NDST2 (N-deacetylase and N-sulfotransferase 2)

Gene

• Entrez ID: 8509
• Gene name: N-deacetylase and N-sulfotransferase 2
• Gene symbol: NDST2
• Synonyms: HSST2, N-HSST 2, NST2
• Chromosome: 10
• Chromosome location: 10q22.2
• Summary: This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1178437	hsa-miR-1909	CLIP-seq
MIRT1178438	hsa-miR-2355-3p	CLIP-seq
MIRT1178439	hsa-miR-3153	CLIP-seq
MIRT1178440	hsa-miR-3162-5p	CLIP-seq
MIRT1178441	hsa-miR-4318	CLIP-seq
MIRT1178442	hsa-miR-4646-3p	CLIP-seq
MIRT1178443	hsa-miR-4648	CLIP-seq
MIRT1178444	hsa-miR-4654	CLIP-seq
MIRT1178445	hsa-miR-4668-5p	CLIP-seq
MIRT1178446	hsa-miR-4769-5p	CLIP-seq
MIRT2051660	hsa-miR-150	CLIP-seq
MIRT1178438	hsa-miR-2355-3p	CLIP-seq
MIRT1178439	hsa-miR-3153	CLIP-seq
MIRT1178440	hsa-miR-3162-5p	CLIP-seq
MIRT1178441	hsa-miR-4318	CLIP-seq
MIRT1178442	hsa-miR-4646-3p	CLIP-seq
MIRT1178443	hsa-miR-4648	CLIP-seq
MIRT1178444	hsa-miR-4654	CLIP-seq
MIRT1178445	hsa-miR-4668-5p	CLIP-seq
MIRT1178446	hsa-miR-4769-5p	CLIP-seq
MIRT2051660	hsa-miR-150	CLIP-seq
MIRT2280715	hsa-miR-4728-5p	CLIP-seq
MIRT2454988	hsa-miR-1291	CLIP-seq
MIRT2454989	hsa-miR-1913	CLIP-seq
MIRT2454990	hsa-miR-3173-5p	CLIP-seq
MIRT2454991	hsa-miR-3194-3p	CLIP-seq
MIRT2454992	hsa-miR-324-3p	CLIP-seq
MIRT2454993	hsa-miR-378	CLIP-seq
MIRT2454994	hsa-miR-378b	CLIP-seq
MIRT2454995	hsa-miR-378c	CLIP-seq
MIRT2454996	hsa-miR-378d	CLIP-seq
MIRT2454997	hsa-miR-378e	CLIP-seq
MIRT2454998	hsa-miR-378f	CLIP-seq
MIRT2454999	hsa-miR-378h	CLIP-seq
MIRT2455000	hsa-miR-378i	CLIP-seq
MIRT2455001	hsa-miR-422a	CLIP-seq
MIRT2455002	hsa-miR-4535	CLIP-seq
MIRT2455003	hsa-miR-4638-3p	CLIP-seq
MIRT2455004	hsa-miR-4749-3p	CLIP-seq
MIRT2455005	hsa-miR-492	CLIP-seq
MIRT2579175	hsa-miR-103b	CLIP-seq
MIRT2579176	hsa-miR-1224-3p	CLIP-seq
MIRT2579177	hsa-miR-1254	CLIP-seq
MIRT2579178	hsa-miR-1321	CLIP-seq
MIRT2579179	hsa-miR-1470	CLIP-seq
MIRT2051660	hsa-miR-150	CLIP-seq
MIRT2579180	hsa-miR-181a	CLIP-seq
MIRT2579181	hsa-miR-181b	CLIP-seq
MIRT2579182	hsa-miR-181c	CLIP-seq
MIRT2579183	hsa-miR-181d	CLIP-seq
MIRT2579184	hsa-miR-3116	CLIP-seq
MIRT2579185	hsa-miR-3156-3p	CLIP-seq
MIRT1178440	hsa-miR-3162-5p	CLIP-seq
MIRT2579186	hsa-miR-3620	CLIP-seq
MIRT2579187	hsa-miR-3690	CLIP-seq
MIRT2579188	hsa-miR-374c	CLIP-seq
MIRT2579189	hsa-miR-3927	CLIP-seq
MIRT2579190	hsa-miR-3936	CLIP-seq
MIRT2579191	hsa-miR-4262	CLIP-seq
MIRT2579192	hsa-miR-4286	CLIP-seq
MIRT2579193	hsa-miR-4301	CLIP-seq
MIRT2579194	hsa-miR-4509	CLIP-seq
MIRT2579195	hsa-miR-451b	CLIP-seq
MIRT2579196	hsa-miR-4667-3p	CLIP-seq
MIRT2579197	hsa-miR-4676-5p	CLIP-seq
MIRT2579198	hsa-miR-4691-5p	CLIP-seq
MIRT2579199	hsa-miR-4708-3p	CLIP-seq
MIRT2579200	hsa-miR-4713-5p	CLIP-seq
MIRT2579201	hsa-miR-4739	CLIP-seq
MIRT2579202	hsa-miR-4756-5p	CLIP-seq
MIRT2579203	hsa-miR-4794	CLIP-seq
MIRT2579204	hsa-miR-532-3p	CLIP-seq
MIRT2579205	hsa-miR-548m	CLIP-seq
MIRT2579206	hsa-miR-575	CLIP-seq
MIRT2579207	hsa-miR-615-5p	CLIP-seq
MIRT2579208	hsa-miR-655	CLIP-seq
MIRT2579209	hsa-miR-661	CLIP-seq
MIRT2579210	hsa-miR-711	CLIP-seq
MIRT2579176	hsa-miR-1224-3p	CLIP-seq
MIRT2579177	hsa-miR-1254	CLIP-seq
MIRT2579178	hsa-miR-1321	CLIP-seq
MIRT2051660	hsa-miR-150	CLIP-seq
MIRT2579180	hsa-miR-181a	CLIP-seq
MIRT2579181	hsa-miR-181b	CLIP-seq
MIRT2579182	hsa-miR-181c	CLIP-seq
MIRT2579183	hsa-miR-181d	CLIP-seq
MIRT2579184	hsa-miR-3116	CLIP-seq
MIRT2579185	hsa-miR-3156-3p	CLIP-seq
MIRT1178440	hsa-miR-3162-5p	CLIP-seq
MIRT2579186	hsa-miR-3620	CLIP-seq
MIRT2579187	hsa-miR-3690	CLIP-seq
MIRT2579188	hsa-miR-374c	CLIP-seq
MIRT2579189	hsa-miR-3927	CLIP-seq
MIRT2579191	hsa-miR-4262	CLIP-seq
MIRT2579192	hsa-miR-4286	CLIP-seq
MIRT2579193	hsa-miR-4301	CLIP-seq
MIRT2579194	hsa-miR-4509	CLIP-seq
MIRT2579198	hsa-miR-4691-5p	CLIP-seq
MIRT2579201	hsa-miR-4739	CLIP-seq
MIRT2579202	hsa-miR-4756-5p	CLIP-seq
MIRT2579203	hsa-miR-4794	CLIP-seq
MIRT2579205	hsa-miR-548m	CLIP-seq
MIRT2579208	hsa-miR-655	CLIP-seq
MIRT2579209	hsa-miR-661	CLIP-seq
MIRT2579210	hsa-miR-711	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0006024	Process	Glycosaminoglycan biosynthetic process	TAS
GO:0015014	Process	Heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	IBA	21873635
GO:0015016	Function	[heparan sulfate]-glucosamine N-sulfotransferase activity	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0019213	Function	Deacetylase activity	IBA	21873635
GO:0030210	Process	Heparin biosynthetic process	IEA

