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RGS5 (regulator of G protein signaling 5)

Gene

8490

Regulator of G protein signaling 5

RGS5

MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129

1q23.3

This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-i

Show/Hide all(190)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021577	hsa-miR-142-3p	Microarray	17612493
MIRT437944	hsa-miR-20a-5p	ChIP-seq, qRT-PCR, Luciferase reporter assay	23308108
MIRT437943	hsa-miR-92a-3p	ChIP-seq, qRT-PCR, Luciferase reporter assay	23308108
MIRT437942	hsa-miR-181a-5p	ChIP-seq, qRT-PCR, Luciferase reporter assay	23308108
MIRT437944	hsa-miR-20a-5p	ChIP-seq, qRT-PCR, Luciferase reporter assay	23308108
MIRT437943	hsa-miR-92a-3p	ChIP-seq, qRT-PCR, Luciferase reporter assay	23308108
MIRT437942	hsa-miR-181a-5p	ChIP-seq, qRT-PCR, Luciferase reporter assay	23308108
MIRT647924	hsa-miR-1243	HITS-CLIP	23824327
MIRT647923	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT647922	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT647921	hsa-miR-378j	HITS-CLIP	23824327
MIRT647920	hsa-miR-6839-5p	HITS-CLIP	23824327
MIRT647919	hsa-miR-3167	HITS-CLIP	23824327
MIRT647918	hsa-miR-876-5p	HITS-CLIP	23824327
MIRT647917	hsa-miR-1290	HITS-CLIP	23824327
MIRT647916	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT647915	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT639591	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT639590	hsa-miR-1248	HITS-CLIP	23824327
MIRT639589	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT639588	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT639587	hsa-miR-6083	HITS-CLIP	23824327
MIRT639586	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT569856	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT569855	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT569854	hsa-miR-595	PAR-CLIP	20371350
MIRT569853	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT569852	hsa-miR-4706	PAR-CLIP	20371350
MIRT569851	hsa-miR-4749-5p	PAR-CLIP	20371350
MIRT569850	hsa-miR-1908-5p	PAR-CLIP	20371350
MIRT569849	hsa-miR-663a	PAR-CLIP	20371350
MIRT569848	hsa-miR-6787-5p	PAR-CLIP	20371350
MIRT569847	hsa-miR-567	PAR-CLIP	20371350
MIRT569846	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT569845	hsa-miR-3911	PAR-CLIP	20371350
MIRT569843	hsa-miR-644a	PAR-CLIP	20371350
MIRT569844	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569842	hsa-miR-297	PAR-CLIP	20371350
MIRT569841	hsa-miR-147a	PAR-CLIP	20371350
MIRT569840	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT446907	hsa-miR-4255	PAR-CLIP	22100165
MIRT446905	hsa-miR-4635	PAR-CLIP	22100165
MIRT446906	hsa-miR-124-5p	PAR-CLIP	22100165
MIRT446904	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446903	hsa-miR-578	PAR-CLIP	22100165
MIRT647924	hsa-miR-1243	HITS-CLIP	23824327
MIRT647923	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT647922	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT647921	hsa-miR-378j	HITS-CLIP	23824327
MIRT647920	hsa-miR-6839-5p	HITS-CLIP	23824327
MIRT647919	hsa-miR-3167	HITS-CLIP	23824327
MIRT647918	hsa-miR-876-5p	HITS-CLIP	23824327
MIRT647917	hsa-miR-1290	HITS-CLIP	23824327
