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CUL3 (cullin 3)

Gene

8452

Cullin 3

CUL3

CUL-3, NEDAUS, PHA2E

2q36.2

This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase com

Show/Hide all(19)

SNP ID	Visualize variation	Clinical significance	Consequence
rs199469649	A>C	Pathogenic	Intron variant
rs199469650	T>C	Pathogenic	Intron variant
rs199469651	A>C	Pathogenic	Intron variant
rs199469652	A>T	Pathogenic	Intron variant
rs199469653	G>A	Pathogenic	Intron variant
rs199469654	C>T	Pathogenic	Splice acceptor variant
rs199469655	C>T	Pathogenic	Coding sequence variant, synonymous variant
rs199469656	T>C	Pathogenic	Coding sequence variant, missense variant
rs199469657	CCTTTA>-	Pathogenic	Coding sequence variant, intron variant, splice donor variant
rs199469658	T>C	Pathogenic	Coding sequence variant, missense variant
rs199469659	->C	Pathogenic	Coding sequence variant, splice donor variant
rs199469660	C>G	Pathogenic	Splice donor variant
rs199469661	T>C	Pathogenic	Intron variant
rs201496024	G>A,T	Likely-pathogenic	Coding sequence variant, stop gained, synonymous variant
rs886038765	C>T	Likely-pathogenic	Synonymous variant, coding sequence variant
rs1553521389	AG>-	Pathogenic	Stop gained, coding sequence variant
rs1553535841	T>C	Likely-pathogenic	5 prime UTR variant, intron variant, coding sequence variant, missense variant
rs1553602498	G>A	Pathogenic	Stop gained, coding sequence variant
rs1574631977	C>T	Likely-pathogenic	Coding sequence variant, missense variant

