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ZIC5 (Zic family member 5)

Gene

Zic family member 5

ZIC5

13q32.3

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. The encoded protein may act as a transcriptional repressor. Studies in mouse and Xenopus support a role for this gene in neural crest development. Elevated expression of this gene has been observed in various human cancers and may contribute to cancer progression. This gene is closely linked to a related family member on chromosome 13. [provided by RefSeq, Mar 2017]

Show/Hide all(125)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019534	hsa-miR-340-5p	Sequencing	20371350
MIRT021085	hsa-miR-186-5p	Sequencing	20371350
MIRT021085	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT021906	hsa-miR-128-3p	Sequencing	20371350
MIRT023467	hsa-miR-23b-3p	Sequencing	20371350
MIRT024611	hsa-miR-215-5p	Microarray	19074876
MIRT026278	hsa-miR-192-5p	Microarray	19074876
MIRT027950	hsa-miR-93-5p	Sequencing	20371350
MIRT043243	hsa-miR-324-5p	CLASH	23622248
MIRT067662	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT067662	hsa-miR-1277-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT067662	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT067666	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT067666	hsa-miR-5011-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT067666	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT275501	hsa-miR-556-3p	PAR-CLIP	21572407
MIRT275508	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT275509	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT275525	hsa-miR-586	PAR-CLIP	23592263
MIRT275531	hsa-miR-5700	PAR-CLIP	23592263
MIRT275561	hsa-miR-4477a	PAR-CLIP	23446348
MIRT275561	hsa-miR-4477a	PAR-CLIP	20371350
MIRT339811	hsa-miR-130b-5p	PAR-CLIP	21572407
MIRT368653	hsa-miR-5692a	PAR-CLIP	23446348
MIRT368653	hsa-miR-5692a	PAR-CLIP, HITS-CLIP	21572407
MIRT368653	hsa-miR-5692a	PAR-CLIP	20371350
MIRT463241	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT463242	hsa-miR-6077	PAR-CLIP	23592263
MIRT463243	hsa-miR-7-5p	PAR-CLIP	23592263
MIRT463244	hsa-miR-3934-3p	PAR-CLIP	23592263
MIRT463245	hsa-miR-152-3p	PAR-CLIP	23592263
MIRT463246	hsa-miR-148b-3p	PAR-CLIP	23592263
MIRT463247	hsa-miR-148a-3p	PAR-CLIP	23592263
MIRT463248	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT463249	hsa-miR-764	PAR-CLIP	23592263
MIRT463250	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT463251	hsa-miR-4692	PAR-CLIP	23592263
MIRT463251	hsa-miR-4692	PAR-CLIP	20371350
MIRT463252	hsa-miR-4514	PAR-CLIP	23592263
MIRT463252	hsa-miR-4514	PAR-CLIP	20371350
MIRT463253	hsa-miR-6715b-5p	PAR-CLIP	23592263
MIRT463253	hsa-miR-6715b-5p	PAR-CLIP	20371350
MIRT463254	hsa-miR-4269	PAR-CLIP	23592263
MIRT463254	hsa-miR-4269	PAR-CLIP	20371350
MIRT463255	hsa-miR-4742-5p	PAR-CLIP	23592263
MIRT463255	hsa-miR-4742-5p	PAR-CLIP	20371350
MIRT463256	hsa-miR-3662	PAR-CLIP	23592263
MIRT463257	hsa-miR-524-5p	PAR-CLIP	23592263
MIRT463258	hsa-miR-520d-5p	PAR-CLIP	23592263
MIRT463259	hsa-miR-5093	PAR-CLIP	23592263
MIRT463260	hsa-miR-545-5p	PAR-CLIP	23592263
MIRT463261	hsa-miR-383-5p	PAR-CLIP	23592263
MIRT463262	hsa-miR-3156-5p	PAR-CLIP	23592263
MIRT463263	hsa-miR-548c-3p	PAR-CLIP	23592263
MIRT463263	hsa-miR-548c-3p	PAR-CLIP	23446348
MIRT505066	hsa-miR-496	PAR-CLIP	23446348
MIRT505066	hsa-miR-496	PAR-CLIP	21572407
MIRT505066	hsa-miR-496	PAR-CLIP	20371350
MIRT505067	hsa-miR-486-5p	PAR-CLIP	23446348
MIRT505067	hsa-miR-486-5p	PAR-CLIP	21572407
MIRT505067	hsa-miR-486-5p	PAR-CLIP	20371350
MIRT505068	hsa-miR-3163	PAR-CLIP	23446348
MIRT505068	hsa-miR-3163	PAR-CLIP	20371350
MIRT505069	hsa-miR-500a-5p	PAR-CLIP	23446348
MIRT505069	hsa-miR-500a-5p	PAR-CLIP	21572407
MIRT505069	hsa-miR-500a-5p	PAR-CLIP	20371350
MIRT510435	hsa-miR-3924	PAR-CLIP	23446348
MIRT510435	hsa-miR-3924	PAR-CLIP, HITS-CLIP	21572407
MIRT510435	hsa-miR-3924	PAR-CLIP	20371350
MIRT510436	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT510436	hsa-miR-190a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT510436	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT510437	hsa-miR-92b-3p	PAR-CLIP	23446348
MIRT510437	hsa-miR-92b-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT510437	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT510438	hsa-miR-92a-3p	PAR-CLIP	23446348
MIRT510438	hsa-miR-92a-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT510438	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT510439	hsa-miR-367-3p	PAR-CLIP	23446348
MIRT510439	hsa-miR-367-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT510439	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT510440	hsa-miR-363-3p	PAR-CLIP	23446348
MIRT510440	hsa-miR-363-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT510440	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT510441	hsa-miR-32-5p	PAR-CLIP	23446348
MIRT510441	hsa-miR-32-5p	PAR-CLIP, HITS-CLIP	21572407
MIRT510441	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT510442	hsa-miR-25-3p	PAR-CLIP	23446348
MIRT510442	hsa-miR-25-3p	PAR-CLIP, HITS-CLIP	21572407
MIRT510442	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT510443	hsa-miR-5692c	PAR-CLIP	23446348
MIRT510443	hsa-miR-5692c	PAR-CLIP, HITS-CLIP	21572407
MIRT510443	hsa-miR-5692c	PAR-CLIP	20371350
MIRT510444	hsa-miR-5692b	PAR-CLIP	23446348
MIRT510444	hsa-miR-5692b	PAR-CLIP, HITS-CLIP	21572407
MIRT510444	hsa-miR-5692b	PAR-CLIP	20371350
MIRT552513	hsa-miR-4671-3p	PAR-CLIP	21572407
MIRT552514	hsa-miR-3137	PAR-CLIP	21572407
MIRT552515	hsa-miR-6507-5p	PAR-CLIP	21572407
MIRT552516	hsa-miR-649	PAR-CLIP	21572407
MIRT552517	hsa-miR-3133	PAR-CLIP	21572407
MIRT552518	hsa-miR-3666	PAR-CLIP	21572407
MIRT552519	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT552520	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT552521	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT552522	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT552523	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT552524	hsa-miR-4295	PAR-CLIP	21572407
MIRT552525	hsa-miR-7850-5p	PAR-CLIP	21572407
MIRT552526	hsa-miR-4529-3p	PAR-CLIP	21572407
MIRT552527	hsa-miR-4520-2-3p	PAR-CLIP	21572407
MIRT552528	hsa-miR-4520-3p	PAR-CLIP	21572407
MIRT552529	hsa-miR-4753-3p	PAR-CLIP	21572407
MIRT552530	hsa-miR-4672	PAR-CLIP	21572407
MIRT552531	hsa-miR-3941	PAR-CLIP	21572407
MIRT552532	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT552533	hsa-miR-4801	PAR-CLIP	21572407
MIRT552534	hsa-miR-4731-3p	PAR-CLIP	21572407
MIRT552535	hsa-miR-216b-5p	PAR-CLIP	21572407
MIRT552536	hsa-miR-3185	PAR-CLIP	21572407
MIRT552536	hsa-miR-3185	PAR-CLIP	20371350
MIRT552537	hsa-miR-4724-5p	PAR-CLIP	21572407
MIRT552537	hsa-miR-4724-5p	PAR-CLIP	20371350
MIRT561263	hsa-miR-1256	PAR-CLIP	20371350
MIRT561264	hsa-miR-3121-3p	PAR-CLIP	20371350

