MCHR2 (melanin concentrating hormone receptor 2)

Gene

• Entrez ID: 84539
• Gene name: Melanin concentrating hormone receptor 2
• Gene symbol: MCHR2
• Synonyms: GPR145, GPRv17, MCH-2R, MCH-R2, MCH2, MCH2R, MCHR-2, SLT
• Chromosome: 6
• Chromosome location: 6q16.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018648	hsa-miR-335-5p	Microarray	18185580
MIRT1137155	hsa-miR-3145-5p	CLIP-seq
MIRT1137156	hsa-miR-3691-3p	CLIP-seq
MIRT1137157	hsa-miR-151-3p	CLIP-seq
MIRT1137158	hsa-miR-4662a-5p	CLIP-seq
MIRT1137159	hsa-miR-590-3p	CLIP-seq
MIRT2039036	hsa-miR-106a	CLIP-seq
MIRT2039037	hsa-miR-106b	CLIP-seq
MIRT2039038	hsa-miR-150	CLIP-seq
MIRT2039039	hsa-miR-17	CLIP-seq
MIRT2039040	hsa-miR-20a	CLIP-seq
MIRT2039041	hsa-miR-20b	CLIP-seq
MIRT2039042	hsa-miR-302a	CLIP-seq
MIRT2039043	hsa-miR-302b	CLIP-seq
MIRT2039044	hsa-miR-302c	CLIP-seq
MIRT2039045	hsa-miR-302d	CLIP-seq
MIRT2039046	hsa-miR-302e	CLIP-seq
MIRT2039047	hsa-miR-3130-3p	CLIP-seq
MIRT2039048	hsa-miR-372	CLIP-seq
MIRT2039049	hsa-miR-373	CLIP-seq
MIRT2039050	hsa-miR-4252	CLIP-seq
MIRT2039051	hsa-miR-4438	CLIP-seq
MIRT2039052	hsa-miR-4731-5p	CLIP-seq
MIRT2039053	hsa-miR-5095	CLIP-seq
MIRT2039054	hsa-miR-512-3p	CLIP-seq
MIRT2039055	hsa-miR-519d	CLIP-seq
MIRT2039056	hsa-miR-520a-3p	CLIP-seq
MIRT2039057	hsa-miR-520b	CLIP-seq
MIRT2039058	hsa-miR-520c-3p	CLIP-seq
MIRT2039059	hsa-miR-520d-3p	CLIP-seq
MIRT2039060	hsa-miR-520e	CLIP-seq
MIRT2039061	hsa-miR-520g	CLIP-seq
MIRT2039062	hsa-miR-520h	CLIP-seq
MIRT2039063	hsa-miR-93	CLIP-seq
MIRT2039064	hsa-miR-941	CLIP-seq
MIRT2039036	hsa-miR-106a	CLIP-seq
MIRT2039037	hsa-miR-106b	CLIP-seq
MIRT2039038	hsa-miR-150	CLIP-seq
MIRT2039039	hsa-miR-17	CLIP-seq
MIRT2039040	hsa-miR-20a	CLIP-seq
MIRT2039041	hsa-miR-20b	CLIP-seq
MIRT2269060	hsa-miR-27a	CLIP-seq
MIRT2269061	hsa-miR-27b	CLIP-seq
MIRT2039042	hsa-miR-302a	CLIP-seq
MIRT2039043	hsa-miR-302b	CLIP-seq
MIRT2039044	hsa-miR-302c	CLIP-seq
MIRT2039045	hsa-miR-302d	CLIP-seq
MIRT2039046	hsa-miR-302e	CLIP-seq
MIRT2039047	hsa-miR-3130-3p	CLIP-seq
MIRT2269062	hsa-miR-3187-3p	CLIP-seq
MIRT2039048	hsa-miR-372	CLIP-seq
MIRT2039049	hsa-miR-373	CLIP-seq
MIRT2269063	hsa-miR-380	CLIP-seq
MIRT2039050	hsa-miR-4252	CLIP-seq
MIRT2269064	hsa-miR-4435	CLIP-seq
MIRT2039051	hsa-miR-4438	CLIP-seq
MIRT2269065	hsa-miR-4463	CLIP-seq
MIRT2269066	hsa-miR-4464	CLIP-seq
MIRT2269067	hsa-miR-4494	CLIP-seq
MIRT2269068	hsa-miR-4666-5p	CLIP-seq
MIRT2269069	hsa-miR-4701-5p	CLIP-seq
MIRT2039052	hsa-miR-4731-5p	CLIP-seq
MIRT2269070	hsa-miR-4748	CLIP-seq
MIRT2269071	hsa-miR-4781-3p	CLIP-seq
MIRT2269072	hsa-miR-490-5p	CLIP-seq
MIRT2039053	hsa-miR-5095	CLIP-seq
MIRT2039054	hsa-miR-512-3p	CLIP-seq
MIRT2269073	hsa-miR-513a-5p	CLIP-seq
MIRT2039055	hsa-miR-519d	CLIP-seq
MIRT2039056	hsa-miR-520a-3p	CLIP-seq
MIRT2039057	hsa-miR-520b	CLIP-seq
MIRT2039058	hsa-miR-520c-3p	CLIP-seq
MIRT2039059	hsa-miR-520d-3p	CLIP-seq
MIRT2039060	hsa-miR-520e	CLIP-seq
MIRT2039061	hsa-miR-520g	CLIP-seq
MIRT2039062	hsa-miR-520h	CLIP-seq
MIRT2269074	hsa-miR-548s	CLIP-seq
MIRT2269075	hsa-miR-588	CLIP-seq
MIRT2039063	hsa-miR-93	CLIP-seq
MIRT2039064	hsa-miR-941	CLIP-seq
MIRT2039038	hsa-miR-150	CLIP-seq
MIRT2684735	hsa-miR-640	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007218	Process	Neuropeptide signaling pathway	IBA	21873635
GO:0008528	Function	G protein-coupled peptide receptor activity	IBA	21873635

Other IDs

• MIM: 606111
• HGNC: 20867
• e!Ensembl: ENSG00000152034

Protein

• UniProt ID: Q969V1
• Protein name: Melanin-concentrating hormone receptor 2 (MCH receptor 2) (MCH-R2) (MCHR-2) (G-protein coupled receptor 145) (GPRv17) (MCH-2R) (MCH2) (MCH2R)
• Protein function: Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
• PDB: 8WST
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	51 → 306	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTII
  RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC
  SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG
  VESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPS
  VPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSS
  INPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF

• Sequence length: 340

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Hormone signaling

Reactome:

Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	19502010

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		19502010, 19927306