SYDE1 (synapse defective Rho GTPase activating protein 1)

Gene

• Entrez ID: 85360
• Gene name: Synapse defective Rho GTPase activating protein 1
• Gene symbol: SYDE1
• Synonyms: 7h3, SYD1
• Chromosome: 19
• Chromosome location: 19p13.12
• Summary: The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intraut

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1405129	hsa-miR-1178	CLIP-seq
MIRT1405130	hsa-miR-128	CLIP-seq
MIRT1405131	hsa-miR-1321	CLIP-seq
MIRT1405132	hsa-miR-148a	CLIP-seq
MIRT1405133	hsa-miR-148b	CLIP-seq
MIRT1405134	hsa-miR-152	CLIP-seq
MIRT1405135	hsa-miR-15a	CLIP-seq
MIRT1405136	hsa-miR-15b	CLIP-seq
MIRT1405137	hsa-miR-16	CLIP-seq
MIRT1405138	hsa-miR-195	CLIP-seq
MIRT1405139	hsa-miR-197	CLIP-seq
MIRT1405140	hsa-miR-200b	CLIP-seq
MIRT1405141	hsa-miR-200c	CLIP-seq
MIRT1405142	hsa-miR-2110	CLIP-seq
MIRT1405143	hsa-miR-27a	CLIP-seq
MIRT1405144	hsa-miR-27b	CLIP-seq
MIRT1405145	hsa-miR-3127-5p	CLIP-seq
MIRT1405146	hsa-miR-3150a-3p	CLIP-seq
MIRT1405147	hsa-miR-3167	CLIP-seq
MIRT1405148	hsa-miR-330-3p	CLIP-seq
MIRT1405149	hsa-miR-424	CLIP-seq
MIRT1405150	hsa-miR-429	CLIP-seq
MIRT1405151	hsa-miR-4419a	CLIP-seq
MIRT1405152	hsa-miR-4450	CLIP-seq
MIRT1405153	hsa-miR-4510	CLIP-seq
MIRT1405154	hsa-miR-451b	CLIP-seq
MIRT1405155	hsa-miR-4728-5p	CLIP-seq
MIRT1405156	hsa-miR-4733-3p	CLIP-seq
MIRT1405157	hsa-miR-4739	CLIP-seq
MIRT1405158	hsa-miR-4756-5p	CLIP-seq
MIRT1405159	hsa-miR-4787-5p	CLIP-seq
MIRT1405160	hsa-miR-497	CLIP-seq
MIRT1405161	hsa-miR-582-3p	CLIP-seq
MIRT1405162	hsa-miR-592	CLIP-seq
MIRT1405163	hsa-miR-599	CLIP-seq
MIRT1405164	hsa-miR-659	CLIP-seq
MIRT1405165	hsa-miR-767-5p	CLIP-seq
MIRT1405166	hsa-miR-876-5p	CLIP-seq
MIRT2121540	hsa-miR-136	CLIP-seq
MIRT2121541	hsa-miR-31	CLIP-seq
MIRT1405145	hsa-miR-3127-5p	CLIP-seq
MIRT1405147	hsa-miR-3167	CLIP-seq
MIRT2121542	hsa-miR-3612	CLIP-seq
MIRT2121543	hsa-miR-3664-5p	CLIP-seq
MIRT2121544	hsa-miR-3978	CLIP-seq
MIRT1405151	hsa-miR-4419a	CLIP-seq
MIRT2121545	hsa-miR-4426	CLIP-seq
MIRT1405152	hsa-miR-4450	CLIP-seq
MIRT2121546	hsa-miR-4459	CLIP-seq
MIRT1405153	hsa-miR-4510	CLIP-seq
MIRT2121547	hsa-miR-4522	CLIP-seq
MIRT2121548	hsa-miR-4647	CLIP-seq
