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KMO (kynurenine 3-monooxygenase)

Gene

8564

Kynurenine 3-monooxygenase

KMO

dJ317G22.1

1q43

This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provi

Show/Hide all(167)

miRTarBase ID	miRNA	Experiments	Reference
MIRT512965	hsa-miR-4803	PAR-CLIP	22012620
MIRT512964	hsa-miR-302f	PAR-CLIP	22012620
MIRT528926	hsa-miR-501-3p	PAR-CLIP	22012620
MIRT528925	hsa-miR-502-3p	PAR-CLIP	22012620
MIRT512962	hsa-miR-3143	PAR-CLIP	22012620
MIRT512961	hsa-miR-106a-3p	PAR-CLIP	22012620
MIRT512960	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT512965	hsa-miR-4803	PAR-CLIP	23446348
MIRT512964	hsa-miR-302f	PAR-CLIP	23446348
MIRT512963	hsa-miR-6793-3p	PAR-CLIP	23446348
MIRT512962	hsa-miR-3143	PAR-CLIP	23446348
MIRT512961	hsa-miR-106a-3p	PAR-CLIP	23446348
MIRT512960	hsa-miR-302c-5p	PAR-CLIP	23446348
MIRT738677	hsa-miR-3682-3p	HITS-CLIP	33718276
MIRT512965	hsa-miR-4803	PAR-CLIP	22012620
MIRT512964	hsa-miR-302f	PAR-CLIP	22012620
MIRT528926	hsa-miR-501-3p	PAR-CLIP	22012620
MIRT528925	hsa-miR-502-3p	PAR-CLIP	22012620
MIRT512962	hsa-miR-3143	PAR-CLIP	22012620
MIRT512961	hsa-miR-106a-3p	PAR-CLIP	22012620
MIRT512960	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT512965	hsa-miR-4803	PAR-CLIP	23446348
MIRT512964	hsa-miR-302f	PAR-CLIP	23446348
MIRT512963	hsa-miR-6793-3p	PAR-CLIP	23446348
MIRT512962	hsa-miR-3143	PAR-CLIP	23446348
MIRT512961	hsa-miR-106a-3p	PAR-CLIP	23446348
MIRT512960	hsa-miR-302c-5p	PAR-CLIP	23446348
MIRT1099421	hsa-miR-1183	CLIP-seq
MIRT1099422	hsa-miR-3121-3p	CLIP-seq
MIRT1099423	hsa-miR-3122	CLIP-seq
MIRT1099424	hsa-miR-3200-5p	CLIP-seq
MIRT1099425	hsa-miR-337-3p	CLIP-seq
MIRT1099426	hsa-miR-339-5p	CLIP-seq
MIRT1099427	hsa-miR-3607-3p	CLIP-seq
MIRT1099428	hsa-miR-3675-5p	CLIP-seq
MIRT1099429	hsa-miR-3689a-3p	CLIP-seq
MIRT1099430	hsa-miR-3689c	CLIP-seq
MIRT1099431	hsa-miR-382	CLIP-seq
MIRT1099432	hsa-miR-3913-5p	CLIP-seq
MIRT1099433	hsa-miR-3929	CLIP-seq
MIRT739500	hsa-miR-3976	CLIP-seq
MIRT1099434	hsa-miR-4419b	CLIP-seq
MIRT1099435	hsa-miR-4426	CLIP-seq
MIRT1099436	hsa-miR-4478	CLIP-seq
MIRT1099437	hsa-miR-4540	CLIP-seq
MIRT1099438	hsa-miR-4647	CLIP-seq
MIRT1099439	hsa-miR-4662b	CLIP-seq
MIRT1099440	hsa-miR-4693-5p	CLIP-seq
MIRT1099441	hsa-miR-4728-5p	CLIP-seq
MIRT1099442	hsa-miR-485-5p	CLIP-seq
MIRT1099443	hsa-miR-486-5p	CLIP-seq
MIRT1099444	hsa-miR-548c-3p	CLIP-seq
MIRT1099445	hsa-miR-618	CLIP-seq
MIRT1099446	hsa-miR-676	CLIP-seq
MIRT1099447	hsa-miR-891a	CLIP-seq
MIRT2026968	hsa-miR-1225-3p	CLIP-seq
MIRT2026969	hsa-miR-1233	CLIP-seq
MIRT2026970	hsa-miR-1246	CLIP-seq
MIRT2026971	hsa-miR-1273e	CLIP-seq
MIRT2026972	hsa-miR-137	CLIP-seq
MIRT2026973	hsa-miR-147	CLIP-seq
MIRT2026974	hsa-miR-1827	CLIP-seq
MIRT2026975	hsa-miR-2052	CLIP-seq
MIRT2026976	hsa-miR-2467-3p	CLIP-seq
MIRT1099423	hsa-miR-3122	CLIP-seq
MIRT2026977	hsa-miR-3612	CLIP-seq
MIRT2026978	hsa-miR-3616-5p	CLIP-seq
MIRT2026979	hsa-miR-3647-5p	CLIP-seq
MIRT2026980	hsa-miR-3667-3p	CLIP-seq
MIRT1099429	hsa-miR-3689a-3p	CLIP-seq
MIRT1099430	hsa-miR-3689c	CLIP-seq
MIRT1099432	hsa-miR-3913-5p	CLIP-seq
MIRT2026981	hsa-miR-3919	CLIP-seq
MIRT1099433	hsa-miR-3929	CLIP-seq
MIRT2026982	hsa-miR-4257	CLIP-seq
MIRT2026983	hsa-miR-4282	CLIP-seq
