Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
8428 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Serine/threonine kinase 24 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
STK24 |
SynonymsGene synonyms aliases
|
HEL-S-95, MST3, MST3B, STE20, STK3 |
ChromosomeChromosome number
|
13 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
13q32.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0004672 |
Function |
Protein kinase activity |
TAS |
9353338 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IDA |
16314523, 17046825 |
GO:0005515 |
Function |
Protein binding |
IPI |
16189514, 17657516, 18782753, 20332113, 21516116, 23455922, 23541896, 25531779, 27807006, 28169274, 31515488 |
GO:0005524 |
Function |
ATP binding |
IEA |
|
GO:0005634 |
Component |
Nucleus |
IDA |
12107159 |
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005730 |
Component |
Nucleolus |
IDA |
|
GO:0005737 |
Component |
Cytoplasm |
IDA |
12107159, 25468996 |
GO:0005737 |
Component |
Cytoplasm |
TAS |
27807006 |
GO:0005794 |
Component |
Golgi apparatus |
TAS |
27807006 |
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0006468 |
Process |
Protein phosphorylation |
IDA |
19604147 |
GO:0007165 |
Process |
Signal transduction |
TAS |
9353338 |
GO:0008631 |
Process |
Intrinsic apoptotic signaling pathway in response to oxidative stress |
IMP |
19604147 |
GO:0009267 |
Process |
Cellular response to starvation |
IMP |
27807006 |
GO:0016020 |
Component |
Membrane |
IEA |
|
GO:0030336 |
Process |
Negative regulation of cell migration |
IMP |
17046825, 27807006 |
GO:0042542 |
Process |
Response to hydrogen peroxide |
IDA |
22291017 |
GO:0045296 |
Function |
Cadherin binding |
HDA |
25468996 |
GO:0046777 |
Process |
Protein autophosphorylation |
IDA |
17046825, 17657516 |
GO:0046777 |
Process |
Protein autophosphorylation |
IMP |
27807006 |
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:0048679 |
Process |
Regulation of axon regeneration |
IMP |
19855390 |
GO:0070062 |
Component |
Extracellular exosome |
HDA |
19056867, 23533145 |
GO:0097194 |
Process |
Execution phase of apoptosis |
IMP |
12107159 |
GO:0097194 |
Process |
Execution phase of apoptosis |
TAS |
|
GO:0106310 |
Function |
Protein serine kinase activity |
IEA |
|
GO:0106311 |
Function |
Protein threonine kinase activity |
IEA |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q9Y6E0 |
Protein name |
Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/ |
Protein function |
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 |
PDB |
3A7F
,
3A7G
,
3A7H
,
3A7I
,
3A7J
,
3CKW
,
3CKX
,
3ZHP
,
4O27
,
4QML
,
4QMM
,
4QMN
,
4QMO
,
4QMP
,
4QMQ
,
4QMS
,
4QMT
,
4QMU
,
4QMV
,
4QMW
,
4QMX
,
4QMY
,
4QMZ
,
4QNA
,
4QO9
,
4U8Z
,
4W8D
,
4W8E
,
7B30
,
7B31
,
7B32
,
7B33
,
7B34
,
7B35
,
8BZI
,
8BZJ
,
8QLQ
,
8QLR
,
8QLS
,
8QLT
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069 |
Pkinase |
36 → 286 |
Protein kinase domain |
Domain |
|
Sequence |
|
Sequence length |
443 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
31374203 |
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