USO1 (USO1 vesicle transport factor)

Gene

• Entrez ID: 8615
• Gene name: USO1 vesicle transport factor
• Gene symbol: USO1
• Synonyms: P115, TAP, VDP
• Chromosome: 4
• Chromosome location: 4q21.1
• Summary: The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003825	hsa-miR-197-3p	Microarray	16822819
MIRT017638	hsa-miR-335-5p	Microarray	18185580
MIRT032299	hsa-let-7b-5p	Proteomics	18668040
MIRT039355	hsa-miR-421	CLASH	23622248
MIRT1477270	hsa-let-7a	CLIP-seq
MIRT1477271	hsa-let-7b	CLIP-seq
MIRT1477272	hsa-let-7c	CLIP-seq
MIRT1477273	hsa-let-7d	CLIP-seq
MIRT1477274	hsa-let-7e	CLIP-seq
MIRT1477275	hsa-let-7f	CLIP-seq
MIRT1477276	hsa-let-7g	CLIP-seq
MIRT1477277	hsa-let-7i	CLIP-seq
MIRT1477278	hsa-miR-1	CLIP-seq
MIRT1477279	hsa-miR-1208	CLIP-seq
MIRT1477280	hsa-miR-127-5p	CLIP-seq
MIRT1477281	hsa-miR-1293	CLIP-seq
MIRT1477282	hsa-miR-1305	CLIP-seq
MIRT1477283	hsa-miR-197	CLIP-seq
MIRT1477284	hsa-miR-202	CLIP-seq
MIRT1477285	hsa-miR-206	CLIP-seq
MIRT1477286	hsa-miR-23a	CLIP-seq
MIRT1477287	hsa-miR-23b	CLIP-seq
MIRT1477288	hsa-miR-23c	CLIP-seq
MIRT1477289	hsa-miR-3200-5p	CLIP-seq
MIRT1477290	hsa-miR-323-3p	CLIP-seq
MIRT1477291	hsa-miR-345	CLIP-seq
MIRT1477292	hsa-miR-3662	CLIP-seq
MIRT1477293	hsa-miR-3668	CLIP-seq
MIRT1477294	hsa-miR-3673	CLIP-seq
MIRT1477295	hsa-miR-3688-3p	CLIP-seq
MIRT1477296	hsa-miR-3688-5p	CLIP-seq
MIRT1477297	hsa-miR-374c	CLIP-seq
MIRT1477298	hsa-miR-412	CLIP-seq
MIRT1477299	hsa-miR-4291	CLIP-seq
MIRT1477300	hsa-miR-4310	CLIP-seq
MIRT1477301	hsa-miR-4420	CLIP-seq
MIRT1477302	hsa-miR-4458	CLIP-seq
MIRT1477303	hsa-miR-4483	CLIP-seq
MIRT1477304	hsa-miR-4500	CLIP-seq
MIRT1477305	hsa-miR-4684-3p	CLIP-seq
MIRT1477306	hsa-miR-4694-5p	CLIP-seq
MIRT1477307	hsa-miR-4705	CLIP-seq
MIRT1477308	hsa-miR-4778-3p	CLIP-seq
MIRT1477309	hsa-miR-518a-5p	CLIP-seq
MIRT1477310	hsa-miR-520d-5p	CLIP-seq
MIRT1477311	hsa-miR-522	CLIP-seq
MIRT1477312	hsa-miR-524-5p	CLIP-seq
MIRT1477313	hsa-miR-527	CLIP-seq
MIRT1477314	hsa-miR-532-5p	CLIP-seq
MIRT1477315	hsa-miR-545	CLIP-seq
MIRT1477316	hsa-miR-548aa	CLIP-seq
MIRT1477317	hsa-miR-548p	CLIP-seq
MIRT1477318	hsa-miR-561	CLIP-seq
MIRT1477319	hsa-miR-592	CLIP-seq
MIRT1477320	hsa-miR-597	CLIP-seq
MIRT1477321	hsa-miR-613	CLIP-seq
MIRT1477322	hsa-miR-655	CLIP-seq
MIRT1477323	hsa-miR-892a	CLIP-seq
MIRT1477324	hsa-miR-98	CLIP-seq
MIRT1477270	hsa-let-7a	CLIP-seq
MIRT1477271	hsa-let-7b	CLIP-seq
MIRT1477272	hsa-let-7c	CLIP-seq
MIRT1477273	hsa-let-7d	CLIP-seq
MIRT1477274	hsa-let-7e	CLIP-seq
MIRT1477275	hsa-let-7f	CLIP-seq
MIRT1477276	hsa-let-7g	CLIP-seq
MIRT1477277	hsa-let-7i	CLIP-seq
MIRT1477278	hsa-miR-1	CLIP-seq
MIRT2143738	hsa-miR-124	CLIP-seq
MIRT1477284	hsa-miR-202	CLIP-seq
MIRT1477285	hsa-miR-206	CLIP-seq