Show/Hide all(8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0007417	Process	Central nervous system development	IBA	21873635
GO:0030154	Process	Cell differentiation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
617896	20322	ENSG00000139800

Protein

UniProt ID

Q96T25

Protein name

Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5)

Protein function

Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18366	zf_ZIC	422 → 453	Zic proteins zinc finger domain	Domain
PF00096	zf-C2H2	491 → 515	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	551 → 575	Zinc finger, C2H2 type	Domain

Sequence

MFLKAGRGNKVPPVRVYGPDCVVLMEPPLSKRNPPALRLADLATAQVQPLQNMTGFPALA
GPPAHSQLRAAVAHLRLRDLGADPGVATTPLGPEHMAQASTLGLSPPSQAFPAHPEAPAA
AARAAALVAHPGAGSYPCGGGSSGAQPSAPPPPAPPLPPTPSPPPPPPPPPPPALSGYTT
TNSGGGGSSGKGHSRDFVLRRDLSATAPAAAMHGAPLGGEQRSGTGSPQHPAPPPHSAGM
FISASGTYAGPDGSGGPALFPALHDTPGAPGGHPHPLNGQMRLGLAAAAAAAAAELYGRA
EPPFAPRSGDAHYGAVAAAAAAALHGYGAVNLNLNLAAAAAAAAAGPGPHLQHHAPPPAP
PPPPAPAQHPHQHHPHLPGAAGAFLRYMRQPIKQELICKWIDPDELAGLPPPPPPPPPPP
PPPPAGGAKPCSKTFGTMHELVNHVTVEHVGGPEQSSHVCFWEDCPREGKPFKAKYKLIN
HIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEFDGCDRKFANSSDRKK
HSHVHTSDKPYYCKIRGCDKSYTHPSSLRKHMKIHCKSPPPSPGPLGYSSVGTPVGAPLS
PVLDPARSHSSTLSPQVTNLNEWYVCQASGAPSHLHTPSSNGTTSETEDEEIYGNPEVVR
TIH

Sequence length

663

Interactions

View interactions

Associated diseases

Show/Hide all(9)

Disease name	Disease term	References

	Acrania	15136147

	Iniencephaly	15136147
	Exencephaly	15136147

	Craniorachischisis	15136147

	Diastematomyelia	15136147

	Liver carcinoma	28284560

	Neural Tube Defects	15136147

	Neurenteric Cyst	15136147

	Tethered Cord Syndrome	15136147

	Spinal Cord Myelodysplasia	15136147

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