PPFIBP2 (PPFIB scaffold protein 2)

Gene

• Entrez ID: 8495
• Gene name: PPFIB scaffold protein 2
• Gene symbol: PPFIBP2
• Synonyms: Cclp1
• Chromosome: 11
• Chromosome location: 11p15.4
• Summary: This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1252593	hsa-miR-124	CLIP-seq
MIRT1252594	hsa-miR-3714	CLIP-seq
MIRT1252595	hsa-miR-3910	CLIP-seq
MIRT1252596	hsa-miR-506	CLIP-seq
MIRT2074413	hsa-miR-1208	CLIP-seq
MIRT2074414	hsa-miR-668	CLIP-seq
MIRT2301318	hsa-miR-1206	CLIP-seq
MIRT2074413	hsa-miR-1208	CLIP-seq
MIRT1252593	hsa-miR-124	CLIP-seq
MIRT2301319	hsa-miR-1294	CLIP-seq
MIRT2301320	hsa-miR-3607-5p	CLIP-seq
MIRT2301321	hsa-miR-3692	CLIP-seq
MIRT1252594	hsa-miR-3714	CLIP-seq
MIRT2301322	hsa-miR-3907	CLIP-seq
MIRT1252595	hsa-miR-3910	CLIP-seq
MIRT2301323	hsa-miR-4318	CLIP-seq
MIRT2301324	hsa-miR-4436b-5p	CLIP-seq
MIRT2301325	hsa-miR-4699-5p	CLIP-seq
MIRT2301326	hsa-miR-4706	CLIP-seq
MIRT2301327	hsa-miR-4710	CLIP-seq
MIRT2301328	hsa-miR-4749-5p	CLIP-seq
MIRT2301329	hsa-miR-4787-5p	CLIP-seq
MIRT1252596	hsa-miR-506	CLIP-seq
MIRT2301330	hsa-miR-548q	CLIP-seq
MIRT2074414	hsa-miR-668	CLIP-seq
MIRT2301331	hsa-miR-744	CLIP-seq
MIRT2598107	hsa-miR-1287	CLIP-seq
MIRT2598108	hsa-miR-1915	CLIP-seq
MIRT2598109	hsa-miR-302f	CLIP-seq
MIRT2598110	hsa-miR-3135b	CLIP-seq
MIRT2598111	hsa-miR-3136-3p	CLIP-seq
MIRT2598112	hsa-miR-4731-3p	CLIP-seq
MIRT2598113	hsa-miR-4801	CLIP-seq
MIRT2598107	hsa-miR-1287	CLIP-seq
MIRT2598108	hsa-miR-1915	CLIP-seq
MIRT2598109	hsa-miR-302f	CLIP-seq
MIRT2598110	hsa-miR-3135b	CLIP-seq
MIRT2598111	hsa-miR-3136-3p	CLIP-seq
MIRT2598112	hsa-miR-4731-3p	CLIP-seq
MIRT2598113	hsa-miR-4801	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	19447967, 26871637, 32296183
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005829	Component	Cytosol	TAS
GO:0007528	Process	Neuromuscular junction development	IBA	21873635
GO:0042802	Function	Identical protein binding	IDA	21462929
GO:0048786	Component	Presynaptic active zone	IBA	21873635
GO:0050808	Process	Synapse organization	IBA	21873635

Other IDs

• MIM: 603142
• HGNC: 9250
• e!Ensembl: ENSG00000166387

Protein

• UniProt ID: Q8ND30
• Protein name: Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2)
• Protein function: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.
• PDB: 3QH9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00536	SAM_1	556 → 620	SAM domain (Sterile alpha motif)	Domain
  PF00536	SAM_1	631 → 691	SAM domain (Sterile alpha motif)	Domain
  PF07647	SAM_2	715 → 785	SAM domain (Sterile alpha motif)	Domain

• Sequence:

  MASDASHALEAALEQMDGIIAGTKTGADLSDGTCEPGLASPASYMNPFPVLHLIEDLRLA
  LEMLELPQERAALLSQIPGPTAAYIKEWFEESLSQVNHHSAASNETYQERLARLEGDKES
  LILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELLSRTSLETQKLDLMTE
  VSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLKATKAEV
  AQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRI
  EELTGLLNQYRKVKEIVMVTQGPSERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPR
  CSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDSPFLAEH
  KYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSG
  TESGPQSPLTPDGKRNPKGIKKFWGKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSR
  TRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATPQDMEKE
  LGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRM
  LQYLTVNDLLFLKVTSQLHHLSIKCAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSN
  HRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRRHLTTK
  FNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPME
  PSDGVSDSHRVYSGYRGLSPLDAPELDGLDQVGQIS

• Sequence length: 876

Pathways

Reactome:

Receptor-type tyrosine-protein phosphatases

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate, Prostate carcinoma, Prostate cancer, familial	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	26443449, 29892016, 26443449, 29892016
Prostate cancer, hereditary	PROSTATE CANCER, HEREDITARY, 1	rs387906327, rs193929331, rs74315365, rs10993994, rs397516896, rs794729219, rs121913349, rs587782641, rs1114167673, rs1597371666, rs2073394466	29892016

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		26443449