Show/Hide all(467)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004141	hsa-miR-192-5p	Microarray	16822819
MIRT032239	hsa-let-7b-5p	Proteomics	18668040
MIRT048703	hsa-miR-99a-5p	CLASH	23622248
MIRT047577	hsa-miR-10a-5p	CLASH	23622248
MIRT040752	hsa-miR-18a-3p	CLASH	23622248
MIRT659260	hsa-miR-15a-5p	HITS-CLIP	23824327
MIRT659259	hsa-miR-15b-5p	HITS-CLIP	23824327
MIRT659258	hsa-miR-16-5p	HITS-CLIP	23824327
MIRT659257	hsa-miR-195-5p	HITS-CLIP	23824327
MIRT659256	hsa-miR-424-5p	HITS-CLIP	23824327
MIRT659255	hsa-miR-497-5p	HITS-CLIP	23824327
MIRT659253	hsa-miR-6838-5p	HITS-CLIP	23824327
MIRT659254	hsa-miR-503-5p	HITS-CLIP	23824327
MIRT659252	hsa-miR-646	HITS-CLIP	23824327
MIRT659250	hsa-miR-4705	HITS-CLIP	23824327
MIRT659251	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT659249	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT659248	hsa-miR-4524a-5p	HITS-CLIP	23824327
MIRT659247	hsa-miR-4524b-5p	HITS-CLIP	23824327
MIRT659246	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT538276	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT538275	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT538274	hsa-miR-3666	PAR-CLIP	21572407
MIRT538273	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT538272	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT538271	hsa-miR-4295	PAR-CLIP	21572407
MIRT538270	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT538269	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT538268	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT538267	hsa-miR-302e	PAR-CLIP	21572407
MIRT538266	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT538265	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT538264	hsa-miR-520b	PAR-CLIP	21572407
MIRT538263	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT538262	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT538261	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT538260	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT538259	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT538258	hsa-miR-520e	PAR-CLIP	21572407
MIRT538257	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT538256	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT538255	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT538254	hsa-miR-3120-3p	PAR-CLIP	21572407
MIRT538253	hsa-miR-5197-3p	PAR-CLIP	21572407
MIRT538252	hsa-miR-4650-3p	PAR-CLIP	21572407
MIRT538251	hsa-miR-3529-5p	PAR-CLIP	21572407
MIRT538250	hsa-miR-379-5p	PAR-CLIP	21572407
MIRT538249	hsa-miR-4451	PAR-CLIP	21572407
MIRT538248	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT538276	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT538275	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT538274	hsa-miR-3666	PAR-CLIP	22012620
MIRT538273	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT538272	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT538271	hsa-miR-4295	PAR-CLIP	22012620
MIRT538270	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT538269	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT538268	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT538267	hsa-miR-302e	PAR-CLIP	22012620
MIRT538266	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT538265	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT538264	hsa-miR-520b	PAR-CLIP	22012620
MIRT538263	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT538262	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT538261	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT538260	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT538259	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT538258	hsa-miR-520e	PAR-CLIP	22012620
MIRT538257	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT538256	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT538255	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT538254	hsa-miR-3120-3p	PAR-CLIP	22012620
