Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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84687 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Protein phosphatase 1 regulatory subunit 9B |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PPP1R9B |
SynonymsGene synonyms aliases
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PPP1R6, PPP1R9, SPINO, Spn |
ChromosomeChromosome number
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17 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
17q21.33 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the cent |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000164 |
Component |
Protein phosphatase type 1 complex |
TAS |
11278317 |
GO:0001560 |
Process |
Regulation of cell growth by extracellular stimulus |
TAS |
11278317 |
GO:0001932 |
Process |
Regulation of protein phosphorylation |
IEA |
|
GO:0001975 |
Process |
Response to amphetamine |
IEA |
|
GO:0003006 |
Process |
Developmental process involved in reproduction |
IEA |
|
GO:0004672 |
Function |
Protein kinase activity |
IEA |
|
GO:0004864 |
Function |
Protein phosphatase inhibitor activity |
NAS |
11278317 |
GO:0005515 |
Function |
Protein binding |
IPI |
11278317, 15231748, 19151759, 22321011, 24114805, 24366813, 25593058, 25785436, 26496610, 28330616, 28514442 |
GO:0005654 |
Component |
Nucleoplasm |
IMP |
11278317 |
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
11278317, 19151759 |
GO:0005886 |
Component |
Plasma membrane |
IDA |
19151759 |
GO:0005912 |
Component |
Adherens junction |
IEA |
|
GO:0006468 |
Process |
Protein phosphorylation |
IEA |
|
GO:0007015 |
Process |
Actin filament organization |
IBA |
21873635 |
GO:0007050 |
Process |
Cell cycle arrest |
TAS |
11278317 |
GO:0007096 |
Process |
Regulation of exit from mitosis |
NAS |
11278317 |
GO:0007568 |
Process |
Aging |
IEA |
|
GO:0007612 |
Process |
Learning |
IEA |
|
GO:0008022 |
Function |
Protein C-terminus binding |
IEA |
|
GO:0008157 |
Function |
Protein phosphatase 1 binding |
NAS |
11278317 |
GO:0008380 |
Process |
RNA splicing |
NAS |
11278317 |
GO:0014069 |
Component |
Postsynaptic density |
IBA |
21873635 |
GO:0015629 |
Component |
Actin cytoskeleton |
IBA |
21873635 |
GO:0016358 |
Process |
Dendrite development |
IEA |
|
GO:0016477 |
Process |
Cell migration |
IMP |
19151759 |
GO:0019722 |
Process |
Calcium-mediated signaling |
IBA |
21873635 |
GO:0019900 |
Function |
Kinase binding |
IEA |
|
GO:0021766 |
Process |
Hippocampus development |
IEA |
|
GO:0021987 |
Process |
Cerebral cortex development |
IEA |
|
GO:0030027 |
Component |
Lamellipodium |
IDA |
19151759 |
GO:0030042 |
Process |
Actin filament depolymerization |
IEA |
|
GO:0030175 |
Component |
Filopodium |
IDA |
19151759 |
GO:0030308 |
Process |
Negative regulation of cell growth |
IDA |
11278317 |
GO:0030425 |
Component |
Dendrite |
IBA |
21873635 |
GO:0030426 |
Component |
Growth cone |
IEA |
|
GO:0030864 |
Component |
Cortical actin cytoskeleton |
IEA |
|
GO:0031175 |
Process |
Neuron projection development |
IBA |
21873635 |
GO:0031749 |
Function |
D2 dopamine receptor binding |
IEA |
|
GO:0032515 |
Process |
Negative regulation of phosphoprotein phosphatase activity |
IEA |
|
GO:0032587 |
Component |
Ruffle membrane |
IDA |
19151759 |
GO:0034695 |
Process |
Response to prostaglandin E |
IEA |
|
GO:0035094 |
Process |
Response to nicotine |
IEA |
|
GO:0035690 |
Process |