MIRT2026984	hsa-miR-4289	CLIP-seq
MIRT1099434	hsa-miR-4419b	CLIP-seq
MIRT2026985	hsa-miR-4459	CLIP-seq
MIRT1099436	hsa-miR-4478	CLIP-seq
MIRT2026986	hsa-miR-4684-5p	CLIP-seq
MIRT2026987	hsa-miR-4695-5p	CLIP-seq
MIRT1099441	hsa-miR-4728-5p	CLIP-seq
MIRT2026988	hsa-miR-4761-5p	CLIP-seq
MIRT2026989	hsa-miR-4768-5p	CLIP-seq
MIRT2026990	hsa-miR-4795-5p	CLIP-seq
MIRT2026991	hsa-miR-4802-3p	CLIP-seq
MIRT1099442	hsa-miR-485-5p	CLIP-seq
MIRT2026992	hsa-miR-490-5p	CLIP-seq
MIRT1099444	hsa-miR-548c-3p	CLIP-seq
MIRT2026993	hsa-miR-573	CLIP-seq
MIRT2026994	hsa-miR-650	CLIP-seq
MIRT2026995	hsa-miR-665	CLIP-seq
MIRT2258192	hsa-miR-1182	CLIP-seq
MIRT2258193	hsa-miR-1229	CLIP-seq
MIRT2258194	hsa-miR-133a	CLIP-seq
MIRT2258195	hsa-miR-133b	CLIP-seq
MIRT2026973	hsa-miR-147	CLIP-seq
MIRT2258196	hsa-miR-193a-3p	CLIP-seq
MIRT2258197	hsa-miR-193b	CLIP-seq
MIRT2258198	hsa-miR-197	CLIP-seq
MIRT2258199	hsa-miR-3145-3p	CLIP-seq
MIRT2258200	hsa-miR-3176	CLIP-seq
MIRT2026980	hsa-miR-3667-3p	CLIP-seq
MIRT2258201	hsa-miR-3672	CLIP-seq
MIRT2258202	hsa-miR-3689a-5p	CLIP-seq
MIRT2258203	hsa-miR-3689b	CLIP-seq
MIRT2258204	hsa-miR-3689e	CLIP-seq
MIRT2258205	hsa-miR-3689f	CLIP-seq
MIRT2258206	hsa-miR-3922-3p	CLIP-seq
MIRT2258207	hsa-miR-3977	CLIP-seq
MIRT2258208	hsa-miR-421	CLIP-seq
MIRT2026984	hsa-miR-4289	CLIP-seq
MIRT2258209	hsa-miR-4303	CLIP-seq
MIRT2258210	hsa-miR-4433	CLIP-seq
MIRT2258211	hsa-miR-4463	CLIP-seq
MIRT2258212	hsa-miR-4649-3p	CLIP-seq
MIRT2258213	hsa-miR-4709-5p	CLIP-seq
MIRT2258214	hsa-miR-4720-3p	CLIP-seq
MIRT2258215	hsa-miR-4729	CLIP-seq
MIRT2258216	hsa-miR-4766-5p	CLIP-seq
MIRT2258217	hsa-miR-4775	CLIP-seq
MIRT2258218	hsa-miR-4793-3p	CLIP-seq
MIRT2258219	hsa-miR-4797-5p	CLIP-seq
MIRT2258220	hsa-miR-4804-3p	CLIP-seq
MIRT2258221	hsa-miR-505	CLIP-seq
MIRT2258222	hsa-miR-508-5p	CLIP-seq
MIRT2258223	hsa-miR-590-3p	CLIP-seq
MIRT2258224	hsa-miR-651	CLIP-seq
MIRT2258225	hsa-miR-656	CLIP-seq
MIRT2026995	hsa-miR-665	CLIP-seq
MIRT1099446	hsa-miR-676	CLIP-seq
MIRT2258226	hsa-miR-766	CLIP-seq
MIRT2026968	hsa-miR-1225-3p	CLIP-seq
MIRT2258193	hsa-miR-1229	CLIP-seq
MIRT2026969	hsa-miR-1233	CLIP-seq
MIRT2258198	hsa-miR-197	CLIP-seq
MIRT2258199	hsa-miR-3145-3p	CLIP-seq
MIRT1099431	hsa-miR-382	CLIP-seq
MIRT2258208	hsa-miR-421	CLIP-seq
MIRT2258213	hsa-miR-4709-5p	CLIP-seq
MIRT2258218	hsa-miR-4793-3p	CLIP-seq
MIRT2258221	hsa-miR-505	CLIP-seq
MIRT2258222	hsa-miR-508-5p	CLIP-seq
MIRT2026995	hsa-miR-665	CLIP-seq
MIRT2258226	hsa-miR-766	CLIP-seq
MIRT2452714	hsa-miR-200b	CLIP-seq
MIRT2452715	hsa-miR-200c	CLIP-seq
MIRT1099424	hsa-miR-3200-5p	CLIP-seq
MIRT2452716	hsa-miR-369-3p	CLIP-seq
MIRT2452717	hsa-miR-429	CLIP-seq
MIRT2452718	hsa-miR-4428	CLIP-seq
MIRT2452719	hsa-miR-493	CLIP-seq
MIRT2452714	hsa-miR-200b	CLIP-seq
MIRT2452715	hsa-miR-200c	CLIP-seq
MIRT2452716	hsa-miR-369-3p	CLIP-seq
MIRT2452717	hsa-miR-429	CLIP-seq
MIRT2452719	hsa-miR-493	CLIP-seq
MIRT739500	hsa-miR-3976	CLIP-seq
MIRT2559138	hsa-miR-4307	CLIP-seq
MIRT2559139	hsa-miR-4753-3p	CLIP-seq
MIRT2026989	hsa-miR-4768-5p	CLIP-seq
MIRT2559140	hsa-miR-513a-3p	CLIP-seq
MIRT2559138	hsa-miR-4307	CLIP-seq
MIRT2559139	hsa-miR-4753-3p	CLIP-seq
MIRT2026989	hsa-miR-4768-5p	CLIP-seq
MIRT2559140	hsa-miR-513a-3p	CLIP-seq

