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STK24 (serine/threonine kinase 24)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8428
Gene nameGene Name - the full gene name approved by the HGNC.
Serine/threonine kinase 24
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
STK24
SynonymsGene synonyms aliases
HEL-S-95, MST3, MST3B, STE20, STK3
ChromosomeChromosome number
13
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q32.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020540 hsa-miR-155-5p Proteomics 18668040
MIRT023521 hsa-miR-1-3p Proteomics 18668040
MIRT045062 hsa-miR-186-5p CLASH 23622248
MIRT036877 hsa-miR-877-3p CLASH 23622248
MIRT720090 hsa-miR-140-5p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004672 Function Protein kinase activity TAS 9353338
GO:0004674 Function Protein serine/threonine kinase activity IDA 16314523, 17046825
GO:0005515 Function Protein binding IPI 16189514, 17657516, 18782753, 20332113, 21516116, 23455922, 23541896, 25531779, 27807006, 28169274, 31515488
GO:0005524 Function ATP binding IEA
GO:0005634 Component Nucleus IDA 12107159
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9Y6E0
Protein name Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/
Protein function Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2
PDB 3A7F , 3A7G , 3A7H , 3A7I , 3A7J , 3CKW , 3CKX , 3ZHP , 4O27 , 4QML , 4QMM , 4QMN , 4QMO , 4QMP , 4QMQ , 4QMS , 4QMT , 4QMU , 4QMV , 4QMW , 4QMX , 4QMY , 4QMZ , 4QNA , 4QO9 , 4U8Z , 4W8D , 4W8E , 7B30 , 7B31 , 7B32 , 7B33 , 7B34 , 7B35 , 8BZI , 8BZJ , 8QLQ , 8QLR , 8QLS , 8QLT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase
36 286
Protein kinase domain
Domain
Sequence
MDSRAQLWGLALNKRRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQK
VVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSAL
DLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQ
LTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVL
FLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI
LRNAKKTSYLTELI
DRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLD
RNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISD
TMVAQLVQRLQRYSLSGGGTSSH
Sequence length 443
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 31374203
Unknown
Disease name Disease term dbSNP ID References
Mental depression Major Depressive Disorder rs587778876, rs587778877 30718901

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