GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

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CGNL1 (cingulin like 1)

Gene

Cingulin like 1

CGNL1

JACOP, PCING

15

15q21.3

This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chro

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SNP ID	Visualize variation	Clinical significance	Consequence
rs483352760	T>C	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant

Show/Hide all(281)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018735	hsa-miR-335-5p	Microarray	18185580
MIRT024620	hsa-miR-215-5p	Microarray	19074876
MIRT026805	hsa-miR-192-5p	Microarray	19074876
MIRT045751	hsa-miR-125a-5p	CLASH	23622248
MIRT038313	hsa-miR-130b-5p	CLASH	23622248
MIRT037512	hsa-miR-744-5p	CLASH	23622248
MIRT437659	hsa-miR-195-5p	Microarray, qRT-PCR	22815788
MIRT737077	hsa-miR-31-3p	Luciferase reporter assay, Western blotting, qRT-PCR	34201353
MIRT888295	hsa-miR-1229	CLIP-seq
MIRT888296	hsa-miR-1236	CLIP-seq
MIRT888297	hsa-miR-1243	CLIP-seq
MIRT888298	hsa-miR-1321	CLIP-seq
MIRT888299	hsa-miR-1322	CLIP-seq
MIRT888300	hsa-miR-193a-3p	CLIP-seq
MIRT888301	hsa-miR-193b	CLIP-seq
MIRT888302	hsa-miR-2052	CLIP-seq
MIRT888303	hsa-miR-216a	CLIP-seq
MIRT888304	hsa-miR-216b	CLIP-seq
MIRT888305	hsa-miR-219-5p	CLIP-seq
MIRT888306	hsa-miR-2467-3p	CLIP-seq
MIRT888307	hsa-miR-25	CLIP-seq
MIRT888308	hsa-miR-2909	CLIP-seq
MIRT888309	hsa-miR-297	CLIP-seq
MIRT888310	hsa-miR-3133	CLIP-seq
MIRT888311	hsa-miR-3163	CLIP-seq
MIRT888312	hsa-miR-3184	CLIP-seq
MIRT888313	hsa-miR-3187-3p	CLIP-seq
MIRT888314	hsa-miR-3189-5p	CLIP-seq
MIRT888315	hsa-miR-3194-5p	CLIP-seq
MIRT888316	hsa-miR-32	CLIP-seq
MIRT888317	hsa-miR-33a	CLIP-seq
MIRT888318	hsa-miR-33b	CLIP-seq
MIRT888319	hsa-miR-342-3p	CLIP-seq
MIRT888320	hsa-miR-34b	CLIP-seq
MIRT888321	hsa-miR-3609	CLIP-seq
MIRT888322	hsa-miR-3612	CLIP-seq
MIRT888323	hsa-miR-3614-5p	CLIP-seq
MIRT888324	hsa-miR-363	CLIP-seq
MIRT888325	hsa-miR-3654	CLIP-seq
MIRT888326	hsa-miR-3661	CLIP-seq
MIRT888327	hsa-miR-3668	CLIP-seq
MIRT888328	hsa-miR-367	CLIP-seq
MIRT888329	hsa-miR-3670	CLIP-seq
MIRT888330	hsa-miR-375	CLIP-seq
MIRT888331	hsa-miR-3978	CLIP-seq
MIRT888332	hsa-miR-423-5p	CLIP-seq
MIRT888333	hsa-miR-4257	CLIP-seq
MIRT888334	hsa-miR-4268	CLIP-seq
MIRT888335	hsa-miR-4270	CLIP-seq
MIRT888336	hsa-miR-4323	CLIP-seq
MIRT888337	hsa-miR-4325	CLIP-seq
MIRT888338	hsa-miR-4433	CLIP-seq
MIRT888339	hsa-miR-4435	CLIP-seq
MIRT888340	hsa-miR-4441	CLIP-seq
MIRT888341	hsa-miR-4445	CLIP-seq
MIRT888342	hsa-miR-4448	CLIP-seq
MIRT888343	hsa-miR-4511	CLIP-seq
MIRT888344	hsa-miR-4529-5p	CLIP-seq
MIRT888345	hsa-miR-4676-5p	CLIP-seq
MIRT888346	hsa-miR-4688	CLIP-seq
MIRT888347	hsa-miR-4700-3p	CLIP-seq