MIRT1477286	hsa-miR-23a	CLIP-seq
MIRT1477287	hsa-miR-23b	CLIP-seq
MIRT1477288	hsa-miR-23c	CLIP-seq
MIRT2143739	hsa-miR-320e	CLIP-seq
MIRT1477294	hsa-miR-3673	CLIP-seq
MIRT1477295	hsa-miR-3688-3p	CLIP-seq
MIRT2143740	hsa-miR-3689d	CLIP-seq
MIRT2143741	hsa-miR-3692	CLIP-seq
MIRT2143742	hsa-miR-3908	CLIP-seq
MIRT2143743	hsa-miR-3922-5p	CLIP-seq
MIRT2143744	hsa-miR-3942-5p	CLIP-seq
MIRT1477298	hsa-miR-412	CLIP-seq
MIRT2143745	hsa-miR-4263	CLIP-seq
MIRT2143746	hsa-miR-4307	CLIP-seq
MIRT1477301	hsa-miR-4420	CLIP-seq
MIRT1477302	hsa-miR-4458	CLIP-seq
MIRT1477304	hsa-miR-4500	CLIP-seq
MIRT2143747	hsa-miR-4703-5p	CLIP-seq
MIRT1477307	hsa-miR-4705	CLIP-seq
MIRT2143748	hsa-miR-4766-3p	CLIP-seq
MIRT1477308	hsa-miR-4778-3p	CLIP-seq
MIRT2143749	hsa-miR-4799-5p	CLIP-seq
MIRT2143750	hsa-miR-4802-5p	CLIP-seq
MIRT2143751	hsa-miR-506	CLIP-seq
MIRT2143752	hsa-miR-513a-3p	CLIP-seq
MIRT1477318	hsa-miR-561	CLIP-seq
MIRT2143753	hsa-miR-576-3p	CLIP-seq
MIRT2143754	hsa-miR-576-5p	CLIP-seq
MIRT2143755	hsa-miR-587	CLIP-seq
MIRT1477321	hsa-miR-613	CLIP-seq
MIRT2143756	hsa-miR-676	CLIP-seq
MIRT1477324	hsa-miR-98	CLIP-seq
MIRT1477270	hsa-let-7a	CLIP-seq
MIRT1477271	hsa-let-7b	CLIP-seq
MIRT1477272	hsa-let-7c	CLIP-seq
MIRT1477273	hsa-let-7d	CLIP-seq
MIRT1477274	hsa-let-7e	CLIP-seq
MIRT1477275	hsa-let-7f	CLIP-seq
MIRT1477276	hsa-let-7g	CLIP-seq
MIRT1477277	hsa-let-7i	CLIP-seq
MIRT1477278	hsa-miR-1	CLIP-seq
MIRT1477279	hsa-miR-1208	CLIP-seq
MIRT2143738	hsa-miR-124	CLIP-seq
MIRT1477281	hsa-miR-1293	CLIP-seq
MIRT2364038	hsa-miR-1303	CLIP-seq
MIRT1477282	hsa-miR-1305	CLIP-seq
MIRT2364039	hsa-miR-193a-5p	CLIP-seq
MIRT1477284	hsa-miR-202	CLIP-seq
MIRT1477285	hsa-miR-206	CLIP-seq
MIRT1477286	hsa-miR-23a	CLIP-seq
MIRT1477287	hsa-miR-23b	CLIP-seq
MIRT1477288	hsa-miR-23c	CLIP-seq
MIRT2364040	hsa-miR-3074-3p	CLIP-seq
MIRT2143739	hsa-miR-320e	CLIP-seq
MIRT1477290	hsa-miR-323-3p	CLIP-seq
MIRT2364041	hsa-miR-365	CLIP-seq
MIRT1477293	hsa-miR-3668	CLIP-seq
MIRT1477294	hsa-miR-3673	CLIP-seq
MIRT1477295	hsa-miR-3688-3p	CLIP-seq
MIRT1477296	hsa-miR-3688-5p	CLIP-seq
MIRT2143740	hsa-miR-3689d	CLIP-seq
MIRT1477297	hsa-miR-374c	CLIP-seq
MIRT2143743	hsa-miR-3922-5p	CLIP-seq
MIRT1477298	hsa-miR-412	CLIP-seq
MIRT2143745	hsa-miR-4263	CLIP-seq
MIRT1477300	hsa-miR-4310	CLIP-seq
MIRT2364042	hsa-miR-4328	CLIP-seq
MIRT1477301	hsa-miR-4420	CLIP-seq
MIRT1477302	hsa-miR-4458	CLIP-seq
MIRT2364043	hsa-miR-4477b	CLIP-seq
MIRT1477303	hsa-miR-4483	CLIP-seq
MIRT1477304	hsa-miR-4500	CLIP-seq
MIRT1477305	hsa-miR-4684-3p	CLIP-seq
MIRT1477307	hsa-miR-4705	CLIP-seq
MIRT1477308	hsa-miR-4778-3p	CLIP-seq
MIRT2143750	hsa-miR-4802-5p	CLIP-seq
MIRT2364044	hsa-miR-487a	CLIP-seq
MIRT2364045	hsa-miR-499-3p	CLIP-seq
