GediPNet logo

GAS7 (growth arrest specific 7)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8522
Gene nameGene Name - the full gene name approved by the HGNC.
Growth arrest specific 7
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
GAS7
SynonymsGene synonyms aliases
-
ChromosomeChromosome number
17
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.1
SummarySummary of gene provided in NCBI Entrez Gene.
Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021949 hsa-miR-128-3p Microarray 17612493
MIRT526756 hsa-miR-6837-3p PAR-CLIP 22012620
MIRT526755 hsa-miR-3124-3p PAR-CLIP 22012620
MIRT526754 hsa-miR-337-3p PAR-CLIP 22012620
MIRT526753 hsa-miR-202-5p PAR-CLIP 22012620
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 31515488
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005856 Component Cytoskeleton IBA 21873635
GO:0005884 Component Actin filament IBA 21873635
GO:0005886 Component Plasma membrane IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O60861
Protein name Growth arrest-specific protein 7 (GAS-7)
Protein function May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
PDB 2LX7 , 2YSH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14604 SH3_9
8 58
Variant SH3 domain
Domain
PF00397 WW
79 108
WW domain
Domain
PF16623 WW_FCH_linker
109 201
Disordered
PF00611 FCH
219 291
Fes/CIP4, and EFC/F-BAR homology domain
Family
Sequence
MSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLL
EKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGS
HRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVT
FPHPDTMPEQQLLKPTEWSYC
DYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEF
IRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLK
FSAKLHSEV
EKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIK
LSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIR
QHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI
Sequence length 476
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Obesity Obesity rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840 19270708

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412