Cellular response to drug |
IEA |
|
GO:0035902 |
Process |
Response to immobilization stress |
IEA |
|
GO:0042127 |
Process |
Regulation of cell population proliferation |
NAS |
11278317 |
GO:0043025 |
Component |
Neuronal cell body |
IEA |
|
GO:0044325 |
Function |
Ion channel binding |
IEA |
|
GO:0044326 |
Component |
Dendritic spine neck |
IEA |
|
GO:0044327 |
Component |
Dendritic spine head |
IEA |
|
GO:0046847 |
Process |
Filopodium assembly |
IMP |
19151759 |
GO:0048545 |
Process |
Response to steroid hormone |
IEA |
|
GO:0050804 |
Process |
Modulation of chemical synaptic transmission |
IEA |
|
GO:0051015 |
Function |
Actin filament binding |
IBA |
21873635 |
GO:0060179 |
Process |
Male mating behavior |
IEA |
|
GO:0061458 |
Process |
Reproductive system development |
IEA |
|
GO:0071315 |
Process |
Cellular response to morphine |
ISS |
|
GO:0071364 |
Process |
Cellular response to epidermal growth factor stimulus |
IEA |
|
GO:0071392 |
Process |
Cellular response to estradiol stimulus |
IEA |
|
GO:0097338 |
Process |
Response to clozapine |
IEA |
|
GO:1901653 |
Process |
Cellular response to peptide |
IEA |
|
GO:1903078 |
Process |
Positive regulation of protein localization to plasma membrane |
IEA |
|
GO:1903119 |
Process |
Protein localization to actin cytoskeleton |
IEA |
|
GO:1904372 |
Process |
Positive regulation of protein localization to actin cortical patch |
IEA |
|
GO:1904373 |
Process |
Response to kainic acid |
IEA |
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GO:1904386 |
Process |
Response to L-phenylalanine derivative |
IEA |
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GO:1990778 |
Process |
Protein localization to cell periphery |
IEA |
|
GO:1990780 |
Component |
Cytoplasmic side of dendritic spine plasma membrane |
IEA |
|
GO:2000474 |
Process |
Regulation of opioid receptor signaling pathway |
ISS |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q96SB3 |
Protein name |
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin) |
Protein function |
Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-act |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF17817 |
PDZ_5 |
426 → 489 |
PDZ domain |
Domain |
PF00595 |
PDZ |
496 → 581 |
PDZ domain |
Domain |
|
Sequence |
MMKTEPRGPGGPLRSASPHRSAYEAGIQALKPPDAPGPDEAPKGAHHKKYGSNVHRIKSM FLQMGTTAGPSGEAGGGAGLAEAPRASERGVRLSLPRASSLNENVDHSALLKLGTSVSER VSRFDSKPAPSAQPAPPPHPPSRLQETRKLFERSAPAAAGGDKEAAARRLLRQERAGLQD RKLDVVVRFNGSTEALDKLDADAVSPTVSQLSAVFEKADSRTGLHRGPGLPRAAGVPQVN SKLVSKRSRVFQPPPPPPPAPSGDAPAEKERCPAGQQPPQHRVAPARPPPKPREVRKIKP VEVEESGESEAESAPGEVIQAEVTVHAALENGSTVATAASPAPEEPKAQAAPEKEAAAVA PPERGVGNGRAPDVAPEEVDESKKEDFSEADLVDVSAYSGLGEDSAGSALEEDDEDDEED GEPPYEPESGCVEIPGLSEEEDPAPSRKIHFSTAPIQVFSTYSNEDYDRRNEDVDPMAAS AEYELEKRVERLELFPVELEKDSEGLGISIIGMGAGADMGLEKLGIFVKTVTEGGAAHRD GRIQVNDLLVEVDGTSLVGVTQSFAASVLRNTKGRVRFMIGRERPGEQSEVAQLIQQTLE QERWQREMMEQRYAQYGEDDEETGEYATDEDEELSPTFPGGEMAIEVFELAENEDALSPV DMEPEKLVHKFKELQIKHAVTEAEIQQLKRKLQSLEQEKGRWRVEKAQLEQSVEENKERM EKLEGYWGEAQSLCQAVDEHLRETQAQYQALERKYSKAKRLIKDYQQKEIEFLKKETAQR RVLEESELARKEEMDKLLDKISELEGNLQTLRNSNST
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Sequence length |
817 |
Interactions |
View interactions |
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
16786528, 15465982 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Sinusitis |
Sinusitis |
|
18391768 |
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