MIRT538253	hsa-miR-5197-3p	PAR-CLIP	22012620
MIRT538252	hsa-miR-4650-3p	PAR-CLIP	22012620
MIRT538251	hsa-miR-3529-5p	PAR-CLIP	22012620
MIRT538250	hsa-miR-379-5p	PAR-CLIP	22012620
MIRT538249	hsa-miR-4451	PAR-CLIP	22012620
MIRT538248	hsa-miR-4536-5p	PAR-CLIP	22012620
MIRT447627	hsa-miR-1265	PAR-CLIP	22100165
MIRT447626	hsa-miR-511-3p	PAR-CLIP	22100165
MIRT447625	hsa-miR-1225-3p	PAR-CLIP	22100165
MIRT447624	hsa-miR-1233-3p	PAR-CLIP	22100165
MIRT447622	hsa-miR-4764-5p	PAR-CLIP	22100165
MIRT447623	hsa-miR-3177-5p	PAR-CLIP	22100165
MIRT447621	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT447620	hsa-miR-591	PAR-CLIP	22100165
MIRT447619	hsa-miR-3613-5p	PAR-CLIP	22100165
MIRT447618	hsa-miR-4668-3p	PAR-CLIP	22100165
MIRT447617	hsa-miR-1266-3p	PAR-CLIP	22100165
MIRT447616	hsa-miR-4635	PAR-CLIP	22100165
MIRT447615	hsa-miR-4477a	PAR-CLIP	22100165
MIRT447614	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447627	hsa-miR-1265	PAR-CLIP	22100165
MIRT447626	hsa-miR-511-3p	PAR-CLIP	22100165
MIRT447625	hsa-miR-1225-3p	PAR-CLIP	22100165
MIRT447624	hsa-miR-1233-3p	PAR-CLIP	22100165
MIRT447622	hsa-miR-4764-5p	PAR-CLIP	22100165
MIRT447623	hsa-miR-3177-5p	PAR-CLIP	22100165
MIRT447621	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT447620	hsa-miR-591	PAR-CLIP	22100165
MIRT447619	hsa-miR-3613-5p	PAR-CLIP	22100165
MIRT447618	hsa-miR-4668-3p	PAR-CLIP	22100165
MIRT447617	hsa-miR-1266-3p	PAR-CLIP	22100165
MIRT447616	hsa-miR-4635	PAR-CLIP	22100165
MIRT447615	hsa-miR-4477a	PAR-CLIP	22100165
MIRT447614	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT440856	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440856	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT659260	hsa-miR-15a-5p	Luciferase reporter assay, Microarray, qRT-PCR	31658856
MIRT659258	hsa-miR-16-5p	Microarray	33530159
MIRT659260	hsa-miR-15a-5p	HITS-CLIP	23824327
MIRT659259	hsa-miR-15b-5p	HITS-CLIP	23824327
MIRT659258	hsa-miR-16-5p	HITS-CLIP	23824327
MIRT659257	hsa-miR-195-5p	HITS-CLIP	23824327
MIRT659256	hsa-miR-424-5p	HITS-CLIP	23824327
MIRT659255	hsa-miR-497-5p	HITS-CLIP	23824327
MIRT659253	hsa-miR-6838-5p	HITS-CLIP	23824327
MIRT659254	hsa-miR-503-5p	HITS-CLIP	23824327
MIRT659252	hsa-miR-646	HITS-CLIP	23824327
MIRT659250	hsa-miR-4705	HITS-CLIP	23824327
MIRT659251	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT659249	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT659248	hsa-miR-4524a-5p	HITS-CLIP	23824327
MIRT659247	hsa-miR-4524b-5p	HITS-CLIP	23824327
MIRT659246	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT538276	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT538275	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT538274	hsa-miR-3666	PAR-CLIP	21572407
MIRT538273	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT538272	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT538271	hsa-miR-4295	PAR-CLIP	21572407
MIRT538270	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT538269	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT538268	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT538267	hsa-miR-302e	PAR-CLIP	21572407
MIRT538266	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT538265	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT538264	hsa-miR-520b	PAR-CLIP	21572407
MIRT538263	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT538262	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT538261	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT538260	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT538259	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT538258	hsa-miR-520e	PAR-CLIP	21572407
MIRT538257	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT538256	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT538255	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT538254	hsa-miR-3120-3p	PAR-CLIP	21572407
MIRT538253	hsa-miR-5197-3p	PAR-CLIP	21572407