MIRT647916	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT647915	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT639591	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT639590	hsa-miR-1248	HITS-CLIP	23824327
MIRT639589	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT639588	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT639587	hsa-miR-6083	HITS-CLIP	23824327
MIRT639586	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT569856	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT569855	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT569854	hsa-miR-595	PAR-CLIP	20371350
MIRT569853	hsa-miR-511-3p	PAR-CLIP	20371350
MIRT569852	hsa-miR-4706	PAR-CLIP	20371350
MIRT569851	hsa-miR-4749-5p	PAR-CLIP	20371350
MIRT569850	hsa-miR-1908-5p	PAR-CLIP	20371350
MIRT569849	hsa-miR-663a	PAR-CLIP	20371350
MIRT569848	hsa-miR-6787-5p	PAR-CLIP	20371350
MIRT569847	hsa-miR-567	PAR-CLIP	20371350
MIRT569846	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT569845	hsa-miR-3911	PAR-CLIP	20371350
MIRT569843	hsa-miR-644a	PAR-CLIP	20371350
MIRT569844	hsa-miR-6867-5p	PAR-CLIP	20371350
MIRT569842	hsa-miR-297	PAR-CLIP	20371350
MIRT569841	hsa-miR-147a	PAR-CLIP	20371350
MIRT569840	hsa-miR-574-5p	PAR-CLIP	20371350
MIRT446907	hsa-miR-4255	PAR-CLIP	22100165
MIRT446905	hsa-miR-4635	PAR-CLIP	22100165
MIRT446906	hsa-miR-124-5p	PAR-CLIP	22100165
MIRT446904	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446903	hsa-miR-578	PAR-CLIP	22100165
MIRT1304441	hsa-miR-129-5p	CLIP-seq
MIRT1304442	hsa-miR-450b-5p	CLIP-seq
MIRT1304443	hsa-miR-4652-3p	CLIP-seq
MIRT1304444	hsa-miR-4698	CLIP-seq
MIRT1304445	hsa-miR-4778-5p	CLIP-seq
MIRT1304446	hsa-miR-507	CLIP-seq
MIRT1304447	hsa-miR-518a-5p	CLIP-seq
MIRT1304448	hsa-miR-527	CLIP-seq
MIRT1304449	hsa-miR-557	CLIP-seq
MIRT1304450	hsa-miR-1228	CLIP-seq
MIRT1304451	hsa-miR-1289	CLIP-seq
MIRT1304452	hsa-miR-129-3p	CLIP-seq
MIRT1304453	hsa-miR-219-2-3p	CLIP-seq
MIRT1304454	hsa-miR-2964a-3p	CLIP-seq
MIRT1304455	hsa-miR-3198	CLIP-seq
MIRT1304456	hsa-miR-323-3p	CLIP-seq
MIRT1304457	hsa-miR-3616-5p	CLIP-seq
MIRT1304458	hsa-miR-3647-5p	CLIP-seq
MIRT1304459	hsa-miR-3682-5p	CLIP-seq
MIRT1304460	hsa-miR-3688-3p	CLIP-seq
MIRT1304461	hsa-miR-377	CLIP-seq
MIRT1304462	hsa-miR-3908	CLIP-seq
MIRT1304463	hsa-miR-3942-3p	CLIP-seq
MIRT1304464	hsa-miR-3942-5p	CLIP-seq
MIRT1304465	hsa-miR-4279	CLIP-seq
MIRT1304466	hsa-miR-4294	CLIP-seq
MIRT1304467	hsa-miR-4309	CLIP-seq
MIRT1304468	hsa-miR-455-3p	CLIP-seq
MIRT1304469	hsa-miR-4670-3p	CLIP-seq
MIRT1304470	hsa-miR-4703-5p	CLIP-seq
MIRT1304471	hsa-miR-4729	CLIP-seq
MIRT1304472	hsa-miR-4742-3p	CLIP-seq
MIRT1304473	hsa-miR-4766-3p	CLIP-seq
MIRT1304474	hsa-miR-4775	CLIP-seq
MIRT1304475	hsa-miR-513a-5p	CLIP-seq
MIRT1304476	hsa-miR-556-3p	CLIP-seq
MIRT1304477	hsa-miR-572	CLIP-seq
MIRT1304478	hsa-miR-573	CLIP-seq
MIRT1304479	hsa-miR-579	CLIP-seq
MIRT1304480	hsa-miR-587	CLIP-seq
MIRT1304481	hsa-miR-590-3p	CLIP-seq
MIRT1304482	hsa-miR-718	CLIP-seq
MIRT1304483	hsa-miR-924	CLIP-seq
MIRT1304484	hsa-miR-944	CLIP-seq
MIRT1553090	hsa-miR-501-3p	CLIP-seq
MIRT1553091	hsa-miR-502-3p	CLIP-seq
MIRT1553092	hsa-miR-767-5p	CLIP-seq
MIRT2090207	hsa-miR-135a	CLIP-seq
MIRT2090208	hsa-miR-135b	CLIP-seq
MIRT1304453	hsa-miR-219-2-3p	CLIP-seq