MIRT2121549	hsa-miR-4662b	CLIP-seq
MIRT2121550	hsa-miR-4667-3p	CLIP-seq
MIRT2121551	hsa-miR-4707-5p	CLIP-seq
MIRT2121552	hsa-miR-4753-5p	CLIP-seq
MIRT2121553	hsa-miR-4779	CLIP-seq
MIRT2121554	hsa-miR-628-5p	CLIP-seq
MIRT2121555	hsa-miR-650	CLIP-seq
MIRT1405166	hsa-miR-876-5p	CLIP-seq
MIRT2121540	hsa-miR-136	CLIP-seq
MIRT1405135	hsa-miR-15a	CLIP-seq
MIRT1405136	hsa-miR-15b	CLIP-seq
MIRT1405137	hsa-miR-16	CLIP-seq
MIRT1405138	hsa-miR-195	CLIP-seq
MIRT1405140	hsa-miR-200b	CLIP-seq
MIRT1405141	hsa-miR-200c	CLIP-seq
MIRT1405145	hsa-miR-3127-5p	CLIP-seq
MIRT1405148	hsa-miR-330-3p	CLIP-seq
MIRT2343595	hsa-miR-3664-3p	CLIP-seq
MIRT2121543	hsa-miR-3664-5p	CLIP-seq
MIRT2121544	hsa-miR-3978	CLIP-seq
MIRT1405149	hsa-miR-424	CLIP-seq
MIRT1405150	hsa-miR-429	CLIP-seq
MIRT2343596	hsa-miR-4293	CLIP-seq
MIRT2343597	hsa-miR-4313	CLIP-seq
MIRT2121545	hsa-miR-4426	CLIP-seq
MIRT1405154	hsa-miR-451b	CLIP-seq
MIRT2121547	hsa-miR-4522	CLIP-seq
MIRT2121548	hsa-miR-4647	CLIP-seq
MIRT2121549	hsa-miR-4662b	CLIP-seq
MIRT2121552	hsa-miR-4753-5p	CLIP-seq
MIRT1405160	hsa-miR-497	CLIP-seq
MIRT1405164	hsa-miR-659	CLIP-seq
MIRT2343598	hsa-miR-873	CLIP-seq
MIRT2343599	hsa-miR-885-3p	CLIP-seq
MIRT1405135	hsa-miR-15a	CLIP-seq
MIRT1405136	hsa-miR-15b	CLIP-seq
MIRT1405137	hsa-miR-16	CLIP-seq
MIRT1405138	hsa-miR-195	CLIP-seq
MIRT1405149	hsa-miR-424	CLIP-seq
MIRT1405154	hsa-miR-451b	CLIP-seq
MIRT1405160	hsa-miR-497	CLIP-seq
MIRT2343599	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IDA	27917469
GO:0005096	Function	GTPase activator activity	IMP	27917469
GO:0005096	Function	GTPase activator activity	ISS
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0016477	Process	Cell migration	IDA	27917469
GO:0016477	Process	Cell migration	IMP	27917469
GO:0030695	Function	GTPase regulator activity	IDA	27917469
GO:0030695	Function	GTPase regulator activity	IMP	27917469
GO:0031532	Process	Actin cytoskeleton reorganization	IDA	27917469
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051493	Process	Regulation of cytoskeleton organization	IMP	27917469
GO:0090630	Process	Activation of GTPase activity	ISS
GO:1901165	Process	Positive regulation of trophoblast cell migration	IMP	27917469