MIRT538252	hsa-miR-4650-3p	PAR-CLIP	21572407
MIRT538251	hsa-miR-3529-5p	PAR-CLIP	21572407
MIRT538250	hsa-miR-379-5p	PAR-CLIP	21572407
MIRT538249	hsa-miR-4451	PAR-CLIP	21572407
MIRT538248	hsa-miR-4536-5p	PAR-CLIP	21572407
MIRT538276	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT538275	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT538274	hsa-miR-3666	PAR-CLIP	22012620
MIRT538273	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT538272	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT538271	hsa-miR-4295	PAR-CLIP	22012620
MIRT538270	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT538269	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT538268	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT538267	hsa-miR-302e	PAR-CLIP	22012620
MIRT538266	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT538265	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT538264	hsa-miR-520b	PAR-CLIP	22012620
MIRT538263	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT538262	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT538261	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT538260	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT538259	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT538258	hsa-miR-520e	PAR-CLIP	22012620
MIRT538257	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT538256	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT538255	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT538254	hsa-miR-3120-3p	PAR-CLIP	22012620
MIRT538253	hsa-miR-5197-3p	PAR-CLIP	22012620
MIRT538252	hsa-miR-4650-3p	PAR-CLIP	22012620
MIRT538251	hsa-miR-3529-5p	PAR-CLIP	22012620
MIRT538250	hsa-miR-379-5p	PAR-CLIP	22012620
MIRT538249	hsa-miR-4451	PAR-CLIP	22012620
MIRT538248	hsa-miR-4536-5p	PAR-CLIP	22012620
MIRT447627	hsa-miR-1265	PAR-CLIP	22100165
MIRT447626	hsa-miR-511-3p	PAR-CLIP	22100165
MIRT447625	hsa-miR-1225-3p	PAR-CLIP	22100165
MIRT447624	hsa-miR-1233-3p	PAR-CLIP	22100165
MIRT447622	hsa-miR-4764-5p	PAR-CLIP	22100165
MIRT447623	hsa-miR-3177-5p	PAR-CLIP	22100165
MIRT447621	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT447620	hsa-miR-591	PAR-CLIP	22100165
MIRT447619	hsa-miR-3613-5p	PAR-CLIP	22100165
MIRT447618	hsa-miR-4668-3p	PAR-CLIP	22100165
MIRT447617	hsa-miR-1266-3p	PAR-CLIP	22100165
MIRT447616	hsa-miR-4635	PAR-CLIP	22100165
MIRT447615	hsa-miR-4477a	PAR-CLIP	22100165
MIRT447614	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT447627	hsa-miR-1265	PAR-CLIP	22100165
MIRT447626	hsa-miR-511-3p	PAR-CLIP	22100165
MIRT447625	hsa-miR-1225-3p	PAR-CLIP	22100165
MIRT447624	hsa-miR-1233-3p	PAR-CLIP	22100165
MIRT447622	hsa-miR-4764-5p	PAR-CLIP	22100165
MIRT447623	hsa-miR-3177-5p	PAR-CLIP	22100165
MIRT447621	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT447620	hsa-miR-591	PAR-CLIP	22100165
MIRT447619	hsa-miR-3613-5p	PAR-CLIP	22100165
MIRT447618	hsa-miR-4668-3p	PAR-CLIP	22100165
MIRT447617	hsa-miR-1266-3p	PAR-CLIP	22100165
MIRT447616	hsa-miR-4635	PAR-CLIP	22100165
MIRT447615	hsa-miR-4477a	PAR-CLIP	22100165
MIRT447614	hsa-miR-203a-3p	PAR-CLIP	22100165
MIRT916453	hsa-let-7a	CLIP-seq
MIRT916454	hsa-let-7b	CLIP-seq
MIRT916455	hsa-let-7c	CLIP-seq
MIRT916456	hsa-let-7d	CLIP-seq
MIRT916457	hsa-let-7e	CLIP-seq
MIRT916458	hsa-let-7f	CLIP-seq
MIRT916459	hsa-let-7g	CLIP-seq
MIRT916460	hsa-let-7i	CLIP-seq
MIRT916461	hsa-miR-101	CLIP-seq
MIRT916462	hsa-miR-1246	CLIP-seq
MIRT916463	hsa-miR-1251	CLIP-seq
MIRT916464	hsa-miR-127-5p	CLIP-seq
MIRT916465	hsa-miR-1278	CLIP-seq
MIRT916466	hsa-miR-1279	CLIP-seq
MIRT916467	hsa-miR-1294	CLIP-seq
MIRT916468	hsa-miR-1299	CLIP-seq
MIRT916469	hsa-miR-137	CLIP-seq
MIRT916470	hsa-miR-139-5p	CLIP-seq
MIRT916471	hsa-miR-140-5p	CLIP-seq
MIRT916472	hsa-miR-141	CLIP-seq
MIRT916473	hsa-miR-144	CLIP-seq
MIRT916474	hsa-miR-15a	CLIP-seq
MIRT916475	hsa-miR-15b	CLIP-seq
MIRT916476	hsa-miR-16	CLIP-seq
MIRT916477	hsa-miR-181a	CLIP-seq
MIRT916478	hsa-miR-181b	CLIP-seq