MIRT888348	hsa-miR-4701-5p	CLIP-seq
MIRT888349	hsa-miR-4719	CLIP-seq
MIRT888350	hsa-miR-4722-5p	CLIP-seq
MIRT888351	hsa-miR-4738-3p	CLIP-seq
MIRT888352	hsa-miR-4739	CLIP-seq
MIRT888353	hsa-miR-4756-5p	CLIP-seq
MIRT888354	hsa-miR-4779	CLIP-seq
MIRT888355	hsa-miR-4782-3p	CLIP-seq
MIRT888356	hsa-miR-486-3p	CLIP-seq
MIRT888357	hsa-miR-508-3p	CLIP-seq
MIRT888358	hsa-miR-508-5p	CLIP-seq
MIRT888359	hsa-miR-520d-5p	CLIP-seq
MIRT888360	hsa-miR-524-5p	CLIP-seq
MIRT888361	hsa-miR-548ah	CLIP-seq
MIRT888362	hsa-miR-548s	CLIP-seq
MIRT888363	hsa-miR-548t	CLIP-seq
MIRT888364	hsa-miR-567	CLIP-seq
MIRT888365	hsa-miR-575	CLIP-seq
MIRT888366	hsa-miR-588	CLIP-seq
MIRT888367	hsa-miR-593	CLIP-seq
MIRT888368	hsa-miR-631	CLIP-seq
MIRT888369	hsa-miR-650	CLIP-seq
MIRT888370	hsa-miR-766	CLIP-seq
MIRT888371	hsa-miR-767-3p	CLIP-seq
MIRT888372	hsa-miR-875-3p	CLIP-seq
MIRT888373	hsa-miR-92a	CLIP-seq
MIRT888374	hsa-miR-92b	CLIP-seq
MIRT888295	hsa-miR-1229	CLIP-seq
MIRT888296	hsa-miR-1236	CLIP-seq
MIRT1963327	hsa-miR-1255a	CLIP-seq
MIRT1963328	hsa-miR-1255b	CLIP-seq
MIRT1963329	hsa-miR-125b	CLIP-seq
MIRT1963330	hsa-miR-1268	CLIP-seq
MIRT1963331	hsa-miR-1268b	CLIP-seq
MIRT888298	hsa-miR-1321	CLIP-seq
MIRT1963332	hsa-miR-1324	CLIP-seq
MIRT1963333	hsa-miR-15a	CLIP-seq
MIRT1963334	hsa-miR-15b	CLIP-seq
MIRT1963335	hsa-miR-16	CLIP-seq
MIRT1963336	hsa-miR-195	CLIP-seq
MIRT1963337	hsa-miR-214	CLIP-seq
MIRT888303	hsa-miR-216a	CLIP-seq
MIRT888304	hsa-miR-216b	CLIP-seq
MIRT888305	hsa-miR-219-5p	CLIP-seq
MIRT1963338	hsa-miR-22	CLIP-seq
MIRT1963339	hsa-miR-24	CLIP-seq
MIRT888306	hsa-miR-2467-3p	CLIP-seq
MIRT888307	hsa-miR-25	CLIP-seq
MIRT1963340	hsa-miR-3183	CLIP-seq
MIRT888316	hsa-miR-32	CLIP-seq
MIRT888317	hsa-miR-33a	CLIP-seq
MIRT888318	hsa-miR-33b	CLIP-seq
MIRT888320	hsa-miR-34b	CLIP-seq
MIRT1963341	hsa-miR-3605-5p	CLIP-seq
MIRT888322	hsa-miR-3612	CLIP-seq
MIRT888323	hsa-miR-3614-5p	CLIP-seq
MIRT1963342	hsa-miR-3619-5p	CLIP-seq
MIRT888324	hsa-miR-363	CLIP-seq
MIRT1963343	hsa-miR-3652	CLIP-seq
MIRT888326	hsa-miR-3661	CLIP-seq
MIRT888328	hsa-miR-367	CLIP-seq
MIRT1963344	hsa-miR-3909	CLIP-seq
MIRT1963345	hsa-miR-424	CLIP-seq
MIRT1963346	hsa-miR-4256	CLIP-seq
MIRT888333	hsa-miR-4257	CLIP-seq
MIRT888335	hsa-miR-4270	CLIP-seq
MIRT1963347	hsa-miR-4284	CLIP-seq
MIRT1963348	hsa-miR-4287	CLIP-seq
MIRT1963349	hsa-miR-4319	CLIP-seq
MIRT1963350	hsa-miR-4430	CLIP-seq
MIRT888338	hsa-miR-4433	CLIP-seq
MIRT1963351	hsa-miR-4434	CLIP-seq
MIRT888340	hsa-miR-4441	CLIP-seq
MIRT888341	hsa-miR-4445	CLIP-seq
MIRT1963352	hsa-miR-4469	CLIP-seq
MIRT1963353	hsa-miR-4486	CLIP-seq
MIRT1963354	hsa-miR-4505	CLIP-seq
MIRT1963355	hsa-miR-4516	CLIP-seq
MIRT1963356	hsa-miR-4685-3p	CLIP-seq
MIRT888347	hsa-miR-4700-3p	CLIP-seq
