CNTNAP4 (contactin associated protein family member 4)

Gene

• Entrez ID: 85445
• Gene name: Contactin associated protein family member 4
• Gene symbol: CNTNAP4
• Synonyms: CASPR4
• Chromosome: 16
• Chromosome location: 16q23.1
• Summary: This gene encodes a member of the neurexin protein family. Members of this family function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein contains epidermal growth factor repeats and laminin G domains. In addition,

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT735607	hsa-miR-34a-3p	Immunohistochemistry (IHC)	32107390
MIRT901893	hsa-miR-4252	CLIP-seq
MIRT901894	hsa-miR-4474-3p	CLIP-seq
MIRT901895	hsa-miR-4699-5p	CLIP-seq
MIRT901896	hsa-miR-4701-5p	CLIP-seq
MIRT901897	hsa-miR-588	CLIP-seq
MIRT901898	hsa-miR-663b	CLIP-seq
MIRT2506155	hsa-miR-181a	CLIP-seq
MIRT2506156	hsa-miR-181b	CLIP-seq
MIRT2506157	hsa-miR-181c	CLIP-seq
MIRT2506158	hsa-miR-181d	CLIP-seq
MIRT2506159	hsa-miR-3120-3p	CLIP-seq
MIRT2506160	hsa-miR-3942-5p	CLIP-seq
MIRT2506161	hsa-miR-4262	CLIP-seq
MIRT2506162	hsa-miR-4276	CLIP-seq
MIRT2506163	hsa-miR-4302	CLIP-seq
MIRT2506164	hsa-miR-4703-5p	CLIP-seq
MIRT2506165	hsa-miR-4735-5p	CLIP-seq
MIRT2506166	hsa-miR-486-5p	CLIP-seq
MIRT2506167	hsa-miR-578	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0007155	Process	Cell adhesion	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0032225	Process	Regulation of synaptic transmission, dopaminergic	ISS
GO:0032228	Process	Regulation of synaptic transmission, GABAergic	ISS
GO:0042734	Component	Presynaptic membrane	ISS
GO:0042995	Component	Cell projection	IEA
GO:2000821	Process	Regulation of grooming behavior	ISS

Other IDs

• MIM: 610518
• HGNC: 18747
• e!Ensembl: ENSG00000152910

Protein

• UniProt ID: Q9C0A0
• Protein name: Contactin-associated protein-like 4 (Cell recognition molecule Caspr4)
• Protein function: Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuatin
• PDB: 4NXQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00754	F5_F8_type_C	41 → 174	F5/8 type C domain	Domain
  PF02210	Laminin_G_2	212 → 341	Laminin G domain	Domain
  PF02210	Laminin_G_2	398 → 524	Laminin G domain	Domain
  PF02210	Laminin_G_2	821 → 940	Laminin G domain	Domain
  PF02210	Laminin_G_2	1046 → 1176	Laminin G domain	Domain

• Sequence:

  MGSVTGAVLKTLLLLSTQNWNRVEAGNSYDCDDPLVSALPQASFSSSSELSSSHGPGFAR
  LNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYLLMFSDSGWNW
  KQYRQEDSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYR
  SEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRAR
  LFLLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGE
  FNLMNLDYEISFGGIPAPGKSVSFPHRNFHGCLENLYYNGVDIIDLAKQQKPQIIAMGNV
  SFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSELQLISGGIL
  LFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLL
  GPEQIYSGGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNFS
  DLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSIYEQSCEAYKHR
  GNTSGFYYIDSDGSGPLEPFLLYCNMTETAWTIIQHNGSDLTRVRNTNPENPYAGFFEYV
  ASMEQLQATINRAEHCEQEFTYYCKKSRLVNKQDGTPLSWWVGRTNETQTYWGGSSPDLQ
  KCTCGLEGNCIDSQYYCNCDADRNEWTNDTGLLAYKEHLPVTKIVITDTGRLHSEAAYKL
  GPLLCQGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIADFI
  RIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQ
  PAPADGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRG
  HCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLL
  SKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRY
  KLNKYQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEIDDNRRRQVHLSSGTEFSAVKS
  LVLGRILEHSDVDQDTALAGAQGFTGCLSAVQLSHVAPLKAALHPSHPDPVTVTGHVTES
  SCMAQPGTDATSRERTHSFADHSGTIDDREPLANAIKSDSAVIGGLIAVVIFILLCITAI
  AVRIYQQKRLYKRSEAKRSENVDSAEAVLKSELNIQNAVNENQKEYFF

• Sequence length: 1308

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560