LOXL3 (lysyl oxidase like 3)

Gene

• Entrez ID: 84695
• Gene name: Lysyl oxidase like 3
• Gene symbol: LOXL3
• Synonyms: LOXL, MYP28
• Chromosome: 2
• Chromosome location: 2p13.1
• Summary: This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1115386	hsa-miR-2113	CLIP-seq
MIRT1115387	hsa-miR-2467-3p	CLIP-seq
MIRT1115388	hsa-miR-323-5p	CLIP-seq
MIRT1115389	hsa-miR-34a	CLIP-seq
MIRT1115390	hsa-miR-34c-5p	CLIP-seq
MIRT1115391	hsa-miR-3616-3p	CLIP-seq
MIRT1115392	hsa-miR-3678-3p	CLIP-seq
MIRT1115393	hsa-miR-4265	CLIP-seq
MIRT1115394	hsa-miR-4296	CLIP-seq
MIRT1115395	hsa-miR-4322	CLIP-seq
MIRT1115396	hsa-miR-4417	CLIP-seq
MIRT1115397	hsa-miR-4436b-3p	CLIP-seq
MIRT1115398	hsa-miR-449a	CLIP-seq
MIRT1115399	hsa-miR-449b	CLIP-seq
MIRT1115400	hsa-miR-876-3p	CLIP-seq
MIRT2262964	hsa-miR-320a	CLIP-seq
MIRT2262965	hsa-miR-320b	CLIP-seq
MIRT2262966	hsa-miR-320c	CLIP-seq
MIRT2262967	hsa-miR-320d	CLIP-seq
MIRT2262968	hsa-miR-361-3p	CLIP-seq
MIRT2262969	hsa-miR-3679-3p	CLIP-seq
MIRT2262970	hsa-miR-4429	CLIP-seq
MIRT2262971	hsa-miR-4446-5p	CLIP-seq
MIRT2438380	hsa-let-7a	CLIP-seq
MIRT2438381	hsa-let-7b	CLIP-seq
MIRT2438382	hsa-let-7c	CLIP-seq
MIRT2438383	hsa-let-7d	CLIP-seq
MIRT2438384	hsa-let-7e	CLIP-seq
MIRT2438385	hsa-let-7f	CLIP-seq
MIRT2438386	hsa-let-7g	CLIP-seq
MIRT2438387	hsa-let-7i	CLIP-seq
MIRT2438388	hsa-miR-1200	CLIP-seq
MIRT2438389	hsa-miR-202	CLIP-seq
MIRT2438390	hsa-miR-4324	CLIP-seq
MIRT2438391	hsa-miR-4458	CLIP-seq
MIRT2438392	hsa-miR-4500	CLIP-seq
MIRT2438393	hsa-miR-544b	CLIP-seq
MIRT2438394	hsa-miR-578	CLIP-seq
MIRT2438395	hsa-miR-629	CLIP-seq
MIRT2438396	hsa-miR-98	CLIP-seq
MIRT2453202	hsa-miR-1226	CLIP-seq
MIRT2453203	hsa-miR-1343	CLIP-seq
MIRT2453204	hsa-miR-1470	CLIP-seq
MIRT2453205	hsa-miR-3144-3p	CLIP-seq
MIRT2453206	hsa-miR-3163	CLIP-seq
MIRT2453207	hsa-miR-3185	CLIP-seq
MIRT2453208	hsa-miR-3646	CLIP-seq
MIRT2453209	hsa-miR-378g	CLIP-seq
MIRT2453210	hsa-miR-410	CLIP-seq
MIRT2453211	hsa-miR-4282	CLIP-seq
MIRT2453212	hsa-miR-4437	CLIP-seq
MIRT2453213	hsa-miR-4447	CLIP-seq
MIRT2453214	hsa-miR-4472	CLIP-seq
MIRT2453215	hsa-miR-4488	CLIP-seq
MIRT2453216	hsa-miR-4667-3p	CLIP-seq
MIRT2453217	hsa-miR-4674	CLIP-seq
MIRT2453218	hsa-miR-4697-5p	CLIP-seq
MIRT2453219	hsa-miR-4736	CLIP-seq
MIRT2453220	hsa-miR-486-3p	CLIP-seq
MIRT2453221	hsa-miR-634	CLIP-seq
MIRT2453222	hsa-miR-760	CLIP-seq
MIRT2453223	hsa-miR-875-5p	CLIP-seq
MIRT2438380	hsa-let-7a	CLIP-seq
MIRT2438381	hsa-let-7b	CLIP-seq
MIRT2438382	hsa-let-7c	CLIP-seq
MIRT2438383	hsa-let-7d	CLIP-seq
MIRT2438384	hsa-let-7e	CLIP-seq
MIRT2438385	hsa-let-7f	CLIP-seq
MIRT2438386	hsa-let-7g	CLIP-seq