MIRT1304454	hsa-miR-2964a-3p	CLIP-seq
MIRT1304461	hsa-miR-377	CLIP-seq
MIRT1304463	hsa-miR-3942-3p	CLIP-seq
MIRT2314937	hsa-miR-103a	CLIP-seq
MIRT2314938	hsa-miR-107	CLIP-seq
MIRT2314939	hsa-miR-15a	CLIP-seq
MIRT2314940	hsa-miR-15b	CLIP-seq
MIRT2314941	hsa-miR-16	CLIP-seq
MIRT2314942	hsa-miR-195	CLIP-seq
MIRT2314943	hsa-miR-214	CLIP-seq
MIRT1304453	hsa-miR-219-2-3p	CLIP-seq
MIRT2314944	hsa-miR-224	CLIP-seq
MIRT1304454	hsa-miR-2964a-3p	CLIP-seq
MIRT2314945	hsa-miR-3153	CLIP-seq
MIRT2314946	hsa-miR-3160-5p	CLIP-seq
MIRT1304457	hsa-miR-3616-5p	CLIP-seq
MIRT2314947	hsa-miR-3619-5p	CLIP-seq
MIRT2314948	hsa-miR-3622b-5p	CLIP-seq
MIRT1304458	hsa-miR-3647-5p	CLIP-seq
MIRT1304461	hsa-miR-377	CLIP-seq
MIRT1304463	hsa-miR-3942-3p	CLIP-seq
MIRT2314949	hsa-miR-3945	CLIP-seq
MIRT2314950	hsa-miR-424	CLIP-seq
MIRT2314951	hsa-miR-4291	CLIP-seq
MIRT2314952	hsa-miR-4493	CLIP-seq
MIRT2314953	hsa-miR-4524	CLIP-seq
MIRT2314954	hsa-miR-4719	CLIP-seq
MIRT2314955	hsa-miR-4761-3p	CLIP-seq
MIRT2314956	hsa-miR-4768-5p	CLIP-seq
MIRT2314957	hsa-miR-4795-3p	CLIP-seq
MIRT2314958	hsa-miR-485-3p	CLIP-seq
MIRT2314959	hsa-miR-495	CLIP-seq
MIRT2314960	hsa-miR-497	CLIP-seq
MIRT2314961	hsa-miR-503	CLIP-seq
MIRT2314962	hsa-miR-526b	CLIP-seq
MIRT1304478	hsa-miR-573	CLIP-seq
MIRT2314963	hsa-miR-630	CLIP-seq
MIRT2314964	hsa-miR-646	CLIP-seq
MIRT2314965	hsa-miR-656	CLIP-seq
MIRT2314966	hsa-miR-761	CLIP-seq
MIRT2314967	hsa-miR-922	CLIP-seq
MIRT2314968	hsa-miR-936	CLIP-seq
MIRT2458149	hsa-miR-299-3p	CLIP-seq
MIRT2458150	hsa-miR-34c-3p	CLIP-seq
MIRT2458151	hsa-miR-4420	CLIP-seq
MIRT1304450	hsa-miR-1228	CLIP-seq
MIRT1304461	hsa-miR-377	CLIP-seq
MIRT1304462	hsa-miR-3908	CLIP-seq
MIRT1304464	hsa-miR-3942-5p	CLIP-seq
MIRT1304470	hsa-miR-4703-5p	CLIP-seq
MIRT1304473	hsa-miR-4766-3p	CLIP-seq
MIRT1304450	hsa-miR-1228	CLIP-seq
MIRT1304461	hsa-miR-377	CLIP-seq
MIRT1304462	hsa-miR-3908	CLIP-seq
MIRT1304464	hsa-miR-3942-5p	CLIP-seq
MIRT1304470	hsa-miR-4703-5p	CLIP-seq
MIRT1304473	hsa-miR-4766-3p	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	TAS
GO:0005096	Function	GTPase activator activity	TAS	10471929
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	10471929
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0043547	Process	Positive regulation of GTPase activity	IEA

MIM	HGNC	e!Ensembl
603276	10001	ENSG00000143248

Protein

UniProt ID

O15539

Protein name

Regulator of G-protein signaling 5 (RGS5)

Protein function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha (By similarity).

PDB

2CRP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00615	RGS	64 → 179	Regulator of G protein signaling domain	Domain

Sequence

MCKGLAALPHSCLERAKEIKIKLGILLQKPDSVGDLVIPYNEKPEKPAKTQKTSLDEALQ
WRDSLDKLLQNNYGLASFKSFLKSEFSEENLEFWIACEDYKKIKSPAKMAEKAKQIYEEF
IQTEAPKEVNIDHFTKDITMKNLVEPSLSSFDMAQKRIHALMEKDSLPRFVRSEFYQELI
K

Sequence length

181

Interactions

View interactions

	Reactome
			G alpha (q) signalling events G alpha (i) signalling events

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Hypertension	Hypertensive disease, Essential Hypertension	rs13306026, rs13333226	1798635
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	18262772

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