MIRT1963357	hsa-miR-4704-3p	CLIP-seq
MIRT888350	hsa-miR-4722-5p	CLIP-seq
MIRT1963358	hsa-miR-4723-3p	CLIP-seq
MIRT1963359	hsa-miR-4731-3p	CLIP-seq
MIRT1963360	hsa-miR-4732-3p	CLIP-seq
MIRT888352	hsa-miR-4739	CLIP-seq
MIRT888353	hsa-miR-4756-5p	CLIP-seq
MIRT1963361	hsa-miR-4778-5p	CLIP-seq
MIRT888355	hsa-miR-4782-3p	CLIP-seq
MIRT1963362	hsa-miR-4801	CLIP-seq
MIRT1963363	hsa-miR-4802-3p	CLIP-seq
MIRT1963364	hsa-miR-488	CLIP-seq
MIRT1963365	hsa-miR-497	CLIP-seq
MIRT888357	hsa-miR-508-3p	CLIP-seq
MIRT1963366	hsa-miR-513a-5p	CLIP-seq
MIRT1963367	hsa-miR-585	CLIP-seq
MIRT1963368	hsa-miR-591	CLIP-seq
MIRT888367	hsa-miR-593	CLIP-seq
MIRT888368	hsa-miR-631	CLIP-seq
MIRT888369	hsa-miR-650	CLIP-seq
MIRT1963369	hsa-miR-670	CLIP-seq
MIRT1963370	hsa-miR-761	CLIP-seq
MIRT888373	hsa-miR-92a	CLIP-seq
MIRT888374	hsa-miR-92b	CLIP-seq
MIRT1963371	hsa-miR-942	CLIP-seq
MIRT888296	hsa-miR-1236	CLIP-seq
MIRT2199780	hsa-miR-1256	CLIP-seq
MIRT1963329	hsa-miR-125b	CLIP-seq
MIRT1963330	hsa-miR-1268	CLIP-seq
MIRT1963331	hsa-miR-1268b	CLIP-seq
MIRT888303	hsa-miR-216a	CLIP-seq
MIRT888304	hsa-miR-216b	CLIP-seq
MIRT888305	hsa-miR-219-5p	CLIP-seq
MIRT1963338	hsa-miR-22	CLIP-seq
MIRT2199781	hsa-miR-224	CLIP-seq
MIRT2199782	hsa-miR-23a	CLIP-seq
MIRT2199783	hsa-miR-23b	CLIP-seq
MIRT2199784	hsa-miR-23c	CLIP-seq
MIRT1963339	hsa-miR-24	CLIP-seq
MIRT888307	hsa-miR-25	CLIP-seq
MIRT888309	hsa-miR-297	CLIP-seq
MIRT888310	hsa-miR-3133	CLIP-seq
MIRT2199785	hsa-miR-3144-3p	CLIP-seq
MIRT888313	hsa-miR-3187-3p	CLIP-seq
MIRT888316	hsa-miR-32	CLIP-seq
MIRT888317	hsa-miR-33a	CLIP-seq
MIRT888318	hsa-miR-33b	CLIP-seq
MIRT888324	hsa-miR-363	CLIP-seq
MIRT1963343	hsa-miR-3652	CLIP-seq
MIRT888328	hsa-miR-367	CLIP-seq
MIRT2199786	hsa-miR-3674	CLIP-seq
MIRT2199787	hsa-miR-3679-3p	CLIP-seq
MIRT2199788	hsa-miR-3973	CLIP-seq
MIRT888331	hsa-miR-3978	CLIP-seq
MIRT1963347	hsa-miR-4284	CLIP-seq
MIRT1963348	hsa-miR-4287	CLIP-seq
MIRT1963349	hsa-miR-4319	CLIP-seq
MIRT888337	hsa-miR-4325	CLIP-seq
MIRT1963350	hsa-miR-4430	CLIP-seq
MIRT888338	hsa-miR-4433	CLIP-seq
MIRT888339	hsa-miR-4435	CLIP-seq
MIRT888341	hsa-miR-4445	CLIP-seq
MIRT1963352	hsa-miR-4469	CLIP-seq
MIRT1963353	hsa-miR-4486	CLIP-seq
MIRT1963354	hsa-miR-4505	CLIP-seq
MIRT888344	hsa-miR-4529-5p	CLIP-seq
MIRT1963356	hsa-miR-4685-3p	CLIP-seq
MIRT888348	hsa-miR-4701-5p	CLIP-seq
MIRT1963357	hsa-miR-4704-3p	CLIP-seq
MIRT2199789	hsa-miR-4717-3p	CLIP-seq
MIRT1963359	hsa-miR-4731-3p	CLIP-seq
MIRT1963360	hsa-miR-4732-3p	CLIP-seq
MIRT888354	hsa-miR-4779	CLIP-seq
MIRT888355	hsa-miR-4782-3p	CLIP-seq
MIRT1963362	hsa-miR-4801	CLIP-seq
MIRT1963363	hsa-miR-4802-3p	CLIP-seq
MIRT888357	hsa-miR-508-3p	CLIP-seq
MIRT888358	hsa-miR-508-5p	CLIP-seq