MIRT2438387	hsa-let-7i	CLIP-seq
MIRT2438388	hsa-miR-1200	CLIP-seq
MIRT2562327	hsa-miR-1207-3p	CLIP-seq
MIRT2562328	hsa-miR-1252	CLIP-seq
MIRT2562329	hsa-miR-1273e	CLIP-seq
MIRT2562330	hsa-miR-130a	CLIP-seq
MIRT2562331	hsa-miR-130b	CLIP-seq
MIRT2453203	hsa-miR-1343	CLIP-seq
MIRT2438389	hsa-miR-202	CLIP-seq
MIRT2562332	hsa-miR-2277-3p	CLIP-seq
MIRT2562333	hsa-miR-301a	CLIP-seq
MIRT2562334	hsa-miR-301b	CLIP-seq
MIRT2453206	hsa-miR-3163	CLIP-seq
MIRT2562335	hsa-miR-3173-3p	CLIP-seq
MIRT2562336	hsa-miR-3176	CLIP-seq
MIRT2453207	hsa-miR-3185	CLIP-seq
MIRT2562337	hsa-miR-3666	CLIP-seq
MIRT2562338	hsa-miR-3692	CLIP-seq
MIRT2453209	hsa-miR-378g	CLIP-seq
MIRT2562339	hsa-miR-3922-3p	CLIP-seq
MIRT2453210	hsa-miR-410	CLIP-seq
MIRT2562340	hsa-miR-4295	CLIP-seq
MIRT2438390	hsa-miR-4324	CLIP-seq
MIRT2453212	hsa-miR-4437	CLIP-seq
MIRT2438391	hsa-miR-4458	CLIP-seq
MIRT2438392	hsa-miR-4500	CLIP-seq
MIRT2562341	hsa-miR-4502	CLIP-seq
MIRT2562342	hsa-miR-4527	CLIP-seq
MIRT2562343	hsa-miR-454	CLIP-seq
MIRT2562344	hsa-miR-4645-3p	CLIP-seq
MIRT2562345	hsa-miR-4671-3p	CLIP-seq
MIRT2453217	hsa-miR-4674	CLIP-seq
MIRT2562346	hsa-miR-4757-5p	CLIP-seq
MIRT2562347	hsa-miR-4779	CLIP-seq
MIRT2438393	hsa-miR-544b	CLIP-seq
MIRT2562348	hsa-miR-570	CLIP-seq
MIRT2438394	hsa-miR-578	CLIP-seq
MIRT2562349	hsa-miR-628-5p	CLIP-seq
MIRT2438395	hsa-miR-629	CLIP-seq
MIRT2453222	hsa-miR-760	CLIP-seq
MIRT2562350	hsa-miR-885-3p	CLIP-seq
MIRT2438396	hsa-miR-98	CLIP-seq
MIRT2438380	hsa-let-7a	CLIP-seq
MIRT2438381	hsa-let-7b	CLIP-seq
MIRT2438382	hsa-let-7c	CLIP-seq
MIRT2438383	hsa-let-7d	CLIP-seq
MIRT2438384	hsa-let-7e	CLIP-seq
MIRT2438385	hsa-let-7f	CLIP-seq
MIRT2438386	hsa-let-7g	CLIP-seq
MIRT2438387	hsa-let-7i	CLIP-seq
MIRT2438388	hsa-miR-1200	CLIP-seq
MIRT2562327	hsa-miR-1207-3p	CLIP-seq
MIRT2562328	hsa-miR-1252	CLIP-seq
MIRT2562329	hsa-miR-1273e	CLIP-seq
MIRT2562330	hsa-miR-130a	CLIP-seq
MIRT2562331	hsa-miR-130b	CLIP-seq
MIRT2453203	hsa-miR-1343	CLIP-seq
MIRT2438389	hsa-miR-202	CLIP-seq
MIRT2562332	hsa-miR-2277-3p	CLIP-seq
MIRT2562333	hsa-miR-301a	CLIP-seq
MIRT2562334	hsa-miR-301b	CLIP-seq
MIRT2453205	hsa-miR-3144-3p	CLIP-seq
MIRT2453206	hsa-miR-3163	CLIP-seq
MIRT2562335	hsa-miR-3173-3p	CLIP-seq
MIRT2562336	hsa-miR-3176	CLIP-seq
MIRT2453207	hsa-miR-3185	CLIP-seq
MIRT1115388	hsa-miR-323-5p	CLIP-seq
MIRT2453208	hsa-miR-3646	CLIP-seq
MIRT2562337	hsa-miR-3666	CLIP-seq
MIRT2562338	hsa-miR-3692	CLIP-seq
MIRT2453209	hsa-miR-378g	CLIP-seq
MIRT2562339	hsa-miR-3922-3p	CLIP-seq
MIRT2453210	hsa-miR-410	CLIP-seq
MIRT2684069	hsa-miR-4278	CLIP-seq
MIRT2453211	hsa-miR-4282	CLIP-seq
MIRT2562340	hsa-miR-4295	CLIP-seq