MIRT916479	hsa-miR-181c	CLIP-seq
MIRT916480	hsa-miR-181d	CLIP-seq
MIRT916481	hsa-miR-186	CLIP-seq
MIRT916482	hsa-miR-1911	CLIP-seq
MIRT916483	hsa-miR-195	CLIP-seq
MIRT916484	hsa-miR-200a	CLIP-seq
MIRT916485	hsa-miR-202	CLIP-seq
MIRT916486	hsa-miR-2113	CLIP-seq
MIRT916487	hsa-miR-2467-5p	CLIP-seq
MIRT916488	hsa-miR-25	CLIP-seq
MIRT916489	hsa-miR-3123	CLIP-seq
MIRT916490	hsa-miR-3133	CLIP-seq
MIRT916491	hsa-miR-3143	CLIP-seq
MIRT916492	hsa-miR-3159	CLIP-seq
MIRT916493	hsa-miR-3161	CLIP-seq
MIRT916494	hsa-miR-3174	CLIP-seq
MIRT916495	hsa-miR-3180-5p	CLIP-seq
MIRT916496	hsa-miR-3188	CLIP-seq
MIRT916497	hsa-miR-3189-5p	CLIP-seq
MIRT916498	hsa-miR-32	CLIP-seq
MIRT916499	hsa-miR-33a	CLIP-seq
MIRT916500	hsa-miR-33b	CLIP-seq
MIRT916501	hsa-miR-340	CLIP-seq
MIRT916502	hsa-miR-3545-5p	CLIP-seq
MIRT916503	hsa-miR-3613-3p	CLIP-seq
MIRT916504	hsa-miR-363	CLIP-seq
MIRT916505	hsa-miR-3646	CLIP-seq
MIRT916506	hsa-miR-3647-3p	CLIP-seq
MIRT916507	hsa-miR-3664-5p	CLIP-seq
MIRT916508	hsa-miR-367	CLIP-seq
MIRT916509	hsa-miR-3675-3p	CLIP-seq
MIRT916510	hsa-miR-3690	CLIP-seq
MIRT916511	hsa-miR-3714	CLIP-seq
MIRT916512	hsa-miR-3919	CLIP-seq
MIRT916513	hsa-miR-3935	CLIP-seq
MIRT916514	hsa-miR-3973	CLIP-seq
MIRT916515	hsa-miR-3974	CLIP-seq
MIRT916516	hsa-miR-3975	CLIP-seq
MIRT916517	hsa-miR-424	CLIP-seq
MIRT916518	hsa-miR-4254	CLIP-seq
MIRT916519	hsa-miR-4262	CLIP-seq
MIRT916520	hsa-miR-4282	CLIP-seq
MIRT916521	hsa-miR-4293	CLIP-seq
MIRT916522	hsa-miR-4316	CLIP-seq
MIRT916523	hsa-miR-4452	CLIP-seq
MIRT916524	hsa-miR-4458	CLIP-seq
MIRT916525	hsa-miR-4460	CLIP-seq
MIRT916526	hsa-miR-4477b	CLIP-seq
MIRT916527	hsa-miR-4493	CLIP-seq
MIRT916528	hsa-miR-4500	CLIP-seq
MIRT916529	hsa-miR-451b	CLIP-seq
MIRT916530	hsa-miR-4524	CLIP-seq
MIRT916531	hsa-miR-4684-5p	CLIP-seq
MIRT916532	hsa-miR-4695-3p	CLIP-seq
MIRT916533	hsa-miR-4698	CLIP-seq
MIRT916534	hsa-miR-4699-5p	CLIP-seq
MIRT916535	hsa-miR-4709-3p	CLIP-seq
MIRT916536	hsa-miR-4714-5p	CLIP-seq
MIRT916537	hsa-miR-4758-3p	CLIP-seq
MIRT916538	hsa-miR-4760-5p	CLIP-seq
MIRT916539	hsa-miR-4761-5p	CLIP-seq
MIRT916540	hsa-miR-4781-3p	CLIP-seq
MIRT916541	hsa-miR-485-3p	CLIP-seq
MIRT916542	hsa-miR-485-5p	CLIP-seq
MIRT916543	hsa-miR-494	CLIP-seq
MIRT916544	hsa-miR-497	CLIP-seq
MIRT916545	hsa-miR-503	CLIP-seq
MIRT916546	hsa-miR-515-5p	CLIP-seq
MIRT916547	hsa-miR-520a-5p	CLIP-seq
MIRT916548	hsa-miR-525-5p	CLIP-seq
MIRT916549	hsa-miR-543	CLIP-seq
MIRT916550	hsa-miR-545	CLIP-seq
MIRT916551	hsa-miR-548ag	CLIP-seq
MIRT916552	hsa-miR-548ai	CLIP-seq
MIRT916553	hsa-miR-548c-3p	CLIP-seq
MIRT916554	hsa-miR-548l	CLIP-seq
MIRT916555	hsa-miR-548p	CLIP-seq
MIRT916556	hsa-miR-570	CLIP-seq
MIRT916557	hsa-miR-577	CLIP-seq
MIRT916558	hsa-miR-579	CLIP-seq
MIRT916559	hsa-miR-671-5p	CLIP-seq
MIRT916560	hsa-miR-758	CLIP-seq
MIRT916561	hsa-miR-802	CLIP-seq
MIRT916562	hsa-miR-875-3p	CLIP-seq
MIRT916563	hsa-miR-885-5p	CLIP-seq
MIRT916564	hsa-miR-92a	CLIP-seq
MIRT916565	hsa-miR-92b	CLIP-seq
MIRT916566	hsa-miR-98	CLIP-seq
MIRT916461	hsa-miR-101	CLIP-seq
MIRT1971835	hsa-miR-124	CLIP-seq
MIRT916470	hsa-miR-139-5p	CLIP-seq
MIRT916473	hsa-miR-144	CLIP-seq
MIRT916474	hsa-miR-15a	CLIP-seq
MIRT916475	hsa-miR-15b	CLIP-seq
MIRT916476	hsa-miR-16	CLIP-seq
MIRT916477	hsa-miR-181a	CLIP-seq
MIRT916478	hsa-miR-181b	CLIP-seq
MIRT916479	hsa-miR-181c	CLIP-seq
MIRT916480	hsa-miR-181d	CLIP-seq
MIRT916483	hsa-miR-195	CLIP-seq
MIRT1971836	hsa-miR-2054	CLIP-seq
MIRT1971837	hsa-miR-23a	CLIP-seq
MIRT1971838	hsa-miR-23b	CLIP-seq
MIRT1971839	hsa-miR-23c	CLIP-seq
MIRT916488	hsa-miR-25	CLIP-seq
MIRT1971840	hsa-miR-3074-5p	CLIP-seq
MIRT1971841	hsa-miR-3140-3p	CLIP-seq
MIRT916491	hsa-miR-3143	CLIP-seq
MIRT916495	hsa-miR-3180-5p	CLIP-seq
MIRT1971842	hsa-miR-3184	CLIP-seq
MIRT916498	hsa-miR-32	CLIP-seq
MIRT1971843	hsa-miR-3607-3p	CLIP-seq
MIRT916504	hsa-miR-363	CLIP-seq
MIRT916508	hsa-miR-367	CLIP-seq
MIRT916509	hsa-miR-3675-3p	CLIP-seq
MIRT1971844	hsa-miR-371-5p	CLIP-seq