MIRT2199790	hsa-miR-520g	CLIP-seq
MIRT2199791	hsa-miR-520h	CLIP-seq
MIRT888362	hsa-miR-548s	CLIP-seq
MIRT888364	hsa-miR-567	CLIP-seq
MIRT1963367	hsa-miR-585	CLIP-seq
MIRT888366	hsa-miR-588	CLIP-seq
MIRT888367	hsa-miR-593	CLIP-seq
MIRT2199792	hsa-miR-619	CLIP-seq
MIRT888370	hsa-miR-766	CLIP-seq
MIRT888372	hsa-miR-875-3p	CLIP-seq
MIRT2199793	hsa-miR-875-5p	CLIP-seq
MIRT888373	hsa-miR-92a	CLIP-seq
MIRT888374	hsa-miR-92b	CLIP-seq
MIRT2199794	hsa-miR-95	CLIP-seq
MIRT2385996	hsa-miR-2355-5p	CLIP-seq
MIRT2385997	hsa-miR-4530	CLIP-seq
MIRT2385998	hsa-miR-503	CLIP-seq
MIRT2446978	hsa-miR-186	CLIP-seq
MIRT888303	hsa-miR-216a	CLIP-seq
MIRT888304	hsa-miR-216b	CLIP-seq
MIRT2446979	hsa-miR-371-5p	CLIP-seq
MIRT2446980	hsa-miR-371b-5p	CLIP-seq
MIRT888351	hsa-miR-4738-3p	CLIP-seq
MIRT888298	hsa-miR-1321	CLIP-seq
MIRT2502429	hsa-miR-1912	CLIP-seq
MIRT888303	hsa-miR-216a	CLIP-seq
MIRT888304	hsa-miR-216b	CLIP-seq
MIRT888306	hsa-miR-2467-3p	CLIP-seq
MIRT2502430	hsa-miR-3130-5p	CLIP-seq
MIRT888320	hsa-miR-34b	CLIP-seq
MIRT2502431	hsa-miR-3545-3p	CLIP-seq
MIRT2502432	hsa-miR-3607-5p	CLIP-seq
MIRT888322	hsa-miR-3612	CLIP-seq
MIRT888323	hsa-miR-3614-5p	CLIP-seq
MIRT888333	hsa-miR-4257	CLIP-seq
MIRT888335	hsa-miR-4270	CLIP-seq
MIRT888338	hsa-miR-4433	CLIP-seq
MIRT888340	hsa-miR-4441	CLIP-seq
MIRT2502433	hsa-miR-4482	CLIP-seq
MIRT888350	hsa-miR-4722-5p	CLIP-seq
MIRT888352	hsa-miR-4739	CLIP-seq
MIRT888353	hsa-miR-4756-5p	CLIP-seq
MIRT1963368	hsa-miR-591	CLIP-seq
MIRT888369	hsa-miR-650	CLIP-seq
MIRT888298	hsa-miR-1321	CLIP-seq
MIRT888303	hsa-miR-216a	CLIP-seq
MIRT888304	hsa-miR-216b	CLIP-seq
MIRT888306	hsa-miR-2467-3p	CLIP-seq
MIRT888320	hsa-miR-34b	CLIP-seq
MIRT888322	hsa-miR-3612	CLIP-seq
MIRT888323	hsa-miR-3614-5p	CLIP-seq
MIRT888333	hsa-miR-4257	CLIP-seq
MIRT888335	hsa-miR-4270	CLIP-seq
MIRT888338	hsa-miR-4433	CLIP-seq
MIRT888340	hsa-miR-4441	CLIP-seq
MIRT2678076	hsa-miR-4662a-5p	CLIP-seq
MIRT888345	hsa-miR-4676-5p	CLIP-seq
MIRT888350	hsa-miR-4722-5p	CLIP-seq
MIRT888352	hsa-miR-4739	CLIP-seq
MIRT888353	hsa-miR-4756-5p	CLIP-seq
MIRT888365	hsa-miR-575	CLIP-seq
MIRT888369	hsa-miR-650	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003774	Function	Motor activity	IEA
GO:0005515	Function	Protein binding	IPI	22891260, 25753039
GO:0005923	Component	Bicellular tight junction	IEA
GO:0007015	Process	Actin filament organization	IMP	22891260
GO:0016459	Component	Myosin complex	IEA
GO:0032991	Component	Protein-containing complex	IDA	25753039
GO:0051058	Process	Negative regulation of small GTPase mediated signal transduction	IMP	22891260
GO:0051497	Process	Negative regulation of stress fiber assembly	IMP	25753039
GO:0150105	Process	Protein localization to cell-cell junction	IMP	25753039