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004502	Function	Kynurenine 3-monooxygenase activity	IBA	21873635
GO:0004502	Function	Kynurenine 3-monooxygenase activity	IDA	9237672, 10672018, 23575632, 26752518, 29208702, 29429898
GO:0004502	Function	Kynurenine 3-monooxygenase activity	TAS
GO:0005615	Component	Extracellular space	IEA
GO:0005741	Component	Mitochondrial outer membrane	IBA	21873635
GO:0005741	Component	Mitochondrial outer membrane	ISS	10672018
GO:0005829	Component	Cytosol	TAS
GO:0006569	Process	Tryptophan catabolic process	TAS
GO:0007568	Process	Aging	IEA
GO:0009651	Process	Response to salt stress	IDA	10672018
GO:0016021	Component	Integral component of membrane	IEA
GO:0016174	Function	NAD(P)H oxidase H2O2-forming activity	IBA	21873635
GO:0016174	Function	NAD(P)H oxidase H2O2-forming activity	IDA	10672018, 23575632, 29429898
GO:0019674	Process	NAD metabolic process	IBA	21873635
GO:0019674	Process	NAD metabolic process	IDA	23575632, 29429898
GO:0019805	Process	Quinolinate biosynthetic process	IEA
GO:0034276	Process	Kynurenic acid biosynthetic process	IEA
GO:0034354	Process	'de novo' NAD biosynthetic process from tryptophan	IEA
GO:0043420	Process	Anthranilate metabolic process	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	IBA	21873635
GO:0050660	Function	Flavin adenine dinucleotide binding	IDA	10672018
GO:0070189	Process	Kynurenine metabolic process	IBA	21873635
GO:0070189	Process	Kynurenine metabolic process	IDA	10672018, 26752518, 29208702, 29429898
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071347	Process	Cellular response to interleukin-1	IEA
GO:0071949	Function	FAD binding	IDA	29429898
GO:0097052	Process	L-kynurenine metabolic process	IEA
GO:1901216	Process	Positive regulation of neuron death	IEA
GO:1903296	Process	Positive regulation of glutamate secretion, neurotransmission	IEA

MIM	HGNC	e!Ensembl
603538	6381	ENSG00000117009

Protein

UniProt ID

O15229

Protein name

Kynurenine 3-monooxygenase (EC 1.14.13.9) (Kynurenine 3-hydroxylase)

Protein function

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702, PubMed:29429898). Required for synthesis of quinolinic acid, a neurotoxic NMDA rec

PDB

5X68

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01494	FAD_binding_3	8 → 331	FAD binding domain	Family

Sequence

MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR

Sequence length

486

Interactions

View interactions

	KEGG		Reactome
	Tryptophan metabolism Metabolic pathways Biosynthesis of cofactors		Tryptophan catabolism

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Dermatitis, Allergic Contact	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	16033404
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	16716206, 21693093, 21727251, 25464917, 23459468

Show/Hide Unknown Diseases (2)

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Depression, Bipolar		21492941
Mental depression	Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	21492941, 22683764, 22683764, 21492941

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