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CAV2 (caveolin 2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
858
Gene nameGene Name - the full gene name approved by the HGNC.
Caveolin 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
CAV2
SynonymsGene synonyms aliases
CAV
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q31.2
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control a
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006655 hsa-miR-199a-3p Luciferase reporter assay, qRT-PCR, Western blot 21807947
MIRT006655 hsa-miR-199a-3p Luciferase reporter assay, qRT-PCR, Western blot 21807947
MIRT006655 hsa-miR-199a-3p Luciferase reporter assay, qRT-PCR, Western blot 21807947
MIRT006655 hsa-miR-199a-3p Luciferase reporter assay, qRT-PCR, Western blot 21807947
MIRT028136 hsa-miR-93-5p Sequencing 20371350
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0001937 Process Negative regulation of endothelial cell proliferation IBA 21873635
GO:0001937 Process Negative regulation of endothelial cell proliferation ISS
GO:0001938 Process Positive regulation of endothelial cell proliferation IEA
GO:0002080 Component Acrosomal membrane IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P51636
Protein name Caveolin-2
Protein function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driv
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01146 Caveolin
16 160
Caveolin
Family
Sequence
Sequence length 162
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Endocytosis
Focal adhesion
Prion disease
Bacterial invasion of epithelial cells
Proteoglycans in cancer
Fluid shear stress and atherosclerosis
  Extra-nuclear estrogen signaling
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Atrial fibrillation Atrial Fibrillation rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675 20062060
Glaucoma Glaucoma, Open-Angle, Glaucoma, Primary Open Angle rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs1558603396, rs387907175, rs587778873, rs587778875, rs104894979, rs137854895, rs766425037, rs72549380, rs148542782, rs541217363, rs753021890, rs771076928, rs56010818, rs777678299, rs1446110883, rs1573274915, rs1587545234, rs751768343, rs944452644 20835238
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601 27903959
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 15583422
Unknown
Disease name Disease term dbSNP ID References
Cardioembolic stroke Cardioembolic stroke 29531354
Paroxysmal atrial fibrillation Paroxysmal atrial fibrillation rs199865688, rs397515994, rs757096307 20062060
Prostatic neoplasms Prostatic Neoplasms 15583422

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