MIRT1971845	hsa-miR-371b-5p	CLIP-seq
MIRT1971846	hsa-miR-3928	CLIP-seq
MIRT1971847	hsa-miR-3942-3p	CLIP-seq
MIRT1971848	hsa-miR-410	CLIP-seq
MIRT1971849	hsa-miR-423-5p	CLIP-seq
MIRT916517	hsa-miR-424	CLIP-seq
MIRT1971850	hsa-miR-4257	CLIP-seq
MIRT916519	hsa-miR-4262	CLIP-seq
MIRT1971851	hsa-miR-4270	CLIP-seq
MIRT1971852	hsa-miR-4441	CLIP-seq
MIRT1971853	hsa-miR-4443	CLIP-seq
MIRT1971854	hsa-miR-4446-5p	CLIP-seq
MIRT1971855	hsa-miR-4496	CLIP-seq
MIRT1971856	hsa-miR-4522	CLIP-seq
MIRT916530	hsa-miR-4524	CLIP-seq
MIRT1971857	hsa-miR-4656	CLIP-seq
MIRT1971858	hsa-miR-4680-3p	CLIP-seq
MIRT916531	hsa-miR-4684-5p	CLIP-seq
MIRT916532	hsa-miR-4695-3p	CLIP-seq
MIRT1971859	hsa-miR-4740-3p	CLIP-seq
MIRT916541	hsa-miR-485-3p	CLIP-seq
MIRT916544	hsa-miR-497	CLIP-seq
MIRT916545	hsa-miR-503	CLIP-seq
MIRT1971860	hsa-miR-506	CLIP-seq
MIRT1971861	hsa-miR-513a-3p	CLIP-seq
MIRT1971862	hsa-miR-514	CLIP-seq
MIRT1971863	hsa-miR-514b-3p	CLIP-seq
MIRT916547	hsa-miR-520a-5p	CLIP-seq
MIRT916548	hsa-miR-525-5p	CLIP-seq
MIRT916549	hsa-miR-543	CLIP-seq
MIRT1971864	hsa-miR-548an	CLIP-seq
MIRT916556	hsa-miR-570	CLIP-seq
MIRT1971865	hsa-miR-576-5p	CLIP-seq
MIRT916558	hsa-miR-579	CLIP-seq
MIRT1971866	hsa-miR-765	CLIP-seq
MIRT1971867	hsa-miR-9	CLIP-seq
MIRT916564	hsa-miR-92a	CLIP-seq
MIRT916565	hsa-miR-92b	CLIP-seq
MIRT916461	hsa-miR-101	CLIP-seq
MIRT2207496	hsa-miR-1200	CLIP-seq
MIRT2207497	hsa-miR-1284	CLIP-seq
MIRT2207498	hsa-miR-1343	CLIP-seq
MIRT916470	hsa-miR-139-5p	CLIP-seq
MIRT916473	hsa-miR-144	CLIP-seq
MIRT916474	hsa-miR-15a	CLIP-seq
MIRT916475	hsa-miR-15b	CLIP-seq
MIRT916476	hsa-miR-16	CLIP-seq
MIRT916482	hsa-miR-1911	CLIP-seq
MIRT916483	hsa-miR-195	CLIP-seq
MIRT1971837	hsa-miR-23a	CLIP-seq
MIRT1971838	hsa-miR-23b	CLIP-seq
MIRT1971839	hsa-miR-23c	CLIP-seq
MIRT2207499	hsa-miR-300	CLIP-seq
MIRT916490	hsa-miR-3133	CLIP-seq
MIRT916491	hsa-miR-3143	CLIP-seq
MIRT2207500	hsa-miR-3160-3p	CLIP-seq
MIRT916494	hsa-miR-3174	CLIP-seq
MIRT916495	hsa-miR-3180-5p	CLIP-seq
MIRT2207501	hsa-miR-3618	CLIP-seq
MIRT2207502	hsa-miR-381	CLIP-seq
MIRT916517	hsa-miR-424	CLIP-seq
MIRT2207503	hsa-miR-4251	CLIP-seq
MIRT2207504	hsa-miR-4274	CLIP-seq
MIRT2207505	hsa-miR-4324	CLIP-seq
MIRT2207506	hsa-miR-4487	CLIP-seq
MIRT2207507	hsa-miR-4511	CLIP-seq
MIRT2207508	hsa-miR-4519	CLIP-seq
MIRT916530	hsa-miR-4524	CLIP-seq
MIRT2207509	hsa-miR-455-3p	CLIP-seq
MIRT2207510	hsa-miR-4666-3p	CLIP-seq
MIRT916532	hsa-miR-4695-3p	CLIP-seq
MIRT916544	hsa-miR-497	CLIP-seq
MIRT916545	hsa-miR-503	CLIP-seq
MIRT1971861	hsa-miR-513a-3p	CLIP-seq
MIRT916547	hsa-miR-520a-5p	CLIP-seq
MIRT916548	hsa-miR-525-5p	CLIP-seq
MIRT916549	hsa-miR-543	CLIP-seq
MIRT916550	hsa-miR-545	CLIP-seq
MIRT916555	hsa-miR-548p	CLIP-seq
MIRT2207511	hsa-miR-558	CLIP-seq
MIRT1971865	hsa-miR-576-5p	CLIP-seq
MIRT2207512	hsa-miR-590-3p	CLIP-seq
MIRT2207513	hsa-miR-664	CLIP-seq
MIRT2207514	hsa-miR-934	CLIP-seq
MIRT2510722	hsa-miR-106a	CLIP-seq
MIRT2510723	hsa-miR-106b	CLIP-seq
MIRT2510724	hsa-miR-1283	CLIP-seq
MIRT2510725	hsa-miR-17	CLIP-seq
MIRT916481	hsa-miR-186	CLIP-seq
MIRT2510726	hsa-miR-20a	CLIP-seq
MIRT2510727	hsa-miR-20b	CLIP-seq
MIRT2510728	hsa-miR-302a	CLIP-seq
MIRT2510729	hsa-miR-302b	CLIP-seq
MIRT2510730	hsa-miR-302c	CLIP-seq
MIRT2510731	hsa-miR-302d	CLIP-seq
MIRT916490	hsa-miR-3133	CLIP-seq
MIRT2510732	hsa-miR-372	CLIP-seq
MIRT2510733	hsa-miR-373	CLIP-seq
MIRT2510734	hsa-miR-3941	CLIP-seq
MIRT2510735	hsa-miR-4639-5p	CLIP-seq
MIRT2510736	hsa-miR-466	CLIP-seq
MIRT2510737	hsa-miR-4661-5p	CLIP-seq
MIRT2510738	hsa-miR-4672	CLIP-seq
MIRT2510739	hsa-miR-4731-3p	CLIP-seq
MIRT2510740	hsa-miR-4744	CLIP-seq
MIRT2510741	hsa-miR-4801	CLIP-seq
MIRT2510742	hsa-miR-519d	CLIP-seq
MIRT2510743	hsa-miR-520g	CLIP-seq
MIRT2510744	hsa-miR-520h	CLIP-seq
MIRT2510745	hsa-miR-93	CLIP-seq
MIRT916481	hsa-miR-186	CLIP-seq
MIRT916490	hsa-miR-3133	CLIP-seq
MIRT2510737	hsa-miR-4661-5p	CLIP-seq
MIRT2510740	hsa-miR-4744	CLIP-seq