MIM	HGNC	e!Ensembl
607856	25931	ENSG00000128849

Protein

UniProt ID

Protein name

Cingulin-like protein 1 (Junction-associated coiled-coil protein) (Paracingulin)

Protein function

May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01576	Myosin_tail_1	576 → 1042	Myosin tail	Coiled-coil
PF01576	Myosin_tail_1	1015 → 1257	Myosin tail	Coiled-coil

Sequence

MELYFGEYQHVQQEYGVHLRLASDDTQKSRSSQNSKAGSYGVSIRVQGIDGHPYIVLNNT
ERCLAGTSFSENGPPFPPPVINNLPLHSSNGSVPKENSEELQLPENPYAQPSPIRNLKQP
LLHEGKNGVLDRKDGSVKPSHLLNFQRHPELLQPYDPEKNELNLQNHQPSESNWLKTLTE
EGINNKKPWTCFPKPSNSQPTSPSLEDPAKSGVTAIRLCSSVVIEDPKKQTSVCVNVQSC
TKERVGEEALFTSGRPLTAHSPHAHPETKKTRPDVLPFRRQDSAGPVLDGARSRRSSSSS
TTPTSANSLYRFLLDDQECAIHADNVNRHENRRYIPFLPGTGRDIDTGSIPGVDQLIEKF
DQKPGLQRRGRSGKRNRINTDDRKRSRSVDSAFPFGLQGNSEYLIEFSRNLGKSSEHLLR
PSQVCPQRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQEST
VIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLL
KGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNN
QACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNE
KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS
EDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDK
LKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEE
LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE
LEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI
VEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE
LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE
RNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSY
RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ
KDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLK
KLPSKVLDDMDDDDDLSTDGGSLYEAPVSYTFSKDSTVASQI

Sequence length

1302

Interactions

View interactions

	KEGG
	Tight junction

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	24163246

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		21305692

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