MIRT2438390	hsa-miR-4324	CLIP-seq
MIRT2453212	hsa-miR-4437	CLIP-seq
MIRT2453213	hsa-miR-4447	CLIP-seq
MIRT2438391	hsa-miR-4458	CLIP-seq
MIRT2453214	hsa-miR-4472	CLIP-seq
MIRT2438392	hsa-miR-4500	CLIP-seq
MIRT2562341	hsa-miR-4502	CLIP-seq
MIRT2562342	hsa-miR-4527	CLIP-seq
MIRT2562343	hsa-miR-454	CLIP-seq
MIRT2684070	hsa-miR-4640-5p	CLIP-seq
MIRT2562344	hsa-miR-4645-3p	CLIP-seq
MIRT2562345	hsa-miR-4671-3p	CLIP-seq
MIRT2453217	hsa-miR-4674	CLIP-seq
MIRT2684071	hsa-miR-4688	CLIP-seq
MIRT2684072	hsa-miR-4722-3p	CLIP-seq
MIRT2684073	hsa-miR-4726-5p	CLIP-seq
MIRT2562346	hsa-miR-4757-5p	CLIP-seq
MIRT2684074	hsa-miR-4769-3p	CLIP-seq
MIRT2562347	hsa-miR-4779	CLIP-seq
MIRT2438393	hsa-miR-544b	CLIP-seq
MIRT2562348	hsa-miR-570	CLIP-seq
MIRT2438394	hsa-miR-578	CLIP-seq
MIRT2562349	hsa-miR-628-5p	CLIP-seq
MIRT2438395	hsa-miR-629	CLIP-seq
MIRT2453222	hsa-miR-760	CLIP-seq
MIRT2453223	hsa-miR-875-5p	CLIP-seq
MIRT1115400	hsa-miR-876-3p	CLIP-seq
MIRT2562350	hsa-miR-885-3p	CLIP-seq
MIRT2438396	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001837	Process	Epithelial to mesenchymal transition	IDA	16096638
GO:0001968	Function	Fibronectin binding	ISS
GO:0004720	Function	Protein-lysine 6-oxidase activity	IBA	21873635
GO:0004720	Function	Protein-lysine 6-oxidase activity	IDA	28065600
GO:0004720	Function	Protein-lysine 6-oxidase activity	NAS	11284725
GO:0005044	Function	Scavenger receptor activity	IEA
GO:0005507	Function	Copper ion binding	NAS	11284725
GO:0005515	Function	Protein binding	IPI	16096638, 28065600, 29758265
GO:0005576	Component	Extracellular region	IDA	11284725
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	ISS
GO:0005634	Component	Nucleus	IDA	28065600
GO:0005634	Component	Nucleus	TAS	16096638
GO:0005737	Component	Cytoplasm	IDA	28065600
GO:0006897	Process	Endocytosis	IEA
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0006954	Process	Inflammatory response	ISS
GO:0016020	Component	Membrane	IEA
GO:0018057	Process	Peptidyl-lysine oxidation	IBA	21873635
GO:0018057	Process	Peptidyl-lysine oxidation	IDA	28065600
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0021510	Process	Spinal cord development	ISS
GO:0030199	Process	Collagen fibril organization	IBA	21873635
GO:0030324	Process	Lung development	ISS
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IDA	16096638
GO:0060021	Process	Roof of mouth development	ISS
GO:0061053	Process	Somite development	ISS
GO:1905590	Process	Fibronectin fibril organization	ISS
GO:2000329	Process	Negative regulation of T-helper 17 cell lineage commitment	ISS
GO:2001046	Process	Positive regulation of integrin-mediated signaling pathway	ISS

