, rs9332964, rs121912562, rs1594344233, rs727504317, rs111033204, rs1801086, rs587784464, rs724159948, rs764659822, rs794727977, rs796052733, rs796052728, rs762292772, rs864321694, rs869312878, rs758432471, rs750896617, rs886039692, rs886039770, rs201037487, rs200483989, rs1057518198, rs1057517708, rs780267761, rs1555910143, rs1057519632, rs775225727, rs751037529, rs1064794848, rs1064795655, rs1131691548, rs1135401811, rs1553248081, rs1454466097, rs1554480537, rs1553578503, rs1553518509, rs774152851, rs1554481395, rs1554464807, rs1554401434, rs1452048149, rs370498156, rs756691187, rs1557863430, rs1557863440, rs1557863546, rs769581210, rs202098093, rs1276388879, rs778792467, rs760059077, rs373783340, rs1557867853, rs772572695, rs753214391, rs749270162, rs548226228, rs1557870645, rs1557874046, rs749548928, rs754532606, rs1557901347, rs1557902023, rs1557909572, rs574335012, rs1557909821, rs1372713010, rs561369202, rs1476293577, rs1557910728, rs1557911386, rs375045125, rs998675361, rs1557916296, rs1557935477, rs866632178, rs1561824498, rs1396313317, rs1564801388, rs1564801473, rs1564950387, rs1565527302, rs1569513495, rs1569305431, rs143944436, rs1563183492, rs1561846159, rs1565819425, rs1562957809, rs1585645641, rs1585016242, rs1595127294, rs1585667374, rs1585653028, rs1585653240, rs1592919048, rs1585645384, rs1789927813	30804558
Glaucoma	Glaucoma, Open-Angle	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs1558603396, rs387907175, rs587778873, rs587778875, rs104894979, rs137854895, rs766425037, rs72549380, rs148542782, rs541217363, rs753021890, rs771076928, rs56010818, rs777678299, rs1446110883, rs1573274915, rs1587545234, rs751768343, rs944452644	22605921

Show/Hide Unknown Diseases (2)

Unknown
Disease name	Disease term	dbSNP ID	References
Development disorder	Child Development Disorders, Pervasive		30804558
Impaired cognition	Impaired cognition		26252872

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