Other IDs

• MIM: 617377
• HGNC: 25824
• e!Ensembl: ENSG00000105137

Protein

• UniProt ID: Q6ZW31
• Protein name: Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1)
• Protein function: GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPas
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	414 → 570	RhoGAP domain	Domain

• Sequence:

  MAEPLLRKTFSRLRGREKLPRKKSDAKERGHPAQRPEPSPPEPEPQAPEGSQAGAEGPSS
  PEASRSPARGAYLQSLEPSSRRWVLGGAKPAEDTSLGPGVPGTGEPAGEIWYNPIPEEDP
  RPPAPEPPGPQPGSAESEGLAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRRRL
  SLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAGPGGTRSPRAGYLSDGDSPERPA
  GPPSPTSFRPYEVGPAARAPPAALWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDGEAR
  ARTGPLRGGPDFLRLDHTFHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGC
  QAQQLAVRLEPQGLLYAKLTLSEQQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKC
  VGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGILKDYLR
  ELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVS
  SFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHHIEVLHYLLQSW
  PDPRLPRQSPDVAPYLRPKRQPPLHLPLADPEVVTRPRGRGGPESPPSNRYAGDWSVCGR
  DFLPCGRDFLSGPDYDHVTGSDSEDEDEEVGEPRVTGDFEDDFDAPFNPHLNLKDFDALI
  LDLERELSKQINVCL

• Sequence length: 735

Pathways

Reactome:

Rho GTPase cycle

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Pancreatic adenocarcinoma	Pancreatic Ductal Adenocarcinoma	rs121908291, rs139375029, rs587780197, rs587780198, rs587780200, rs374741161, rs368806050, rs113676921, rs587780753, rs550499593, rs143544548, rs587780754, rs587780755, rs587780756, rs114593924, rs587780757, rs587780758, rs532961259, rs587780759, rs535155432, rs543821321, rs587780760, rs587780761, rs368350042, rs368890611, rs200060953, rs559000839, rs587780762, rs142116575, rs150764613, rs62333013, rs59633770, rs370602081, rs759105985, rs535118290, rs528879194, rs863224705, rs758706279, rs780516159, rs863224383, rs863224384, rs777359545, rs863224385, rs570874237, rs863224386, rs753092219, rs769161509, rs143417961, rs140360991, rs201707558, rs863224702, rs754158038, rs863224382, rs761530979, rs780692056, rs863224703, rs114250766, rs113515140, rs863224704, rs561750970, rs864622627, rs864622590, rs864622422, rs864622140, rs730882137, rs864622087, rs864622226, rs864622591, rs864622321, rs864622158, rs864622531, rs767729090, rs749041581, rs768485147, rs864622234, rs864622355, rs864622316, rs864622388, rs764242515, rs778134231, rs771679229, rs746599370, rs551131343, rs878854264, rs878854265, rs878854266, rs878854267, rs878854268, rs376654786, rs373500403, rs114171764, rs376394488, rs61051061, rs1806729, rs548068667, rs781516286, rs1059444, rs750112132, rs7673220, rs1060502975, rs778471055, rs925242863, rs143717202, rs372414187, rs927644209, rs764265611, rs1060502976, rs554297134, rs997146277, rs1060502974, rs1060504775, rs200020758, rs1060502973, rs777453756, rs952110792, rs1553965295, rs1553973196, rs1177108180, rs1477864263, rs368472947, rs182571219, rs1553984987, rs1263751006, rs201979617, rs1358006173, rs151071844, rs115937217, rs568490721, rs189021816, rs1319983866, rs1553965480, rs1553969553, rs1385898569, rs1553965526, rs1553968628, rs763802548, rs752296365, rs1553965214, rs1474793366, rs1553965326, rs778313832, rs1318598425, rs1470434769, rs755223646, rs557697540, rs747702421, rs1560940853, rs1560839872, rs1216822754, rs751364707, rs372708613, rs1560929667, rs1306250811, rs774034818, rs551420048, rs1581871066, rs1221751077, rs1220928329, rs759161069, rs757164572, rs115274645, rs769973229, rs115988233, rs767384375, rs778210310, rs1305250587, rs1239099971, rs1025237623, rs1211489449, rs900642927, rs1400689367, rs140584890, rs757885388, rs1231114395, rs996343137, rs1275232115, rs1046350904, rs762267147, rs373066707, rs867266337, rs1460784357, rs748432333, rs769517051, rs1560937938, rs750033888, rs781065277, rs1751999027, rs1246689760, rs1752077261, rs1754079127, rs1754736103, rs1757056910, rs114673468, rs756934356, rs1176026649, rs1762161869, rs200399043, rs1447433925, rs1389221540, rs893660432, rs1762582426