Other IDs

• MIM: 607163
• HGNC: 13869
• e!Ensembl: ENSG00000115318

Protein

• UniProt ID: P58215
• Protein name: Lysyl oxidase homolog 3 (EC 1.4.3.-) (EC 1.4.3.13) (Lysyl oxidase-like protein 3)
• Protein function: Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00530	SRCR	50 → 145	Scavenger receptor cysteine-rich domain	Domain
  PF00530	SRCR	181 → 282	Scavenger receptor cysteine-rich domain	Domain
  PF00530	SRCR	310 → 407	Scavenger receptor cysteine-rich domain	Domain
  PF00530	SRCR	420 → 525	Scavenger receptor cysteine-rich domain	Domain
  PF01186	Lysyl_oxidase	529 → 729	Lysyl oxidase	Family

• Sequence:

  MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEI
  QRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQS
  VTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRR
  PLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHS
  FGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSK
  PQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGA
  RMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLS
  GGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSG
  NITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQE
  TAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHS
  WVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQ
  GITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGH
  RIWVHNCHIGDAFSEEANRRFERYPGQTSNQII

• Sequence length: 753

Pathways

Reactome:

Elastic fibre formation
Crosslinking of collagen fibrils

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Cataract	Cataract	rs118203965, rs118203966, rs104893685, rs121908938, rs104894175, rs121909048, rs28937573, rs121909049, rs121909050, rs74315488, rs80358200, rs80358203, rs121434643, rs56141211, rs132630322, rs121917775, rs121917735, rs121917736, rs137853199, rs137853200, rs121917867, rs121917869, rs121913555, rs104893736, rs121909595, rs121909596, rs121909597, rs28931605, rs121909598, rs104893618, rs1695062782, rs74315486, rs74315487, rs74315490, rs74315489, rs745938679, rs1566402656, rs74315439, rs74315441, rs121912973, rs121917823, rs1593332981, rs121917825, rs121917827, rs113994108, rs387906963, rs387906964, rs1240503246, rs387906965, rs387906966, rs750207077, rs387907336, rs387907337, rs387907342, rs140332366, rs397514703, rs398122937, rs398122378, rs398122392, rs398122944, rs137853924, rs398122947, rs397515623, rs397515624, rs397515625, rs397515626, rs398122948, rs587778872, rs398123066, rs587777601, rs370424081, rs786205221, rs786205222, rs864309684, rs864309688, rs864309701, rs864309689, rs864309690, rs864309681, rs864309686, rs864309696, rs864309693, rs864309687, rs864309691, rs864309692, rs864309695, rs864309678, rs864309685, rs864309700, rs864309698, rs864309683, rs864309682, rs864309679, rs111534978, rs864309680, rs864309702, rs864622780, rs756898971, rs869312732, rs775038545, rs878852983, rs1114167312, rs1114167313, rs1114167314, rs1114167315, rs1114167307, rs886041410, rs886041412, rs1057518738, rs1057517926, rs1057518878, rs1057519616, rs12799308, rs1064793935, rs1064797219, rs1085307126, rs1085307127, rs765628635, rs1114167427, rs1114167433, rs1554744860, rs1554743428, rs747093432, rs1411557416, rs1555179713, rs1481963503, rs1555549755, rs1456161420, rs1555547008, rs1555889308, rs1555888762, rs766522434, rs1264025914, rs1553585262, rs1567671947, rs1337897299, rs764945940, rs1307969607, rs949335475, rs1184095219, rs776129797, rs1569203234, rs1567668570, rs749141857, rs764098604, rs1184398243, rs1578956689, rs1568480054, rs1564745688, rs1564722302, rs1564723150, rs1571175950, rs1569602837, rs1576552712, rs1575369255, rs981126461, rs1570403798, rs200557771, rs1477743112, rs1651879427, rs1651881222, rs1651919374, rs2024441691, rs148284531, rs1246080692
Epiphyseal dysplasia	Epiphyseal dysplasia	rs137852652, rs28936668, rs1600786629, rs1600786748, rs606231367, rs1569763139, rs1569763108, rs1085307973, rs1555821817
