PTPN5 (protein tyrosine phosphatase non-receptor type 5)

Gene

• Entrez ID: 84867
• Gene name: Protein tyrosine phosphatase non-receptor type 5
• Gene symbol: PTPN5
• Synonyms: PTPSTEP, STEP, STEP61
• Chromosome: 11
• Chromosome location: 11p15.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1275706	hsa-miR-128	CLIP-seq
MIRT1275707	hsa-miR-1343	CLIP-seq
MIRT1275708	hsa-miR-3064-5p	CLIP-seq
MIRT1275709	hsa-miR-3150b-3p	CLIP-seq
MIRT1275710	hsa-miR-3667-3p	CLIP-seq
MIRT1275711	hsa-miR-3670	CLIP-seq
MIRT1275712	hsa-miR-4689	CLIP-seq
MIRT1275713	hsa-miR-4784	CLIP-seq
MIRT1275714	hsa-miR-101	CLIP-seq
MIRT1275715	hsa-miR-1285	CLIP-seq
MIRT1275716	hsa-miR-1287	CLIP-seq
MIRT1275717	hsa-miR-144	CLIP-seq
MIRT1275718	hsa-miR-1587	CLIP-seq
MIRT1275719	hsa-miR-3120-5p	CLIP-seq
MIRT1275720	hsa-miR-3135b	CLIP-seq
MIRT1275721	hsa-miR-3187-5p	CLIP-seq
MIRT1275722	hsa-miR-378g	CLIP-seq
MIRT1275723	hsa-miR-3908	CLIP-seq
MIRT1275724	hsa-miR-4286	CLIP-seq
MIRT1275725	hsa-miR-4476	CLIP-seq
MIRT1275726	hsa-miR-4486	CLIP-seq
MIRT1275727	hsa-miR-4492	CLIP-seq
MIRT1275728	hsa-miR-4498	CLIP-seq
MIRT1275729	hsa-miR-4656	CLIP-seq
MIRT1275730	hsa-miR-4675	CLIP-seq
MIRT1275731	hsa-miR-4741	CLIP-seq
MIRT1275732	hsa-miR-593	CLIP-seq
MIRT1275733	hsa-miR-612	CLIP-seq
MIRT1275734	hsa-miR-762	CLIP-seq
MIRT2081137	hsa-miR-1273f	CLIP-seq
MIRT2081138	hsa-miR-3134	CLIP-seq
MIRT2081139	hsa-miR-4756-3p	CLIP-seq
MIRT2307066	hsa-miR-1260	CLIP-seq
MIRT2307067	hsa-miR-1260b	CLIP-seq
MIRT1275706	hsa-miR-128	CLIP-seq
MIRT1275715	hsa-miR-1285	CLIP-seq
MIRT2307068	hsa-miR-188-3p	CLIP-seq
MIRT2307069	hsa-miR-3156-3p	CLIP-seq
MIRT1275721	hsa-miR-3187-5p	CLIP-seq
MIRT1275733	hsa-miR-612	CLIP-seq
MIRT2307070	hsa-miR-642b	CLIP-seq
MIRT2457458	hsa-miR-3942-5p	CLIP-seq
MIRT2457459	hsa-miR-4703-5p	CLIP-seq
MIRT2457460	hsa-miR-545	CLIP-seq
MIRT2604586	hsa-miR-1200	CLIP-seq
MIRT2604587	hsa-miR-3660	CLIP-seq
MIRT2604588	hsa-miR-4324	CLIP-seq
MIRT2604589	hsa-miR-4526	CLIP-seq
MIRT2604590	hsa-miR-4667-3p	CLIP-seq
MIRT2604591	hsa-miR-544b	CLIP-seq
MIRT1275711	hsa-miR-3670	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001784	Function	Phosphotyrosine residue binding	IDA	16441242
GO:0004725	Function	Protein tyrosine phosphatase activity	TAS	7490079
GO:0005515	Function	Protein binding	IPI	21044950, 25416956, 31515488, 32296183
GO:0005654	Component	Nucleoplasm	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006470	Process	Protein dephosphorylation	TAS	7490079
GO:0016021	Component	Integral component of membrane	TAS
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IEA
GO:0071345	Process	Cellular response to cytokine stimulus	TAS

Other IDs

• MIM: 176879
• HGNC: 9657
• e!Ensembl: ENSG00000110786

Protein

• UniProt ID: P54829
• Protein name: Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP)
• Protein function: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.
• PDB: 2BIJ, 2BV5, 2CJZ, 5OVR, 5OVX, 5OW1, 6H8R, 8SLS, 8SLT, 8SLU, 9EEX, 9EEY, 9EEZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00102	Y_phosphatase	323 → 553	Protein-tyrosine phosphatase	Domain

• Sequence:

  MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPP
  PPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLV
  SSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPED
  RRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQ
  ERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLL
  QAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIR
  GYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYD
  GVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE
  AAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQ
  TCEQYQFVHHVMSLYEKQLSHQSPE

• Sequence length: 565

Pathways

KEGG:

MAPK signaling pathway

Reactome:

Interleukin-37 signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Myopia	Myopia	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805, rs782555528, rs1554862601, rs1586620121, rs1387950081, rs2051026773, rs1422332023	27182965
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22781170, 22555153