MIRT2364046	hsa-miR-499a-3p	CLIP-seq
MIRT2143751	hsa-miR-506	CLIP-seq
MIRT1477309	hsa-miR-518a-5p	CLIP-seq
MIRT1477310	hsa-miR-520d-5p	CLIP-seq
MIRT1477312	hsa-miR-524-5p	CLIP-seq
MIRT1477313	hsa-miR-527	CLIP-seq
MIRT1477316	hsa-miR-548aa	CLIP-seq
MIRT1477318	hsa-miR-561	CLIP-seq
MIRT2143755	hsa-miR-587	CLIP-seq
MIRT1477321	hsa-miR-613	CLIP-seq
MIRT1477322	hsa-miR-655	CLIP-seq
MIRT2143756	hsa-miR-676	CLIP-seq
MIRT2364047	hsa-miR-759	CLIP-seq
MIRT1477323	hsa-miR-892a	CLIP-seq
MIRT1477324	hsa-miR-98	CLIP-seq
MIRT1477270	hsa-let-7a	CLIP-seq
MIRT1477271	hsa-let-7b	CLIP-seq
MIRT1477272	hsa-let-7c	CLIP-seq
MIRT1477273	hsa-let-7d	CLIP-seq
MIRT1477274	hsa-let-7e	CLIP-seq
MIRT1477275	hsa-let-7f	CLIP-seq
MIRT1477276	hsa-let-7g	CLIP-seq
MIRT1477277	hsa-let-7i	CLIP-seq
MIRT1477278	hsa-miR-1	CLIP-seq
MIRT1477284	hsa-miR-202	CLIP-seq
MIRT1477285	hsa-miR-206	CLIP-seq
MIRT1477294	hsa-miR-3673	CLIP-seq
MIRT1477295	hsa-miR-3688-3p	CLIP-seq
MIRT1477298	hsa-miR-412	CLIP-seq
MIRT1477301	hsa-miR-4420	CLIP-seq
MIRT1477302	hsa-miR-4458	CLIP-seq
MIRT1477304	hsa-miR-4500	CLIP-seq
MIRT1477308	hsa-miR-4778-3p	CLIP-seq
MIRT2143753	hsa-miR-576-3p	CLIP-seq
MIRT1477321	hsa-miR-613	CLIP-seq
MIRT1477324	hsa-miR-98	CLIP-seq
MIRT2434459	hsa-miR-150	CLIP-seq
MIRT1477299	hsa-miR-4291	CLIP-seq
MIRT2434460	hsa-miR-4764-3p	CLIP-seq
MIRT1477315	hsa-miR-545	CLIP-seq
MIRT1477317	hsa-miR-548p	CLIP-seq
MIRT2657754	hsa-miR-105	CLIP-seq
MIRT2657755	hsa-miR-1245b-3p	CLIP-seq
MIRT2657756	hsa-miR-1246	CLIP-seq
MIRT1477280	hsa-miR-127-5p	CLIP-seq
MIRT2657757	hsa-miR-1290	CLIP-seq
MIRT2657758	hsa-miR-1302	CLIP-seq
MIRT1477282	hsa-miR-1305	CLIP-seq
MIRT2434459	hsa-miR-150	CLIP-seq
MIRT2364039	hsa-miR-193a-5p	CLIP-seq
MIRT1477283	hsa-miR-197	CLIP-seq
MIRT2657759	hsa-miR-3122	CLIP-seq
MIRT2657760	hsa-miR-3129-3p	CLIP-seq
MIRT2657761	hsa-miR-3134	CLIP-seq
MIRT2657762	hsa-miR-3140-3p	CLIP-seq
MIRT2657763	hsa-miR-3167	CLIP-seq
MIRT1477292	hsa-miR-3662	CLIP-seq
MIRT2657764	hsa-miR-3913-5p	CLIP-seq
MIRT2657765	hsa-miR-3914	CLIP-seq
MIRT2657766	hsa-miR-3942-3p	CLIP-seq
MIRT1477299	hsa-miR-4291	CLIP-seq
MIRT2657767	hsa-miR-4298	CLIP-seq
MIRT2143746	hsa-miR-4307	CLIP-seq
MIRT2364042	hsa-miR-4328	CLIP-seq
MIRT2364043	hsa-miR-4477b	CLIP-seq
MIRT2657768	hsa-miR-450b-5p	CLIP-seq
MIRT2657769	hsa-miR-4517	CLIP-seq
MIRT2657770	hsa-miR-4521	CLIP-seq
MIRT2657771	hsa-miR-4680-3p	CLIP-seq
MIRT1477306	hsa-miR-4694-5p	CLIP-seq
MIRT2657772	hsa-miR-4728-3p	CLIP-seq
MIRT2657773	hsa-miR-4735-5p	CLIP-seq
MIRT2434460	hsa-miR-4764-3p	CLIP-seq
MIRT2657774	hsa-miR-4803	CLIP-seq
MIRT2364044	hsa-miR-487a	CLIP-seq
MIRT1477309	hsa-miR-518a-5p	CLIP-seq
MIRT1477311	hsa-miR-522	CLIP-seq
MIRT1477313	hsa-miR-527	CLIP-seq
MIRT1477314	hsa-miR-532-5p	CLIP-seq
