PHF5A (PHD finger protein 5A)

Gene

• Entrez ID: 84844
• Gene name: PHD finger protein 5A
• Gene symbol: PHF5A
• Synonyms: INI, Rds3, SAP14b, SF3B7, SF3b14b, bK223H9.2
• Chromosome: 22
• Chromosome location: 22q13.2
• Summary: This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-m

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT052678	hsa-miR-1260b	CLASH	23622248
MIRT532634	hsa-miR-6838-3p	PAR-CLIP	22012620
MIRT532633	hsa-miR-6734-3p	PAR-CLIP	22012620
MIRT532632	hsa-miR-20b-3p	PAR-CLIP	22012620
MIRT532631	hsa-miR-4297	PAR-CLIP	22012620
MIRT532630	hsa-miR-5581-5p	PAR-CLIP	22012620
MIRT532629	hsa-miR-1537-5p	PAR-CLIP	22012620
MIRT532627	hsa-miR-4718	PAR-CLIP	22012620
MIRT532628	hsa-miR-4999-5p	PAR-CLIP	22012620
MIRT532626	hsa-miR-4529-5p	PAR-CLIP	22012620
MIRT532624	hsa-miR-4540	PAR-CLIP	22012620
MIRT532625	hsa-miR-202-5p	PAR-CLIP	22012620
MIRT532623	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT462643	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT462642	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT462641	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT462640	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT462639	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT462638	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT462637	hsa-miR-558	PAR-CLIP	23592263
MIRT462636	hsa-miR-4487	PAR-CLIP	23592263
MIRT462635	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT462634	hsa-miR-6086	PAR-CLIP	23592263
MIRT462633	hsa-miR-924	PAR-CLIP	23592263
MIRT462632	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT462631	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT462630	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT462629	hsa-miR-4314	PAR-CLIP	23592263
MIRT462628	hsa-miR-627-5p	PAR-CLIP	23592263
MIRT462627	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT462626	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT532634	hsa-miR-6838-3p	PAR-CLIP	22012620
MIRT532633	hsa-miR-6734-3p	PAR-CLIP	22012620
MIRT532632	hsa-miR-20b-3p	PAR-CLIP	22012620
MIRT532631	hsa-miR-4297	PAR-CLIP	22012620
MIRT532630	hsa-miR-5581-5p	PAR-CLIP	22012620
MIRT532629	hsa-miR-1537-5p	PAR-CLIP	22012620
MIRT532627	hsa-miR-4718	PAR-CLIP	22012620
MIRT532628	hsa-miR-4999-5p	PAR-CLIP	22012620
MIRT532626	hsa-miR-4529-5p	PAR-CLIP	22012620
MIRT532624	hsa-miR-4540	PAR-CLIP	22012620
MIRT532625	hsa-miR-202-5p	PAR-CLIP	22012620
MIRT532623	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT462643	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT462642	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT462641	hsa-miR-3192-5p	PAR-CLIP	23592263
MIRT462640	hsa-miR-619-5p	PAR-CLIP	23592263
MIRT462639	hsa-miR-6506-5p	PAR-CLIP	23592263
MIRT462638	hsa-miR-3160-3p	PAR-CLIP	23592263
MIRT462637	hsa-miR-558	PAR-CLIP	23592263
MIRT462636	hsa-miR-4487	PAR-CLIP	23592263
MIRT462635	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT462634	hsa-miR-6086	PAR-CLIP	23592263
MIRT462633	hsa-miR-924	PAR-CLIP	23592263
MIRT462632	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT462631	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT462630	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT462629	hsa-miR-4314	PAR-CLIP	23592263
MIRT462628	hsa-miR-627-5p	PAR-CLIP	23592263