Show/Hide all(59)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	TAS	8681378
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000139	Component	Golgi membrane	IEA
GO:0000165	Process	MAPK cascade	TAS
GO:0000209	Process	Protein polyubiquitination	IDA	14528312, 19261606
GO:0000922	Component	Spindle pole	IDA	23213400
GO:0001831	Process	Trophectodermal cellular morphogenesis	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	15983046, 19261606, 19782033, 20389280
GO:0005112	Function	Notch binding	IPI	25401743
GO:0005515	Function	Protein binding	IPI	12609982, 14528312, 18397884, 18573101, 18775313, 18826954, 19261606, 19427028, 19617556, 20389280, 21145461, 21577200, 21778237, 21828050, 21988832, 22466964, 22748208, 22939624, 23213400, 23563313, 23665031, 23776465, 24192928, 25270598, 25416956, 25502805, 26334369, 26906416, 269
GO:0005634	Component	Nucleus	IDA	23213400
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	28395323
GO:0005813	Component	Centrosome	IDA	23213400
GO:0005827	Component	Polar microtubule	IDA	19995937
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	19617556
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	25401743, 27561354
GO:0006513	Process	Protein monoubiquitination	IDA	22358839
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IDA	22358839
GO:0007080	Process	Mitotic metaphase plate congression	IMP	17543862, 19995937
GO:0007229	Process	Integrin-mediated signaling pathway	ISS
GO:0007369	Process	Gastrulation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	TAS	9733711
GO:0016020	Component	Membrane	HDA	19946888
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016477	Process	Cell migration	IMP	19782033
GO:0016567	Process	Protein ubiquitination	IBA	21873635
GO:0016567	Process	Protein ubiquitination	IDA	17543862, 19782033, 19995937, 20389280, 23213400
GO:0017145	Process	Stem cell division	ISS
GO:0030030	Process	Cell projection organization	IEA
GO:0030332	Function	Cyclin binding	IEA
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	IDA	10500095
GO:0031208	Function	POZ domain binding	IDA	14528312, 19261606
GO:0031398	Process	Positive regulation of protein ubiquitination	IGI	24844779
GO:0031461	Component	Cullin-RING ubiquitin ligase complex	IBA	21873635
GO:0031463	Component	Cul3-RING ubiquitin ligase complex	IDA	14528312, 15983046, 17543862, 19158078, 19261606, 19782033, 19995937, 20389280, 22358839, 22578813, 23453970, 23455478, 23576762, 24768539, 26399832
GO:0031625	Function	Ubiquitin protein ligase binding	IBA	21873635
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	14528312
GO:0031648	Process	Protein destabilization	IGI	24844779
GO:0032467	Process	Positive regulation of cytokinesis	IMP	19261606
GO:0035024	Process	Negative regulation of Rho protein signal transduction	IMP	19782033
GO:0036126	Component	Sperm flagellum	IDA	28395323
GO:0040016	Process	Embryonic cleavage	ISS
GO:0043149	Process	Stress fiber assembly	IMP	19782033
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	19261606, 19782033, 20389280
GO:0043687	Process	Post-translational protein modification	TAS
GO:0044346	Process	Fibroblast apoptotic process	IEA
GO:0045842	Process	Positive regulation of mitotic metaphase/anaphase transition	IMP	17543862
GO:0048208	Process	COPII vesicle coating	IMP	22358839
GO:0051865	Process	Protein autoubiquitination	IDA	14528312
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	14528312
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0071630	Process	Nuclear protein quality control by the ubiquitin-proteasome system	IDA	27561354
GO:0072576	Process	Liver morphogenesis	IEA
GO:0072686	Component	Mitotic spindle	IDA	23213400
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	TAS
GO:0097193	Process	Intrinsic apoptotic signaling pathway	TAS	8681378
GO:1901992	Process	Positive regulation of mitotic cell cycle phase transition	IMP	23213400