Other IDs

• MIM: 603268
• HGNC: 7681
• e!Ensembl: ENSG00000166507

Protein

• UniProt ID: P52849
• Protein name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 2) (NDST-2) (N-heparan sulfate sulfotransferase 2) (N-HSST 2) [Includes: Heparan sulfate N-deacetylase 2 (EC 3.-.-.-); Heparan sulf
• Protein function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated hepa
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12062	HSNSD	24 → 514	heparan sulfate-N-deacetylase	Family
  PF00685	Sulfotransfer_1	603 → 866	Sulfotransferase domain	Domain

• Sequence:

  MLQLWKVVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSPKAKEPLPLPLGDCSSGGA
  AGPGPARPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAPG
  RGDMPTLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSLL
  SAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPV
  LLASLRPAEPAVPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYL
  TGKRLCLDLDRYILVDIDDIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGK
  FYHTGTEEEDAGDDMLLKHRKEFWWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHGI
  PTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVL
  PRQTCGLFTHTIFYNEYPGGSRELDRSIRGGELFLTVLLNPISIFMTHLSNYGNDRLGLY
  TFESLVRFLQCWTRLRLQTLPPVPLAQKYFELFPQERSPLWQNPCDDKRHKDIWSKEKTC
  DRLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFNSPNYHKGIDWYMDF
  FPVPSNASTDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLTNPADRAYSWYQHQRAHG
  DPVALNYTFYQVISASSQTPLALRSLQNRCLVPGYYSTHLQRWLTYYPSGQLLIVDGQEL
  RTNPAASMESIQKFLGITPFLNYTRTLRFDDDKGFWCQGLEGGKTRCLGRSKGRRYPDMD
  TESRLFLTDFFRNHNLELSKLLSRLGQPVPSWLREELQHSSLG

• Sequence length: 883

Pathways

KEGG:

Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Metabolic pathways

Reactome:

HS-GAG biosynthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		29610475