MIRT462627	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT462626	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT1231128	hsa-miR-1183	CLIP-seq
MIRT1231129	hsa-miR-1231	CLIP-seq
MIRT1231130	hsa-miR-1262	CLIP-seq
MIRT1231131	hsa-miR-1268	CLIP-seq
MIRT1231132	hsa-miR-1268b	CLIP-seq
MIRT1231133	hsa-miR-1275	CLIP-seq
MIRT1231134	hsa-miR-128	CLIP-seq
MIRT1231135	hsa-miR-187	CLIP-seq
MIRT1231136	hsa-miR-223	CLIP-seq
MIRT1231137	hsa-miR-2276	CLIP-seq
MIRT1231138	hsa-miR-27a	CLIP-seq
MIRT1231139	hsa-miR-27b	CLIP-seq
MIRT1231140	hsa-miR-298	CLIP-seq
MIRT1231141	hsa-miR-3137	CLIP-seq
MIRT1231142	hsa-miR-3147	CLIP-seq
MIRT1231143	hsa-miR-3162-3p	CLIP-seq
MIRT1231144	hsa-miR-3179	CLIP-seq
MIRT1231145	hsa-miR-3202	CLIP-seq
MIRT1231146	hsa-miR-4277	CLIP-seq
MIRT1231147	hsa-miR-4307	CLIP-seq
MIRT1231148	hsa-miR-4326	CLIP-seq
MIRT1231149	hsa-miR-4420	CLIP-seq
MIRT1231150	hsa-miR-4425	CLIP-seq
MIRT1231151	hsa-miR-4476	CLIP-seq
MIRT1231152	hsa-miR-4486	CLIP-seq
MIRT1231153	hsa-miR-4638-3p	CLIP-seq
MIRT1231154	hsa-miR-4665-5p	CLIP-seq
MIRT1231155	hsa-miR-4696	CLIP-seq
MIRT1231156	hsa-miR-4701-3p	CLIP-seq
MIRT1231157	hsa-miR-4723-5p	CLIP-seq
MIRT1231158	hsa-miR-4781-3p	CLIP-seq
MIRT1231159	hsa-miR-500a	CLIP-seq
MIRT1231160	hsa-miR-501-5p	CLIP-seq
MIRT1231161	hsa-miR-5096	CLIP-seq
MIRT1231162	hsa-miR-513a-5p	CLIP-seq
MIRT1231163	hsa-miR-585	CLIP-seq
MIRT1231164	hsa-miR-587	CLIP-seq
MIRT2067824	hsa-miR-103a	CLIP-seq
MIRT2067825	hsa-miR-107	CLIP-seq
MIRT2067826	hsa-miR-1184	CLIP-seq
MIRT2067827	hsa-miR-22	CLIP-seq
MIRT2067828	hsa-miR-31	CLIP-seq
MIRT2067829	hsa-miR-3128	CLIP-seq
MIRT1231144	hsa-miR-3179	CLIP-seq
MIRT1231145	hsa-miR-3202	CLIP-seq
MIRT2067830	hsa-miR-3688-5p	CLIP-seq
MIRT2067831	hsa-miR-3977	CLIP-seq
MIRT1231147	hsa-miR-4307	CLIP-seq
MIRT2067832	hsa-miR-4434	CLIP-seq
MIRT1231151	hsa-miR-4476	CLIP-seq
MIRT2067833	hsa-miR-4494	CLIP-seq
MIRT2067834	hsa-miR-4499	CLIP-seq
MIRT2067835	hsa-miR-4516	CLIP-seq
MIRT2067836	hsa-miR-4531	CLIP-seq
MIRT2067837	hsa-miR-4704-5p	CLIP-seq
MIRT2067838	hsa-miR-4712-5p	CLIP-seq
MIRT2067839	hsa-miR-4720-5p	CLIP-seq
MIRT1231157	hsa-miR-4723-5p	CLIP-seq
MIRT2067840	hsa-miR-4771	CLIP-seq
MIRT2067841	hsa-miR-4773	CLIP-seq
MIRT2067842	hsa-miR-4799-3p	CLIP-seq
MIRT2067843	hsa-miR-4802-5p	CLIP-seq
MIRT2067844	hsa-miR-770-5p	CLIP-seq
MIRT2067845	hsa-miR-885-3p	CLIP-seq
MIRT2067846	hsa-miR-922	CLIP-seq
MIRT2067824	hsa-miR-103a	CLIP-seq
MIRT2067825	hsa-miR-107	CLIP-seq
MIRT2067826	hsa-miR-1184	CLIP-seq
MIRT2295286	hsa-miR-1244	CLIP-seq
MIRT2295287	hsa-miR-138	CLIP-seq
MIRT2067827	hsa-miR-22	CLIP-seq
MIRT2067829	hsa-miR-3128	CLIP-seq
MIRT1231147	hsa-miR-4307	CLIP-seq
MIRT1231148	hsa-miR-4326	CLIP-seq
MIRT2067833	hsa-miR-4494	CLIP-seq
MIRT2067834	hsa-miR-4499	CLIP-seq
MIRT2295288	hsa-miR-4690-5p	CLIP-seq
MIRT2067837	hsa-miR-4704-5p	CLIP-seq
MIRT2067838	hsa-miR-4712-5p	CLIP-seq
MIRT2067839	hsa-miR-4720-5p	CLIP-seq
MIRT2067840	hsa-miR-4771	CLIP-seq
MIRT2067842	hsa-miR-4799-3p	CLIP-seq
MIRT2295289	hsa-miR-544	CLIP-seq
MIRT2067844	hsa-miR-770-5p	CLIP-seq
MIRT2067845	hsa-miR-885-3p	CLIP-seq
MIRT2067846	hsa-miR-922	CLIP-seq
MIRT1231131	hsa-miR-1268	CLIP-seq
MIRT1231132	hsa-miR-1268b	CLIP-seq
MIRT1231134	hsa-miR-128	CLIP-seq
MIRT1231136	hsa-miR-223	CLIP-seq
MIRT1231138	hsa-miR-27a	CLIP-seq
