Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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858 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Caveolin 2 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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CAV2 |
SynonymsGene synonyms aliases
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CAV |
ChromosomeChromosome number
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7 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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7q31.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control a |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000139 |
Component |
Golgi membrane |
IEA |
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GO:0001937 |
Process |
Negative regulation of endothelial cell proliferation |
IBA |
21873635 |
GO:0001937 |
Process |
Negative regulation of endothelial cell proliferation |
ISS |
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GO:0001938 |
Process |
Positive regulation of endothelial cell proliferation |
IEA |
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GO:0002080 |
Component |
Acrosomal membrane |
IEA |
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GO:0002095 |
Component |
Caveolar macromolecular signaling complex |
IEA |
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GO:0005515 |
Function |
Protein binding |
IPI |
10212252, 11294831, 15703204, 16799092, 19931615, 24013648, 24658140, 25556234, 31980649, 32296183 |
GO:0005634 |
Component |
Nucleus |
IEA |
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GO:0005794 |
Component |
Golgi apparatus |
IBA |
21873635 |
GO:0005794 |
Component |
Golgi apparatus |
ISS |
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GO:0005886 |
Component |
Plasma membrane |
IDA |
12743374, 15569306, 15788404 |
GO:0005887 |
Component |
Integral component of plasma membrane |
IBA |
21873635 |
GO:0005887 |
Component |
Integral component of plasma membrane |
IDA |
8552590 |
GO:0005901 |
Component |
Caveola |
IDA |
8552590, 9361015, 15703204, 18081315, 24013648, 25556234 |
GO:0005925 |
Component |
Focal adhesion |
IBA |
21873635 |
GO:0005925 |
Component |
Focal adhesion |
IDA |
12091389 |
GO:0006906 |
Process |
Vesicle fusion |
IDA |
12743374 |
GO:0007005 |
Process |
Mitochondrion organization |
ISS |
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GO:0007029 |
Process |
Endoplasmic reticulum organization |
ISS |
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GO:0007088 |
Process |
Regulation of mitotic nuclear division |
IEP |
18081315 |
GO:0008286 |
Process |
Insulin receptor signaling pathway |
IBA |
21873635 |
GO:0008286 |
Process |
Insulin receptor signaling pathway |
IDA |
20455999 |
GO:0016050 |
Process |
Vesicle organization |
IDA |
12743374 |
GO:0019065 |
Process |
Receptor-mediated endocytosis of virus by host cell |
IGI |
21047970 |
GO:0019901 |
Function |
Protein kinase binding |
IBA |
21873635 |
GO:0030133 |
Component |
Transport vesicle |
IDA |
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GO:0030154 |
Process |
Cell differentiation |
IBA |
21873635 |
GO:0030512 |
Process |
Negative regulation of transforming growth factor beta receptor signaling pathway |
IEA |
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GO:0030674 |
Function |
Protein-macromolecule adaptor activity |
IEA |
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GO:0031234 |
Component |
Extrinsic component of cytoplasmic side of plasma membrane |
IDA |
15569306 |
GO:0031410 |
Component |
Cytoplasmic vesicle |
IBA |
21873635 |
GO:0031410 |
Component |
Cytoplasmic vesicle |
IDA |
22792322 |
GO:0032991 |
Component |
Protein-containing complex |
IDA |
24013648 |
GO:0042383 |
Component |
Sarcolemma |
IBA |
21873635 |
GO:0042803 |
Function |
Protein homodimerization activity |
IDA |
8552590 |
GO:0043410 |
Process |
Positive regulation of MAPK cascade |
IBA |
21873635 |
GO:0043410 |
Process |
Positive regulation of MAPK cascade |
IDA |
20455999 |
GO:0043547 |
Process |
Positive regulation of GTPase activity |
IDA |
8552590 |
GO:0044791 |
Process |
Positive regulation by host of viral release from host cell |
IMP |
25556234 |
GO:0044794 |
Process |
Positive regulation by host of viral process |
IMP |
25556234 |
GO:0045121 |
Component |
Membrane raft |
IDA |
11294831 |
GO:0046982 |
Function |
Protein heterodimerization activity |
IEA |
|
GO:0048278 |
Process |
Vesicle docking |
IDA |
12743374 |
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
IBA |
21873635 |
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
IDA |
18081315 |
GO:0048741 |
Process |
Skeletal muscle fiber development |
ISS |
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GO:0051480 |
Process |
Regulation of cytosolic calcium ion concentration |
IBA |
21873635 |
GO:0060090 |
Function |
Molecular adaptor activity |
IBA |
21873635 |
GO:0060161 |
Process |
Positive regulation of dopamine receptor signaling pathway |
IMP |
15569306 |
GO:0070836 |
Process |
Caveola assembly |
IBA |
21873635 |
GO:0070836 |
Process |
Caveola assembly |
IDA |
12743374 |
GO:0070836 |
Process |
Caveola assembly |
IMP |
12633858 |
GO:0071711 |
Process |
Basement membrane organization |
IEA |
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GO:0097110 |
Function |
Scaffold protein binding |
IEA |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P51636 |
Protein name |
Caveolin-2 |
Protein function |
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driv |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01146 |
Caveolin |
16 → 160 |
Caveolin |
Family |
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Sequence |
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Sequence length |
162 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Atrial fibrillation |
Atrial Fibrillation |
rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675 |
20062060 |
Glaucoma |
Glaucoma, Open-Angle, Glaucoma, Primary Open Angle |
rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs1558603396, rs387907175, rs587778873, rs587778875, rs104894979, rs137854895, rs766425037, rs72549380, rs148542782, rs541217363, rs753021890, rs771076928, rs56010818, rs777678299, rs1446110883, rs1573274915, rs1587545234, rs751768343, rs944452644 |
20835238 |
Leukemia |
Leukemia, Myelocytic, Acute |
rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 |
27903959 |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
15583422 |
Rheumatoid arthritis |
Rheumatoid Arthritis |
rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 |
17379860 |
Open angle glaucoma |
Secondary Open Angle Glaucoma |
rs28939688, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs137854858, rs201794655, rs750643216, rs200148764, rs139006752, rs1057519378, rs1553534421, rs774258585 |
20835238 |
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