MIRT1477315	hsa-miR-545	CLIP-seq
MIRT2657775	hsa-miR-548a-3p	CLIP-seq
MIRT2657776	hsa-miR-548e	CLIP-seq
MIRT2657777	hsa-miR-548f	CLIP-seq
MIRT1477317	hsa-miR-548p	CLIP-seq
MIRT2143753	hsa-miR-576-3p	CLIP-seq
MIRT2657778	hsa-miR-656	CLIP-seq
MIRT2657779	hsa-miR-876-5p	CLIP-seq
MIRT2657780	hsa-miR-888	CLIP-seq
MIRT2657754	hsa-miR-105	CLIP-seq
MIRT2657755	hsa-miR-1245b-3p	CLIP-seq
MIRT2657756	hsa-miR-1246	CLIP-seq
MIRT1477280	hsa-miR-127-5p	CLIP-seq
MIRT2657757	hsa-miR-1290	CLIP-seq
MIRT2657758	hsa-miR-1302	CLIP-seq
MIRT2434459	hsa-miR-150	CLIP-seq
MIRT1477283	hsa-miR-197	CLIP-seq
MIRT2657759	hsa-miR-3122	CLIP-seq
MIRT2657760	hsa-miR-3129-3p	CLIP-seq
MIRT2657761	hsa-miR-3134	CLIP-seq
MIRT2657762	hsa-miR-3140-3p	CLIP-seq
MIRT2657763	hsa-miR-3167	CLIP-seq
MIRT1477292	hsa-miR-3662	CLIP-seq
MIRT2657764	hsa-miR-3913-5p	CLIP-seq
MIRT2657766	hsa-miR-3942-3p	CLIP-seq
MIRT1477299	hsa-miR-4291	CLIP-seq
MIRT2657767	hsa-miR-4298	CLIP-seq
MIRT2657768	hsa-miR-450b-5p	CLIP-seq
MIRT2657770	hsa-miR-4521	CLIP-seq
MIRT1477306	hsa-miR-4694-5p	CLIP-seq
MIRT2657772	hsa-miR-4728-3p	CLIP-seq
MIRT2657773	hsa-miR-4735-5p	CLIP-seq
MIRT2434460	hsa-miR-4764-3p	CLIP-seq
MIRT1477309	hsa-miR-518a-5p	CLIP-seq
MIRT1477311	hsa-miR-522	CLIP-seq
MIRT1477313	hsa-miR-527	CLIP-seq
MIRT1477314	hsa-miR-532-5p	CLIP-seq
MIRT1477315	hsa-miR-545	CLIP-seq
MIRT1477317	hsa-miR-548p	CLIP-seq
MIRT2143753	hsa-miR-576-3p	CLIP-seq
MIRT2657779	hsa-miR-876-5p	CLIP-seq
MIRT2657780	hsa-miR-888	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0001650	Component	Fibrillar center	IDA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA
GO:0005795	Component	Golgi stack	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006886	Process	Intracellular protein transport	IBA	21873635
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA	21873635
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	ISS
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
GO:0007030	Process	Golgi organization	IEA
GO:0007264	Process	Small GTPase mediated signal transduction	IEA
GO:0012507	Component	ER to Golgi transport vesicle membrane	IBA	21873635
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0030133	Component	Transport vesicle	TAS
GO:0032252	Process	Secretory granule localization	IEA
GO:0045056	Process	Transcytosis	IBA	21873635
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0048208	Process	COPII vesicle coating	TAS
GO:0048211	Process	Golgi vesicle docking	IBA	21873635
GO:0048280	Process	Vesicle fusion with Golgi apparatus	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0061025	Process	Membrane fusion	IBA	21873635
GO:1900076	Process	Regulation of cellular response to insulin stimulus	IEA