MIRT1231139	hsa-miR-27b	CLIP-seq
MIRT1231140	hsa-miR-298	CLIP-seq
MIRT1231146	hsa-miR-4277	CLIP-seq
MIRT1231148	hsa-miR-4326	CLIP-seq
MIRT1231149	hsa-miR-4420	CLIP-seq
MIRT1231152	hsa-miR-4486	CLIP-seq
MIRT1231162	hsa-miR-513a-5p	CLIP-seq
MIRT1231163	hsa-miR-585	CLIP-seq
MIRT1231131	hsa-miR-1268	CLIP-seq
MIRT1231132	hsa-miR-1268b	CLIP-seq
MIRT1231134	hsa-miR-128	CLIP-seq
MIRT1231137	hsa-miR-2276	CLIP-seq
MIRT1231138	hsa-miR-27a	CLIP-seq
MIRT1231139	hsa-miR-27b	CLIP-seq
MIRT1231147	hsa-miR-4307	CLIP-seq
MIRT1231149	hsa-miR-4420	CLIP-seq
MIRT1231152	hsa-miR-4486	CLIP-seq
MIRT1231155	hsa-miR-4696	CLIP-seq
MIRT2592893	hsa-miR-4715-3p	CLIP-seq
MIRT1231161	hsa-miR-5096	CLIP-seq
MIRT1231162	hsa-miR-513a-5p	CLIP-seq
MIRT1231163	hsa-miR-585	CLIP-seq
MIRT1231131	hsa-miR-1268	CLIP-seq
MIRT1231132	hsa-miR-1268b	CLIP-seq
MIRT1231134	hsa-miR-128	CLIP-seq
MIRT1231136	hsa-miR-223	CLIP-seq
MIRT1231137	hsa-miR-2276	CLIP-seq
MIRT1231138	hsa-miR-27a	CLIP-seq
MIRT1231139	hsa-miR-27b	CLIP-seq
MIRT1231146	hsa-miR-4277	CLIP-seq
MIRT1231147	hsa-miR-4307	CLIP-seq
MIRT1231149	hsa-miR-4420	CLIP-seq
MIRT1231152	hsa-miR-4486	CLIP-seq
MIRT1231155	hsa-miR-4696	CLIP-seq
MIRT2592893	hsa-miR-4715-3p	CLIP-seq
MIRT1231161	hsa-miR-5096	CLIP-seq
MIRT1231162	hsa-miR-513a-5p	CLIP-seq
MIRT1231163	hsa-miR-585	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA	21873635
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	12234937, 29360106
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IDA	27720643
GO:0005515	Function	Protein binding	IPI	17332742, 24981860, 27720643, 32814053
GO:0005634	Component	Nucleus	IDA	27720643, 28541300, 29360106
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005686	Component	U2 snRNP	IBA	21873635
GO:0005686	Component	U2 snRNP	IDA	12234937
GO:0005689	Component	U12-type spliceosomal complex	IBA	21873635
GO:0005689	Component	U12-type spliceosomal complex	IDA	15146077
GO:0008270	Function	Zinc ion binding	IDA	28541300
GO:0016363	Component	Nuclear matrix	IEA
GO:0016607	Component	Nuclear speck	ISS
GO:0045893	Process	Positive regulation of transcription, DNA-templated	ISS
GO:0048863	Process	Stem cell differentiation	IEA
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	29360106
GO:0071011	Component	Precatalytic spliceosome	IBA	21873635

Other IDs

• MIM: 617846
• HGNC: 18000
• e!Ensembl: ENSG00000100410

Protein

• UniProt ID: Q7RTV0
• Protein name: PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b)
• Protein function: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:28541300, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP c
• PDB: 5IFE, 5O9Z, 5SYB, 5Z56, 5Z57, 5Z58, 5ZYA, 6AH0, 6AHD, 6EN4, 6FF4, 6FF7, 6QX9, 6Y50, 6Y5Q, 7ABG, 7ABH, 7ABI, 7B0I, 7B91, 7B92, 7B9C, 7DVQ, 7EVN, 7EVO, 7OMF, 7ONB, 7OPI, 7Q3L, 7Q4O, 7Q4P, 7QTT, 7VPX, 8CH6, 8H6E, 8H6J, 8H6K, 8H6L, 8HK1, 8I0P, 8I0R, 8I0S, 8I0T, 8I0U, 8I0V, 8QO9, 8QXD, 8QZS, 8R08, 8R09, 8R0A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03660	PHF5	1 → 104	PHF5-like protein	Family

• Sequence:

  MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVI
  CGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR

• Sequence length: 110

Pathways

KEGG:

Spliceosome

Reactome:

mRNA Splicing - Major Pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	30929738