Hearing loss	Sensorineural Hearing Loss (disorder)	rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359, rs180177151, rs180177154, rs180177153, rs35689081, rs35887622, rs80338944, rs104894396, rs104894398, rs80338947, rs80338948, rs80338942, rs104894402, rs104894403, rs80338945, rs28931594, rs80338940, rs80338941, rs80356590, rs80338950, rs387906706, rs387906707, rs387906708, rs398122848, rs387907016, rs587776894, rs387907088, rs397515411, rs370965183, rs398122930, rs199897298, rs111033187, rs111033448, rs199606180, rs111033284, rs397516413, rs111033305, rs111033220, rs111033256, rs111033297, rs111033253, rs104894408, rs111033295, rs397516874, rs76434661, rs111033335, rs397517323, rs111033247, rs367928692, rs374793617, rs143939430, rs397515605, rs80338939, rs200656442, rs779748859, rs587781261, rs587781262, rs143343083, rs200147906, rs730880338, rs797044491, rs146281367, rs756484720, rs869025593, rs201306709, rs540895576, rs777777359, rs879255246, rs1554358720, rs142498437, rs377145777, rs1057517519, rs779077039, rs952741388, rs1060499797, rs764139009, rs1060499590, rs1064794012, rs1064797115, rs756790858, rs775633137, rs1554952443, rs1554952193, rs782063761, rs1199012623, rs756147087, rs1555648043, rs1555661490, rs1553196233, rs781546107, rs111033190, rs775428246, rs782539587, rs537227442, rs148695069, rs1554835827, rs953422571, rs1554834186, rs1554834161, rs1554835103, rs1554577339, rs1554577402, rs768471577, rs782279338, rs781951909, rs998045226, rs375759781, rs755804651, rs1557458426, rs767797828, rs538027448, rs1559366084, rs367688416, rs1558480402, rs1558490542, rs1559870857, rs1560690591, rs1561299289, rs1562817224, rs1562817529, rs1562822565, rs1562835391, rs1564113368, rs1564554255, rs773851192, rs1564555240, rs761261855, rs1564805114, rs1565522273, rs1565127413, rs781790246, rs1565430886, rs1565469959, rs746667217, rs1565819402, rs1565855932, rs150529554, rs1567939793, rs201866631, rs754472294, rs1559372512, rs1558464965, rs1558488902, rs775062249, rs1226171550, rs1561590396, rs765574676, rs762876554, rs757327146, rs1564949059, rs1565519673, rs368050948, rs1565541888, rs781989117, rs1565402473, rs750358148, rs1386887007, rs1209665716, rs1567641234, rs1237955948, rs1569042782, rs752672077, rs146689036, rs1560070780, rs149712664, rs1564556995, rs762226905, rs773573968, rs1568528171, rs1198256157, rs377267777, rs370564476, rs1577876794, rs747787770, rs759432278, rs1043716893, rs1581138934, rs2033773650, rs1421964916, rs771766431, rs780917129, rs1895773215, rs1895769400, rs761543680, rs1565920060
Myopia	Myopia	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805, rs782555528, rs1554862601, rs1586620121, rs1387950081, rs2051026773, rs1422332023
Retinal detachment	Retinal Detachment	rs1555976049, rs1592230091
Stickler syndrome	Stickler syndrome, type 1, Autosomal recessive Stickler syndrome	rs121912943, rs121912931, rs121912866, rs2136528572, rs121912869, rs121912870, rs121912872, rs121912873, rs121912876, rs794727377, rs2136508504, rs2136577259, rs121912882, rs1057524696, rs121912884, rs121912885, rs2136637244, rs121912893, rs1592232116, rs1592196064, rs121912896, rs121912897, rs121912898, rs80356554, rs606231376, rs398122828, rs189754995, rs672601354, rs672601355, rs748459670, rs886041713, rs886043356, rs886043410, rs886044244, rs1057517989, rs1057524114, rs72667036, rs1085307608, rs1131691822, rs1555165494, rs1553404310, rs1555166555, rs1553193910, rs1553223152, rs1555168965, rs1555164735, rs1555165204, rs1555166218, rs1555166295, rs1555166658, rs1025202963, rs1555168309, rs1246771678, rs866783525, rs201035486, rs1565679039, rs1557847904, rs1557877041, rs1557932876, rs1592233968, rs1592196744, rs1592217071, rs1592235241, rs1592202517, rs753342774, rs1592205758, rs1592206729, rs1269619781, rs1592196867, rs1592218346, rs1399676515, rs1939312423	25663169

Unknown
Disease name	Disease term	dbSNP ID	References
Astigmatism	Astigmatism
Dwarfism	Dwarfism
Micrognathism	Micrognathism
Vitreoretinal degeneration	Vitreoretinal degeneration