MIM	HGNC	e!Ensembl
603136	2553	ENSG00000036257

Protein

UniProt ID

Q13618

Protein name

Cullin-3 (CUL-3)

Protein function

Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to m

PDB

2MYL , 2MYM , 4AP2 , 4APF , 4EOZ , 4HXI , 5NLB , 6I2M , 8GQ6 , 8H33 , 8H34 , 8H35 , 8H36 , 8H37 , 8H38 , 8H3A , 8H3F , 8H3Q , 8H3R , 8I79 , 8K8T , 8K9I , 8KHP , 8U80 , 8U81 , 8U82 , 8U83 , 8U84

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00888	Cullin	34 → 665	Cullin family	Family
PF10557	Cullin_Nedd8	698 → 760	Cullin protein neddylation domain	Domain

Sequence

MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRN
AYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIR
DILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR
GAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEAR
INEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMY
KLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESF
NNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFR
FMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSIS
NTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYL
AKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMT
ILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFT
VNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHN
VLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA

Sequence length

768

Interactions

View interactions

	KEGG		Reactome
	Ubiquitin mediated proteolysis Hedgehog signaling pathway		Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Show/Hide Causal Diseases (7)

Causal
Disease name	Disease term	dbSNP ID	References
Hypertension	Hypertensive disease	rs13306026, rs13333226
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22535842
Multiple congenital anomalies	Multiple congenital anomalies	rs1057517732	18687424, 22495309, 23676014, 15071497, 10500095, 20065088, 16162871, 27824329, 21554755, 3002982, 22914163, 15511641, 24266877, 24267886, 23665959, 25969726, 18927510, 16595883, 15843622, 20880695, 24959344, 22266938, 17559828, 25363760, 15136734
Neurodevelopmental disorders	Neurodevelopmental Disorders	rs869312846, rs869312840, rs869312848, rs869312849, rs869312845, rs886041956, rs1064795110, rs1555762734, rs1555764992, rs1568512728, rs1568532361, rs1595472741, rs1595472764, rs1595476797, rs1016320330, rs1595127294, rs1600392059	28191889
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475
Pseudohypoaldosteronism	Pseudohypoaldosteronism, Pseudohypoaldosteronism, Type I, Autosomal Dominant, Pseudohypoaldosteronism, Type II, Pseudohypoaldosteronism, Type IIa, PSEUDOHYPOALDOSTERONISM, TYPE IIE, Pseudohypoaldosteronism type 2E	rs137853092, rs137853093, rs137853094, rs121912562, rs1560949756, rs1560910156, rs121912563, rs1560735659, rs121912564, rs121912565, rs121912566, rs121912567, rs121912568, rs121912569, rs121912570, rs121912571, rs121912572, rs121912573, rs121912574, rs1596779402, rs1567262640, rs1596779433, rs199469656, rs199469639, rs199469641, rs199469636, rs199469638, rs199469640, rs199469635, rs199469632, rs387907155, rs562736621, rs387907156, rs199469651, rs199469654, rs199469650, rs199469649, rs199469653, rs199469652, rs199469655, rs199469658, rs199469657, rs199469659, rs199469660, rs199469661, rs199469644, rs199469647, rs199469648, rs199469633, rs199469623, rs199469626, rs199469625, rs199469642, rs199469624, rs199469634, rs199469637, rs199469627, rs199469629, rs199469631, rs879255348, rs886038765, rs1131691921, rs1553523940, rs748573472, rs1553535841, rs1553986377, rs1560928649, rs550424284	22266938
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	30285260, 25056061, 29483656, 26198764, 28991256, 31268507

Show/Hide Unknown Diseases (3)

Unknown
Disease name	Disease term	dbSNP ID	References
Dysmorphic features	Dysmorphic features		23665959, 15843622, 27824329, 21554755, 23676014, 22266938, 22914163, 20065088, 24266877, 25969726, 25363760, 10500095, 16162871, 15136734, 20880695, 18687424, 18927510, 22495309, 17559828, 24959344, 3002982, 15071497, 24267886, 16595883, 15511641
Hyperchloremia	Hyperchloremia
Prostatic neoplasms	Prostatic Neoplasms		29610475

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