Other IDs

• MIM: 603344
• HGNC: 30904
• e!Ensembl: ENSG00000138768

Protein

• UniProt ID: O60763
• Protein name: General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein)
• Protein function: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacti
• PDB: 2W3C
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF18770	Arm_vescicular	269 → 329	Armadillo tether-repeat of vescicular transport factor	Repeat
  PF04869	Uso1_p115_head	344 → 628	Uso1 / p115 like vesicle tethering protein, head region	Family
  PF04871	Uso1_p115_C	784 → 954	Uso1 / p115 like vesicle tethering protein, C terminal region	Family

• Sequence:

  MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQ
  AMEHLIHVLQTDRSDSEIIGYALDTLYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQ
  QENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSRE
  VIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLL
  KNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGAT
  SSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNP
  PRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVS
  AGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTN
  ILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGL
  CALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPN
  FPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIR
  EQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSE
  GAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVS
  ARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIA
  TKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEIT
  DSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLD
  HI

• Sequence length: 962

Pathways

Reactome:

COPII-mediated vesicle transport
COPI-mediated anterograde transport

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Arsenic encephalopathy	Arsenic Encephalopathy		16835338
Dermatologic disorders	Dermatologic disorders		16835338
Prostatic neoplasms	Prostatic Neoplasms		17013881